Incidental Mutation 'IGL02110:Rasl2-9'
ID280058
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rasl2-9
Ensembl Gene ENSMUSG00000083649
Gene NameRAS-like, family 2, locus 9
SynonymsRasl2-9-ps, Ran/M2
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.917) question?
Stock #IGL02110
Quality Score
Status
Chromosome7
Chromosomal Location5124938-5125950 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 5125347 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Threonine at position 195 (A195T)
Ref Sequence ENSEMBL: ENSMUSP00000129559 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000147835]
Predicted Effect probably benign
Transcript: ENSMUST00000147835
AA Change: A195T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000129559
Gene: ENSMUSG00000083649
AA Change: A195T

DomainStartEndE-ValueType
RAN 16 216 1.25e-161 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175212
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207732
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931409K22Rik A G 5: 24,548,084 probably benign Het
Apol7e A G 15: 77,714,348 probably null Het
Arhgef40 C T 14: 51,989,405 T302M probably damaging Het
Bap1 T C 14: 31,257,414 L458P probably damaging Het
Bbs12 A G 3: 37,319,187 E43G probably benign Het
Bod1l C T 5: 41,816,453 C2506Y probably damaging Het
Ccdc170 A G 10: 4,541,885 probably null Het
Chpf2 A G 5: 24,591,712 E552G probably damaging Het
Comp T A 8: 70,373,639 I23N probably benign Het
Cxcl2 T C 5: 90,904,352 probably benign Het
Dctn5 T C 7: 122,135,151 F73L probably damaging Het
Ddx5 T C 11: 106,785,009 E285G probably damaging Het
Ddx60 T G 8: 62,017,247 probably null Het
Dhcr24 T A 4: 106,573,801 I229N probably damaging Het
Dnah7a G A 1: 53,411,580 T3897I possibly damaging Het
Dvl2 T A 11: 70,008,016 probably benign Het
Dytn A T 1: 63,647,473 V346E possibly damaging Het
Eepd1 T C 9: 25,603,402 probably benign Het
Fbln2 G T 6: 91,234,102 A343S probably benign Het
Flywch1 T C 17: 23,763,092 probably null Het
Gckr A T 5: 31,298,738 T81S possibly damaging Het
Gm6139 T A 5: 129,623,592 noncoding transcript Het
Gpcpd1 A T 2: 132,530,610 C657* probably null Het
Greb1l A G 18: 10,515,271 I89V probably damaging Het
Hdac4 G A 1: 91,984,405 P421S probably benign Het
Klhl1 A G 14: 96,136,603 L669P probably benign Het
Mios A G 6: 8,215,565 R254G probably damaging Het
Mmp19 A G 10: 128,794,858 N116D probably damaging Het
Muc5b T A 7: 141,847,716 C566* probably null Het
Nadsyn1 T C 7: 143,813,427 Y141C probably damaging Het
Nlrp4d T C 7: 10,382,564 noncoding transcript Het
Nob1 A T 8: 107,416,172 *160R probably null Het
Olfr1295 C T 2: 111,564,907 C179Y probably damaging Het
Olfr1366 T A 13: 21,537,942 Q21L possibly damaging Het
Olfr346 A G 2: 36,688,685 T228A probably benign Het
Olfr455 A G 6: 42,538,179 V281A possibly damaging Het
Olfr504 C A 7: 108,565,079 A239S probably damaging Het
Olfr571 C T 7: 102,909,195 V215I probably benign Het
Phc1 T C 6: 122,322,035 D658G possibly damaging Het
Pitx2 T G 3: 129,218,817 S299A probably damaging Het
Plekha7 C A 7: 116,154,628 probably null Het
Ptgfr A G 3: 151,835,460 V137A probably damaging Het
Ptprb T C 10: 116,331,203 probably benign Het
Ripor3 T A 2: 167,994,706 Q121L possibly damaging Het
Sgsh G T 11: 119,352,806 A30E probably damaging Het
Sis G T 3: 72,928,699 C852* probably null Het
Slc17a9 A G 2: 180,732,576 probably benign Het
Slco6b1 A T 1: 96,987,882 noncoding transcript Het
Smarca2 A G 19: 26,672,740 Y704C possibly damaging Het
Spata6 A T 4: 111,784,806 H291L possibly damaging Het
Stra8 T C 6: 34,930,354 probably benign Het
Taldo1 T C 7: 141,402,734 probably benign Het
Tmco6 T C 18: 36,735,166 probably benign Het
Tmpo A C 10: 91,162,865 S353R probably damaging Het
Tpr A T 1: 150,435,742 Q1757L probably damaging Het
Ubn1 T C 16: 5,081,890 probably benign Het
Vmn2r83 T C 10: 79,491,700 V714A possibly damaging Het
Zfp407 G T 18: 84,559,040 A1316D probably benign Het
Zzef1 T A 11: 72,913,112 I2560N probably damaging Het
Other mutations in Rasl2-9
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1500:Rasl2-9 UTSW 7 5125442 nonsense probably null
R4566:Rasl2-9 UTSW 7 5125375 frame shift probably null
R4567:Rasl2-9 UTSW 7 5125375 frame shift probably null
R4568:Rasl2-9 UTSW 7 5125375 frame shift probably null
R4745:Rasl2-9 UTSW 7 5125703 missense possibly damaging 0.90
R7301:Rasl2-9 UTSW 7 5125740 missense probably damaging 1.00
R8025:Rasl2-9 UTSW 7 5125482 missense probably damaging 1.00
R8281:Rasl2-9 UTSW 7 5125352 nonsense probably null
Posted On2015-04-16