Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02131:Zranb3'

281199

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zranb3

Ensembl Gene

ENSMUSG00000036086

Gene Name

zinc finger, RAN-binding domain containing 3

Synonyms

4933425L19Rik

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.315) question?

Stock #

IGL02131

Quality Score

Status

Chromosome

Chromosomal Location

127954184-128103047 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 127992951 bp

Zygosity

Heterozygous

Amino Acid Change

Valine to Aspartic acid at position 412 (V412D)

Ref Sequence

ENSEMBL: ENSMUSP00000108157 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086614] [ENSMUST00000112538]

Predicted Effect

probably damaging
Transcript: ENSMUST00000086614
AA Change: V412D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000083806
Gene: ENSMUSG00000036086
AA Change: V412D

Domain	Start	End	E-Value	Type
DEXDc	33	214	3.37e-19	SMART
HELICc	352	435	3.79e-13	SMART
ZnF_RBZ	619	643	6.93e-5	SMART
HNHc	985	1036	5.64e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000097597

SMART Domains

Protein: ENSMUSP00000095204
Gene: ENSMUSG00000036086

Domain	Start	End	E-Value	Type
DEXDc	33	214	3.37e-19	SMART
HELICc	352	435	3.79e-13	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000112538
AA Change: V412D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000108157
Gene: ENSMUSG00000036086
AA Change: V412D

Domain	Start	End	E-Value	Type
Pfam:SNF2_N	40	98	6.6e-12	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000127393

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131732

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921513D11Rik	T	A	17: 79,627,655		probably benign	Het
Adamts19	A	G	18: 59,052,660	Y1202C	probably damaging	Het
Adgrf1	T	A	17: 43,303,747	F241I	probably damaging	Het
Ankrd11	A	T	8: 122,894,410	I901N	probably damaging	Het
Anxa8	A	T	14: 34,090,631	D46V	possibly damaging	Het
Ap4e1	A	G	2: 127,061,929	Y917C	probably benign	Het
Arhgap40	G	A	2: 158,531,939		probably null	Het
Dnah17	A	G	11: 118,072,908	V2513A	probably damaging	Het
Dnhd1	T	C	7: 105,720,802	L4478P	probably damaging	Het
Dtx3	T	C	10: 127,193,279	D30G	probably damaging	Het
Fat2	A	G	11: 55,309,042	Y1069H	probably damaging	Het
Fbxo21	T	A	5: 118,002,090	N538K	possibly damaging	Het
Frem1	T	C	4: 82,924,854	T1748A	probably benign	Het
Kcnh6	T	C	11: 106,020,175	Y466H	probably damaging	Het
Kif2c	G	A	4: 117,177,953	S41L	possibly damaging	Het
Kir3dl2	T	A	X: 136,457,713	H52L	possibly damaging	Het
Mageb18	A	G	X: 92,120,049	C196R	possibly damaging	Het
Mrpl9	T	A	3: 94,444,713		probably null	Het
Nt5c1b	A	G	12: 10,375,491	I345V	possibly damaging	Het
Olfr137	T	A	17: 38,304,648	H271L	probably benign	Het
Olfr251	A	G	9: 38,377,907	T9A	probably benign	Het
Olfr517	T	C	7: 108,868,208	*315W	probably null	Het
Parp8	T	C	13: 116,910,873	N221S	probably benign	Het
Plbd1	T	C	6: 136,661,683		probably benign	Het
Recql5	C	A	11: 115,923,242	W86L	probably benign	Het
Rgs6	T	C	12: 83,069,495	S232P	probably damaging	Het
Rnf182	A	G	13: 43,668,342	H123R	probably benign	Het
Rtf2	A	G	2: 172,466,292	T204A	unknown	Het
Sema4d	T	C	13: 51,702,937		probably null	Het
Sept8	T	C	11: 53,537,857	S408P	possibly damaging	Het
Serpini1	A	G	3: 75,640,704	N396D	probably benign	Het
Slc26a2	A	C	18: 61,198,812	F516V	possibly damaging	Het
Tcf4	A	G	18: 69,564,626		probably benign	Het
Trrap	G	T	5: 144,840,436	G3045W	probably damaging	Het
Tspo2	T	A	17: 48,449,061	T91S	possibly damaging	Het
Ttn	T	C	2: 76,737,614	D27645G	probably damaging	Het
Uba6	G	T	5: 86,150,077	T246K	probably benign	Het
Vmn2r9	G	A	5: 108,843,636	L620F	probably damaging	Het
Wwp2	T	A	8: 107,552,318	M136K	probably damaging	Het

Other mutations in Zranb3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00565:Zranb3	APN	1	128016140	missense	probably benign	0.01
IGL00818:Zranb3	APN	1	128032867	missense	probably damaging	1.00
IGL01360:Zranb3	APN	1	127959885	nonsense	probably null
IGL01704:Zranb3	APN	1	127967939	missense	possibly damaging	0.93
IGL02466:Zranb3	APN	1	128016092	missense	probably benign	0.08
IGL02825:Zranb3	APN	1	127959752	missense	probably benign	0.13
IGL02836:Zranb3	APN	1	127960825	missense	probably benign	0.00
R0088:Zranb3	UTSW	1	127976462	missense	probably benign
R0279:Zranb3	UTSW	1	127963773	missense	probably benign	0.01
R0423:Zranb3	UTSW	1	128091870	missense	probably damaging	1.00
R0499:Zranb3	UTSW	1	127955080	splice site	probably null
R0562:Zranb3	UTSW	1	128036558	missense	probably benign	0.04
R0972:Zranb3	UTSW	1	127956646	missense	probably damaging	1.00
R1480:Zranb3	UTSW	1	128091862	missense	probably damaging	1.00
R1552:Zranb3	UTSW	1	127960751	splice site	probably benign
R1704:Zranb3	UTSW	1	128092003	start codon destroyed	probably null	0.22
R1817:Zranb3	UTSW	1	128017556	critical splice donor site	probably null
R1818:Zranb3	UTSW	1	128017556	critical splice donor site	probably null
R1819:Zranb3	UTSW	1	128017556	critical splice donor site	probably null
R1951:Zranb3	UTSW	1	127999399	missense	probably damaging	1.00
R1953:Zranb3	UTSW	1	127999399	missense	probably damaging	1.00
R1988:Zranb3	UTSW	1	127959743	missense	probably benign
R2011:Zranb3	UTSW	1	128091901	missense	probably benign	0.00
R3159:Zranb3	UTSW	1	127972949	missense	probably benign
R4179:Zranb3	UTSW	1	127960864	missense	possibly damaging	0.88
R4281:Zranb3	UTSW	1	127963877	missense	possibly damaging	0.69
R4400:Zranb3	UTSW	1	127956655	missense	possibly damaging	0.87
R5236:Zranb3	UTSW	1	128040989	missense	probably damaging	1.00
R5330:Zranb3	UTSW	1	127959720	missense	probably damaging	0.99
R5719:Zranb3	UTSW	1	127963876	missense	probably benign	0.00
R6125:Zranb3	UTSW	1	127959745	missense	probably benign
R6220:Zranb3	UTSW	1	127999404	missense	probably benign	0.44
R6414:Zranb3	UTSW	1	128040957	missense	probably benign	0.08
R6751:Zranb3	UTSW	1	127959819	missense	probably benign
R7229:Zranb3	UTSW	1	128040893	missense	probably benign	0.00
R7419:Zranb3	UTSW	1	127963851	missense	possibly damaging	0.86
R7537:Zranb3	UTSW	1	128032847	critical splice donor site	probably null
R7771:Zranb3	UTSW	1	128032868	missense	probably damaging	1.00

Posted On

2015-04-16