Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02116:Vmn2r31'

280369

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r31

Ensembl Gene

ENSMUSG00000096373

Gene Name

vomeronasal 2, receptor 31

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.192) question?

Stock #

IGL02116

Quality Score

Status

Chromosome

Chromosomal Location

7386984-7402626 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 7397548 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 237 (I237F)

Ref Sequence

ENSEMBL: ENSMUSP00000074613 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075108]

AlphaFold

L7N1Z4

Predicted Effect

probably damaging
Transcript: ENSMUST00000075108
AA Change: I237F

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000074613
Gene: ENSMUSG00000096373
AA Change: I237F

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	1e-33	PFAM
Pfam:NCD3G	512	565	1.4e-20	PFAM
Pfam:7tm_3	598	833	8.1e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg5	A	T	17: 84,981,018 (GRCm39)	N190K	possibly damaging	Het
Adamts19	T	C	18: 58,970,571 (GRCm39)	S52P	probably benign	Het
Ahrr	G	T	13: 74,368,692 (GRCm39)	H160Q	possibly damaging	Het
Ap4s1	T	C	12: 51,769,833 (GRCm39)		probably null	Het
Atrn	T	C	2: 130,800,009 (GRCm39)	V462A	probably damaging	Het
D630003M21Rik	T	C	2: 158,045,130 (GRCm39)	S800G	possibly damaging	Het
Dach1	T	G	14: 98,138,859 (GRCm39)	N528T	probably damaging	Het
Foxl2	T	C	9: 98,838,111 (GRCm39)	M133T	probably damaging	Het
Grsf1	A	G	5: 88,818,033 (GRCm39)		probably null	Het
Gtpbp4	A	G	13: 9,042,772 (GRCm39)	I43T	probably damaging	Het
Helz2	T	C	2: 180,873,978 (GRCm39)	Y2172C	probably damaging	Het
Hey1	G	T	3: 8,731,640 (GRCm39)		probably null	Het
Hnrnph3	A	T	10: 62,851,855 (GRCm39)		probably benign	Het
Hps1	A	T	19: 42,759,568 (GRCm39)	Y81*	probably null	Het
Inhba	A	G	13: 16,201,557 (GRCm39)	H373R	probably benign	Het
Leo1	T	A	9: 75,356,697 (GRCm39)	I359K	probably damaging	Het
Mcoln3	A	G	3: 145,839,664 (GRCm39)	N339D	probably benign	Het
Mrpl19	G	A	6: 81,942,758 (GRCm39)	P51S	probably benign	Het
Nadk	C	A	4: 155,663,763 (GRCm39)		probably benign	Het
Or5an11	A	G	19: 12,246,374 (GRCm39)	Y260C	probably damaging	Het
Or5d39	T	A	2: 87,979,632 (GRCm39)	T244S	probably benign	Het
Pappa2	T	G	1: 158,672,695 (GRCm39)	I1083L	probably benign	Het
R3hdm2	A	G	10: 127,334,421 (GRCm39)	D948G	probably damaging	Het
Rbm15	A	T	3: 107,237,596 (GRCm39)	L934Q	probably damaging	Het
Rec8	T	A	14: 55,862,336 (GRCm39)		probably null	Het
Riok1	A	G	13: 38,243,932 (GRCm39)	E486G	possibly damaging	Het
Rptn	A	C	3: 93,302,404 (GRCm39)	E40A	possibly damaging	Het
Setdb2	C	T	14: 59,639,764 (GRCm39)	R709Q	probably damaging	Het
Slc40a1	T	C	1: 45,950,688 (GRCm39)	T255A	probably benign	Het
Slc5a8	A	T	10: 88,755,362 (GRCm39)	M490L	probably benign	Het
Sned1	C	A	1: 93,209,447 (GRCm39)	C62*	probably null	Het
Sptbn4	T	C	7: 27,063,782 (GRCm39)	T2215A	probably benign	Het
Synpo	T	A	18: 60,736,528 (GRCm39)	R234W	probably damaging	Het
Tmco3	A	T	8: 13,342,706 (GRCm39)		probably benign	Het
Tmprss13	A	G	9: 45,244,972 (GRCm39)	D250G	probably benign	Het
Wdr90	A	G	17: 26,078,466 (GRCm39)	V306A	probably benign	Het
Zfp629	A	G	7: 127,211,890 (GRCm39)	W8R	probably damaging	Het
Zim1	T	C	7: 6,681,253 (GRCm39)	T137A	probably benign	Het

Other mutations in Vmn2r31

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01104:Vmn2r31	APN	7	7,399,565 (GRCm39)	missense	probably damaging	0.98
IGL01536:Vmn2r31	APN	7	7,387,847 (GRCm39)	missense	probably damaging	1.00
IGL01985:Vmn2r31	APN	7	7,397,510 (GRCm39)	missense	probably benign
FR4304:Vmn2r31	UTSW	7	7,387,607 (GRCm39)	missense	probably damaging	1.00
R1609:Vmn2r31	UTSW	7	7,387,888 (GRCm39)	missense	probably damaging	1.00
R4647:Vmn2r31	UTSW	7	7,387,367 (GRCm39)	missense	probably damaging	1.00
R4724:Vmn2r31	UTSW	7	7,387,757 (GRCm39)	missense	possibly damaging	0.63
R4824:Vmn2r31	UTSW	7	7,390,062 (GRCm39)	critical splice donor site	probably null
R5619:Vmn2r31	UTSW	7	7,387,529 (GRCm39)	nonsense	probably null
R6225:Vmn2r31	UTSW	7	7,397,638 (GRCm39)	missense	probably benign	0.19
R6610:Vmn2r31	UTSW	7	7,387,588 (GRCm39)	missense	probably damaging	0.97
R6956:Vmn2r31	UTSW	7	7,397,505 (GRCm39)	missense	probably benign
R7111:Vmn2r31	UTSW	7	7,399,480 (GRCm39)	missense	probably damaging	0.99
R7219:Vmn2r31	UTSW	7	7,397,397 (GRCm39)	missense	probably damaging	0.97
R7219:Vmn2r31	UTSW	7	7,390,105 (GRCm39)	missense	probably benign
R7300:Vmn2r31	UTSW	7	7,387,775 (GRCm39)	missense	possibly damaging	0.61
R7395:Vmn2r31	UTSW	7	7,387,744 (GRCm39)	missense	probably damaging	1.00
R7481:Vmn2r31	UTSW	7	7,387,579 (GRCm39)	missense	possibly damaging	0.94
R8015:Vmn2r31	UTSW	7	7,387,199 (GRCm39)	missense	probably damaging	1.00
R8434:Vmn2r31	UTSW	7	7,387,699 (GRCm39)	missense	probably damaging	1.00
R8781:Vmn2r31	UTSW	7	7,387,400 (GRCm39)	missense	possibly damaging	0.65
R8972:Vmn2r31	UTSW	7	7,399,654 (GRCm39)	missense	probably benign	0.00
R9034:Vmn2r31	UTSW	7	7,397,680 (GRCm39)	missense	probably benign	0.08
R9596:Vmn2r31	UTSW	7	7,397,292 (GRCm39)	missense	probably benign	0.01
R9711:Vmn2r31	UTSW	7	7,387,085 (GRCm39)	missense	probably damaging	0.99
R9714:Vmn2r31	UTSW	7	7,387,367 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16