Incidental Mutation 'IGL02121:Olfr125'
ID280618
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr125
Ensembl Gene ENSMUSG00000050613
Gene Nameolfactory receptor 125
SynonymsGA_x6K02T2PSCP-2291580-2292542, MOR218-8
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.084) question?
Stock #IGL02121
Quality Score
Status
Chromosome17
Chromosomal Location37832949-37838490 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 37835941 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 314 (V314A)
Ref Sequence ENSEMBL: ENSMUSP00000149602 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050255] [ENSMUST00000213857]
Predicted Effect probably benign
Transcript: ENSMUST00000050255
AA Change: V314A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000055221
Gene: ENSMUSG00000050613
AA Change: V314A

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 1.7e-47 PFAM
Pfam:7tm_1 38 318 7.6e-28 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174655
Predicted Effect probably benign
Transcript: ENSMUST00000213857
AA Change: V314A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700029F12Rik A T 13: 97,022,530 V122D unknown Het
4930579F01Rik T G 3: 138,164,373 Y199S possibly damaging Het
Abca6 T A 11: 110,182,924 I1434F probably benign Het
Acsm1 T C 7: 119,658,412 V467A possibly damaging Het
Alg3 T C 16: 20,606,535 T260A possibly damaging Het
Aoc1 A G 6: 48,906,320 probably null Het
Ap5b1 C T 19: 5,570,787 T745I possibly damaging Het
Atp6v1c2 T G 12: 17,291,440 K272Q possibly damaging Het
Brd8 C T 18: 34,602,727 S899N probably damaging Het
Clcn7 C T 17: 25,153,084 A426V possibly damaging Het
Clec14a T C 12: 58,268,437 E133G probably damaging Het
Col4a3bp T G 13: 96,599,474 Y181D probably benign Het
Diexf A T 1: 193,118,278 D411E probably benign Het
Dst T A 1: 34,228,657 V2720E probably damaging Het
Efr3a C T 15: 65,871,150 probably benign Het
Fam83g T C 11: 61,684,783 S84P probably benign Het
Gm10436 T C 12: 88,178,472 D28G possibly damaging Het
Gm7251 T C 13: 49,805,906 noncoding transcript Het
Gnptab T G 10: 88,429,461 S312A possibly damaging Het
Grap2 C A 15: 80,647,875 S230R possibly damaging Het
Grm6 T A 11: 50,859,656 C549S probably damaging Het
Gtf3c1 A T 7: 125,646,731 L1504* probably null Het
Iars A G 13: 49,724,696 M899V probably benign Het
Il1rl1 T A 1: 40,442,303 probably benign Het
Kcna4 T C 2: 107,296,618 Y566H possibly damaging Het
Kcnn2 T C 18: 45,561,273 I175T probably damaging Het
Kcnt1 C T 2: 25,901,865 T609I probably damaging Het
Kif3b A G 2: 153,317,274 R332G probably damaging Het
Mansc1 T C 6: 134,621,837 D39G probably damaging Het
Med12 T C X: 101,288,342 probably benign Het
Mmp1b G T 9: 7,384,935 T238K probably benign Het
Nav3 A G 10: 109,759,036 S1435P probably damaging Het
Npc1l1 A G 11: 6,228,157 S418P probably benign Het
Olfr324 T C 11: 58,597,582 V62A possibly damaging Het
Olfr401 A G 11: 74,121,287 probably benign Het
Olfr522 G T 7: 140,162,694 D85E probably benign Het
Olfr628 A G 7: 103,732,469 Y181C probably damaging Het
Olfr648 A C 7: 104,180,225 M61R probably damaging Het
Olfr918 T C 9: 38,673,415 T23A probably damaging Het
Otoa A G 7: 121,122,024 T421A probably benign Het
Otulin G A 15: 27,608,737 A42V probably damaging Het
Pcdhb1 T A 18: 37,265,785 V263E probably benign Het
Pfkfb4 C T 9: 109,025,110 R351W probably damaging Het
Phip A T 9: 82,893,370 V1053D probably damaging Het
Pkd1 G A 17: 24,575,927 R2196H probably benign Het
Plin4 T A 17: 56,102,131 Q1363L probably damaging Het
Pp2d1 C A 17: 53,507,921 V592L probably damaging Het
Prkdc T G 16: 15,717,184 M1649R probably benign Het
Ptk2b T C 14: 66,213,482 K12E probably benign Het
Rars2 G A 4: 34,657,219 V522I probably damaging Het
Rpgrip1 T A 14: 52,147,374 N646K possibly damaging Het
Sars2 A G 7: 28,752,525 probably benign Het
Sgo2b T C 8: 63,931,282 T227A possibly damaging Het
Smc1b T C 15: 85,097,985 T703A probably benign Het
Stk32a G T 18: 43,313,507 D341Y probably benign Het
Thap11 T C 8: 105,855,914 V185A possibly damaging Het
Ttll10 C A 4: 156,048,433 V65F probably benign Het
Ube2q1 T A 3: 89,780,462 N111K possibly damaging Het
Upf2 C A 2: 6,026,323 probably benign Het
Vasp T A 7: 19,257,712 probably benign Het
Vmn2r104 C T 17: 20,041,794 W358* probably null Het
Vmn2r9 G A 5: 108,843,636 L620F probably damaging Het
Wdfy3 C T 5: 101,898,510 G1826R possibly damaging Het
Wdr7 T A 18: 63,777,545 Y669* probably null Het
Wdr72 T A 9: 74,281,729 probably benign Het
Other mutations in Olfr125
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01943:Olfr125 APN 17 37835053 missense probably benign
IGL02103:Olfr125 APN 17 37835278 missense possibly damaging 0.91
IGL02183:Olfr125 APN 17 37835413 missense probably damaging 1.00
IGL02208:Olfr125 APN 17 37835524 missense probably damaging 1.00
IGL02822:Olfr125 APN 17 37835643 missense possibly damaging 0.95
IGL02833:Olfr125 APN 17 37835940 missense probably benign 0.02
IGL03324:Olfr125 APN 17 37835274 missense probably benign 0.23
R1689:Olfr125 UTSW 17 37835604 missense possibly damaging 0.88
R1719:Olfr125 UTSW 17 37835353 missense possibly damaging 0.76
R1878:Olfr125 UTSW 17 37835362 missense probably benign 0.03
R2064:Olfr125 UTSW 17 37835002 start codon destroyed probably null 0.06
R2696:Olfr125 UTSW 17 37835107 missense probably benign 0.00
R3800:Olfr125 UTSW 17 37835957 missense probably benign
R4469:Olfr125 UTSW 17 37835716 missense probably benign 0.35
R4801:Olfr125 UTSW 17 37835349 missense probably damaging 1.00
R4802:Olfr125 UTSW 17 37835349 missense probably damaging 1.00
R5473:Olfr125 UTSW 17 37835739 missense probably benign 0.04
R6743:Olfr125 UTSW 17 37835803 missense probably damaging 1.00
R7481:Olfr125 UTSW 17 37835398 missense probably damaging 1.00
Posted On2015-04-16