Incidental Mutation 'IGL02112:Arhgap25'
ID 280202
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Arhgap25
Ensembl Gene ENSMUSG00000030047
Gene Name Rho GTPase activating protein 25
Synonyms A130039I20Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02112
Quality Score
Status
Chromosome 6
Chromosomal Location 87435527-87510241 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 87444919 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 286 (Y286F)
Ref Sequence ENSEMBL: ENSMUSP00000109267 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071024] [ENSMUST00000101197] [ENSMUST00000113637]
AlphaFold Q8BYW1
Predicted Effect possibly damaging
Transcript: ENSMUST00000071024
AA Change: Y197F

PolyPhen 2 Score 0.798 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000068964
Gene: ENSMUSG00000030047
AA Change: Y197F

DomainStartEndE-ValueType
PDB:1V89|A 1 63 7e-33 PDB
Blast:RhoGAP 16 66 9e-22 BLAST
RhoGAP 86 262 6.28e-64 SMART
coiled coil region 454 552 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000101197
AA Change: Y260F

PolyPhen 2 Score 0.798 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000098758
Gene: ENSMUSG00000030047
AA Change: Y260F

DomainStartEndE-ValueType
PH 21 127 2.11e-21 SMART
RhoGAP 149 325 6.28e-64 SMART
coiled coil region 517 615 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000113637
AA Change: Y286F

PolyPhen 2 Score 0.798 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000109267
Gene: ENSMUSG00000030047
AA Change: Y286F

DomainStartEndE-ValueType
PH 47 153 2.11e-21 SMART
RhoGAP 175 351 6.28e-64 SMART
coiled coil region 543 641 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145128
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203559
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit altered leukocyte transendothelial migration. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34 T A 8: 44,104,175 (GRCm39) Y490F possibly damaging Het
Appbp2 A T 11: 85,092,446 (GRCm39) H271Q probably benign Het
Arhgap17 A T 7: 122,917,640 (GRCm39) D181E possibly damaging Het
Atf2 T C 2: 73,649,381 (GRCm39) K352R probably damaging Het
Bdp1 G A 13: 100,174,308 (GRCm39) T2076I probably benign Het
C1s2 A G 6: 124,602,267 (GRCm39) V642A probably benign Het
Cldn18 T A 9: 99,580,128 (GRCm39) T170S probably benign Het
Cntnap5c T A 17: 58,620,853 (GRCm39) H977Q probably benign Het
Col15a1 T A 4: 47,253,985 (GRCm39) probably benign Het
Csmd1 A T 8: 16,131,719 (GRCm39) Y1669N probably benign Het
Csmd3 A C 15: 48,177,265 (GRCm39) S424R possibly damaging Het
Cyp4a31 A G 4: 115,428,180 (GRCm39) D306G probably damaging Het
E2f2 A G 4: 135,920,145 (GRCm39) T377A probably benign Het
Edil3 A G 13: 89,328,374 (GRCm39) D276G probably damaging Het
Ei24 A T 9: 36,693,638 (GRCm39) Y305N probably damaging Het
Erbin T C 13: 103,998,844 (GRCm39) N181D probably benign Het
Gli3 A G 13: 15,837,099 (GRCm39) Q494R probably damaging Het
Gm16519 T C 17: 71,236,291 (GRCm39) I80T probably damaging Het
Haus8 T A 8: 71,708,205 (GRCm39) E163V probably damaging Het
Hephl1 G T 9: 14,993,111 (GRCm39) probably benign Het
Hnrnph3 A G 10: 62,852,184 (GRCm39) probably null Het
Liat1 G T 11: 75,894,214 (GRCm39) C197F probably benign Het
Mast2 A T 4: 116,176,961 (GRCm39) C437S probably damaging Het
Mef2a A C 7: 66,914,620 (GRCm39) S91R probably damaging Het
Mfge8 A T 7: 78,793,088 (GRCm39) V126D probably benign Het
Nrdc A G 4: 108,884,629 (GRCm39) probably benign Het
Or7d10 T A 9: 19,831,821 (GRCm39) N105K possibly damaging Het
Panx2 A G 15: 88,953,772 (GRCm39) T576A probably benign Het
Per3 T C 4: 151,113,640 (GRCm39) Y306C probably benign Het
Ppm1h G A 10: 122,638,305 (GRCm39) G192R possibly damaging Het
Prss22 T C 17: 24,212,945 (GRCm39) E264G probably damaging Het
Rasa3 A G 8: 13,635,042 (GRCm39) probably benign Het
Rpl7a-ps8 C A 7: 19,687,985 (GRCm39) probably benign Het
Rundc1 A G 11: 101,324,425 (GRCm39) D377G probably benign Het
Sh3bp1 T C 15: 78,790,084 (GRCm39) probably null Het
Sobp A G 10: 42,897,873 (GRCm39) S571P probably benign Het
Styxl2 C A 1: 165,927,240 (GRCm39) E791* probably null Het
Syce1 C A 7: 140,359,545 (GRCm39) M114I probably benign Het
Tdrd6 G A 17: 43,940,242 (GRCm39) R269W probably damaging Het
Tmprss13 T C 9: 45,250,702 (GRCm39) S408P probably damaging Het
Tonsl T C 15: 76,517,602 (GRCm39) T706A probably benign Het
Tpcn2 A G 7: 144,810,529 (GRCm39) S603P probably benign Het
Trmt12 A T 15: 58,744,665 (GRCm39) Q21L probably damaging Het
Vmn1r68 C T 7: 10,261,787 (GRCm39) G104S probably damaging Het
Vmn2r82 T C 10: 79,231,833 (GRCm39) W611R probably benign Het
Vmn2r90 C A 17: 17,932,465 (GRCm39) T124K probably damaging Het
Vmn2r99 A G 17: 19,600,494 (GRCm39) E506G probably null Het
Other mutations in Arhgap25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01454:Arhgap25 APN 6 87,473,058 (GRCm39) missense possibly damaging 0.92
IGL03051:Arhgap25 APN 6 87,472,896 (GRCm39) missense probably null 1.00
R0462:Arhgap25 UTSW 6 87,436,942 (GRCm39) missense possibly damaging 0.88
R1636:Arhgap25 UTSW 6 87,472,923 (GRCm39) missense probably damaging 1.00
R1777:Arhgap25 UTSW 6 87,440,289 (GRCm39) missense probably benign 0.41
R2077:Arhgap25 UTSW 6 87,436,990 (GRCm39) missense probably damaging 1.00
R2845:Arhgap25 UTSW 6 87,436,949 (GRCm39) missense possibly damaging 0.86
R4091:Arhgap25 UTSW 6 87,440,017 (GRCm39) missense probably benign
R4435:Arhgap25 UTSW 6 87,439,920 (GRCm39) missense possibly damaging 0.56
R4773:Arhgap25 UTSW 6 87,473,053 (GRCm39) missense probably benign
R5121:Arhgap25 UTSW 6 87,509,846 (GRCm39) missense probably benign 0.01
R5169:Arhgap25 UTSW 6 87,440,252 (GRCm39) missense possibly damaging 0.93
R5334:Arhgap25 UTSW 6 87,440,243 (GRCm39) missense possibly damaging 0.77
R5726:Arhgap25 UTSW 6 87,440,441 (GRCm39) missense probably benign
R6696:Arhgap25 UTSW 6 87,443,545 (GRCm39) missense probably damaging 0.99
R6696:Arhgap25 UTSW 6 87,442,633 (GRCm39) missense probably damaging 1.00
R7947:Arhgap25 UTSW 6 87,440,069 (GRCm39) missense probably benign 0.32
R8113:Arhgap25 UTSW 6 87,465,287 (GRCm39) nonsense probably null
R9110:Arhgap25 UTSW 6 87,453,254 (GRCm39) missense probably benign 0.07
R9500:Arhgap25 UTSW 6 87,469,184 (GRCm39) missense probably damaging 1.00
R9591:Arhgap25 UTSW 6 87,440,102 (GRCm39) missense probably benign
Z1176:Arhgap25 UTSW 6 87,453,168 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16