Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02096:Or2n1c'

281103

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or2n1c

Ensembl Gene

ENSMUSG00000057801

Gene Name

olfactory receptor family 2 subfamily N member 1C

Synonyms

MOR256-48, GA_x6K02T2PSCP-2656648-2657586, Olfr135

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL02096

Quality Score

Status

Chromosome

Chromosomal Location

38519138-38520076 bp(+) (GRCm39)

Type of Mutation

makesense

DNA Base Change (assembly)

T to A at 38520074 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Stop codon to Arginine at position 313 (*313R)

Ref Sequence

ENSEMBL: ENSMUSP00000150535 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076245] [ENSMUST00000213217]

AlphaFold

Q8VEY4

Predicted Effect

probably null
Transcript: ENSMUST00000076245
AA Change: *313R

SMART Domains

Protein: ENSMUSP00000075595
Gene: ENSMUSG00000057801
AA Change: *313R

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	7.6e-50	PFAM
Pfam:7tm_1	41	290	9.2e-25	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000213217
AA Change: *313R

Meta Mutation Damage Score

0.9755

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca9	A	G	11: 109,993,359 (GRCm39)	L1584P	probably damaging	Het
Abca9	G	T	11: 110,056,806 (GRCm39)	H5N	probably benign	Het
Acox1	A	T	11: 116,069,024 (GRCm39)	I371N	probably damaging	Het
Aopep	C	A	13: 63,208,903 (GRCm39)	A340E	probably benign	Het
Bmp5	A	G	9: 75,805,833 (GRCm39)	N445S	probably damaging	Het
Cacna1b	G	T	2: 24,568,927 (GRCm39)	A999E	probably benign	Het
Cdc27	A	T	11: 104,419,394 (GRCm39)		probably benign	Het
Dmxl2	T	C	9: 54,308,349 (GRCm39)	E2134G	possibly damaging	Het
Dnttip2	A	G	3: 122,078,062 (GRCm39)	N698S	possibly damaging	Het
Duox1	A	T	2: 122,174,655 (GRCm39)	K1271M	probably damaging	Het
Dync1h1	T	C	12: 110,599,254 (GRCm39)	Y1870H	possibly damaging	Het
Edem3	A	G	1: 151,680,470 (GRCm39)	T532A	probably benign	Het
Epx	A	T	11: 87,760,294 (GRCm39)	L440Q	probably damaging	Het
F11	A	G	8: 45,699,791 (GRCm39)	F432L	probably benign	Het
Fam185a	C	A	5: 21,630,341 (GRCm39)	P59Q	probably damaging	Het
Fsip2	A	G	2: 82,822,204 (GRCm39)	D5979G	possibly damaging	Het
Furin	A	G	7: 80,043,207 (GRCm39)	S335P	probably damaging	Het
Gtf3c1	T	A	7: 125,258,284 (GRCm39)	Q1262L	probably damaging	Het
Hmmr	A	T	11: 40,598,256 (GRCm39)	V652E	probably benign	Het
Iapp	A	T	6: 142,249,199 (GRCm39)	N84I	probably benign	Het
Katnip	G	A	7: 125,413,993 (GRCm39)	C379Y	probably benign	Het
Mmp17	C	T	5: 129,675,752 (GRCm39)	Q304*	probably null	Het
Mpl	T	C	4: 118,314,333 (GRCm39)	T55A	possibly damaging	Het
Mst1r	G	A	9: 107,794,478 (GRCm39)	R1219H	probably damaging	Het
Muc6	T	A	7: 141,226,117 (GRCm39)		probably benign	Het
Nalcn	C	T	14: 123,831,915 (GRCm39)	V120I	probably benign	Het
Nt5dc1	A	T	10: 34,275,806 (GRCm39)	C134*	probably null	Het
Obscn	A	C	11: 58,971,530 (GRCm39)	N2228K	probably damaging	Het
Osbpl10	T	C	9: 115,046,062 (GRCm39)	M566T	possibly damaging	Het
Pabpc1l	G	A	2: 163,886,267 (GRCm39)	V466I	probably benign	Het
Pdcd11	T	G	19: 47,094,860 (GRCm39)	V548G	probably benign	Het
Prss27	G	T	17: 24,263,951 (GRCm39)	K212N	possibly damaging	Het
Ranbp2	T	A	10: 58,297,789 (GRCm39)	S399T	probably damaging	Het
Rgs19	A	G	2: 181,331,076 (GRCm39)	S159P	probably damaging	Het
Sh2b1	A	G	7: 126,068,465 (GRCm39)	S449P	probably damaging	Het
Slc6a18	T	A	13: 73,820,870 (GRCm39)	Y238F	probably benign	Het
Stx11	T	C	10: 12,817,224 (GRCm39)	I167V	probably benign	Het
Sucnr1	A	G	3: 59,994,371 (GRCm39)	M300V	possibly damaging	Het
Synj2	A	G	17: 6,040,628 (GRCm39)	T235A	probably damaging	Het
Ubxn2b	T	A	4: 6,214,749 (GRCm39)	I261N	probably damaging	Het
Vmn2r43	G	A	7: 8,260,512 (GRCm39)		probably benign	Het
Vmn2r45	A	G	7: 8,484,443 (GRCm39)	M454T	probably damaging	Het
Vsig2	T	A	9: 37,451,251 (GRCm39)	S51T	probably damaging	Het
Wdr41	T	C	13: 95,153,964 (GRCm39)		probably benign	Het
Wdr6	A	C	9: 108,453,752 (GRCm39)	L44V	probably damaging	Het
Zfp1001	T	C	2: 150,165,634 (GRCm39)	Y5H	probably damaging	Het
Zfp592	T	C	7: 80,674,796 (GRCm39)	Y587H	probably damaging	Het
Zfp735	A	T	11: 73,602,254 (GRCm39)	K399N	probably benign	Het

Other mutations in Or2n1c

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00978:Or2n1c	APN	17	38,519,873 (GRCm39)	missense	probably damaging	0.99
IGL01316:Or2n1c	APN	17	38,519,388 (GRCm39)	missense	probably damaging	0.98
IGL01666:Or2n1c	APN	17	38,519,780 (GRCm39)	missense	probably benign	0.11
R0255:Or2n1c	UTSW	17	38,519,286 (GRCm39)	missense	probably benign
R0630:Or2n1c	UTSW	17	38,519,304 (GRCm39)	missense	probably damaging	0.97
R1185:Or2n1c	UTSW	17	38,520,074 (GRCm39)	makesense	probably null
R1185:Or2n1c	UTSW	17	38,520,074 (GRCm39)	makesense	probably null
R1185:Or2n1c	UTSW	17	38,520,074 (GRCm39)	makesense	probably null
R1279:Or2n1c	UTSW	17	38,519,678 (GRCm39)	missense	probably benign	0.01
R1878:Or2n1c	UTSW	17	38,519,265 (GRCm39)	missense	probably benign	0.03
R1969:Or2n1c	UTSW	17	38,519,355 (GRCm39)	missense	probably damaging	1.00
R2374:Or2n1c	UTSW	17	38,519,958 (GRCm39)	missense	probably damaging	0.97
R3708:Or2n1c	UTSW	17	38,519,174 (GRCm39)	missense	probably benign	0.01
R5025:Or2n1c	UTSW	17	38,519,334 (GRCm39)	missense	probably damaging	1.00
R5093:Or2n1c	UTSW	17	38,519,208 (GRCm39)	missense	possibly damaging	0.92
R5095:Or2n1c	UTSW	17	38,519,208 (GRCm39)	missense	possibly damaging	0.92
R5103:Or2n1c	UTSW	17	38,519,208 (GRCm39)	missense	possibly damaging	0.92
R5104:Or2n1c	UTSW	17	38,519,208 (GRCm39)	missense	possibly damaging	0.92
R5105:Or2n1c	UTSW	17	38,519,208 (GRCm39)	missense	possibly damaging	0.92
R5149:Or2n1c	UTSW	17	38,519,208 (GRCm39)	missense	possibly damaging	0.92
R5150:Or2n1c	UTSW	17	38,519,208 (GRCm39)	missense	possibly damaging	0.92
R5344:Or2n1c	UTSW	17	38,519,995 (GRCm39)	missense	probably damaging	1.00
R6608:Or2n1c	UTSW	17	38,519,370 (GRCm39)	missense	probably damaging	1.00
R7300:Or2n1c	UTSW	17	38,519,588 (GRCm39)	missense	possibly damaging	0.76
R7324:Or2n1c	UTSW	17	38,519,607 (GRCm39)	missense	probably benign
R7580:Or2n1c	UTSW	17	38,519,934 (GRCm39)	missense	probably benign	0.11
R8062:Or2n1c	UTSW	17	38,520,065 (GRCm39)	missense	probably benign	0.01
R8371:Or2n1c	UTSW	17	38,519,189 (GRCm39)	missense	probably benign	0.01
R8984:Or2n1c	UTSW	17	38,519,304 (GRCm39)	missense	probably damaging	0.97
R9002:Or2n1c	UTSW	17	38,519,555 (GRCm39)	missense	probably benign	0.01

Posted On

2015-04-16