Incidental Mutation 'IGL02120:Mob2'
ID 280575
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mob2
Ensembl Gene ENSMUSG00000025147
Gene Name MOB kinase activator 2
Synonyms 1110017M21Rik, 2700078K21Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02120
Quality Score
Status
Chromosome 7
Chromosomal Location 141562272-141614802 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 141564035 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 33 (V33L)
Ref Sequence ENSEMBL: ENSMUSP00000147608 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084418] [ENSMUST00000209725] [ENSMUST00000209732] [ENSMUST00000210684] [ENSMUST00000211000] [ENSMUST00000211206]
AlphaFold Q8VI63
Predicted Effect possibly damaging
Transcript: ENSMUST00000084418
AA Change: V118L

PolyPhen 2 Score 0.485 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000081455
Gene: ENSMUSG00000025147
AA Change: V118L

DomainStartEndE-ValueType
Mob1_phocein 30 200 6.1e-85 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000209725
Predicted Effect probably benign
Transcript: ENSMUST00000209732
AA Change: V149L

PolyPhen 2 Score 0.115 (Sensitivity: 0.93; Specificity: 0.86)
Predicted Effect probably benign
Transcript: ENSMUST00000210684
Predicted Effect possibly damaging
Transcript: ENSMUST00000211000
AA Change: V33L

PolyPhen 2 Score 0.485 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000211206
AA Change: V33L

PolyPhen 2 Score 0.485 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211633
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 T C 2: 69,087,654 (GRCm39) Y1037C probably damaging Het
Aldh16a1 G A 7: 44,795,459 (GRCm39) P400L probably damaging Het
Ankrd33b T C 15: 31,367,202 (GRCm39) T113A possibly damaging Het
Aox3 T A 1: 58,166,809 (GRCm39) N177K probably benign Het
Arhgap29 T A 3: 121,797,906 (GRCm39) V532E probably benign Het
Brd8 C T 18: 34,735,780 (GRCm39) S899N probably damaging Het
Caskin1 G T 17: 24,719,916 (GRCm39) G401V probably damaging Het
Cemip A T 7: 83,600,771 (GRCm39) M950K probably damaging Het
Cfap107 C T 4: 144,144,981 (GRCm39) R195H probably benign Het
Chrd T C 16: 20,553,291 (GRCm39) V211A probably damaging Het
Ckap2l T C 2: 129,127,542 (GRCm39) N212S possibly damaging Het
Clip1 T C 5: 123,785,946 (GRCm39) D246G probably damaging Het
Dlst T C 12: 85,165,342 (GRCm39) S82P probably benign Het
Dmxl1 T A 18: 50,027,245 (GRCm39) L2118M possibly damaging Het
Dnah7a T C 1: 53,534,876 (GRCm39) K2795E possibly damaging Het
Enpp5 T A 17: 44,391,736 (GRCm39) M55K probably benign Het
Epdr1 A T 13: 19,778,641 (GRCm39) S50T probably damaging Het
Gm7808 T A 9: 19,839,313 (GRCm39) probably benign Het
Huwe1 T A X: 150,690,386 (GRCm39) F2485I possibly damaging Het
Kcnb2 C T 1: 15,780,085 (GRCm39) T319M probably damaging Het
Lama1 G A 17: 68,023,784 (GRCm39) V60M probably damaging Het
Lingo3 A T 10: 80,671,693 (GRCm39) L79Q probably damaging Het
Magi2 T A 5: 20,433,451 (GRCm39) probably null Het
Mus81 G A 19: 5,535,661 (GRCm39) probably benign Het
Nup210l G A 3: 90,044,169 (GRCm39) G490D probably damaging Het
Or13n4 A C 7: 106,422,905 (GRCm39) V276G possibly damaging Het
Pbp2 A G 6: 135,286,816 (GRCm39) V177A probably damaging Het
Pomt2 T C 12: 87,158,326 (GRCm39) D656G probably benign Het
Ppp2r1b A G 9: 50,773,069 (GRCm39) probably benign Het
Prp2rt G T 13: 97,235,285 (GRCm39) probably benign Het
Ptprq T C 10: 107,503,333 (GRCm39) E775G probably damaging Het
Rad54l T C 4: 115,956,181 (GRCm39) I549V probably benign Het
Ranbp10 T C 8: 106,532,214 (GRCm39) Y145C probably damaging Het
Runx1t1 A T 4: 13,846,884 (GRCm39) T223S probably benign Het
Stxbp6 G T 12: 44,948,831 (GRCm39) probably benign Het
Syne2 A G 12: 75,993,480 (GRCm39) D2085G probably damaging Het
Szt2 C T 4: 118,245,761 (GRCm39) R1064Q probably benign Het
Taar3 A G 10: 23,826,065 (GRCm39) T204A probably benign Het
Tdpoz1 A G 3: 93,577,750 (GRCm39) S345P probably damaging Het
Tgm4 T A 9: 122,875,594 (GRCm39) I149N probably damaging Het
Tubal3 T A 13: 3,980,675 (GRCm39) I129N probably damaging Het
Vegfc T C 8: 54,634,436 (GRCm39) F372L possibly damaging Het
Vmn2r9 G A 5: 108,991,502 (GRCm39) L620F probably damaging Het
Vwf C A 6: 125,592,997 (GRCm39) L786M probably benign Het
Other mutations in Mob2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1809:Mob2 UTSW 7 141,570,111 (GRCm39) missense probably damaging 1.00
R5197:Mob2 UTSW 7 141,563,274 (GRCm39) splice site probably null
R5527:Mob2 UTSW 7 141,563,147 (GRCm39) missense probably damaging 1.00
R6611:Mob2 UTSW 7 141,563,293 (GRCm39) missense probably damaging 1.00
R7881:Mob2 UTSW 7 141,563,177 (GRCm39) missense probably damaging 1.00
R8906:Mob2 UTSW 7 141,563,261 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16