Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02105:Dync2h1'

279944

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dync2h1

Ensembl Gene

ENSMUSG00000047193

Gene Name

dynein cytoplasmic 2 heavy chain 1

Synonyms

4432416O06Rik, DHC2, D030010H02Rik, D330044F14Rik, Dnchc2, DHC1b, b2b414Clo

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL02105

Quality Score

Status

Chromosome

Chromosomal Location

6928503-7184446 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 7075892 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Arginine at position 2992 (G2992R)

Ref Sequence

ENSEMBL: ENSMUSP00000116679 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000048417] [ENSMUST00000140466] [ENSMUST00000147193]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000048417
AA Change: G2992R

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000046733
Gene: ENSMUSG00000047193
AA Change: G2992R

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	187	676	1.6e-43	PFAM
Pfam:DHC_N2	1117	1523	4.1e-120	PFAM
AAA	1684	1830	3.72e-2	SMART
AAA	1971	2127	2.18e0	SMART
AAA	2283	2431	1.66e0	SMART
low complexity region	2588	2602	N/A	INTRINSIC
Pfam:AAA_8	2618	2881	6.8e-27	PFAM
Pfam:MT	2894	3230	5.4e-28	PFAM
Pfam:AAA_9	3242	3471	1.1e-50	PFAM
Pfam:Dynein_heavy	3605	4304	2.3e-136	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000139671

SMART Domains

Protein: ENSMUSP00000116242
Gene: ENSMUSG00000047193

Domain	Start	End	E-Value	Type
low complexity region	59	73	N/A	INTRINSIC
Pfam:AAA_8	89	352	3e-29	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000140466
AA Change: G2992R

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000120007
Gene: ENSMUSG00000047193
AA Change: G2992R

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	187	676	1.6e-43	PFAM
Pfam:DHC_N2	1117	1523	4.1e-120	PFAM
AAA	1684	1830	3.72e-2	SMART
AAA	1971	2127	2.18e0	SMART
AAA	2283	2431	1.66e0	SMART
low complexity region	2588	2602	N/A	INTRINSIC
Pfam:AAA_8	2618	2881	6.8e-27	PFAM
Pfam:MT	2894	3230	5.4e-28	PFAM
Pfam:AAA_9	3242	3471	1.1e-50	PFAM
Pfam:Dynein_heavy	3605	4304	2.3e-136	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000147193
AA Change: G2992R

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000116679
Gene: ENSMUSG00000047193
AA Change: G2992R

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	188	674	4e-45	PFAM
Pfam:DHC_N2	1118	1521	5.5e-111	PFAM
AAA	1684	1830	3.72e-2	SMART
AAA	1971	2127	2.18e0	SMART
AAA	2283	2431	1.66e0	SMART
low complexity region	2588	2602	N/A	INTRINSIC
Pfam:AAA_8	2618	2880	4.4e-27	PFAM
Pfam:MT	2894	3230	1.3e-27	PFAM
Pfam:AAA_9	3246	3477	1e-79	PFAM
Pfam:Dynein_heavy	3618	4310	8.5e-158	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large cytoplasmic dynein protein that is involved in retrograde transport in the cilium and has a role in intraflagellar transport, a process required for ciliary/flagellar assembly. Mutations in this gene cause a heterogeneous spectrum of conditions related to altered primary cilium function and often involve polydactyly, abnormal skeletogenesis, and polycystic kidneys. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]
PHENOTYPE: Homozygotes for a gene trap allele show complete embryonic lethality with altered heart looping and brain morphology. Chemically induced mutants show randomized heart looping and polydactyly. Holoprosencephaly or exencephaly, micrognathia, and cardiac, renal, airway and eye defects may be observed. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamtsl4	G	T	3: 95,680,064 (GRCm38)	P734H	probably damaging	Het
Arfip2	A	T	7: 105,639,383 (GRCm38)	I14N	probably damaging	Het
Asap3	G	T	4: 136,228,474 (GRCm38)		probably null	Het
Atg2a	T	A	19: 6,250,403 (GRCm38)		probably benign	Het
Bbs12	T	C	3: 37,320,147 (GRCm38)	L248P	probably damaging	Het
Brd3	A	T	2: 27,459,776 (GRCm38)	I255N	probably damaging	Het
Ccdc141	A	G	2: 77,049,577 (GRCm38)		probably null	Het
Cdc45	C	T	16: 18,798,729 (GRCm38)	M200I	probably benign	Het
Chd9	T	A	8: 90,932,488 (GRCm38)	D25E	probably damaging	Het
Cobl	T	C	11: 12,249,651 (GRCm38)	K1325R	probably damaging	Het
Dnmt1	T	A	9: 20,907,882 (GRCm38)	E1486V	unknown	Het
Dock2	T	C	11: 34,714,525 (GRCm38)	N256D	probably damaging	Het
Dpp3	G	A	19: 4,916,771 (GRCm38)	S408L	probably damaging	Het
Eef1a1	T	C	9: 78,480,551 (GRCm38)	D35G	probably benign	Het
Fntb	A	G	12: 76,862,489 (GRCm38)	K84E	probably benign	Het
Gfi1	A	G	5: 107,723,722 (GRCm38)		probably null	Het
Glb1l3	T	A	9: 26,818,527 (GRCm38)	I516F	probably damaging	Het
Hltf	A	G	3: 20,092,757 (GRCm38)	N560S	probably damaging	Het
Kif21b	A	G	1: 136,171,303 (GRCm38)	N1443S	probably benign	Het
Knl1	T	A	2: 119,071,808 (GRCm38)	I1330K	probably benign	Het
Krt20	C	T	11: 99,438,001 (GRCm38)	V33M	probably benign	Het
Lao1	A	G	4: 118,968,443 (GRCm38)	T487A	probably damaging	Het
Larp4	A	G	15: 99,986,071 (GRCm38)	E63G	probably damaging	Het
Lrp1	A	G	10: 127,544,579 (GRCm38)	V3901A	probably damaging	Het
Lrrc17	A	G	5: 21,570,257 (GRCm38)	I272M	probably benign	Het
Malrd1	A	T	2: 16,127,863 (GRCm38)	Q1865L	unknown	Het
Mtg1	T	C	7: 140,150,206 (GRCm38)	L305P	probably damaging	Het
Mylk4	T	A	13: 32,720,562 (GRCm38)	E427D	probably benign	Het
Myom1	G	T	17: 71,047,716 (GRCm38)		probably benign	Het
Nbeal1	A	G	1: 60,253,501 (GRCm38)	E1104G	probably damaging	Het
Obox5	A	G	7: 15,758,575 (GRCm38)	M152V	probably benign	Het
Olfm2	C	T	9: 20,672,180 (GRCm38)	V203M	probably damaging	Het
Olfr166	T	G	16: 19,487,261 (GRCm38)	L141R	probably benign	Het
Olfr876	A	T	9: 37,804,595 (GRCm38)	H228L	possibly damaging	Het
Pf4	A	G	5: 90,773,255 (GRCm38)	S105G	probably damaging	Het
Phlpp2	T	A	8: 109,904,408 (GRCm38)	I228N	probably damaging	Het
Sall1	T	G	8: 89,032,568 (GRCm38)	S303R	probably damaging	Het
Setd5	A	G	6: 113,117,580 (GRCm38)	E486G	probably damaging	Het
Slc9a5	C	T	8: 105,349,443 (GRCm38)	P23S	probably damaging	Het
Tbc1d9b	T	A	11: 50,149,826 (GRCm38)	I390N	probably damaging	Het
Trp53	T	C	11: 69,588,503 (GRCm38)	V169A	probably damaging	Het
Usp4	A	G	9: 108,384,932 (GRCm38)	D791G	probably damaging	Het
Vmn1r76	A	G	7: 11,930,490 (GRCm38)	S266P	possibly damaging	Het
Vmn2r27	A	G	6: 124,197,349 (GRCm38)		probably benign	Het
Xirp1	C	T	9: 120,016,997 (GRCm38)	G940E	probably damaging	Het
Zfp407	A	T	18: 84,562,720 (GRCm38)	C89*	probably null	Het

Other mutations in Dync2h1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00159:Dync2h1	APN	9	7,158,839 (GRCm38)	missense	probably benign	0.42
IGL00310:Dync2h1	APN	9	7,155,072 (GRCm38)	splice site	probably benign
IGL00499:Dync2h1	APN	9	7,168,700 (GRCm38)	missense	possibly damaging	0.95
IGL00579:Dync2h1	APN	9	7,035,728 (GRCm38)	splice site	probably benign
IGL00660:Dync2h1	APN	9	7,075,797 (GRCm38)	missense	probably damaging	0.98
IGL00964:Dync2h1	APN	9	7,174,881 (GRCm38)	splice site	probably benign
IGL01025:Dync2h1	APN	9	7,162,789 (GRCm38)	missense	probably damaging	1.00
IGL01093:Dync2h1	APN	9	7,145,611 (GRCm38)	missense	probably benign	0.01
IGL01108:Dync2h1	APN	9	7,176,771 (GRCm38)	missense	possibly damaging	0.87
IGL01126:Dync2h1	APN	9	7,116,588 (GRCm38)	missense	probably benign	0.00
IGL01474:Dync2h1	APN	9	7,102,493 (GRCm38)	missense	probably benign	0.01
IGL01531:Dync2h1	APN	9	7,071,111 (GRCm38)	missense	probably benign	0.11
IGL01548:Dync2h1	APN	9	7,071,922 (GRCm38)	missense	probably damaging	1.00
IGL01621:Dync2h1	APN	9	7,140,897 (GRCm38)	critical splice donor site	probably null
IGL01672:Dync2h1	APN	9	7,118,884 (GRCm38)	nonsense	probably null
IGL01681:Dync2h1	APN	9	7,142,196 (GRCm38)	splice site	probably null
IGL01685:Dync2h1	APN	9	7,142,297 (GRCm38)	missense	probably damaging	1.00
IGL01724:Dync2h1	APN	9	7,081,077 (GRCm38)	missense	probably benign	0.03
IGL01738:Dync2h1	APN	9	7,114,922 (GRCm38)	missense	possibly damaging	0.77
IGL01783:Dync2h1	APN	9	7,118,822 (GRCm38)	unclassified	probably benign
IGL01813:Dync2h1	APN	9	7,122,799 (GRCm38)	missense	probably damaging	1.00
IGL01931:Dync2h1	APN	9	7,114,973 (GRCm38)	missense	probably damaging	1.00
IGL01931:Dync2h1	APN	9	7,011,207 (GRCm38)	missense	probably benign	0.33
IGL02137:Dync2h1	APN	9	7,134,349 (GRCm38)	missense	probably benign
IGL02140:Dync2h1	APN	9	7,147,791 (GRCm38)	missense	probably benign
IGL02175:Dync2h1	APN	9	7,111,548 (GRCm38)	missense	possibly damaging	0.91
IGL02283:Dync2h1	APN	9	7,125,912 (GRCm38)	missense	probably damaging	0.99
IGL02305:Dync2h1	APN	9	7,122,678 (GRCm38)	missense	probably benign
IGL02342:Dync2h1	APN	9	7,142,246 (GRCm38)	missense	probably damaging	1.00
IGL02367:Dync2h1	APN	9	7,158,926 (GRCm38)	missense	probably damaging	0.98
IGL02458:Dync2h1	APN	9	7,117,422 (GRCm38)	missense	probably damaging	1.00
IGL02563:Dync2h1	APN	9	7,035,700 (GRCm38)	missense	possibly damaging	0.95
IGL02825:Dync2h1	APN	9	6,955,901 (GRCm38)	splice site	probably benign
IGL02955:Dync2h1	APN	9	7,142,864 (GRCm38)	missense	probably benign	0.00
IGL02992:Dync2h1	APN	9	7,137,074 (GRCm38)	missense	probably benign	0.01
IGL02996:Dync2h1	APN	9	6,935,279 (GRCm38)	missense	probably damaging	0.99
IGL03224:Dync2h1	APN	9	7,076,235 (GRCm38)	missense	probably benign	0.32
IGL03226:Dync2h1	APN	9	7,125,918 (GRCm38)	missense	probably benign
IGL03233:Dync2h1	APN	9	7,101,525 (GRCm38)	missense	possibly damaging	0.90
deinonychus	UTSW	9	7,159,478 (GRCm38)	splice site	probably null
R0016:Dync2h1	UTSW	9	7,144,346 (GRCm38)	splice site	probably benign
R0016:Dync2h1	UTSW	9	7,144,346 (GRCm38)	splice site	probably benign
R0043:Dync2h1	UTSW	9	7,005,574 (GRCm38)	missense	probably benign	0.05
R0109:Dync2h1	UTSW	9	7,111,487 (GRCm38)	missense	probably damaging	1.00
R0109:Dync2h1	UTSW	9	7,111,487 (GRCm38)	missense	probably damaging	1.00
R0121:Dync2h1	UTSW	9	7,001,327 (GRCm38)	splice site	probably benign
R0277:Dync2h1	UTSW	9	7,129,046 (GRCm38)	missense	probably benign
R0360:Dync2h1	UTSW	9	7,113,182 (GRCm38)	missense	possibly damaging	0.62
R0362:Dync2h1	UTSW	9	7,005,487 (GRCm38)	splice site	probably null
R0389:Dync2h1	UTSW	9	7,167,244 (GRCm38)	splice site	probably null
R0443:Dync2h1	UTSW	9	7,167,244 (GRCm38)	splice site	probably null
R0496:Dync2h1	UTSW	9	7,155,180 (GRCm38)	missense	probably benign	0.42
R0506:Dync2h1	UTSW	9	7,113,153 (GRCm38)	missense	probably benign	0.05
R0511:Dync2h1	UTSW	9	7,122,692 (GRCm38)	missense	probably benign	0.00
R0540:Dync2h1	UTSW	9	7,051,480 (GRCm38)	missense	probably benign	0.00
R0550:Dync2h1	UTSW	9	7,120,954 (GRCm38)	splice site	probably null
R0564:Dync2h1	UTSW	9	7,139,432 (GRCm38)	missense	probably damaging	1.00
R0607:Dync2h1	UTSW	9	7,051,480 (GRCm38)	missense	probably benign	0.00
R0699:Dync2h1	UTSW	9	7,103,680 (GRCm38)	missense	probably benign	0.00
R0725:Dync2h1	UTSW	9	7,015,497 (GRCm38)	missense	possibly damaging	0.93
R0835:Dync2h1	UTSW	9	7,116,642 (GRCm38)	critical splice acceptor site	probably null
R0837:Dync2h1	UTSW	9	7,077,979 (GRCm38)	missense	probably benign	0.07
R0894:Dync2h1	UTSW	9	7,041,734 (GRCm38)	splice site	probably benign
R0938:Dync2h1	UTSW	9	7,002,658 (GRCm38)	missense	probably benign	0.02
R1056:Dync2h1	UTSW	9	7,147,731 (GRCm38)	missense	probably benign	0.15
R1081:Dync2h1	UTSW	9	7,005,488 (GRCm38)	critical splice donor site	probably null
R1178:Dync2h1	UTSW	9	7,101,193 (GRCm38)	splice site	probably benign
R1243:Dync2h1	UTSW	9	7,120,882 (GRCm38)	missense	probably benign
R1295:Dync2h1	UTSW	9	7,075,752 (GRCm38)	splice site	probably benign
R1304:Dync2h1	UTSW	9	7,102,318 (GRCm38)	missense	probably damaging	1.00
R1387:Dync2h1	UTSW	9	7,125,816 (GRCm38)	missense	probably benign
R1513:Dync2h1	UTSW	9	7,103,663 (GRCm38)	missense	possibly damaging	0.74
R1557:Dync2h1	UTSW	9	7,140,911 (GRCm38)	missense	probably damaging	1.00
R1568:Dync2h1	UTSW	9	7,157,553 (GRCm38)	missense	probably null	0.02
R1570:Dync2h1	UTSW	9	7,176,926 (GRCm38)	missense	probably benign	0.12
R1670:Dync2h1	UTSW	9	6,993,942 (GRCm38)	missense	possibly damaging	0.82
R1713:Dync2h1	UTSW	9	7,131,891 (GRCm38)	missense	probably benign
R1766:Dync2h1	UTSW	9	7,015,526 (GRCm38)	critical splice acceptor site	probably null
R1773:Dync2h1	UTSW	9	7,128,256 (GRCm38)	missense	probably damaging	1.00
R1786:Dync2h1	UTSW	9	7,081,084 (GRCm38)	missense	probably damaging	1.00
R1848:Dync2h1	UTSW	9	7,049,166 (GRCm38)	missense	probably benign	0.01
R1850:Dync2h1	UTSW	9	7,001,448 (GRCm38)	missense	probably benign	0.00
R1935:Dync2h1	UTSW	9	7,139,159 (GRCm38)	critical splice donor site	probably null
R1936:Dync2h1	UTSW	9	7,139,159 (GRCm38)	critical splice donor site	probably null
R1937:Dync2h1	UTSW	9	7,139,159 (GRCm38)	critical splice donor site	probably null
R1939:Dync2h1	UTSW	9	7,139,159 (GRCm38)	critical splice donor site	probably null
R1940:Dync2h1	UTSW	9	7,139,159 (GRCm38)	critical splice donor site	probably null
R1944:Dync2h1	UTSW	9	7,001,377 (GRCm38)	missense	probably damaging	1.00
R1976:Dync2h1	UTSW	9	7,129,045 (GRCm38)	missense	probably benign
R2012:Dync2h1	UTSW	9	7,169,589 (GRCm38)	missense	probably benign	0.00
R2020:Dync2h1	UTSW	9	7,162,925 (GRCm38)	missense	probably benign	0.25
R2020:Dync2h1	UTSW	9	7,122,772 (GRCm38)	missense	probably damaging	0.99
R2024:Dync2h1	UTSW	9	7,129,062 (GRCm38)	missense	probably damaging	0.97
R2038:Dync2h1	UTSW	9	6,967,226 (GRCm38)	missense	probably damaging	0.99
R2045:Dync2h1	UTSW	9	7,160,171 (GRCm38)	missense	probably damaging	1.00
R2060:Dync2h1	UTSW	9	7,162,802 (GRCm38)	missense	possibly damaging	0.92
R2094:Dync2h1	UTSW	9	7,148,735 (GRCm38)	missense	probably benign	0.18
R2129:Dync2h1	UTSW	9	7,175,289 (GRCm38)	missense	possibly damaging	0.94
R2130:Dync2h1	UTSW	9	7,011,253 (GRCm38)	missense	probably damaging	1.00
R2136:Dync2h1	UTSW	9	7,122,772 (GRCm38)	missense	probably damaging	0.99
R2164:Dync2h1	UTSW	9	7,124,797 (GRCm38)	missense	probably damaging	1.00
R2242:Dync2h1	UTSW	9	7,037,828 (GRCm38)	splice site	probably null
R2255:Dync2h1	UTSW	9	6,955,905 (GRCm38)	critical splice donor site	probably null
R2357:Dync2h1	UTSW	9	7,081,053 (GRCm38)	missense	probably benign	0.03
R2389:Dync2h1	UTSW	9	7,122,618 (GRCm38)	missense	possibly damaging	0.82
R2412:Dync2h1	UTSW	9	7,144,246 (GRCm38)	missense	probably benign	0.01
R2885:Dync2h1	UTSW	9	7,102,329 (GRCm38)	missense	probably damaging	1.00
R2909:Dync2h1	UTSW	9	7,049,114 (GRCm38)	missense	probably damaging	1.00
R3434:Dync2h1	UTSW	9	7,011,236 (GRCm38)	missense	probably benign
R3719:Dync2h1	UTSW	9	7,006,882 (GRCm38)	splice site	probably benign
R3723:Dync2h1	UTSW	9	7,041,658 (GRCm38)	missense	probably benign	0.17
R3800:Dync2h1	UTSW	9	7,101,525 (GRCm38)	missense	possibly damaging	0.90
R3803:Dync2h1	UTSW	9	6,935,293 (GRCm38)	missense	probably benign	0.00
R3936:Dync2h1	UTSW	9	7,001,482 (GRCm38)	missense	probably damaging	1.00
R3941:Dync2h1	UTSW	9	7,124,825 (GRCm38)	missense	probably benign
R3950:Dync2h1	UTSW	9	7,112,061 (GRCm38)	nonsense	probably null
R4004:Dync2h1	UTSW	9	7,117,404 (GRCm38)	missense	probably damaging	1.00
R4091:Dync2h1	UTSW	9	7,131,881 (GRCm38)	missense	probably benign	0.01
R4233:Dync2h1	UTSW	9	7,134,360 (GRCm38)	missense	probably benign	0.02
R4302:Dync2h1	UTSW	9	7,077,880 (GRCm38)	missense	probably benign	0.02
R4451:Dync2h1	UTSW	9	6,983,477 (GRCm38)	missense	probably benign	0.02
R4512:Dync2h1	UTSW	9	7,085,009 (GRCm38)	nonsense	probably null
R4596:Dync2h1	UTSW	9	6,992,595 (GRCm38)	missense	probably benign
R4604:Dync2h1	UTSW	9	7,140,995 (GRCm38)	missense	probably benign	0.00
R4614:Dync2h1	UTSW	9	7,011,290 (GRCm38)	missense	probably benign	0.03
R4667:Dync2h1	UTSW	9	7,051,411 (GRCm38)	missense	probably benign	0.00
R4671:Dync2h1	UTSW	9	7,169,640 (GRCm38)	missense	possibly damaging	0.82
R4714:Dync2h1	UTSW	9	7,118,932 (GRCm38)	missense	possibly damaging	0.86
R4716:Dync2h1	UTSW	9	7,142,648 (GRCm38)	critical splice donor site	probably null
R4736:Dync2h1	UTSW	9	7,006,862 (GRCm38)	missense	probably benign	0.00
R4807:Dync2h1	UTSW	9	7,139,422 (GRCm38)	missense	probably benign	0.31
R4850:Dync2h1	UTSW	9	7,134,364 (GRCm38)	missense	probably benign	0.14
R4862:Dync2h1	UTSW	9	7,147,717 (GRCm38)	missense	probably benign
R4899:Dync2h1	UTSW	9	7,131,921 (GRCm38)	nonsense	probably null
R4971:Dync2h1	UTSW	9	7,131,949 (GRCm38)	missense	probably benign
R5040:Dync2h1	UTSW	9	6,992,625 (GRCm38)	missense	probably benign	0.09
R5054:Dync2h1	UTSW	9	7,085,007 (GRCm38)	missense	possibly damaging	0.63
R5274:Dync2h1	UTSW	9	7,116,540 (GRCm38)	missense	probably benign	0.00
R5307:Dync2h1	UTSW	9	7,155,099 (GRCm38)	missense	probably damaging	1.00
R5347:Dync2h1	UTSW	9	7,129,727 (GRCm38)	missense	probably damaging	1.00
R5372:Dync2h1	UTSW	9	7,176,962 (GRCm38)	unclassified	probably benign
R5384:Dync2h1	UTSW	9	7,016,791 (GRCm38)	missense	probably damaging	0.99
R5385:Dync2h1	UTSW	9	7,016,791 (GRCm38)	missense	probably damaging	0.99
R5394:Dync2h1	UTSW	9	7,120,899 (GRCm38)	nonsense	probably null
R5402:Dync2h1	UTSW	9	7,114,949 (GRCm38)	missense	probably damaging	1.00
R5446:Dync2h1	UTSW	9	7,144,217 (GRCm38)	missense	probably benign
R5538:Dync2h1	UTSW	9	7,168,630 (GRCm38)	intron	probably benign
R5551:Dync2h1	UTSW	9	7,031,718 (GRCm38)	missense	possibly damaging	0.74
R5619:Dync2h1	UTSW	9	7,118,885 (GRCm38)	missense	probably benign	0.02
R5621:Dync2h1	UTSW	9	7,120,909 (GRCm38)	missense	possibly damaging	0.86
R5652:Dync2h1	UTSW	9	7,116,638 (GRCm38)	missense	probably benign	0.45
R5655:Dync2h1	UTSW	9	7,148,659 (GRCm38)	missense	probably benign	0.01
R5689:Dync2h1	UTSW	9	7,169,689 (GRCm38)	missense	probably damaging	1.00
R5725:Dync2h1	UTSW	9	7,169,528 (GRCm38)	missense	probably benign	0.21
R5742:Dync2h1	UTSW	9	7,165,762 (GRCm38)	missense	possibly damaging	0.64
R5817:Dync2h1	UTSW	9	6,996,905 (GRCm38)	missense	probably damaging	1.00
R5852:Dync2h1	UTSW	9	7,011,290 (GRCm38)	missense	probably benign	0.03
R5898:Dync2h1	UTSW	9	7,148,717 (GRCm38)	missense	probably benign	0.00
R5916:Dync2h1	UTSW	9	7,102,309 (GRCm38)	critical splice donor site	probably null
R5939:Dync2h1	UTSW	9	7,037,801 (GRCm38)	missense	probably damaging	0.99
R5942:Dync2h1	UTSW	9	7,117,466 (GRCm38)	nonsense	probably null
R5982:Dync2h1	UTSW	9	6,955,986 (GRCm38)	missense	probably benign	0.00
R6029:Dync2h1	UTSW	9	7,157,646 (GRCm38)	missense	probably benign
R6125:Dync2h1	UTSW	9	7,168,706 (GRCm38)	missense	probably damaging	1.00
R6209:Dync2h1	UTSW	9	7,165,677 (GRCm38)	missense	probably benign	0.01
R6247:Dync2h1	UTSW	9	7,135,078 (GRCm38)	missense	probably damaging	1.00
R6294:Dync2h1	UTSW	9	7,084,986 (GRCm38)	missense	probably benign	0.01
R6328:Dync2h1	UTSW	9	7,165,717 (GRCm38)	missense	probably benign	0.00
R6376:Dync2h1	UTSW	9	7,165,703 (GRCm38)	missense	probably benign	0.21
R6394:Dync2h1	UTSW	9	7,168,331 (GRCm38)	missense	probably damaging	0.99
R6539:Dync2h1	UTSW	9	7,159,478 (GRCm38)	splice site	probably null
R6554:Dync2h1	UTSW	9	7,037,699 (GRCm38)	missense	probably benign	0.39
R6559:Dync2h1	UTSW	9	7,139,501 (GRCm38)	missense	possibly damaging	0.72
R6563:Dync2h1	UTSW	9	7,120,819 (GRCm38)	missense	probably benign	0.27
R6807:Dync2h1	UTSW	9	7,041,718 (GRCm38)	missense	probably benign	0.10
R6848:Dync2h1	UTSW	9	7,159,632 (GRCm38)	missense	probably benign	0.22
R6901:Dync2h1	UTSW	9	7,131,855 (GRCm38)	missense	probably damaging	1.00
R6921:Dync2h1	UTSW	9	7,102,549 (GRCm38)	missense	probably benign
R6997:Dync2h1	UTSW	9	7,168,743 (GRCm38)	missense	probably null	0.00
R7084:Dync2h1	UTSW	9	7,113,214 (GRCm38)	missense	possibly damaging	0.72
R7113:Dync2h1	UTSW	9	7,075,788 (GRCm38)	missense	probably benign	0.03
R7131:Dync2h1	UTSW	9	7,075,786 (GRCm38)	missense	probably damaging	1.00
R7165:Dync2h1	UTSW	9	7,050,479 (GRCm38)	missense	probably benign
R7196:Dync2h1	UTSW	9	7,147,715 (GRCm38)	nonsense	probably null
R7208:Dync2h1	UTSW	9	7,141,059 (GRCm38)	missense	probably damaging	1.00
R7225:Dync2h1	UTSW	9	7,142,756 (GRCm38)	missense	probably benign
R7237:Dync2h1	UTSW	9	6,993,966 (GRCm38)	missense	probably benign	0.00
R7243:Dync2h1	UTSW	9	7,102,405 (GRCm38)	missense	possibly damaging	0.64
R7291:Dync2h1	UTSW	9	6,929,590 (GRCm38)	missense	possibly damaging	0.69
R7293:Dync2h1	UTSW	9	7,001,454 (GRCm38)	missense	possibly damaging	0.88
R7329:Dync2h1	UTSW	9	7,011,247 (GRCm38)	missense	probably benign
R7351:Dync2h1	UTSW	9	7,167,145 (GRCm38)	missense	probably damaging	1.00
R7358:Dync2h1	UTSW	9	7,159,479 (GRCm38)	critical splice donor site	probably null
R7387:Dync2h1	UTSW	9	7,157,932 (GRCm38)	missense	possibly damaging	0.68
R7446:Dync2h1	UTSW	9	7,041,720 (GRCm38)	missense	probably benign	0.03
R7487:Dync2h1	UTSW	9	7,132,041 (GRCm38)	missense	probably benign	0.26
R7488:Dync2h1	UTSW	9	7,124,855 (GRCm38)	missense	probably benign	0.03
R7496:Dync2h1	UTSW	9	7,135,015 (GRCm38)	splice site	probably null
R7501:Dync2h1	UTSW	9	7,175,336 (GRCm38)	missense	possibly damaging	0.82
R7571:Dync2h1	UTSW	9	7,002,623 (GRCm38)	missense	probably damaging	1.00
R7627:Dync2h1	UTSW	9	7,101,111 (GRCm38)	missense	probably benign	0.00
R7639:Dync2h1	UTSW	9	7,141,254 (GRCm38)	missense	probably damaging	0.97
R7653:Dync2h1	UTSW	9	7,117,570 (GRCm38)	missense	probably benign
R7654:Dync2h1	UTSW	9	7,122,664 (GRCm38)	missense	probably damaging	1.00
R7742:Dync2h1	UTSW	9	7,076,232 (GRCm38)	missense	probably benign	0.00
R7755:Dync2h1	UTSW	9	7,015,490 (GRCm38)	missense	probably benign	0.00
R7762:Dync2h1	UTSW	9	7,129,719 (GRCm38)	missense	probably benign	0.01
R7790:Dync2h1	UTSW	9	7,114,914 (GRCm38)	missense	probably damaging	0.96
R7834:Dync2h1	UTSW	9	7,118,953 (GRCm38)	missense	probably benign	0.04
R7883:Dync2h1	UTSW	9	7,005,566 (GRCm38)	missense	possibly damaging	0.80
R7952:Dync2h1	UTSW	9	7,129,802 (GRCm38)	missense	possibly damaging	0.63
R8111:Dync2h1	UTSW	9	7,148,688 (GRCm38)	missense	probably benign	0.03
R8157:Dync2h1	UTSW	9	7,001,473 (GRCm38)	missense	possibly damaging	0.47
R8166:Dync2h1	UTSW	9	7,129,089 (GRCm38)	nonsense	probably null
R8236:Dync2h1	UTSW	9	7,080,363 (GRCm38)	intron	probably benign
R8326:Dync2h1	UTSW	9	7,147,771 (GRCm38)	missense	probably benign
R8335:Dync2h1	UTSW	9	7,084,941 (GRCm38)	missense	probably benign	0.28
R8347:Dync2h1	UTSW	9	7,116,578 (GRCm38)	missense	possibly damaging	0.81
R8372:Dync2h1	UTSW	9	7,111,514 (GRCm38)	missense	possibly damaging	0.90
R8421:Dync2h1	UTSW	9	7,102,477 (GRCm38)	missense	probably damaging	1.00
R8518:Dync2h1	UTSW	9	7,051,452 (GRCm38)	missense	probably benign	0.04
R8556:Dync2h1	UTSW	9	7,113,198 (GRCm38)	missense	probably benign	0.32
R8690:Dync2h1	UTSW	9	7,075,824 (GRCm38)	missense	probably damaging	1.00
R8713:Dync2h1	UTSW	9	7,141,008 (GRCm38)	nonsense	probably null
R8719:Dync2h1	UTSW	9	7,041,641 (GRCm38)	missense	probably benign	0.05
R8732:Dync2h1	UTSW	9	7,168,326 (GRCm38)	missense	probably damaging	1.00
R8744:Dync2h1	UTSW	9	7,011,220 (GRCm38)	nonsense	probably null
R8749:Dync2h1	UTSW	9	7,035,063 (GRCm38)	missense	probably benign	0.32
R8795:Dync2h1	UTSW	9	7,137,087 (GRCm38)	missense	probably benign	0.00
R8853:Dync2h1	UTSW	9	7,117,645 (GRCm38)	missense	possibly damaging	0.94
R8923:Dync2h1	UTSW	9	7,168,515 (GRCm38)	missense	probably benign
R8969:Dync2h1	UTSW	9	7,130,723 (GRCm38)	missense	probably damaging	1.00
R8988:Dync2h1	UTSW	9	7,037,727 (GRCm38)	missense	probably benign	0.00
R8997:Dync2h1	UTSW	9	7,129,003 (GRCm38)	missense	probably benign
R9025:Dync2h1	UTSW	9	7,139,462 (GRCm38)	nonsense	probably null
R9036:Dync2h1	UTSW	9	7,051,495 (GRCm38)	missense	probably damaging	1.00
R9055:Dync2h1	UTSW	9	6,996,641 (GRCm38)	intron	probably benign
R9165:Dync2h1	UTSW	9	7,114,883 (GRCm38)	missense	probably damaging	0.99
R9172:Dync2h1	UTSW	9	7,031,771 (GRCm38)	missense	probably damaging	1.00
R9286:Dync2h1	UTSW	9	6,941,668 (GRCm38)	missense	probably benign	0.01
R9312:Dync2h1	UTSW	9	7,050,413 (GRCm38)	missense	probably damaging	1.00
R9335:Dync2h1	UTSW	9	7,112,149 (GRCm38)	missense	possibly damaging	0.88
R9344:Dync2h1	UTSW	9	7,148,659 (GRCm38)	missense	probably benign	0.01
R9351:Dync2h1	UTSW	9	7,176,911 (GRCm38)	missense	probably damaging	0.98
R9367:Dync2h1	UTSW	9	7,125,730 (GRCm38)	critical splice donor site	probably null
R9613:Dync2h1	UTSW	9	7,075,769 (GRCm38)	missense	probably damaging	0.99
R9650:Dync2h1	UTSW	9	7,174,849 (GRCm38)	missense	possibly damaging	0.83
R9726:Dync2h1	UTSW	9	7,077,999 (GRCm38)	missense	possibly damaging	0.94
R9731:Dync2h1	UTSW	9	7,141,166 (GRCm38)	missense	probably benign
X0009:Dync2h1	UTSW	9	7,117,576 (GRCm38)	missense	possibly damaging	0.81
Z1176:Dync2h1	UTSW	9	7,168,730 (GRCm38)	frame shift	probably null
Z1176:Dync2h1	UTSW	9	7,142,361 (GRCm38)	missense	probably damaging	0.99
Z1177:Dync2h1	UTSW	9	7,102,427 (GRCm38)	missense	probably damaging	1.00

Posted On

2015-04-16