Incidental Mutation 'IGL02125:Olfr209'
ID280813
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr209
Ensembl Gene ENSMUSG00000095706
Gene Nameolfactory receptor 209
SynonymsMOR182-6, GA_x54KRFPKG5P-55590495-55589578
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.194) question?
Stock #IGL02125
Quality Score
Status
Chromosome16
Chromosomal Location59361160-59363993 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 59361516 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Serine at position 234 (N234S)
Ref Sequence ENSEMBL: ENSMUSP00000147068 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055868] [ENSMUST00000208246] [ENSMUST00000208875] [ENSMUST00000213779]
Predicted Effect probably benign
Transcript: ENSMUST00000055868
AA Change: N234S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000053192
Gene: ENSMUSG00000095706
AA Change: N234S

DomainStartEndE-ValueType
Pfam:7tm_4 30 304 1.3e-49 PFAM
Pfam:7TM_GPCR_Srsx 34 303 1.3e-6 PFAM
Pfam:7tm_1 40 289 6.2e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000208246
Predicted Effect probably benign
Transcript: ENSMUST00000208875
AA Change: N234S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000213779
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700015F17Rik T C 5: 5,450,644 *151W probably null Het
Adam29 A T 8: 55,871,939 C493* probably null Het
Aldh16a1 G A 7: 45,146,035 P400L probably damaging Het
Ankrd12 A G 17: 65,970,144 probably benign Het
Anxa5 G A 3: 36,452,264 T213I probably damaging Het
Baz2b A G 2: 59,968,640 L380S probably benign Het
Brd8 C T 18: 34,602,727 S899N probably damaging Het
Cacna2d2 C T 9: 107,513,904 Q411* probably null Het
Cdh19 A G 1: 110,929,884 V240A possibly damaging Het
Cltc A T 11: 86,704,810 probably benign Het
Dclk3 T A 9: 111,469,107 V573E probably damaging Het
Dhx29 T C 13: 112,955,300 probably benign Het
Dip2b T C 15: 100,186,250 L918P possibly damaging Het
Dzip3 A T 16: 48,927,596 N1150K probably damaging Het
Fgf5 T C 5: 98,254,532 S41P possibly damaging Het
Galc A T 12: 98,231,509 Y120N probably damaging Het
Gldc T C 19: 30,147,241 N219S probably benign Het
Gm11563 A T 11: 99,658,805 V41E unknown Het
Gm597 T C 1: 28,776,338 N871S possibly damaging Het
Gpatch11 T A 17: 78,840,109 N106K probably benign Het
Gpx3 A G 11: 54,907,242 N68S probably damaging Het
Ibtk T C 9: 85,735,070 N150D probably damaging Het
Iglc2 G A 16: 19,198,712 P48S probably benign Het
Itih5 G A 2: 10,240,987 R629H probably benign Het
Kank1 T A 19: 25,410,703 V552E possibly damaging Het
Kmt2a T A 9: 44,848,686 H655L probably damaging Het
Mkl2 A G 16: 13,400,183 probably null Het
Mme A T 3: 63,348,649 N510I probably damaging Het
Obscn A G 11: 59,022,362 I6943T probably damaging Het
Obscn G T 11: 59,093,326 Q1768K possibly damaging Het
Olfr633 T A 7: 103,947,072 C169S probably damaging Het
Otud3 A T 4: 138,896,714 probably null Het
Parp4 A G 14: 56,590,502 K237E probably benign Het
Pfkfb4 C T 9: 109,025,110 R351W probably damaging Het
Rbbp6 T C 7: 122,971,129 probably null Het
Rdh16 G T 10: 127,811,319 probably benign Het
Ropn1 A G 16: 34,666,777 T28A probably benign Het
Sec24d T C 3: 123,358,958 V873A probably damaging Het
Serpinb3b T A 1: 107,154,744 L263F probably damaging Het
Shq1 T C 6: 100,631,006 T315A probably benign Het
Slc13a4 T C 6: 35,278,288 E355G probably benign Het
Slc26a9 T C 1: 131,759,437 S445P probably damaging Het
Slc39a10 G A 1: 46,818,128 A696V probably damaging Het
Slc4a10 A T 2: 62,268,171 M550L probably benign Het
Syt17 T C 7: 118,409,974 D341G probably benign Het
Tmem62 A G 2: 120,996,512 Y430C probably benign Het
Upp1 A G 11: 9,125,650 probably benign Het
Vmn1r91 T G 7: 20,101,504 V116G probably damaging Het
Vmn2r101 A T 17: 19,589,701 I250F possibly damaging Het
Vmn2r116 T G 17: 23,397,627 probably benign Het
Vmn2r72 C T 7: 85,750,711 V377I probably benign Het
Zfp592 G T 7: 81,038,184 A953S probably benign Het
Other mutations in Olfr209
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01083:Olfr209 APN 16 59361835 missense probably damaging 1.00
IGL01137:Olfr209 APN 16 59361972 missense probably benign 0.01
IGL01383:Olfr209 APN 16 59361953 missense probably benign 0.10
IGL01913:Olfr209 APN 16 59361931 missense probably damaging 1.00
IGL01914:Olfr209 APN 16 59361931 missense probably damaging 1.00
IGL02414:Olfr209 APN 16 59361714 missense probably damaging 1.00
IGL02512:Olfr209 APN 16 59361808 missense possibly damaging 0.95
PIT4495001:Olfr209 UTSW 16 59361508 missense probably damaging 0.99
R0029:Olfr209 UTSW 16 59361541 missense probably benign 0.00
R0531:Olfr209 UTSW 16 59361808 missense probably damaging 0.99
R1799:Olfr209 UTSW 16 59361880 missense probably benign 0.01
R1901:Olfr209 UTSW 16 59362163 missense probably benign 0.03
R1902:Olfr209 UTSW 16 59362163 missense probably benign 0.03
R1903:Olfr209 UTSW 16 59362163 missense probably benign 0.03
R1972:Olfr209 UTSW 16 59362113 missense probably damaging 0.96
R2471:Olfr209 UTSW 16 59361581 missense possibly damaging 0.79
R5013:Olfr209 UTSW 16 59361704 missense probably damaging 1.00
R5160:Olfr209 UTSW 16 59361766 missense probably damaging 1.00
R5883:Olfr209 UTSW 16 59361715 missense probably damaging 1.00
R6272:Olfr209 UTSW 16 59361585 missense possibly damaging 0.76
R6296:Olfr209 UTSW 16 59361406 missense probably benign 0.06
R6741:Olfr209 UTSW 16 59361555 missense probably damaging 1.00
R6928:Olfr209 UTSW 16 59361463 missense probably damaging 1.00
X0017:Olfr209 UTSW 16 59361639 missense probably damaging 0.97
Posted On2015-04-16