Incidental Mutation 'IGL02115:Zc3h4'
ID 280331
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zc3h4
Ensembl Gene ENSMUSG00000059273
Gene Name zinc finger CCCH-type containing 4
Synonyms Kiaa1064-hp, Bwq1, LOC330474
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02115
Quality Score
Status
Chromosome 7
Chromosomal Location 16134835-16171621 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 16159708 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 426 (D426G)
Ref Sequence ENSEMBL: ENSMUSP00000147665 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098789] [ENSMUST00000209289]
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000098789
AA Change: D418G
SMART Domains Protein: ENSMUSP00000096386
Gene: ENSMUSG00000059273
AA Change: D418G

DomainStartEndE-ValueType
low complexity region 2 22 N/A INTRINSIC
low complexity region 35 97 N/A INTRINSIC
low complexity region 144 170 N/A INTRINSIC
low complexity region 184 247 N/A INTRINSIC
low complexity region 264 324 N/A INTRINSIC
ZnF_C3H1 341 366 1.95e-3 SMART
ZnF_C3H1 370 395 6.17e-6 SMART
ZnF_C3H1 396 419 3.38e-1 SMART
low complexity region 433 451 N/A INTRINSIC
low complexity region 456 486 N/A INTRINSIC
low complexity region 489 505 N/A INTRINSIC
low complexity region 552 641 N/A INTRINSIC
low complexity region 705 720 N/A INTRINSIC
coiled coil region 729 760 N/A INTRINSIC
internal_repeat_2 767 822 3.38e-5 PROSPERO
low complexity region 837 850 N/A INTRINSIC
low complexity region 863 880 N/A INTRINSIC
low complexity region 881 892 N/A INTRINSIC
internal_repeat_2 986 1037 3.38e-5 PROSPERO
low complexity region 1049 1072 N/A INTRINSIC
low complexity region 1077 1097 N/A INTRINSIC
low complexity region 1175 1195 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000209289
AA Change: D426G
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of CCCH (C-x8-C-x5-C-x3-H type) zinc finger domain-containing proteins. These zinc finger domains, which coordinate zinc finger binding and are characterized by three cysteine residues and one histidine residue, are nucleic acid-binding. Other family members are known to function in post-transcriptional regulation. [provided by RefSeq, Aug 2011]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933440M02Rik A T 7: 124,930,781 (GRCm39) noncoding transcript Het
Abca7 A T 10: 79,833,913 (GRCm39) N76Y probably damaging Het
Apob A G 12: 8,042,923 (GRCm39) K755R probably benign Het
BC034090 A T 1: 155,108,397 (GRCm39) probably benign Het
Brinp1 T C 4: 68,680,635 (GRCm39) T632A probably benign Het
Cdcp1 C A 9: 123,014,462 (GRCm39) C104F probably damaging Het
Cfap206 C T 4: 34,722,623 (GRCm39) V153I possibly damaging Het
Chd1l A T 3: 97,497,220 (GRCm39) probably null Het
Ckb A G 12: 111,636,415 (GRCm39) F271L possibly damaging Het
Col6a3 T A 1: 90,735,373 (GRCm39) I759L probably damaging Het
Ddr2 A T 1: 169,822,278 (GRCm39) M390K probably benign Het
Dhx8 C T 11: 101,643,214 (GRCm39) P762L probably damaging Het
Dnah3 A T 7: 119,628,277 (GRCm39) V1449E probably damaging Het
Dzip3 T C 16: 48,768,848 (GRCm39) I629M probably benign Het
Ep300 T C 15: 81,533,019 (GRCm39) I1692T unknown Het
Ercc6 T A 14: 32,298,950 (GRCm39) L1446Q probably damaging Het
Gm10092 T C 16: 35,957,993 (GRCm39) noncoding transcript Het
Gm6900 A T 7: 10,390,503 (GRCm39) noncoding transcript Het
Gpr149 T C 3: 62,502,336 (GRCm39) T507A probably benign Het
Hmcn1 T A 1: 150,506,479 (GRCm39) D3776V probably damaging Het
Irgm2 A G 11: 58,110,948 (GRCm39) E225G probably benign Het
Kif14 T C 1: 136,424,305 (GRCm39) probably benign Het
Klhl22 T C 16: 17,594,459 (GRCm39) V196A probably damaging Het
Lig4 T C 8: 10,023,247 (GRCm39) S178G possibly damaging Het
Lzts2 A G 19: 45,014,809 (GRCm39) probably benign Het
Mcoln3 C T 3: 145,843,056 (GRCm39) S380L probably damaging Het
Med12l A T 3: 58,975,740 (GRCm39) T223S probably benign Het
Mrpl54 A G 10: 81,101,483 (GRCm39) probably null Het
Myo1c A T 11: 75,552,417 (GRCm39) I397F probably damaging Het
Nbas A T 12: 13,367,693 (GRCm39) probably benign Het
Ncoa2 G A 1: 13,223,041 (GRCm39) H1195Y probably damaging Het
Nol3 A G 8: 106,006,263 (GRCm39) M171V probably benign Het
Or2l5 A T 16: 19,333,853 (GRCm39) C178S probably damaging Het
Or52s1 A G 7: 102,861,681 (GRCm39) T194A probably damaging Het
Pdpr C T 8: 111,830,630 (GRCm39) L107F probably damaging Het
Ppfibp2 G A 7: 107,338,525 (GRCm39) probably benign Het
Rusc2 T C 4: 43,426,136 (GRCm39) probably benign Het
Sdk2 G T 11: 113,725,639 (GRCm39) probably benign Het
Sema7a T C 9: 57,868,183 (GRCm39) C539R probably damaging Het
Senp6 T C 9: 80,029,208 (GRCm39) C524R probably damaging Het
Setdb2 C T 14: 59,639,764 (GRCm39) R709Q probably damaging Het
Slc15a1 A T 14: 121,718,073 (GRCm39) Y269N possibly damaging Het
Synj2 T A 17: 6,067,865 (GRCm39) Y113N probably damaging Het
Tm6sf1 A T 7: 81,525,551 (GRCm39) Y172F probably damaging Het
Trpv4 T C 5: 114,763,090 (GRCm39) D773G probably damaging Het
Ttc39a A G 4: 109,283,491 (GRCm39) probably benign Het
Tut1 C T 19: 8,942,676 (GRCm39) R588W probably damaging Het
Unc79 A T 12: 102,964,933 (GRCm39) Y74F probably damaging Het
Usp53 A T 3: 122,741,039 (GRCm39) I737K probably benign Het
Vmn2r67 A T 7: 84,800,787 (GRCm39) M383K probably damaging Het
Zfp622 A G 15: 25,987,286 (GRCm39) N308S probably damaging Het
Other mutations in Zc3h4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Zc3h4 APN 7 16,156,159 (GRCm39) missense unknown
IGL00923:Zc3h4 APN 7 16,163,617 (GRCm39) missense unknown
IGL01541:Zc3h4 APN 7 16,168,257 (GRCm39) missense unknown
IGL02303:Zc3h4 APN 7 16,168,002 (GRCm39) missense unknown
IGL02336:Zc3h4 APN 7 16,159,702 (GRCm39) missense unknown
IGL02734:Zc3h4 APN 7 16,157,849 (GRCm39) missense unknown
IGL02736:Zc3h4 APN 7 16,151,308 (GRCm39) nonsense probably null
BB008:Zc3h4 UTSW 7 16,166,909 (GRCm39) missense unknown
BB018:Zc3h4 UTSW 7 16,166,909 (GRCm39) missense unknown
R0032:Zc3h4 UTSW 7 16,168,565 (GRCm39) missense unknown
R0032:Zc3h4 UTSW 7 16,168,565 (GRCm39) missense unknown
R0220:Zc3h4 UTSW 7 16,163,198 (GRCm39) missense unknown
R0336:Zc3h4 UTSW 7 16,169,103 (GRCm39) missense unknown
R0416:Zc3h4 UTSW 7 16,154,200 (GRCm39) missense probably damaging 1.00
R0666:Zc3h4 UTSW 7 16,168,697 (GRCm39) missense unknown
R0864:Zc3h4 UTSW 7 16,154,104 (GRCm39) missense probably damaging 0.99
R1068:Zc3h4 UTSW 7 16,163,161 (GRCm39) missense unknown
R1145:Zc3h4 UTSW 7 16,150,838 (GRCm39) missense possibly damaging 0.53
R1145:Zc3h4 UTSW 7 16,150,838 (GRCm39) missense possibly damaging 0.53
R1472:Zc3h4 UTSW 7 16,168,695 (GRCm39) missense unknown
R1665:Zc3h4 UTSW 7 16,163,505 (GRCm39) missense unknown
R2087:Zc3h4 UTSW 7 16,150,865 (GRCm39) missense possibly damaging 0.72
R2182:Zc3h4 UTSW 7 16,156,441 (GRCm39) missense unknown
R2508:Zc3h4 UTSW 7 16,168,264 (GRCm39) missense unknown
R3037:Zc3h4 UTSW 7 16,155,410 (GRCm39) missense unknown
R4439:Zc3h4 UTSW 7 16,163,036 (GRCm39) missense unknown
R4576:Zc3h4 UTSW 7 16,168,579 (GRCm39) missense unknown
R5030:Zc3h4 UTSW 7 16,156,155 (GRCm39) missense unknown
R5160:Zc3h4 UTSW 7 16,168,573 (GRCm39) missense unknown
R5270:Zc3h4 UTSW 7 16,168,440 (GRCm39) missense unknown
R5490:Zc3h4 UTSW 7 16,162,930 (GRCm39) missense unknown
R5519:Zc3h4 UTSW 7 16,169,157 (GRCm39) missense unknown
R5770:Zc3h4 UTSW 7 16,163,536 (GRCm39) missense unknown
R7067:Zc3h4 UTSW 7 16,162,976 (GRCm39) nonsense probably null
R7234:Zc3h4 UTSW 7 16,162,961 (GRCm39) missense unknown
R7316:Zc3h4 UTSW 7 16,169,260 (GRCm39) missense unknown
R7771:Zc3h4 UTSW 7 16,163,824 (GRCm39) missense unknown
R7852:Zc3h4 UTSW 7 16,156,392 (GRCm39) missense unknown
R7922:Zc3h4 UTSW 7 16,159,647 (GRCm39) missense unknown
R7931:Zc3h4 UTSW 7 16,166,909 (GRCm39) missense unknown
R7965:Zc3h4 UTSW 7 16,163,770 (GRCm39) missense unknown
R8827:Zc3h4 UTSW 7 16,163,123 (GRCm39) missense unknown
R8859:Zc3h4 UTSW 7 16,168,939 (GRCm39) missense unknown
R9457:Zc3h4 UTSW 7 16,168,675 (GRCm39) missense unknown
R9562:Zc3h4 UTSW 7 16,168,891 (GRCm39) missense unknown
R9609:Zc3h4 UTSW 7 16,150,751 (GRCm39) missense unknown
R9721:Zc3h4 UTSW 7 16,168,770 (GRCm39) missense unknown
RF001:Zc3h4 UTSW 7 16,163,612 (GRCm39) small insertion probably benign
RF039:Zc3h4 UTSW 7 16,163,543 (GRCm39) small deletion probably benign
X0064:Zc3h4 UTSW 7 16,156,441 (GRCm39) missense unknown
Posted On 2015-04-16