Incidental Mutation 'IGL02117:Or11g7'
ID 280414
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or11g7
Ensembl Gene ENSMUSG00000095917
Gene Name olfactory receptor family 11 subfamily G member 7
Synonyms MOR106-4, Olfr740, GA_x6K02T2PMLR-6167145-6168080
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # IGL02117
Quality Score
Status
Chromosome 14
Chromosomal Location 50690511-50693135 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 50691399 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 297 (R297G)
Ref Sequence ENSEMBL: ENSMUSP00000148916 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089838] [ENSMUST00000214792]
AlphaFold E9PV79
Predicted Effect possibly damaging
Transcript: ENSMUST00000089838
AA Change: R297G

PolyPhen 2 Score 0.908 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000087276
Gene: ENSMUSG00000095917
AA Change: R297G

DomainStartEndE-ValueType
Pfam:7tm_4 35 311 2.3e-56 PFAM
Pfam:7tm_1 45 294 1.6e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214792
AA Change: R297G

PolyPhen 2 Score 0.908 (Sensitivity: 0.81; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921509C19Rik T A 2: 151,315,466 (GRCm39) M71L probably benign Het
Abcb11 A G 2: 69,154,169 (GRCm39) probably benign Het
Ago4 T C 4: 126,410,645 (GRCm39) T249A probably benign Het
Ahr A T 12: 35,562,922 (GRCm39) C92* probably null Het
Arhgap17 G A 7: 122,885,996 (GRCm39) probably benign Het
Arid1a G T 4: 133,420,126 (GRCm39) T992K unknown Het
Camk2a A G 18: 61,111,061 (GRCm39) I83M probably damaging Het
Ccdc154 T C 17: 25,386,792 (GRCm39) probably null Het
Chtf18 T C 17: 25,941,177 (GRCm39) H607R possibly damaging Het
Col25a1 T C 3: 130,313,422 (GRCm39) probably benign Het
Col9a1 C T 1: 24,276,574 (GRCm39) Q530* probably null Het
Cryl1 G T 14: 57,523,904 (GRCm39) D219E probably damaging Het
Cul3 A T 1: 80,300,781 (GRCm39) probably benign Het
Cul9 C A 17: 46,851,301 (GRCm39) R373L probably benign Het
Exo1 A G 1: 175,721,309 (GRCm39) Y316C possibly damaging Het
Fam114a1 G A 5: 65,187,465 (GRCm39) V408M probably benign Het
Hmcn2 A T 2: 31,347,185 (GRCm39) S4792C possibly damaging Het
Hps5 A G 7: 46,432,940 (GRCm39) F260S probably damaging Het
Hrh4 T C 18: 13,155,477 (GRCm39) S339P probably benign Het
Ist1 A T 8: 110,405,584 (GRCm39) L152Q probably damaging Het
Marco A G 1: 120,418,683 (GRCm39) V190A probably benign Het
Mdn1 T C 4: 32,709,364 (GRCm39) V1711A probably benign Het
Mmp9 A G 2: 164,791,644 (GRCm39) Y179C probably damaging Het
Mrgprb5 A G 7: 47,818,742 (GRCm39) probably benign Het
Mrgprx1 G T 7: 47,671,371 (GRCm39) C125* probably null Het
Msh6 A G 17: 88,298,234 (GRCm39) probably benign Het
Myot C A 18: 44,488,177 (GRCm39) R441S probably benign Het
Paf1 A G 7: 28,098,115 (GRCm39) probably benign Het
Pde11a A G 2: 75,821,606 (GRCm39) L891P probably damaging Het
Prkar2a T A 9: 108,596,460 (GRCm39) I135N probably damaging Het
Rap1gap C T 4: 137,454,355 (GRCm39) T646M probably damaging Het
Rgs7bp T C 13: 105,088,087 (GRCm39) D229G possibly damaging Het
Rhobtb3 C T 13: 76,025,547 (GRCm39) S523N probably damaging Het
Setd7 A T 3: 51,428,826 (GRCm39) Y335N probably damaging Het
Setdb2 C T 14: 59,639,764 (GRCm39) R709Q probably damaging Het
Socs4 T C 14: 47,528,264 (GRCm39) Y400H probably damaging Het
Spag16 A T 1: 69,909,479 (GRCm39) H192L probably damaging Het
Ssh1 A T 5: 114,084,541 (GRCm39) C566* probably null Het
Stap1 T G 5: 86,234,552 (GRCm39) I98S possibly damaging Het
Tgs1 C T 4: 3,585,836 (GRCm39) H238Y probably damaging Het
Tifab T C 13: 56,324,275 (GRCm39) Y56C probably benign Het
Tssk2 A G 16: 17,717,653 (GRCm39) E352G probably benign Het
Vmn2r57 A T 7: 41,049,874 (GRCm39) V625D probably benign Het
Wbp1l T C 19: 46,632,876 (GRCm39) Y75H probably benign Het
Wnt5a T C 14: 28,228,077 (GRCm39) probably benign Het
Other mutations in Or11g7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01663:Or11g7 APN 14 50,690,607 (GRCm39) missense probably benign 0.04
IGL02663:Or11g7 APN 14 50,691,309 (GRCm39) missense probably benign 0.02
IGL02858:Or11g7 APN 14 50,690,507 (GRCm39) utr 5 prime probably benign
IGL02955:Or11g7 APN 14 50,691,442 (GRCm39) missense probably damaging 0.99
IGL03210:Or11g7 APN 14 50,691,440 (GRCm39) missense probably benign 0.10
IGL03249:Or11g7 APN 14 50,690,668 (GRCm39) missense probably damaging 0.98
G1Funyon:Or11g7 UTSW 14 50,691,021 (GRCm39) missense probably benign 0.08
R0946:Or11g7 UTSW 14 50,691,130 (GRCm39) missense probably benign 0.13
R1449:Or11g7 UTSW 14 50,691,378 (GRCm39) missense probably damaging 1.00
R1465:Or11g7 UTSW 14 50,690,634 (GRCm39) missense possibly damaging 0.91
R1465:Or11g7 UTSW 14 50,690,634 (GRCm39) missense possibly damaging 0.91
R1513:Or11g7 UTSW 14 50,691,138 (GRCm39) missense probably benign 0.00
R1908:Or11g7 UTSW 14 50,691,295 (GRCm39) missense probably damaging 0.99
R2422:Or11g7 UTSW 14 50,690,893 (GRCm39) missense probably damaging 1.00
R3406:Or11g7 UTSW 14 50,690,653 (GRCm39) missense probably benign 0.14
R4184:Or11g7 UTSW 14 50,690,827 (GRCm39) missense probably damaging 1.00
R4795:Or11g7 UTSW 14 50,690,874 (GRCm39) missense probably damaging 0.96
R5028:Or11g7 UTSW 14 50,691,196 (GRCm39) missense probably damaging 1.00
R5436:Or11g7 UTSW 14 50,691,184 (GRCm39) missense probably damaging 1.00
R6057:Or11g7 UTSW 14 50,691,201 (GRCm39) nonsense probably null
R6455:Or11g7 UTSW 14 50,691,042 (GRCm39) missense possibly damaging 0.92
R6903:Or11g7 UTSW 14 50,691,412 (GRCm39) missense possibly damaging 0.93
R6998:Or11g7 UTSW 14 50,690,890 (GRCm39) missense probably benign 0.29
R7671:Or11g7 UTSW 14 50,691,342 (GRCm39) missense probably benign 0.04
R8048:Or11g7 UTSW 14 50,691,373 (GRCm39) missense possibly damaging 0.52
R8301:Or11g7 UTSW 14 50,691,021 (GRCm39) missense probably benign 0.08
X0066:Or11g7 UTSW 14 50,691,115 (GRCm39) missense probably benign 0.00
Posted On 2015-04-16