Incidental Mutation 'IGL02113:Mettl6'
ID 280247
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mettl6
Ensembl Gene ENSMUSG00000021891
Gene Name methyltransferase like 6
Synonyms 1600013P15Rik
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.554) question?
Stock # IGL02113
Quality Score
Chromosome 14
Chromosomal Location 31473578-31495040 bp(-) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 31482831 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 211 (Y211*)
Ref Sequence ENSEMBL: ENSMUSP00000154679 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055303] [ENSMUST00000226986] [ENSMUST00000227595] [ENSMUST00000227777] [ENSMUST00000228181] [ENSMUST00000228727]
AlphaFold Q8BVH9
Predicted Effect probably null
Transcript: ENSMUST00000055303
AA Change: Y211*
SMART Domains Protein: ENSMUSP00000077138
Gene: ENSMUSG00000021891
AA Change: Y211*

Pfam:Methyltransf_23 49 241 3.3e-13 PFAM
Pfam:Methyltransf_31 77 215 5.1e-9 PFAM
Pfam:Methyltransf_18 79 190 5.8e-10 PFAM
Pfam:Methyltransf_12 84 183 5.9e-17 PFAM
Pfam:Methyltransf_11 84 187 3.2e-9 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000226986
AA Change: Y50*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227095
Predicted Effect probably null
Transcript: ENSMUST00000227595
AA Change: Y166*
Predicted Effect probably null
Transcript: ENSMUST00000227777
AA Change: Y211*
Predicted Effect probably benign
Transcript: ENSMUST00000228181
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228309
Predicted Effect probably null
Transcript: ENSMUST00000228727
AA Change: Y211*
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced 3-methylcytidine (m3C) methyltransferases modification of tRNA. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 A T 3: 122,110,478 H726L possibly damaging Het
Aqr A T 2: 114,120,027 Y900* probably null Het
Atp11a G T 8: 12,865,048 R1155S probably benign Het
Bahd1 A G 2: 118,917,205 D435G probably benign Het
Brca2 A G 5: 150,540,979 T1403A possibly damaging Het
Cc2d2a T A 5: 43,685,248 probably null Het
Cog7 A G 7: 121,925,480 I697T probably damaging Het
Dclre1a A G 19: 56,541,532 V791A probably damaging Het
Dgki A G 6: 36,913,625 probably benign Het
Dpyd A G 3: 118,999,219 Y525C probably benign Het
Eepd1 T C 9: 25,482,713 L91P probably damaging Het
Foxf1 T A 8: 121,084,565 L56H probably damaging Het
Fry A T 5: 150,399,605 M1074L probably benign Het
Gbx1 T C 5: 24,504,876 T324A probably damaging Het
Gfpt1 T A 6: 87,087,367 N646K probably benign Het
Gm10258 C T 3: 30,268,393 probably benign Het
Gm12887 T C 4: 121,616,495 M53V probably benign Het
Hoxa11 C T 6: 52,245,317 G135S probably damaging Het
Moxd2 T C 6: 40,885,404 I160M probably benign Het
Mphosph10 G A 7: 64,376,807 probably benign Het
Mrpl19 T A 6: 81,965,915 M5L probably benign Het
Nbea A G 3: 55,992,492 V1412A probably benign Het
Nceh1 G T 3: 27,222,891 S121I probably damaging Het
Ntan1 A G 16: 13,835,144 T217A probably damaging Het
Ogfod1 C T 8: 94,064,213 A504V probably damaging Het
Olfr584 A T 7: 103,085,850 I111L possibly damaging Het
Pde3b G A 7: 114,526,906 V792M probably damaging Het
Pde9a A T 17: 31,459,970 M262L probably benign Het
Pi4ka A G 16: 17,373,415 V206A probably benign Het
Pkp1 A T 1: 135,883,914 N406K possibly damaging Het
Rcn3 A G 7: 45,083,338 I302T probably damaging Het
Rfx6 A G 10: 51,678,012 Q68R probably benign Het
Rpgrip1 A G 14: 52,133,844 D340G possibly damaging Het
Scn10a C T 9: 119,609,890 G1638S probably damaging Het
Serpinb9f A T 13: 33,334,468 H317L probably damaging Het
Setdb2 C T 14: 59,402,315 R709Q probably damaging Het
Slc40a1 A G 1: 45,910,894 I466T probably benign Het
Smyd2 A T 1: 189,882,217 S371R probably damaging Het
Snap47 A C 11: 59,428,436 I292S probably damaging Het
Tbx4 A G 11: 85,912,264 E322G possibly damaging Het
Tg A G 15: 66,705,330 T1501A probably benign Het
Tmem259 A G 10: 79,978,709 V300A probably benign Het
Usp7 A G 16: 8,716,513 probably null Het
Vmn2r94 G T 17: 18,257,675 T158K probably damaging Het
Vmn2r95 G T 17: 18,439,907 A194S possibly damaging Het
Zfp944 A T 17: 22,339,066 I400N possibly damaging Het
Zmynd12 T A 4: 119,433,997 I53K probably damaging Het
Other mutations in Mettl6
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4171:Mettl6 UTSW 14 31493667 missense probably damaging 1.00
R4979:Mettl6 UTSW 14 31479795 missense probably damaging 1.00
R6408:Mettl6 UTSW 14 31479726 missense probably damaging 1.00
R9147:Mettl6 UTSW 14 31482898 missense probably damaging 1.00
R9445:Mettl6 UTSW 14 31487570 critical splice donor site probably null
Posted On 2015-04-16