Incidental Mutation 'IGL02115:Or2l5'
ID 280339
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2l5
Ensembl Gene ENSMUSG00000045341
Gene Name olfactory receptor family 2 subfamily L member 5
Synonyms MOR272-1, GA_x54KRFPKG5P-15963726-15962788, Olfr167
Accession Numbers
Essential gene? Probably non essential (E-score: 0.248) question?
Stock # IGL02115
Quality Score
Status
Chromosome 16
Chromosomal Location 19333446-19334384 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 19333853 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 178 (C178S)
Ref Sequence ENSEMBL: ENSMUSP00000150102 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054606] [ENSMUST00000214315]
AlphaFold Q8VGJ5
Predicted Effect probably damaging
Transcript: ENSMUST00000054606
AA Change: C178S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000055344
Gene: ENSMUSG00000045341
AA Change: C178S

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 4.8e-46 PFAM
Pfam:7TM_GPCR_Srsx 33 295 1.2e-6 PFAM
Pfam:7tm_1 40 289 1.8e-26 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214315
AA Change: C178S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217566
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933440M02Rik A T 7: 124,930,781 (GRCm39) noncoding transcript Het
Abca7 A T 10: 79,833,913 (GRCm39) N76Y probably damaging Het
Apob A G 12: 8,042,923 (GRCm39) K755R probably benign Het
BC034090 A T 1: 155,108,397 (GRCm39) probably benign Het
Brinp1 T C 4: 68,680,635 (GRCm39) T632A probably benign Het
Cdcp1 C A 9: 123,014,462 (GRCm39) C104F probably damaging Het
Cfap206 C T 4: 34,722,623 (GRCm39) V153I possibly damaging Het
Chd1l A T 3: 97,497,220 (GRCm39) probably null Het
Ckb A G 12: 111,636,415 (GRCm39) F271L possibly damaging Het
Col6a3 T A 1: 90,735,373 (GRCm39) I759L probably damaging Het
Ddr2 A T 1: 169,822,278 (GRCm39) M390K probably benign Het
Dhx8 C T 11: 101,643,214 (GRCm39) P762L probably damaging Het
Dnah3 A T 7: 119,628,277 (GRCm39) V1449E probably damaging Het
Dzip3 T C 16: 48,768,848 (GRCm39) I629M probably benign Het
Ep300 T C 15: 81,533,019 (GRCm39) I1692T unknown Het
Ercc6 T A 14: 32,298,950 (GRCm39) L1446Q probably damaging Het
Gm10092 T C 16: 35,957,993 (GRCm39) noncoding transcript Het
Gm6900 A T 7: 10,390,503 (GRCm39) noncoding transcript Het
Gpr149 T C 3: 62,502,336 (GRCm39) T507A probably benign Het
Hmcn1 T A 1: 150,506,479 (GRCm39) D3776V probably damaging Het
Irgm2 A G 11: 58,110,948 (GRCm39) E225G probably benign Het
Kif14 T C 1: 136,424,305 (GRCm39) probably benign Het
Klhl22 T C 16: 17,594,459 (GRCm39) V196A probably damaging Het
Lig4 T C 8: 10,023,247 (GRCm39) S178G possibly damaging Het
Lzts2 A G 19: 45,014,809 (GRCm39) probably benign Het
Mcoln3 C T 3: 145,843,056 (GRCm39) S380L probably damaging Het
Med12l A T 3: 58,975,740 (GRCm39) T223S probably benign Het
Mrpl54 A G 10: 81,101,483 (GRCm39) probably null Het
Myo1c A T 11: 75,552,417 (GRCm39) I397F probably damaging Het
Nbas A T 12: 13,367,693 (GRCm39) probably benign Het
Ncoa2 G A 1: 13,223,041 (GRCm39) H1195Y probably damaging Het
Nol3 A G 8: 106,006,263 (GRCm39) M171V probably benign Het
Or52s1 A G 7: 102,861,681 (GRCm39) T194A probably damaging Het
Pdpr C T 8: 111,830,630 (GRCm39) L107F probably damaging Het
Ppfibp2 G A 7: 107,338,525 (GRCm39) probably benign Het
Rusc2 T C 4: 43,426,136 (GRCm39) probably benign Het
Sdk2 G T 11: 113,725,639 (GRCm39) probably benign Het
Sema7a T C 9: 57,868,183 (GRCm39) C539R probably damaging Het
Senp6 T C 9: 80,029,208 (GRCm39) C524R probably damaging Het
Setdb2 C T 14: 59,639,764 (GRCm39) R709Q probably damaging Het
Slc15a1 A T 14: 121,718,073 (GRCm39) Y269N possibly damaging Het
Synj2 T A 17: 6,067,865 (GRCm39) Y113N probably damaging Het
Tm6sf1 A T 7: 81,525,551 (GRCm39) Y172F probably damaging Het
Trpv4 T C 5: 114,763,090 (GRCm39) D773G probably damaging Het
Ttc39a A G 4: 109,283,491 (GRCm39) probably benign Het
Tut1 C T 19: 8,942,676 (GRCm39) R588W probably damaging Het
Unc79 A T 12: 102,964,933 (GRCm39) Y74F probably damaging Het
Usp53 A T 3: 122,741,039 (GRCm39) I737K probably benign Het
Vmn2r67 A T 7: 84,800,787 (GRCm39) M383K probably damaging Het
Zc3h4 A G 7: 16,159,708 (GRCm39) D426G unknown Het
Zfp622 A G 15: 25,987,286 (GRCm39) N308S probably damaging Het
Other mutations in Or2l5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01535:Or2l5 APN 16 19,334,228 (GRCm39) missense probably benign 0.01
IGL02562:Or2l5 APN 16 19,333,714 (GRCm39) missense possibly damaging 0.74
BB008:Or2l5 UTSW 16 19,334,258 (GRCm39) missense possibly damaging 0.94
BB018:Or2l5 UTSW 16 19,334,258 (GRCm39) missense possibly damaging 0.94
R0366:Or2l5 UTSW 16 19,333,598 (GRCm39) missense probably benign 0.13
R0673:Or2l5 UTSW 16 19,334,146 (GRCm39) missense probably damaging 1.00
R1187:Or2l5 UTSW 16 19,333,796 (GRCm39) missense probably benign 0.01
R1237:Or2l5 UTSW 16 19,334,375 (GRCm39) missense probably benign 0.01
R1975:Or2l5 UTSW 16 19,333,586 (GRCm39) missense probably damaging 0.99
R1977:Or2l5 UTSW 16 19,333,586 (GRCm39) missense probably damaging 0.99
R1997:Or2l5 UTSW 16 19,333,792 (GRCm39) missense probably damaging 1.00
R2225:Or2l5 UTSW 16 19,333,996 (GRCm39) missense probably benign 0.05
R2226:Or2l5 UTSW 16 19,333,996 (GRCm39) missense probably benign 0.05
R4078:Or2l5 UTSW 16 19,333,982 (GRCm39) missense possibly damaging 0.76
R5019:Or2l5 UTSW 16 19,334,285 (GRCm39) missense probably damaging 0.99
R5071:Or2l5 UTSW 16 19,333,777 (GRCm39) missense probably benign 0.00
R5278:Or2l5 UTSW 16 19,334,128 (GRCm39) nonsense probably null
R5415:Or2l5 UTSW 16 19,333,996 (GRCm39) missense possibly damaging 0.94
R5744:Or2l5 UTSW 16 19,334,086 (GRCm39) missense probably benign 0.00
R5991:Or2l5 UTSW 16 19,333,507 (GRCm39) missense probably damaging 0.99
R6151:Or2l5 UTSW 16 19,334,281 (GRCm39) missense probably damaging 1.00
R6540:Or2l5 UTSW 16 19,333,571 (GRCm39) missense probably benign
R7014:Or2l5 UTSW 16 19,334,206 (GRCm39) missense probably benign 0.20
R7145:Or2l5 UTSW 16 19,333,649 (GRCm39) missense probably damaging 0.99
R7535:Or2l5 UTSW 16 19,333,544 (GRCm39) missense probably damaging 1.00
R7677:Or2l5 UTSW 16 19,333,678 (GRCm39) missense probably benign 0.42
R7715:Or2l5 UTSW 16 19,333,480 (GRCm39) missense probably benign 0.00
R7931:Or2l5 UTSW 16 19,334,258 (GRCm39) missense possibly damaging 0.94
R8137:Or2l5 UTSW 16 19,333,846 (GRCm39) missense possibly damaging 0.89
R8671:Or2l5 UTSW 16 19,333,804 (GRCm39) missense possibly damaging 0.63
Posted On 2015-04-16