Incidental Mutation 'IGL02131:Rtf2'
ID281202
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rtf2
Ensembl Gene ENSMUSG00000027502
Gene Namereplication termination factor 2
Synonyms
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.936) question?
Stock #IGL02131
Quality Score
Status
Chromosome2
Chromosomal Location172440556-172469908 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 172466292 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 204 (T204A)
Ref Sequence ENSEMBL: ENSMUSP00000029005 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029005]
Predicted Effect unknown
Transcript: ENSMUST00000029005
AA Change: T204A
SMART Domains Protein: ENSMUSP00000029005
Gene: ENSMUSG00000027502
AA Change: T204A

DomainStartEndE-ValueType
Pfam:Rtf2 1 290 1.5e-99 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000109132
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140048
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921513D11Rik T A 17: 79,627,655 probably benign Het
Adamts19 A G 18: 59,052,660 Y1202C probably damaging Het
Adgrf1 T A 17: 43,303,747 F241I probably damaging Het
Ankrd11 A T 8: 122,894,410 I901N probably damaging Het
Anxa8 A T 14: 34,090,631 D46V possibly damaging Het
Ap4e1 A G 2: 127,061,929 Y917C probably benign Het
Arhgap40 G A 2: 158,531,939 probably null Het
Dnah17 A G 11: 118,072,908 V2513A probably damaging Het
Dnhd1 T C 7: 105,720,802 L4478P probably damaging Het
Dtx3 T C 10: 127,193,279 D30G probably damaging Het
Fat2 A G 11: 55,309,042 Y1069H probably damaging Het
Fbxo21 T A 5: 118,002,090 N538K possibly damaging Het
Frem1 T C 4: 82,924,854 T1748A probably benign Het
Kcnh6 T C 11: 106,020,175 Y466H probably damaging Het
Kif2c G A 4: 117,177,953 S41L possibly damaging Het
Kir3dl2 T A X: 136,457,713 H52L possibly damaging Het
Mageb18 A G X: 92,120,049 C196R possibly damaging Het
Mrpl9 T A 3: 94,444,713 probably null Het
Nt5c1b A G 12: 10,375,491 I345V possibly damaging Het
Olfr137 T A 17: 38,304,648 H271L probably benign Het
Olfr251 A G 9: 38,377,907 T9A probably benign Het
Olfr517 T C 7: 108,868,208 *315W probably null Het
Parp8 T C 13: 116,910,873 N221S probably benign Het
Plbd1 T C 6: 136,661,683 probably benign Het
Recql5 C A 11: 115,923,242 W86L probably benign Het
Rgs6 T C 12: 83,069,495 S232P probably damaging Het
Rnf182 A G 13: 43,668,342 H123R probably benign Het
Sema4d T C 13: 51,702,937 probably null Het
Sept8 T C 11: 53,537,857 S408P possibly damaging Het
Serpini1 A G 3: 75,640,704 N396D probably benign Het
Slc26a2 A C 18: 61,198,812 F516V possibly damaging Het
Tcf4 A G 18: 69,564,626 probably benign Het
Trrap G T 5: 144,840,436 G3045W probably damaging Het
Tspo2 T A 17: 48,449,061 T91S possibly damaging Het
Ttn T C 2: 76,737,614 D27645G probably damaging Het
Uba6 G T 5: 86,150,077 T246K probably benign Het
Vmn2r9 G A 5: 108,843,636 L620F probably damaging Het
Wwp2 T A 8: 107,552,318 M136K probably damaging Het
Zranb3 A T 1: 127,992,951 V412D probably damaging Het
Other mutations in Rtf2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02268:Rtf2 APN 2 172468719 missense probably damaging 1.00
IGL02340:Rtf2 APN 2 172468591 unclassified probably benign
R0040:Rtf2 UTSW 2 172444696 missense probably damaging 1.00
R0621:Rtf2 UTSW 2 172466296 missense possibly damaging 0.60
R1080:Rtf2 UTSW 2 172468746 missense probably damaging 1.00
R1580:Rtf2 UTSW 2 172445365 missense probably damaging 1.00
R2105:Rtf2 UTSW 2 172445365 missense probably damaging 1.00
R5461:Rtf2 UTSW 2 172445332 missense probably damaging 1.00
Posted On2015-04-16