Incidental Mutation 'IGL02124:Vmn1r231'
ID280772
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r231
Ensembl Gene ENSMUSG00000050933
Gene Namevomeronasal 1 receptor 231
SynonymsV1re7
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.057) question?
Stock #IGL02124
Quality Score
Status
Chromosome17
Chromosomal Location20889716-20890651 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 20890306 bp
ZygosityHeterozygous
Amino Acid Change Serine to Glycine at position 116 (S116G)
Ref Sequence ENSEMBL: ENSMUSP00000056228 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061278]
Predicted Effect probably damaging
Transcript: ENSMUST00000061278
AA Change: S116G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000056228
Gene: ENSMUSG00000050933
AA Change: S116G

DomainStartEndE-ValueType
Pfam:TAS2R 6 294 1.6e-13 PFAM
Pfam:V1R 36 297 1.6e-27 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232004
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810024B03Rik T C 2: 127,186,734 R182G possibly damaging Het
Casd1 A T 6: 4,624,142 I312F probably benign Het
Cdc27 T C 11: 104,522,731 T395A probably damaging Het
Cep152 A G 2: 125,563,461 I1717T probably benign Het
Ces1f A T 8: 93,265,860 V321E possibly damaging Het
Chrnb3 T C 8: 27,396,804 probably benign Het
Col14a1 T A 15: 55,463,703 F1416L unknown Het
Cplx4 T C 18: 65,970,052 probably benign Het
Cubn A T 2: 13,381,837 I1539N probably damaging Het
Dapk1 A G 13: 60,730,882 T562A probably benign Het
Dnmt1 C A 9: 20,908,549 V1433F probably damaging Het
Dytn A G 1: 63,641,092 L436P probably damaging Het
Evpl T C 11: 116,227,015 I783V probably benign Het
Fat4 T A 3: 38,888,404 V482E probably damaging Het
Fcrlb T A 1: 170,907,358 E400V probably benign Het
Folh1 T C 7: 86,725,418 D656G probably damaging Het
Frem3 A C 8: 80,613,094 D672A probably damaging Het
G3bp2 A G 5: 92,073,247 M3T possibly damaging Het
Gm973 C T 1: 59,582,473 Q26* probably null Het
Hsp90b1 T C 10: 86,705,358 probably benign Het
Hspg2 G A 4: 137,518,814 probably null Het
Lpin3 T C 2: 160,895,833 probably null Het
Mtss1l G A 8: 110,737,624 R295Q probably damaging Het
Muc5b G T 7: 141,855,632 W1151L unknown Het
Myo3a A G 2: 22,577,526 Y264C probably benign Het
Olfr1230 A G 2: 89,297,063 V69A probably benign Het
Olfr484 T A 7: 108,125,042 I74L probably benign Het
Olfr543 T C 7: 102,477,535 T112A possibly damaging Het
Pecam1 C T 11: 106,690,981 G380S probably damaging Het
Phf21a C T 2: 92,349,422 T345I probably damaging Het
Polg G A 7: 79,459,737 S444L probably damaging Het
Prickle1 A G 15: 93,503,146 Y486H probably damaging Het
Scg5 G A 2: 113,792,037 probably benign Het
Sept5 G T 16: 18,624,829 D123E probably damaging Het
Skint6 G A 4: 113,087,796 T483I probably benign Het
Tep1 A T 14: 50,854,124 probably benign Het
Tepsin T C 11: 120,091,721 R440G probably benign Het
Tmem214 G A 5: 30,872,746 A296T probably benign Het
Trpm4 A T 7: 45,310,523 V649E probably damaging Het
Usf3 C A 16: 44,219,656 Q1500K possibly damaging Het
Vmn1r45 T A 6: 89,933,053 I312L probably benign Het
Other mutations in Vmn1r231
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00233:Vmn1r231 APN 17 20890566 missense possibly damaging 0.68
IGL02151:Vmn1r231 APN 17 20889735 missense probably benign 0.06
R0066:Vmn1r231 UTSW 17 20889736 missense probably benign 0.27
R0066:Vmn1r231 UTSW 17 20889736 missense probably benign 0.27
R0396:Vmn1r231 UTSW 17 20890399 missense probably damaging 0.98
R0427:Vmn1r231 UTSW 17 20890228 missense probably benign 0.05
R0470:Vmn1r231 UTSW 17 20890003 nonsense probably null
R0848:Vmn1r231 UTSW 17 20890171 missense probably damaging 1.00
R1692:Vmn1r231 UTSW 17 20890609 missense probably benign 0.02
R1987:Vmn1r231 UTSW 17 20889950 missense probably damaging 1.00
R1988:Vmn1r231 UTSW 17 20889950 missense probably damaging 1.00
R2105:Vmn1r231 UTSW 17 20890118 missense possibly damaging 0.66
R4440:Vmn1r231 UTSW 17 20890456 missense possibly damaging 0.48
R4634:Vmn1r231 UTSW 17 20890398 missense possibly damaging 0.46
R4646:Vmn1r231 UTSW 17 20890309 missense probably damaging 1.00
R4678:Vmn1r231 UTSW 17 20890227 missense possibly damaging 0.94
R4696:Vmn1r231 UTSW 17 20890639 missense possibly damaging 0.63
R4938:Vmn1r231 UTSW 17 20890351 missense possibly damaging 0.76
R5544:Vmn1r231 UTSW 17 20890578 missense probably damaging 1.00
R5942:Vmn1r231 UTSW 17 20890155 missense possibly damaging 0.83
R6053:Vmn1r231 UTSW 17 20889819 missense probably damaging 1.00
R6692:Vmn1r231 UTSW 17 20890483 missense possibly damaging 0.46
R6712:Vmn1r231 UTSW 17 20889730 missense possibly damaging 0.54
R7131:Vmn1r231 UTSW 17 20889878 missense possibly damaging 0.87
R7854:Vmn1r231 UTSW 17 20890632 missense probably damaging 0.98
R8187:Vmn1r231 UTSW 17 20890631 missense probably benign 0.10
R8238:Vmn1r231 UTSW 17 20890378 missense probably benign 0.08
R8313:Vmn1r231 UTSW 17 20890027 missense probably benign 0.02
RF010:Vmn1r231 UTSW 17 20889993 missense probably damaging 0.99
Posted On2015-04-16