Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02121:Il1rl1'

280644

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Il1rl1

Ensembl Gene

ENSMUSG00000026069

Gene Name

interleukin 1 receptor-like 1

Synonyms

DER4, Ly84, St2-rs1, St2, T1/ST2, ST2L, ST2, Fit-1, T1, T1 gene

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02121

Quality Score

Status

Chromosome

Chromosomal Location

40468730-40504575 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 40481463 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000134351 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000053043] [ENSMUST00000097772] [ENSMUST00000173514] [ENSMUST00000173881] [ENSMUST00000174335]

AlphaFold

P14719

Predicted Effect

probably benign
Transcript: ENSMUST00000053043

SMART Domains

Protein: ENSMUSP00000054914
Gene: ENSMUSG00000026069

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
IGc2	33	100	7.35e-11	SMART
IGc2	130	194	8.85e-5	SMART
IG_like	225	326	2.66e1	SMART
transmembrane domain	333	355	N/A	INTRINSIC
TIR	381	543	4.23e-35	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000097772

SMART Domains

Protein: ENSMUSP00000095379
Gene: ENSMUSG00000026069

Domain	Start	End	E-Value	Type
IGc2	33	100	7.35e-11	SMART
IGc2	130	194	8.85e-5	SMART
IG_like	225	326	2.66e1	SMART
transmembrane domain	333	355	N/A	INTRINSIC
TIR	381	543	4.23e-35	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000173514

SMART Domains

Protein: ENSMUSP00000133784
Gene: ENSMUSG00000026069

Domain	Start	End	E-Value	Type
IGc2	33	100	7.35e-11	SMART
IGc2	130	194	8.85e-5	SMART
IG_like	225	326	2.66e1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000173881

SMART Domains

Protein: ENSMUSP00000134225
Gene: ENSMUSG00000026069

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
PDB:4KC3\|B	27	65	4e-16	PDB
Blast:IGc2	33	65	2e-17	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000174335

SMART Domains

Protein: ENSMUSP00000134351
Gene: ENSMUSG00000026069

Domain	Start	End	E-Value	Type
IGc2	33	100	7.35e-11	SMART
IGc2	130	194	8.85e-5	SMART
IG_like	225	326	2.66e1	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene display an abnormal Th2 type inflammatory response. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700029F12Rik	A	T	13: 97,159,038 (GRCm39)	V122D	unknown	Het
4930579F01Rik	T	G	3: 137,870,134 (GRCm39)	Y199S	possibly damaging	Het
Abca6	T	A	11: 110,073,750 (GRCm39)	I1434F	probably benign	Het
Acsm1	T	C	7: 119,257,635 (GRCm39)	V467A	possibly damaging	Het
Alg3	T	C	16: 20,425,285 (GRCm39)	T260A	possibly damaging	Het
Aoc1	A	G	6: 48,883,254 (GRCm39)		probably null	Het
Ap5b1	C	T	19: 5,620,815 (GRCm39)	T745I	possibly damaging	Het
Atp6v1c2	T	G	12: 17,341,441 (GRCm39)	K272Q	possibly damaging	Het
Brd8	C	T	18: 34,735,780 (GRCm39)	S899N	probably damaging	Het
Cert1	T	G	13: 96,735,982 (GRCm39)	Y181D	probably benign	Het
Clcn7	C	T	17: 25,372,058 (GRCm39)	A426V	possibly damaging	Het
Clec14a	T	C	12: 58,315,223 (GRCm39)	E133G	probably damaging	Het
Dst	T	A	1: 34,267,738 (GRCm39)	V2720E	probably damaging	Het
Efr3a	C	T	15: 65,742,999 (GRCm39)		probably benign	Het
Fam83g	T	C	11: 61,575,609 (GRCm39)	S84P	probably benign	Het
Gm7251	T	C	13: 49,959,382 (GRCm39)		noncoding transcript	Het
Gnptab	T	G	10: 88,265,323 (GRCm39)	S312A	possibly damaging	Het
Grap2	C	A	15: 80,532,076 (GRCm39)	S230R	possibly damaging	Het
Grm6	T	A	11: 50,750,483 (GRCm39)	C549S	probably damaging	Het
Gtf3c1	A	T	7: 125,245,903 (GRCm39)	L1504*	probably null	Het
Iars1	A	G	13: 49,878,172 (GRCm39)	M899V	probably benign	Het
Kcna4	T	C	2: 107,126,963 (GRCm39)	Y566H	possibly damaging	Het
Kcnn2	T	C	18: 45,694,340 (GRCm39)	I175T	probably damaging	Het
Kcnt1	C	T	2: 25,791,877 (GRCm39)	T609I	probably damaging	Het
Kif3b	A	G	2: 153,159,194 (GRCm39)	R332G	probably damaging	Het
Mansc1	T	C	6: 134,598,800 (GRCm39)	D39G	probably damaging	Het
Med12	T	C	X: 100,331,948 (GRCm39)		probably benign	Het
Mmp1b	G	T	9: 7,384,935 (GRCm39)	T238K	probably benign	Het
Nav3	A	G	10: 109,594,897 (GRCm39)	S1435P	probably damaging	Het
Npc1l1	A	G	11: 6,178,157 (GRCm39)	S418P	probably benign	Het
Or14j1	T	C	17: 38,146,832 (GRCm39)	V314A	probably benign	Het
Or2ab1	T	C	11: 58,488,408 (GRCm39)	V62A	possibly damaging	Het
Or3a1b	A	G	11: 74,012,113 (GRCm39)		probably benign	Het
Or52a24	A	G	7: 103,381,676 (GRCm39)	Y181C	probably damaging	Het
Or52h1	A	C	7: 103,829,432 (GRCm39)	M61R	probably damaging	Het
Or6ae1	G	T	7: 139,742,607 (GRCm39)	D85E	probably benign	Het
Or8b3b	T	C	9: 38,584,711 (GRCm39)	T23A	probably damaging	Het
Otoa	A	G	7: 120,721,247 (GRCm39)	T421A	probably benign	Het
Otulin	G	A	15: 27,608,823 (GRCm39)	A42V	probably damaging	Het
Pcdhb1	T	A	18: 37,398,838 (GRCm39)	V263E	probably benign	Het
Pfkfb4	C	T	9: 108,854,178 (GRCm39)	R351W	probably damaging	Het
Phip	A	T	9: 82,775,423 (GRCm39)	V1053D	probably damaging	Het
Pkd1	G	A	17: 24,794,901 (GRCm39)	R2196H	probably benign	Het
Plin4	T	A	17: 56,409,131 (GRCm39)	Q1363L	probably damaging	Het
Pp2d1	C	A	17: 53,814,949 (GRCm39)	V592L	probably damaging	Het
Pramel51	T	C	12: 88,145,242 (GRCm39)	D28G	possibly damaging	Het
Prkdc	T	G	16: 15,535,048 (GRCm39)	M1649R	probably benign	Het
Ptk2b	T	C	14: 66,450,931 (GRCm39)	K12E	probably benign	Het
Rars2	G	A	4: 34,657,219 (GRCm39)	V522I	probably damaging	Het
Rpgrip1	T	A	14: 52,384,831 (GRCm39)	N646K	possibly damaging	Het
Sars2	A	G	7: 28,451,950 (GRCm39)		probably benign	Het
Sgo2b	T	C	8: 64,384,316 (GRCm39)	T227A	possibly damaging	Het
Smc1b	T	C	15: 84,982,186 (GRCm39)	T703A	probably benign	Het
Stk32a	G	T	18: 43,446,572 (GRCm39)	D341Y	probably benign	Het
Thap11	T	C	8: 106,582,546 (GRCm39)	V185A	possibly damaging	Het
Ttll10	C	A	4: 156,132,890 (GRCm39)	V65F	probably benign	Het
Ube2q1	T	A	3: 89,687,769 (GRCm39)	N111K	possibly damaging	Het
Upf2	C	A	2: 6,031,134 (GRCm39)		probably benign	Het
Utp25	A	T	1: 192,800,586 (GRCm39)	D411E	probably benign	Het
Vasp	T	A	7: 18,991,637 (GRCm39)		probably benign	Het
Vmn2r104	C	T	17: 20,262,056 (GRCm39)	W358*	probably null	Het
Vmn2r9	G	A	5: 108,991,502 (GRCm39)	L620F	probably damaging	Het
Wdfy3	C	T	5: 102,046,376 (GRCm39)	G1826R	possibly damaging	Het
Wdr7	T	A	18: 63,910,616 (GRCm39)	Y669*	probably null	Het
Wdr72	T	A	9: 74,189,011 (GRCm39)		probably benign	Het

Other mutations in Il1rl1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01293:Il1rl1	APN	1	40,485,376 (GRCm39)	missense	possibly damaging	0.75
IGL01413:Il1rl1	APN	1	40,485,329 (GRCm39)	missense	possibly damaging	0.85
IGL01939:Il1rl1	APN	1	40,501,168 (GRCm39)	missense	possibly damaging	0.80
IGL02160:Il1rl1	APN	1	40,500,997 (GRCm39)	missense	probably benign	0.00
IGL02695:Il1rl1	APN	1	40,485,718 (GRCm39)	missense	possibly damaging	0.47
R0007:Il1rl1	UTSW	1	40,485,331 (GRCm39)	missense	possibly damaging	0.95
R0105:Il1rl1	UTSW	1	40,481,734 (GRCm39)	splice site	probably benign
R0200:Il1rl1	UTSW	1	40,480,463 (GRCm39)	missense	possibly damaging	0.95
R0363:Il1rl1	UTSW	1	40,481,734 (GRCm39)	splice site	probably benign
R0508:Il1rl1	UTSW	1	40,490,877 (GRCm39)	missense	possibly damaging	0.87
R0637:Il1rl1	UTSW	1	40,481,734 (GRCm39)	splice site	probably benign
R0676:Il1rl1	UTSW	1	40,481,734 (GRCm39)	splice site	probably benign
R1371:Il1rl1	UTSW	1	40,481,873 (GRCm39)	missense	probably damaging	0.96
R2074:Il1rl1	UTSW	1	40,501,204 (GRCm39)	missense	probably damaging	0.99
R2309:Il1rl1	UTSW	1	40,481,817 (GRCm39)	missense	possibly damaging	0.46
R2426:Il1rl1	UTSW	1	40,485,779 (GRCm39)	missense	probably damaging	1.00
R3983:Il1rl1	UTSW	1	40,485,823 (GRCm39)	missense	possibly damaging	0.73
R4601:Il1rl1	UTSW	1	40,480,460 (GRCm39)	missense	possibly damaging	0.88
R4707:Il1rl1	UTSW	1	40,489,348 (GRCm39)	missense	probably damaging	0.96
R4720:Il1rl1	UTSW	1	40,485,838 (GRCm39)	missense	probably benign	0.24
R4784:Il1rl1	UTSW	1	40,489,348 (GRCm39)	missense	probably damaging	0.96
R5137:Il1rl1	UTSW	1	40,489,285 (GRCm39)	missense	probably benign
R5765:Il1rl1	UTSW	1	40,501,103 (GRCm39)	missense	probably benign	0.06
R5953:Il1rl1	UTSW	1	40,481,833 (GRCm39)	missense	probably benign	0.05
R6339:Il1rl1	UTSW	1	40,501,016 (GRCm39)	missense	possibly damaging	0.88
R7176:Il1rl1	UTSW	1	40,485,766 (GRCm39)	missense	probably damaging	1.00
R7677:Il1rl1	UTSW	1	40,485,864 (GRCm39)	makesense	probably null
R8129:Il1rl1	UTSW	1	40,490,987 (GRCm39)	missense	probably damaging	0.98
R8670:Il1rl1	UTSW	1	40,480,559 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16