Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02112:Vmn2r99'

280180

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r99

Ensembl Gene

ENSMUSG00000090304

Gene Name

vomeronasal 2, receptor 99

Synonyms

EG665376

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.118) question?

Stock #

IGL02112

Quality Score

Status

Chromosome

Chromosomal Location

19361949-19401098 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 19380232 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 506 (E506G)

Ref Sequence

ENSEMBL: ENSMUSP00000156067 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000176107] [ENSMUST00000231989]

AlphaFold

H3BK37

Predicted Effect

probably null
Transcript: ENSMUST00000176107
AA Change: E506G

PolyPhen 2 Score 0.931 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000135236
Gene: ENSMUSG00000090304
AA Change: E506G

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	81	448	5.7e-33	PFAM
Pfam:NCD3G	508	561	1.8e-21	PFAM
Pfam:7tm_3	593	829	4.6e-52	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000231989
AA Change: E506G

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700016K19Rik	G	T	11: 76,003,388	C197F	probably benign	Het
Adam34	T	A	8: 43,651,138	Y490F	possibly damaging	Het
Appbp2	A	T	11: 85,201,620	H271Q	probably benign	Het
Arhgap17	A	T	7: 123,318,417	D181E	possibly damaging	Het
Arhgap25	T	A	6: 87,467,937	Y286F	possibly damaging	Het
Atf2	T	C	2: 73,819,037	K352R	probably damaging	Het
Bdp1	G	A	13: 100,037,800	T2076I	probably benign	Het
C1s2	A	G	6: 124,625,308	V642A	probably benign	Het
Cldn18	T	A	9: 99,698,075	T170S	probably benign	Het
Cntnap5c	T	A	17: 58,313,858	H977Q	probably benign	Het
Col15a1	T	A	4: 47,253,985		probably benign	Het
Csmd1	A	T	8: 16,081,705	Y1669N	probably benign	Het
Csmd3	A	C	15: 48,313,869	S424R	possibly damaging	Het
Cyp4a31	A	G	4: 115,570,983	D306G	probably damaging	Het
Dusp27	C	A	1: 166,099,671	E791*	probably null	Het
E2f2	A	G	4: 136,192,834	T377A	probably benign	Het
Edil3	A	G	13: 89,180,255	D276G	probably damaging	Het
Ei24	A	T	9: 36,782,342	Y305N	probably damaging	Het
Erbin	T	C	13: 103,862,336	N181D	probably benign	Het
Gli3	A	G	13: 15,662,514	Q494R	probably damaging	Het
Gm16519	T	C	17: 70,929,296	I80T	probably damaging	Het
Haus8	T	A	8: 71,255,561	E163V	probably damaging	Het
Hephl1	G	T	9: 15,081,815		probably benign	Het
Hnrnph3	A	G	10: 63,016,405		probably null	Het
Mast2	A	T	4: 116,319,764	C437S	probably damaging	Het
Mef2a	A	C	7: 67,264,872	S91R	probably damaging	Het
Mfge8	A	T	7: 79,143,340	V126D	probably benign	Het
Nrd1	A	G	4: 109,027,432		probably benign	Het
Olfr77	T	A	9: 19,920,525	N105K	possibly damaging	Het
Panx2	A	G	15: 89,069,569	T576A	probably benign	Het
Per3	T	C	4: 151,029,183	Y306C	probably benign	Het
Ppm1h	G	A	10: 122,802,400	G192R	possibly damaging	Het
Prss22	T	C	17: 23,993,971	E264G	probably damaging	Het
Rasa3	A	G	8: 13,585,042		probably benign	Het
Rpl7a-ps8	C	A	7: 19,954,060		probably benign	Het
Rundc1	A	G	11: 101,433,599	D377G	probably benign	Het
Sh3bp1	T	C	15: 78,905,884		probably null	Het
Sobp	A	G	10: 43,021,877	S571P	probably benign	Het
Syce1	C	A	7: 140,779,632	M114I	probably benign	Het
Tdrd6	G	A	17: 43,629,351	R269W	probably damaging	Het
Tmprss13	T	C	9: 45,339,404	S408P	probably damaging	Het
Tonsl	T	C	15: 76,633,402	T706A	probably benign	Het
Tpcn2	A	G	7: 145,256,792	S603P	probably benign	Het
Trmt12	A	T	15: 58,872,816	Q21L	probably damaging	Het
Vmn1r68	C	T	7: 10,527,860	G104S	probably damaging	Het
Vmn2r82	T	C	10: 79,395,999	W611R	probably benign	Het
Vmn2r90	C	A	17: 17,712,203	T124K	probably damaging	Het

Other mutations in Vmn2r99

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00503:Vmn2r99	APN	17	19378854	missense	probably benign	0.01
IGL01113:Vmn2r99	APN	17	19394256	missense	probably benign	0.20
IGL01138:Vmn2r99	APN	17	19382623	missense	probably damaging	0.97
IGL01646:Vmn2r99	APN	17	19393658	splice site	probably benign
IGL01769:Vmn2r99	APN	17	19380115	missense	probably damaging	1.00
IGL02891:Vmn2r99	APN	17	19378690	nonsense	probably null
IGL03132:Vmn2r99	APN	17	19378223	nonsense	probably null
FR4548:Vmn2r99	UTSW	17	19394285	missense	probably damaging	0.97
FR4976:Vmn2r99	UTSW	17	19394285	missense	probably damaging	0.97
PIT4382001:Vmn2r99	UTSW	17	19394343	missense	probably damaging	1.00
R0196:Vmn2r99	UTSW	17	19394573	missense	probably benign	0.00
R0720:Vmn2r99	UTSW	17	19379043	missense	probably benign	0.00
R1501:Vmn2r99	UTSW	17	19362259	missense	possibly damaging	0.93
R1519:Vmn2r99	UTSW	17	19380060	missense	probably benign	0.00
R1670:Vmn2r99	UTSW	17	19362252	missense	probably benign	0.37
R1682:Vmn2r99	UTSW	17	19377945	missense	probably damaging	0.97
R1873:Vmn2r99	UTSW	17	19362153	missense	probably benign	0.25
R1967:Vmn2r99	UTSW	17	19378815	missense	probably benign	0.01
R2101:Vmn2r99	UTSW	17	19377991	missense	probably damaging	1.00
R2474:Vmn2r99	UTSW	17	19378629	missense	probably benign	0.04
R2519:Vmn2r99	UTSW	17	19378708	missense	probably damaging	0.99
R3911:Vmn2r99	UTSW	17	19394373	missense	possibly damaging	0.92
R3947:Vmn2r99	UTSW	17	19378990	missense	probably benign	0.40
R3949:Vmn2r99	UTSW	17	19378990	missense	probably benign	0.40
R4016:Vmn2r99	UTSW	17	19378570	missense	possibly damaging	0.86
R4413:Vmn2r99	UTSW	17	19379260	missense	probably damaging	1.00
R4594:Vmn2r99	UTSW	17	19393662	missense	probably damaging	1.00
R4999:Vmn2r99	UTSW	17	19362135	start codon destroyed	probably null	0.96
R5206:Vmn2r99	UTSW	17	19378606	missense	probably benign	0.40
R5362:Vmn2r99	UTSW	17	19379339	missense	probably benign	0.00
R5377:Vmn2r99	UTSW	17	19379269	missense	probably damaging	1.00
R5455:Vmn2r99	UTSW	17	19394146	nonsense	probably null
R6021:Vmn2r99	UTSW	17	19377948	missense	probably damaging	1.00
R6059:Vmn2r99	UTSW	17	19378980	missense	probably benign	0.00
R6214:Vmn2r99	UTSW	17	19382558	missense	probably benign	0.19
R6215:Vmn2r99	UTSW	17	19382558	missense	probably benign	0.19
R6313:Vmn2r99	UTSW	17	19382605	missense	probably damaging	1.00
R6646:Vmn2r99	UTSW	17	19380031	missense	probably damaging	1.00
R6810:Vmn2r99	UTSW	17	19380034	missense	probably benign	0.20
R6885:Vmn2r99	UTSW	17	19380195	missense	possibly damaging	0.52
R6991:Vmn2r99	UTSW	17	19378110	missense	probably benign	0.03
R7060:Vmn2r99	UTSW	17	19394564	nonsense	probably null
R7090:Vmn2r99	UTSW	17	19393710	missense	possibly damaging	0.83
R7094:Vmn2r99	UTSW	17	19379311	missense	probably benign	0.00
R7449:Vmn2r99	UTSW	17	19379145	missense	probably benign	0.01
R7789:Vmn2r99	UTSW	17	19393817	missense	possibly damaging	0.91
R8039:Vmn2r99	UTSW	17	19380040	missense	probably benign	0.00
R8493:Vmn2r99	UTSW	17	19393758	missense	probably benign	0.15
R8511:Vmn2r99	UTSW	17	19394181	missense	probably damaging	1.00
R8715:Vmn2r99	UTSW	17	19393660	critical splice acceptor site	probably benign
R9462:Vmn2r99	UTSW	17	19378126	nonsense	probably null
Z1088:Vmn2r99	UTSW	17	19379301	missense	probably benign	0.18

Posted On

2015-04-16