Incidental Mutation 'IGL02104:Olfr1440'
ID279880
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1440
Ensembl Gene ENSMUSG00000046650
Gene Nameolfactory receptor 1440
SynonymsMOR215-1, GA_x6K02T2RE5P-2725206-2726153
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.075) question?
Stock #IGL02104
Quality Score
Status
Chromosome19
Chromosomal Location12387279-12401584 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 12394899 bp
ZygosityHeterozygous
Amino Acid Change Valine to Aspartic acid at position 212 (V212D)
Ref Sequence ENSEMBL: ENSMUSP00000148978 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054567] [ENSMUST00000213657] [ENSMUST00000213894] [ENSMUST00000216145] [ENSMUST00000217062]
AlphaFold Q8VFV4
Predicted Effect probably damaging
Transcript: ENSMUST00000054567
AA Change: V212D

PolyPhen 2 Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000054798
Gene: ENSMUSG00000046650
AA Change: V212D

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 7.5e-52 PFAM
Pfam:7tm_1 42 291 7.2e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208644
AA Change: V212D
Predicted Effect probably damaging
Transcript: ENSMUST00000213657
AA Change: V212D

PolyPhen 2 Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000213894
AA Change: V212D

PolyPhen 2 Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214082
Predicted Effect probably damaging
Transcript: ENSMUST00000216145
AA Change: V212D

PolyPhen 2 Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216169
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216773
Predicted Effect probably damaging
Transcript: ENSMUST00000217062
AA Change: V212D

PolyPhen 2 Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933440M02Rik T C 7: 125,331,542 noncoding transcript Het
Abcb5 T A 12: 118,940,680 Q125L probably damaging Het
Acap3 G A 4: 155,905,085 R662H probably damaging Het
Aox4 T A 1: 58,236,657 probably benign Het
Aqp6 T C 15: 99,604,278 S285P probably benign Het
Arhgef5 A T 6: 43,272,411 Q32L probably damaging Het
B3gnt6 G T 7: 98,194,101 D217E probably damaging Het
Chd6 T C 2: 160,977,512 I1338V probably benign Het
Clic6 A G 16: 92,498,479 E9G possibly damaging Het
Col11a1 T A 3: 114,181,397 probably null Het
Dcdc2b T A 4: 129,611,074 D88V probably benign Het
Dis3l T A 9: 64,310,329 K791N possibly damaging Het
Dmxl2 A T 9: 54,404,015 Y1008* probably null Het
Dnah11 A G 12: 118,192,390 V175A probably benign Het
Efl1 A G 7: 82,658,055 probably null Het
Fam117b C T 1: 59,949,119 T219I probably benign Het
Fgf21 T A 7: 45,615,224 Q28L probably benign Het
Folh1 T C 7: 86,744,430 Q391R possibly damaging Het
Gars A G 6: 55,077,697 D663G probably damaging Het
Lats2 A G 14: 57,734,012 F69L probably damaging Het
Lrp2 C T 2: 69,510,418 V1038M probably damaging Het
Map3k1 A T 13: 111,756,243 V826E probably damaging Het
Mapkap1 T A 2: 34,623,470 Y497* probably null Het
Mast3 T C 8: 70,787,906 I296V possibly damaging Het
Mon1a T G 9: 107,901,615 L346R probably damaging Het
Mphosph8 T C 14: 56,674,579 L353S probably benign Het
Muc5ac T C 7: 141,811,078 Y2634H probably damaging Het
Mylk A G 16: 34,815,435 T9A probably benign Het
Olfr1031 G T 2: 85,992,386 D190Y probably damaging Het
Olfr1484 T A 19: 13,585,604 M57K probably damaging Het
Olfr418 T C 1: 173,271,036 V287A probably damaging Het
Olfr543 C A 7: 102,477,337 V178F probably damaging Het
Olfr761 A C 17: 37,952,291 H244Q probably damaging Het
Olfr843 A T 9: 19,248,870 H176Q probably benign Het
Pabpc2 A C 18: 39,774,883 Q400H possibly damaging Het
Pigg A G 5: 108,342,097 Y856C probably damaging Het
Plekhn1 A T 4: 156,222,408 V508E probably benign Het
Pom121l2 C A 13: 21,982,275 H239N possibly damaging Het
Prdm2 A G 4: 143,133,427 S1098P probably benign Het
Rnf212 A G 5: 108,747,440 I41T possibly damaging Het
Rngtt A G 4: 33,320,517 probably null Het
Rpn2 C T 2: 157,321,827 T613M probably damaging Het
Scd4 G T 19: 44,344,747 V304F possibly damaging Het
Sez6l A G 5: 112,426,764 probably benign Het
Shroom3 A G 5: 92,940,389 R158G probably benign Het
Stil T C 4: 115,041,482 L1103P probably damaging Het
Tanc2 T C 11: 105,780,133 probably benign Het
Tmc1 C T 19: 20,832,454 D255N probably benign Het
Trank1 C A 9: 111,390,712 D2172E possibly damaging Het
Tyro3 G A 2: 119,813,200 R718H probably damaging Het
Vamp2 C A 11: 69,090,657 F114L probably benign Het
Wdr66 T A 5: 123,302,698 L1106* probably null Het
Other mutations in Olfr1440
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02517:Olfr1440 APN 19 12394901 missense probably benign
IGL03173:Olfr1440 APN 19 12395046 missense possibly damaging 0.79
IGL03412:Olfr1440 APN 19 12394379 missense probably damaging 1.00
F5770:Olfr1440 UTSW 19 12394550 missense probably benign 0.19
R0240:Olfr1440 UTSW 19 12394963 missense probably benign 0.01
R0240:Olfr1440 UTSW 19 12394963 missense probably benign 0.01
R1184:Olfr1440 UTSW 19 12394857 missense probably benign 0.02
R1430:Olfr1440 UTSW 19 12394437 missense probably benign 0.34
R4111:Olfr1440 UTSW 19 12394301 missense probably damaging 1.00
R5751:Olfr1440 UTSW 19 12394416 missense probably benign 0.01
R6796:Olfr1440 UTSW 19 12394928 missense probably damaging 0.99
R7392:Olfr1440 UTSW 19 12394465 missense probably damaging 1.00
R8048:Olfr1440 UTSW 19 12394355 missense not run
V7580:Olfr1440 UTSW 19 12394550 missense probably benign 0.19
Z1088:Olfr1440 UTSW 19 12394299 missense probably benign 0.37
Posted On2015-04-16