Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02110:Or10ac1'

280101

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or10ac1

Ensembl Gene

ENSMUSG00000071494

Gene Name

olfactory receptor family 10 subfamily AC member 1

Synonyms

MORO-2, Olfr455, Olfr455-ps1, GA_x6K02T2P3E9-5021913-5022918, EG546896, MOR0-17_p, MOR0-2P

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.103) question?

Stock #

IGL02110

Quality Score

Status

Chromosome

Chromosomal Location

42515001-42515954 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 42515113 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 281 (V281A)

Ref Sequence

ENSEMBL: ENSMUSP00000151418 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171307] [ENSMUST00000217978]

AlphaFold

A0A0B4J1M2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000171307
AA Change: V281A

PolyPhen 2 Score 0.846 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000130187
Gene: ENSMUSG00000071494
AA Change: V281A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	312	8.4e-41	PFAM
Pfam:7tm_1	42	265	5.8e-20	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000217978
AA Change: V281A

PolyPhen 2 Score 0.846 (Sensitivity: 0.83; Specificity: 0.93)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jun 2009]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Apol7e	A	G	15: 77,598,548 (GRCm39)		probably null	Het
Arhgef40	C	T	14: 52,226,862 (GRCm39)	T302M	probably damaging	Het
Bap1	T	C	14: 30,979,371 (GRCm39)	L458P	probably damaging	Het
Bbs12	A	G	3: 37,373,336 (GRCm39)	E43G	probably benign	Het
Bod1l	C	T	5: 41,973,796 (GRCm39)	C2506Y	probably damaging	Het
Ccdc170	A	G	10: 4,491,885 (GRCm39)		probably null	Het
Chpf2	A	G	5: 24,796,710 (GRCm39)	E552G	probably damaging	Het
Comp	T	A	8: 70,826,289 (GRCm39)	I23N	probably benign	Het
Cxcl2	T	C	5: 91,052,211 (GRCm39)		probably benign	Het
Dctn5	T	C	7: 121,734,374 (GRCm39)	F73L	probably damaging	Het
Ddx5	T	C	11: 106,675,835 (GRCm39)	E285G	probably damaging	Het
Ddx60	T	G	8: 62,470,281 (GRCm39)		probably null	Het
Dhcr24	T	A	4: 106,430,998 (GRCm39)	I229N	probably damaging	Het
Dnah7a	G	A	1: 53,450,739 (GRCm39)	T3897I	possibly damaging	Het
Dvl2	T	A	11: 69,898,842 (GRCm39)		probably benign	Het
Dytn	A	T	1: 63,686,632 (GRCm39)	V346E	possibly damaging	Het
Eepd1	T	C	9: 25,514,698 (GRCm39)		probably benign	Het
Fbln2	G	T	6: 91,211,084 (GRCm39)	A343S	probably benign	Het
Flywch1	T	C	17: 23,982,066 (GRCm39)		probably null	Het
Gckr	A	T	5: 31,456,082 (GRCm39)	T81S	possibly damaging	Het
Gm6139	T	A	5: 129,700,656 (GRCm39)		noncoding transcript	Het
Gpcpd1	A	T	2: 132,372,530 (GRCm39)	C657*	probably null	Het
Greb1l	A	G	18: 10,515,271 (GRCm39)	I89V	probably damaging	Het
Hdac4	G	A	1: 91,912,127 (GRCm39)	P421S	probably benign	Het
Iqca1l	A	G	5: 24,753,082 (GRCm39)		probably benign	Het
Klhl1	A	G	14: 96,374,039 (GRCm39)	L669P	probably benign	Het
Mios	A	G	6: 8,215,565 (GRCm39)	R254G	probably damaging	Het
Mmp19	A	G	10: 128,630,727 (GRCm39)	N116D	probably damaging	Het
Muc5b	T	A	7: 141,401,453 (GRCm39)	C566*	probably null	Het
Nadsyn1	T	C	7: 143,367,164 (GRCm39)	Y141C	probably damaging	Het
Nlrp4d	T	C	7: 10,116,491 (GRCm39)		noncoding transcript	Het
Nob1	A	T	8: 108,142,804 (GRCm39)	*160R	probably null	Het
Or1f12	T	A	13: 21,722,112 (GRCm39)	Q21L	possibly damaging	Het
Or1j17	A	G	2: 36,578,697 (GRCm39)	T228A	probably benign	Het
Or4k45	C	T	2: 111,395,252 (GRCm39)	C179Y	probably damaging	Het
Or51s1	C	T	7: 102,558,402 (GRCm39)	V215I	probably benign	Het
Or56b1b	C	A	7: 108,164,286 (GRCm39)	A239S	probably damaging	Het
Phc1	T	C	6: 122,298,994 (GRCm39)	D658G	possibly damaging	Het
Pitx2	T	G	3: 129,012,466 (GRCm39)	S299A	probably damaging	Het
Plekha7	C	A	7: 115,753,863 (GRCm39)		probably null	Het
Ptgfr	A	G	3: 151,541,097 (GRCm39)	V137A	probably damaging	Het
Ptprb	T	C	10: 116,167,108 (GRCm39)		probably benign	Het
Rasl2-9	C	T	7: 5,128,346 (GRCm39)	A195T	probably benign	Het
Ripor3	T	A	2: 167,836,626 (GRCm39)	Q121L	possibly damaging	Het
Sgsh	G	T	11: 119,243,632 (GRCm39)	A30E	probably damaging	Het
Sis	G	T	3: 72,836,032 (GRCm39)	C852*	probably null	Het
Slc17a9	A	G	2: 180,374,369 (GRCm39)		probably benign	Het
Slco6b1	A	T	1: 96,915,607 (GRCm39)		noncoding transcript	Het
Smarca2	A	G	19: 26,650,140 (GRCm39)	Y704C	possibly damaging	Het
Spata6	A	T	4: 111,642,003 (GRCm39)	H291L	possibly damaging	Het
Stra8	T	C	6: 34,907,289 (GRCm39)		probably benign	Het
Taldo1	T	C	7: 140,982,647 (GRCm39)		probably benign	Het
Tmco6	T	C	18: 36,868,219 (GRCm39)		probably benign	Het
Tmpo	A	C	10: 90,998,727 (GRCm39)	S353R	probably damaging	Het
Tpr	A	T	1: 150,311,493 (GRCm39)	Q1757L	probably damaging	Het
Ubn1	T	C	16: 4,899,754 (GRCm39)		probably benign	Het
Vmn2r83	T	C	10: 79,327,534 (GRCm39)	V714A	possibly damaging	Het
Zfp407	G	T	18: 84,577,165 (GRCm39)	A1316D	probably benign	Het
Zzef1	T	A	11: 72,803,938 (GRCm39)	I2560N	probably damaging	Het

Other mutations in Or10ac1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
PIT4519001:Or10ac1	UTSW	6	42,515,534 (GRCm39)	missense	probably damaging	0.98
R0931:Or10ac1	UTSW	6	42,515,020 (GRCm39)	missense	probably benign	0.00
R1696:Or10ac1	UTSW	6	42,515,537 (GRCm39)	missense	probably benign	0.04
R1774:Or10ac1	UTSW	6	42,515,453 (GRCm39)	missense	probably damaging	0.99
R4627:Or10ac1	UTSW	6	42,515,375 (GRCm39)	missense	possibly damaging	0.46
R4835:Or10ac1	UTSW	6	42,515,770 (GRCm39)	missense	probably damaging	1.00
R5140:Or10ac1	UTSW	6	42,515,449 (GRCm39)	missense	probably benign	0.00
R5322:Or10ac1	UTSW	6	42,515,950 (GRCm39)	missense	probably benign	0.06
R7237:Or10ac1	UTSW	6	42,515,581 (GRCm39)	missense	probably damaging	1.00
R7399:Or10ac1	UTSW	6	42,515,662 (GRCm39)	missense	possibly damaging	0.79
R7422:Or10ac1	UTSW	6	42,515,053 (GRCm39)	missense	possibly damaging	0.72
R7982:Or10ac1	UTSW	6	42,515,225 (GRCm39)	missense	probably damaging	1.00
R8697:Or10ac1	UTSW	6	42,515,629 (GRCm39)	missense	probably damaging	1.00
R9120:Or10ac1	UTSW	6	42,515,583 (GRCm39)	nonsense	probably null

Posted On

2015-04-16