Incidental Mutation 'IGL02124:Vmn1r231'
ID 280772
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r231
Ensembl Gene ENSMUSG00000050933
Gene Name vomeronasal 1 receptor 231
Synonyms V1re7
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # IGL02124
Quality Score
Status
Chromosome 17
Chromosomal Location 21109978-21110913 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 21110568 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 116 (S116G)
Ref Sequence ENSEMBL: ENSMUSP00000056228 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061278]
AlphaFold Q8R2A3
Predicted Effect probably damaging
Transcript: ENSMUST00000061278
AA Change: S116G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000056228
Gene: ENSMUSG00000050933
AA Change: S116G

DomainStartEndE-ValueType
Pfam:TAS2R 6 294 1.6e-13 PFAM
Pfam:V1R 36 297 1.6e-27 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232004
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810024B03Rik T C 2: 127,028,654 (GRCm39) R182G possibly damaging Het
Casd1 A T 6: 4,624,142 (GRCm39) I312F probably benign Het
Cdc27 T C 11: 104,413,557 (GRCm39) T395A probably damaging Het
Cep152 A G 2: 125,405,381 (GRCm39) I1717T probably benign Het
Ces1f A T 8: 93,992,488 (GRCm39) V321E possibly damaging Het
Chrnb3 T C 8: 27,886,832 (GRCm39) probably benign Het
Col14a1 T A 15: 55,327,099 (GRCm39) F1416L unknown Het
Cplx4 T C 18: 66,103,123 (GRCm39) probably benign Het
Cubn A T 2: 13,386,648 (GRCm39) I1539N probably damaging Het
Dapk1 A G 13: 60,878,696 (GRCm39) T562A probably benign Het
Dnmt1 C A 9: 20,819,845 (GRCm39) V1433F probably damaging Het
Dytn A G 1: 63,680,251 (GRCm39) L436P probably damaging Het
Evpl T C 11: 116,117,841 (GRCm39) I783V probably benign Het
Fat4 T A 3: 38,942,553 (GRCm39) V482E probably damaging Het
Fcrlb T A 1: 170,734,927 (GRCm39) E400V probably benign Het
Folh1 T C 7: 86,374,626 (GRCm39) D656G probably damaging Het
Frem3 A C 8: 81,339,723 (GRCm39) D672A probably damaging Het
G3bp2 A G 5: 92,221,106 (GRCm39) M3T possibly damaging Het
Gm973 C T 1: 59,621,632 (GRCm39) Q26* probably null Het
Hsp90b1 T C 10: 86,541,222 (GRCm39) probably benign Het
Hspg2 G A 4: 137,246,125 (GRCm39) probably null Het
Lpin3 T C 2: 160,737,753 (GRCm39) probably null Het
Mtss2 G A 8: 111,464,256 (GRCm39) R295Q probably damaging Het
Muc5b G T 7: 141,409,369 (GRCm39) W1151L unknown Het
Myo3a A G 2: 22,467,538 (GRCm39) Y264C probably benign Het
Or4c123 A G 2: 89,127,407 (GRCm39) V69A probably benign Het
Or55b3 T C 7: 102,126,742 (GRCm39) T112A possibly damaging Het
Or5p60 T A 7: 107,724,249 (GRCm39) I74L probably benign Het
Pecam1 C T 11: 106,581,807 (GRCm39) G380S probably damaging Het
Phf21a C T 2: 92,179,767 (GRCm39) T345I probably damaging Het
Polg G A 7: 79,109,485 (GRCm39) S444L probably damaging Het
Prickle1 A G 15: 93,401,027 (GRCm39) Y486H probably damaging Het
Scg5 G A 2: 113,622,382 (GRCm39) probably benign Het
Septin5 G T 16: 18,443,579 (GRCm39) D123E probably damaging Het
Skint6 G A 4: 112,944,993 (GRCm39) T483I probably benign Het
Tep1 A T 14: 51,091,581 (GRCm39) probably benign Het
Tepsin T C 11: 119,982,547 (GRCm39) R440G probably benign Het
Tmem214 G A 5: 31,030,090 (GRCm39) A296T probably benign Het
Trpm4 A T 7: 44,959,947 (GRCm39) V649E probably damaging Het
Usf3 C A 16: 44,040,019 (GRCm39) Q1500K possibly damaging Het
Vmn1r45 T A 6: 89,910,035 (GRCm39) I312L probably benign Het
Other mutations in Vmn1r231
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00233:Vmn1r231 APN 17 21,110,828 (GRCm39) missense possibly damaging 0.68
IGL02151:Vmn1r231 APN 17 21,109,997 (GRCm39) missense probably benign 0.06
R0066:Vmn1r231 UTSW 17 21,109,998 (GRCm39) missense probably benign 0.27
R0066:Vmn1r231 UTSW 17 21,109,998 (GRCm39) missense probably benign 0.27
R0396:Vmn1r231 UTSW 17 21,110,661 (GRCm39) missense probably damaging 0.98
R0427:Vmn1r231 UTSW 17 21,110,490 (GRCm39) missense probably benign 0.05
R0470:Vmn1r231 UTSW 17 21,110,265 (GRCm39) nonsense probably null
R0848:Vmn1r231 UTSW 17 21,110,433 (GRCm39) missense probably damaging 1.00
R1692:Vmn1r231 UTSW 17 21,110,871 (GRCm39) missense probably benign 0.02
R1987:Vmn1r231 UTSW 17 21,110,212 (GRCm39) missense probably damaging 1.00
R1988:Vmn1r231 UTSW 17 21,110,212 (GRCm39) missense probably damaging 1.00
R2105:Vmn1r231 UTSW 17 21,110,380 (GRCm39) missense possibly damaging 0.66
R4440:Vmn1r231 UTSW 17 21,110,718 (GRCm39) missense possibly damaging 0.48
R4634:Vmn1r231 UTSW 17 21,110,660 (GRCm39) missense possibly damaging 0.46
R4646:Vmn1r231 UTSW 17 21,110,571 (GRCm39) missense probably damaging 1.00
R4678:Vmn1r231 UTSW 17 21,110,489 (GRCm39) missense possibly damaging 0.94
R4696:Vmn1r231 UTSW 17 21,110,901 (GRCm39) missense possibly damaging 0.63
R4938:Vmn1r231 UTSW 17 21,110,613 (GRCm39) missense possibly damaging 0.76
R5544:Vmn1r231 UTSW 17 21,110,840 (GRCm39) missense probably damaging 1.00
R5942:Vmn1r231 UTSW 17 21,110,417 (GRCm39) missense possibly damaging 0.83
R6053:Vmn1r231 UTSW 17 21,110,081 (GRCm39) missense probably damaging 1.00
R6692:Vmn1r231 UTSW 17 21,110,745 (GRCm39) missense possibly damaging 0.46
R6712:Vmn1r231 UTSW 17 21,109,992 (GRCm39) missense possibly damaging 0.54
R7131:Vmn1r231 UTSW 17 21,110,140 (GRCm39) missense possibly damaging 0.87
R7854:Vmn1r231 UTSW 17 21,110,894 (GRCm39) missense probably damaging 0.98
R7918:Vmn1r231 UTSW 17 21,110,236 (GRCm39) nonsense probably null
R8187:Vmn1r231 UTSW 17 21,110,893 (GRCm39) missense probably benign 0.10
R8238:Vmn1r231 UTSW 17 21,110,640 (GRCm39) missense probably benign 0.08
R8313:Vmn1r231 UTSW 17 21,110,289 (GRCm39) missense probably benign 0.02
R8525:Vmn1r231 UTSW 17 21,110,001 (GRCm39) missense probably benign 0.06
R9276:Vmn1r231 UTSW 17 21,110,560 (GRCm39) missense probably benign 0.00
RF010:Vmn1r231 UTSW 17 21,110,255 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16