Incidental Mutation 'IGL02118:Vmn2r9'
ID280470
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r9
Ensembl Gene ENSMUSG00000091624
Gene Namevomeronasal 2, receptor 9
SynonymsEG435864
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.122) question?
Stock #IGL02118
Quality Score
Status
Chromosome5
Chromosomal Location108842947-108852510 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 108843636 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Phenylalanine at position 620 (L620F)
Ref Sequence ENSEMBL: ENSMUSP00000129520 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170419]
Predicted Effect probably damaging
Transcript: ENSMUST00000170419
AA Change: L620F

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000129520
Gene: ENSMUSG00000091624
AA Change: L620F

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:ANF_receptor 77 412 8.1e-29 PFAM
Pfam:NCD3G 507 561 2.3e-16 PFAM
Pfam:7tm_3 592 829 3.4e-54 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700057G04Rik A T 9: 92,350,958 K45* probably null Het
Acox3 T C 5: 35,601,521 Y359H possibly damaging Het
Actn2 A G 13: 12,276,547 probably benign Het
Actr8 T C 14: 29,982,771 probably null Het
Aldh16a1 G A 7: 45,146,035 P400L probably damaging Het
Aldob T A 4: 49,538,790 K243* probably null Het
Arfgap1 T C 2: 180,980,444 F274S possibly damaging Het
BC080695 A T 4: 143,571,156 T49S probably benign Het
Brd8 C T 18: 34,602,727 S899N probably damaging Het
Cask T C X: 13,559,395 I471V probably damaging Het
Cdc42ep4 C T 11: 113,729,116 G150S probably benign Het
Cpne1 T G 2: 156,077,643 D278A possibly damaging Het
Gcn1l1 A G 5: 115,610,879 E1856G probably damaging Het
Gm8362 A T 14: 6,771,516 V159E probably damaging Het
Golga5 A G 12: 102,495,752 I700V possibly damaging Het
Ifi206 T C 1: 173,481,768 T221A probably benign Het
Ighv2-6-8 T C 12: 113,796,417 K24R possibly damaging Het
Morc1 T C 16: 48,587,104 L661P probably benign Het
Per2 G A 1: 91,424,309 T825I probably damaging Het
Prkar2b A G 12: 31,975,964 V19A probably damaging Het
Psmb8 T A 17: 34,201,224 D263E probably damaging Het
Pum2 T C 12: 8,729,117 I563T probably benign Het
Retreg1 T G 15: 25,966,623 probably null Het
Rfx7 A G 9: 72,617,204 T559A probably benign Het
Rnf31 T G 14: 55,599,112 I801S probably damaging Het
Rom1 G T 19: 8,929,022 T51N possibly damaging Het
Sema6b G T 17: 56,132,821 P7T probably benign Het
Stpg1 A G 4: 135,508,064 probably benign Het
Sugct A T 13: 17,452,520 Y249* probably null Het
Tbc1d21 C T 9: 58,360,463 V317M probably benign Het
Tcea2 A G 2: 181,685,835 I125V probably benign Het
Ttc39b T A 4: 83,297,949 D19V probably damaging Het
Tti2 T A 8: 31,155,509 probably null Het
Usp32 A T 11: 85,032,177 Y142* probably null Het
Vill A G 9: 119,060,398 Y134C probably benign Het
Zfp398 A G 6: 47,858,945 D14G probably damaging Het
Zfp598 T C 17: 24,677,617 Y223H probably damaging Het
Znhit6 G T 3: 145,578,104 C43F probably damaging Het
Other mutations in Vmn2r9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00920:Vmn2r9 APN 5 108848024 missense possibly damaging 0.79
IGL00972:Vmn2r9 APN 5 108849037 missense probably benign 0.02
IGL01102:Vmn2r9 APN 5 108842945 splice site probably null
IGL01892:Vmn2r9 APN 5 108847834 missense probably damaging 1.00
IGL02086:Vmn2r9 APN 5 108847567 missense probably damaging 1.00
IGL02119:Vmn2r9 APN 5 108843636 missense probably damaging 1.00
IGL02120:Vmn2r9 APN 5 108843636 missense probably damaging 1.00
IGL02121:Vmn2r9 APN 5 108843636 missense probably damaging 1.00
IGL02123:Vmn2r9 APN 5 108843636 missense probably damaging 1.00
IGL02131:Vmn2r9 APN 5 108843636 missense probably damaging 1.00
IGL02132:Vmn2r9 APN 5 108843636 missense probably damaging 1.00
IGL02171:Vmn2r9 APN 5 108843636 missense probably damaging 1.00
IGL02185:Vmn2r9 APN 5 108843636 missense probably damaging 1.00
IGL02186:Vmn2r9 APN 5 108843636 missense probably damaging 1.00
IGL02346:Vmn2r9 APN 5 108842984 missense probably benign 0.07
IGL02508:Vmn2r9 APN 5 108848201 missense possibly damaging 0.70
IGL02815:Vmn2r9 APN 5 108842990 missense possibly damaging 0.69
IGL03077:Vmn2r9 APN 5 108848307 splice site probably benign
IGL03269:Vmn2r9 APN 5 108847954 missense probably damaging 1.00
IGL03293:Vmn2r9 APN 5 108848131 missense probably damaging 1.00
R0112:Vmn2r9 UTSW 5 108843125 missense probably damaging 1.00
R0328:Vmn2r9 UTSW 5 108847539 missense probably benign 0.11
R0382:Vmn2r9 UTSW 5 108847597 missense probably damaging 1.00
R0521:Vmn2r9 UTSW 5 108848288 nonsense probably null
R0975:Vmn2r9 UTSW 5 108843303 missense probably damaging 1.00
R1216:Vmn2r9 UTSW 5 108847574 missense probably damaging 1.00
R1458:Vmn2r9 UTSW 5 108848984 missense probably benign 0.44
R1469:Vmn2r9 UTSW 5 108843828 missense probably benign
R1469:Vmn2r9 UTSW 5 108843828 missense probably benign
R1704:Vmn2r9 UTSW 5 108846400 missense probably damaging 1.00
R1967:Vmn2r9 UTSW 5 108847522 missense probably benign 0.03
R1991:Vmn2r9 UTSW 5 108846439 missense probably damaging 0.99
R2410:Vmn2r9 UTSW 5 108848257 missense probably damaging 1.00
R3419:Vmn2r9 UTSW 5 108846433 missense probably damaging 0.96
R3852:Vmn2r9 UTSW 5 108848131 missense probably damaging 1.00
R3873:Vmn2r9 UTSW 5 108847835 missense probably benign 0.14
R3905:Vmn2r9 UTSW 5 108847919 missense probably benign 0.37
R3908:Vmn2r9 UTSW 5 108847919 missense probably benign 0.37
R3921:Vmn2r9 UTSW 5 108849055 missense probably benign
R4156:Vmn2r9 UTSW 5 108847877 missense possibly damaging 0.64
R4477:Vmn2r9 UTSW 5 108846277 missense probably benign
R4478:Vmn2r9 UTSW 5 108846277 missense probably benign
R4544:Vmn2r9 UTSW 5 108847685 missense probably benign 0.00
R4546:Vmn2r9 UTSW 5 108847685 missense probably benign 0.00
R4627:Vmn2r9 UTSW 5 108847597 missense probably damaging 1.00
R5215:Vmn2r9 UTSW 5 108846485 missense probably benign 0.03
R5361:Vmn2r9 UTSW 5 108848063 missense probably damaging 1.00
R5587:Vmn2r9 UTSW 5 108847561 missense probably damaging 1.00
R6054:Vmn2r9 UTSW 5 108848260 missense probably damaging 0.99
R6106:Vmn2r9 UTSW 5 108845036 missense probably benign
R6125:Vmn2r9 UTSW 5 108842970 missense probably benign 0.01
R6137:Vmn2r9 UTSW 5 108849016 missense probably benign 0.00
R6920:Vmn2r9 UTSW 5 108849046 missense possibly damaging 0.72
R7579:Vmn2r9 UTSW 5 108845082 missense probably damaging 1.00
R8683:Vmn2r9 UTSW 5 108849007 missense probably benign
Posted On2015-04-16