Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02113:Zfp944'

280257

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp944

Ensembl Gene

ENSMUSG00000033972

Gene Name

zinc finger protein 944

Synonyms

6330416L07Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.293) question?

Stock #

IGL02113

Quality Score

Status

Chromosome

Chromosomal Location

22337989-22361400 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 22339066 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 400 (I400N)

Ref Sequence

ENSEMBL: ENSMUSP00000111197 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000115535]

AlphaFold

E9PUS4

Predicted Effect

possibly damaging
Transcript: ENSMUST00000115535
AA Change: I400N

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000111197
Gene: ENSMUSG00000033972
AA Change: I400N

Domain	Start	End	E-Value	Type
KRAB	13	76	2.08e-21	SMART
ZnF_C2H2	183	205	1.01e-1	SMART
ZnF_C2H2	211	233	1.07e0	SMART
ZnF_C2H2	239	261	1.95e-3	SMART
ZnF_C2H2	267	289	1.22e-4	SMART
ZnF_C2H2	295	317	2.24e-3	SMART
ZnF_C2H2	323	345	1.82e-3	SMART
ZnF_C2H2	351	373	5.99e-4	SMART
ZnF_C2H2	379	401	4.79e-3	SMART
ZnF_C2H2	407	429	2.99e-4	SMART
ZnF_C2H2	435	457	4.17e-3	SMART
ZnF_C2H2	463	485	1.36e-2	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	A	T	3: 122,110,478	H726L	possibly damaging	Het
Aqr	A	T	2: 114,120,027	Y900*	probably null	Het
Atp11a	G	T	8: 12,865,048	R1155S	probably benign	Het
Bahd1	A	G	2: 118,917,205	D435G	probably benign	Het
Brca2	A	G	5: 150,540,979	T1403A	possibly damaging	Het
Cc2d2a	T	A	5: 43,685,248		probably null	Het
Cog7	A	G	7: 121,925,480	I697T	probably damaging	Het
Dclre1a	A	G	19: 56,541,532	V791A	probably damaging	Het
Dgki	A	G	6: 36,913,625		probably benign	Het
Dpyd	A	G	3: 118,999,219	Y525C	probably benign	Het
Eepd1	T	C	9: 25,482,713	L91P	probably damaging	Het
Foxf1	T	A	8: 121,084,565	L56H	probably damaging	Het
Fry	A	T	5: 150,399,605	M1074L	probably benign	Het
Gbx1	T	C	5: 24,504,876	T324A	probably damaging	Het
Gfpt1	T	A	6: 87,087,367	N646K	probably benign	Het
Gm10258	C	T	3: 30,268,393		probably benign	Het
Gm12887	T	C	4: 121,616,495	M53V	probably benign	Het
Hoxa11	C	T	6: 52,245,317	G135S	probably damaging	Het
Mettl6	A	T	14: 31,482,831	Y211*	probably null	Het
Moxd2	T	C	6: 40,885,404	I160M	probably benign	Het
Mphosph10	G	A	7: 64,376,807		probably benign	Het
Mrpl19	T	A	6: 81,965,915	M5L	probably benign	Het
Nbea	A	G	3: 55,992,492	V1412A	probably benign	Het
Nceh1	G	T	3: 27,222,891	S121I	probably damaging	Het
Ntan1	A	G	16: 13,835,144	T217A	probably damaging	Het
Ogfod1	C	T	8: 94,064,213	A504V	probably damaging	Het
Olfr584	A	T	7: 103,085,850	I111L	possibly damaging	Het
Pde3b	G	A	7: 114,526,906	V792M	probably damaging	Het
Pde9a	A	T	17: 31,459,970	M262L	probably benign	Het
Pi4ka	A	G	16: 17,373,415	V206A	probably benign	Het
Pkp1	A	T	1: 135,883,914	N406K	possibly damaging	Het
Rcn3	A	G	7: 45,083,338	I302T	probably damaging	Het
Rfx6	A	G	10: 51,678,012	Q68R	probably benign	Het
Rpgrip1	A	G	14: 52,133,844	D340G	possibly damaging	Het
Scn10a	C	T	9: 119,609,890	G1638S	probably damaging	Het
Serpinb9f	A	T	13: 33,334,468	H317L	probably damaging	Het
Setdb2	C	T	14: 59,402,315	R709Q	probably damaging	Het
Slc40a1	A	G	1: 45,910,894	I466T	probably benign	Het
Smyd2	A	T	1: 189,882,217	S371R	probably damaging	Het
Snap47	A	C	11: 59,428,436	I292S	probably damaging	Het
Tbx4	A	G	11: 85,912,264	E322G	possibly damaging	Het
Tg	A	G	15: 66,705,330	T1501A	probably benign	Het
Tmem259	A	G	10: 79,978,709	V300A	probably benign	Het
Usp7	A	G	16: 8,716,513		probably null	Het
Vmn2r94	G	T	17: 18,257,675	T158K	probably damaging	Het
Vmn2r95	G	T	17: 18,439,907	A194S	possibly damaging	Het
Zmynd12	T	A	4: 119,433,997	I53K	probably damaging	Het

Other mutations in Zfp944

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00595:Zfp944	APN	17	22339205	missense	probably benign	0.10
IGL00917:Zfp944	APN	17	22339784	missense	probably benign	0.00
IGL01093:Zfp944	APN	17	22343634	splice site	probably benign
IGL02694:Zfp944	APN	17	22339918	missense	probably benign	0.05
IGL03135:Zfp944	APN	17	22339756	missense	probably benign	0.00
IGL03172:Zfp944	APN	17	22340037	missense	probably damaging	0.98
R0121:Zfp944	UTSW	17	22339268	missense	possibly damaging	0.69
R0336:Zfp944	UTSW	17	22339028	missense	probably damaging	1.00
R0755:Zfp944	UTSW	17	22339908	missense	possibly damaging	0.63
R1536:Zfp944	UTSW	17	22339716	nonsense	probably null
R1708:Zfp944	UTSW	17	22339045	missense	probably damaging	0.98
R1886:Zfp944	UTSW	17	22339979	missense	probably benign	0.04
R1928:Zfp944	UTSW	17	22341084	missense	probably damaging	0.96
R1950:Zfp944	UTSW	17	22339700	missense	probably benign	0.16
R2075:Zfp944	UTSW	17	22339197	nonsense	probably null
R2101:Zfp944	UTSW	17	22339828	missense	probably benign	0.41
R2433:Zfp944	UTSW	17	22339212	nonsense	probably null
R4698:Zfp944	UTSW	17	22339199	missense	probably damaging	1.00
R4986:Zfp944	UTSW	17	22339230	missense	probably damaging	1.00
R6451:Zfp944	UTSW	17	22338865	missense	probably benign	0.40
R6566:Zfp944	UTSW	17	22339745	missense	possibly damaging	0.96
R6752:Zfp944	UTSW	17	22339519	missense	probably benign	0.01
R7064:Zfp944	UTSW	17	22339579	missense	probably damaging	1.00
R8193:Zfp944	UTSW	17	22339880	nonsense	probably null
R8323:Zfp944	UTSW	17	22339254	missense	probably benign
R8328:Zfp944	UTSW	17	22339724	nonsense	probably null
R8902:Zfp944	UTSW	17	22339780	missense	probably benign	0.41
R8915:Zfp944	UTSW	17	22339526	missense	probably benign	0.05
R9130:Zfp944	UTSW	17	22341050	missense	probably damaging	1.00
R9248:Zfp944	UTSW	17	22343638	critical splice donor site	probably null

Posted On

2015-04-16