Incidental Mutation 'IGL00901:Tnks'
ID27986
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tnks
Ensembl Gene ENSMUSG00000031529
Gene Nametankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
SynonymsmTNKS1, 4930554K12Rik, D130072O21Rik, TANK1, tankyrase 1
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00901
Quality Score
Status
Chromosome8
Chromosomal Location34826460-34965690 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 34838395 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 92 (Y92*)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033929]
Predicted Effect probably null
Transcript: ENSMUST00000033929
AA Change: Y1236*
SMART Domains Protein: ENSMUSP00000033929
Gene: ENSMUSG00000031529
AA Change: Y1236*

DomainStartEndE-ValueType
low complexity region 8 17 N/A INTRINSIC
low complexity region 20 55 N/A INTRINSIC
low complexity region 68 86 N/A INTRINSIC
low complexity region 91 175 N/A INTRINSIC
ANK 208 237 4.26e-4 SMART
ANK 241 270 3.23e-4 SMART
ANK 274 303 3.28e-5 SMART
ANK 327 355 2.66e3 SMART
ANK 361 390 7.64e-6 SMART
ANK 394 423 2.62e-4 SMART
ANK 427 456 1.99e-4 SMART
ANK 514 546 3.18e-3 SMART
ANK 550 579 1.51e-4 SMART
ANK 583 612 4.26e-4 SMART
ANK 642 670 2.21e3 SMART
ANK 676 705 4.03e-5 SMART
ANK 709 738 2.48e-5 SMART
ANK 742 771 1.64e-5 SMART
low complexity region 792 810 N/A INTRINSIC
ANK 829 858 1.47e-7 SMART
ANK 862 891 2.21e-2 SMART
ANK 895 924 3.13e-2 SMART
low complexity region 996 1010 N/A INTRINSIC
SAM 1017 1082 1.14e-12 SMART
Pfam:PARP 1098 1303 1.5e-28 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000209632
AA Change: Y42*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209904
Predicted Effect probably null
Transcript: ENSMUST00000210014
AA Change: Y92*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210870
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele fail to exhibit any abonormalities. Male mice homozygous for a gene trapped allele exhibit decreased fat pad weight, increased metabolism, hyperinsulinemia, and hypoglycemia. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930432K21Rik A G 8: 84,166,771 D189G probably damaging Het
Acot6 A G 12: 84,106,476 Y164C probably benign Het
Anpep A G 7: 79,839,423 S334P probably benign Het
Arhgef1 A G 7: 24,912,693 E129G probably damaging Het
Bmt2 G T 6: 13,628,749 H312N probably damaging Het
Ces2g A G 8: 104,965,129 Y272C probably benign Het
Cfap69 T A 5: 5,619,162 probably benign Het
Cftr T C 6: 18,268,430 probably null Het
Clec2g A G 6: 128,948,692 probably benign Het
Cyp2b9 A T 7: 26,198,505 I245F probably damaging Het
Fbxo6 T A 4: 148,146,143 I221F probably damaging Het
Fbxw21 A C 9: 109,156,399 C104G probably benign Het
Flna A G X: 74,229,928 S101P probably damaging Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Ift88 T A 14: 57,444,445 F229I probably damaging Het
Map2k3 T C 11: 60,941,921 S31P probably benign Het
Mia2 A G 12: 59,108,029 D176G probably damaging Het
Olfr102 T G 17: 37,313,707 K226Q possibly damaging Het
Olfr1145 A G 2: 87,810,648 Y276C probably damaging Het
Olfr127 T A 17: 37,904,257 V237D probably damaging Het
Pde7b C T 10: 20,619,129 probably null Het
Polr3b T C 10: 84,631,796 I80T possibly damaging Het
Prpf4b T A 13: 34,894,482 Y692N probably damaging Het
Rabl2 T C 15: 89,590,270 probably benign Het
Rasgrp1 T C 2: 117,285,130 K659R probably damaging Het
Ryr3 A T 2: 112,886,589 S774T probably damaging Het
Sema5b C T 16: 35,651,315 T426M probably damaging Het
Serpinb10 A G 1: 107,540,996 K123R probably benign Het
Slc33a1 T C 3: 63,964,012 D60G probably benign Het
Tvp23b T A 11: 62,883,780 probably benign Het
Wnk1 T A 6: 119,960,708 Q1218L probably damaging Het
Other mutations in Tnks
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00498:Tnks APN 8 34861689 splice site probably benign
IGL01448:Tnks APN 8 34839982 missense probably damaging 1.00
IGL01455:Tnks APN 8 34940900 missense probably damaging 0.99
IGL01962:Tnks APN 8 34869524 missense probably damaging 1.00
IGL02088:Tnks APN 8 34839994 missense possibly damaging 0.50
IGL02260:Tnks APN 8 34842983 missense probably damaging 0.99
IGL02454:Tnks APN 8 34831728 unclassified probably benign
IGL02486:Tnks APN 8 34851198 missense probably damaging 1.00
IGL02612:Tnks APN 8 34849299 missense possibly damaging 0.48
IGL03179:Tnks APN 8 34848670 missense probably benign 0.38
IGL03404:Tnks APN 8 34940704 missense probably damaging 1.00
R0256:Tnks UTSW 8 34861547 missense probably benign 0.07
R0265:Tnks UTSW 8 34839970 nonsense probably null
R0334:Tnks UTSW 8 34853259 nonsense probably null
R0414:Tnks UTSW 8 34853309 missense probably damaging 1.00
R0526:Tnks UTSW 8 34853303 missense probably benign 0.23
R0622:Tnks UTSW 8 34940822 missense probably damaging 1.00
R1445:Tnks UTSW 8 34834603 splice site probably benign
R1618:Tnks UTSW 8 34875276 missense probably damaging 1.00
R1779:Tnks UTSW 8 34857518 missense probably benign 0.18
R1919:Tnks UTSW 8 34875232 missense probably damaging 1.00
R1938:Tnks UTSW 8 34838530 missense probably damaging 1.00
R2018:Tnks UTSW 8 34851106 missense probably damaging 1.00
R2198:Tnks UTSW 8 34848649 missense probably benign
R2198:Tnks UTSW 8 34873067 missense probably benign 0.29
R2925:Tnks UTSW 8 34965661 missense unknown
R3828:Tnks UTSW 8 34873178 missense probably damaging 1.00
R3913:Tnks UTSW 8 34873074 missense probably damaging 0.99
R3916:Tnks UTSW 8 34853361 missense probably damaging 1.00
R3917:Tnks UTSW 8 34853361 missense probably damaging 1.00
R3930:Tnks UTSW 8 34940812 missense probably damaging 1.00
R4659:Tnks UTSW 8 34849311 missense possibly damaging 0.53
R4760:Tnks UTSW 8 34851783 missense probably benign 0.38
R5091:Tnks UTSW 8 34841809 missense probably benign 0.40
R5419:Tnks UTSW 8 34965566 missense unknown
R5558:Tnks UTSW 8 34965665 start codon destroyed probably null
R5582:Tnks UTSW 8 34940861 missense probably benign 0.14
R6035:Tnks UTSW 8 34918461 missense possibly damaging 0.93
R6035:Tnks UTSW 8 34918461 missense possibly damaging 0.93
R6495:Tnks UTSW 8 34839966 critical splice donor site probably null
R6527:Tnks UTSW 8 34873093 missense probably benign 0.36
R6991:Tnks UTSW 8 34834493 missense probably damaging 1.00
R7015:Tnks UTSW 8 34838547 missense probably benign 0.04
R7038:Tnks UTSW 8 34851636 missense probably damaging 0.99
R7057:Tnks UTSW 8 34840014 missense probably damaging 1.00
R7167:Tnks UTSW 8 34849304 missense probably damaging 0.98
R7250:Tnks UTSW 8 34851758 missense probably damaging 0.98
R7475:Tnks UTSW 8 34831712 missense probably damaging 1.00
R7790:Tnks UTSW 8 34861540 missense probably benign 0.01
R7818:Tnks UTSW 8 34873028 missense probably benign 0.03
R7909:Tnks UTSW 8 34940704 missense probably damaging 1.00
R7990:Tnks UTSW 8 34940704 missense probably damaging 1.00
Z1177:Tnks UTSW 8 34965145 missense probably benign 0.04
Posted On2013-04-17