Incidental Mutation 'IGL00898:Yipf2'
| ID |
28121 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Yipf2
|
| Ensembl Gene |
ENSMUSG00000032182 |
| Gene Name |
Yip1 domain family, member 2 |
| Synonyms |
1300010K09Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.121)
|
| Stock # |
IGL00898
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
9 |
| Chromosomal Location |
21499978-21504124 bp(-) (GRCm39) |
| Type of Mutation |
splice site (4 bp from exon) |
| DNA Base Change (assembly) |
T to C
at 21503820 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000136463
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000034700]
[ENSMUST00000034703]
[ENSMUST00000062125]
[ENSMUST00000078572]
[ENSMUST00000115394]
[ENSMUST00000115395]
[ENSMUST00000130032]
[ENSMUST00000180365]
[ENSMUST00000213809]
|
| AlphaFold |
Q99LP8 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000034700
|
| SMART Domains |
Protein: ENSMUSP00000034700
Gene: ENSMUSG00000032182
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Yip1
|
84 |
272 |
1.5e-21 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000034703
|
| SMART Domains |
Protein: ENSMUSP00000034703
Gene: ENSMUSG00000032185
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:CARM1
|
27 |
140 |
2.1e-71 |
PFAM |
|
Pfam:PRMT5
|
144 |
447 |
2.3e-16 |
PFAM |
|
Pfam:MTS
|
166 |
308 |
2.7e-10 |
PFAM |
|
Pfam:Methyltransf_9
|
168 |
318 |
1.1e-9 |
PFAM |
|
Pfam:PrmA
|
173 |
287 |
2.2e-12 |
PFAM |
|
Pfam:Methyltransf_31
|
183 |
325 |
7.4e-11 |
PFAM |
|
Pfam:Methyltransf_18
|
185 |
290 |
5.1e-12 |
PFAM |
|
Pfam:Methyltransf_26
|
186 |
287 |
5.3e-10 |
PFAM |
|
Pfam:Methyltransf_11
|
190 |
287 |
8.5e-7 |
PFAM |
|
low complexity region
|
477 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
562 |
576 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000062125
|
| SMART Domains |
Protein: ENSMUSP00000058283
Gene: ENSMUSG00000048429
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF2366
|
26 |
192 |
2.1e-63 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000078572
|
| SMART Domains |
Protein: ENSMUSP00000077649
Gene: ENSMUSG00000032182
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Yip1
|
84 |
272 |
1.5e-21 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115394
|
| SMART Domains |
Protein: ENSMUSP00000111052
Gene: ENSMUSG00000032185
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:CARM1
|
29 |
140 |
4.7e-63 |
PFAM |
|
Pfam:PRMT5
|
145 |
447 |
4.1e-16 |
PFAM |
|
Pfam:Methyltransf_9
|
168 |
318 |
1.4e-9 |
PFAM |
|
Pfam:MTS
|
170 |
299 |
2.5e-9 |
PFAM |
|
Pfam:PrmA
|
175 |
287 |
3.7e-12 |
PFAM |
|
Pfam:Methyltransf_31
|
183 |
326 |
1.9e-10 |
PFAM |
|
Pfam:Methyltransf_18
|
185 |
290 |
4e-9 |
PFAM |
|
Pfam:Methyltransf_11
|
190 |
287 |
6.5e-7 |
PFAM |
|
low complexity region
|
477 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
606 |
619 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115395
|
| SMART Domains |
Protein: ENSMUSP00000111053
Gene: ENSMUSG00000032185
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:CARM1
|
27 |
140 |
2e-71 |
PFAM |
|
Pfam:PRMT5
|
144 |
447 |
2.1e-16 |
PFAM |
|
Pfam:MTS
|
166 |
308 |
2.6e-10 |
PFAM |
|
Pfam:Methyltransf_9
|
168 |
318 |
1.1e-9 |
PFAM |
|
Pfam:PrmA
|
172 |
287 |
2.1e-12 |
PFAM |
|
Pfam:Methyltransf_31
|
183 |
326 |
6.9e-11 |
PFAM |
|
Pfam:Methyltransf_18
|
185 |
290 |
4.8e-12 |
PFAM |
|
Pfam:Methyltransf_26
|
186 |
287 |
5e-10 |
PFAM |
|
Pfam:Methyltransf_11
|
190 |
287 |
8.1e-7 |
PFAM |
|
low complexity region
|
477 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
540 |
553 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000130032
|
| SMART Domains |
Protein: ENSMUSP00000117243
Gene: ENSMUSG00000032185
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:CARM1
|
27 |
140 |
2.8e-73 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000180365
|
| SMART Domains |
Protein: ENSMUSP00000136463
Gene: ENSMUSG00000032182
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Yip1
|
84 |
272 |
1.5e-21 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000154049
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000132011
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000130100
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000213809
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000216160
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 40 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb1a |
G |
A |
5: 8,783,690 (GRCm39) |
G956S |
probably damaging |
Het |
| Alpk2 |
G |
T |
18: 65,483,644 (GRCm39) |
D121E |
probably benign |
Het |
| Apc |
A |
G |
18: 34,450,147 (GRCm39) |
T2314A |
probably damaging |
Het |
| Arhgef11 |
T |
C |
3: 87,636,810 (GRCm39) |
L990P |
probably damaging |
Het |
| Ccar1 |
T |
A |
10: 62,589,013 (GRCm39) |
K823N |
unknown |
Het |
| Celsr2 |
C |
T |
3: 108,321,195 (GRCm39) |
R539H |
possibly damaging |
Het |
| Clca3b |
A |
G |
3: 144,550,389 (GRCm39) |
|
probably benign |
Het |
| Cpxcr1 |
T |
C |
X: 115,387,407 (GRCm39) |
L106S |
possibly damaging |
Het |
| Edc4 |
T |
A |
8: 106,607,755 (GRCm39) |
L16Q |
probably damaging |
Het |
| Emc1 |
A |
G |
4: 139,098,941 (GRCm39) |
E808G |
probably damaging |
Het |
| Epha6 |
A |
T |
16: 59,595,904 (GRCm39) |
|
probably null |
Het |
| Epha7 |
G |
A |
4: 28,938,693 (GRCm39) |
R516Q |
probably damaging |
Het |
| Fancm |
T |
C |
12: 65,152,774 (GRCm39) |
S1077P |
probably benign |
Het |
| Gm4952 |
C |
T |
19: 12,595,772 (GRCm39) |
T54I |
probably damaging |
Het |
| Hnrnpm |
C |
A |
17: 33,868,876 (GRCm39) |
R517L |
probably damaging |
Het |
| Il1b |
T |
C |
2: 129,209,253 (GRCm39) |
R126G |
possibly damaging |
Het |
| Kin |
G |
A |
2: 10,085,515 (GRCm39) |
R25H |
probably damaging |
Het |
| Kin |
T |
C |
2: 10,085,517 (GRCm39) |
W26R |
probably damaging |
Het |
| Lamb3 |
A |
T |
1: 193,021,191 (GRCm39) |
T923S |
possibly damaging |
Het |
| Lrp6 |
C |
T |
6: 134,456,702 (GRCm39) |
S854N |
probably damaging |
Het |
| Ltv1 |
A |
G |
10: 13,058,031 (GRCm39) |
F258L |
probably damaging |
Het |
| Mcm3ap |
T |
C |
10: 76,306,159 (GRCm39) |
S91P |
probably benign |
Het |
| Msra |
A |
G |
14: 64,360,774 (GRCm39) |
I125T |
probably damaging |
Het |
| Nr0b1 |
A |
T |
X: 85,236,077 (GRCm39) |
Q224L |
probably benign |
Het |
| Nr2e1 |
T |
A |
10: 42,444,449 (GRCm39) |
D220V |
probably damaging |
Het |
| Nup160 |
C |
A |
2: 90,523,450 (GRCm39) |
H351Q |
probably damaging |
Het |
| Or5b96 |
T |
A |
19: 12,867,282 (GRCm39) |
M220L |
probably benign |
Het |
| Pcdh12 |
C |
A |
18: 38,414,510 (GRCm39) |
V872L |
probably benign |
Het |
| Pcnx2 |
T |
A |
8: 126,614,324 (GRCm39) |
S376C |
probably damaging |
Het |
| Pkd2 |
A |
G |
5: 104,631,001 (GRCm39) |
E475G |
probably damaging |
Het |
| Psg22 |
A |
G |
7: 18,458,392 (GRCm39) |
Y322C |
probably damaging |
Het |
| Rgl2 |
T |
C |
17: 34,152,392 (GRCm39) |
I363T |
possibly damaging |
Het |
| Rimklb |
G |
T |
6: 122,433,590 (GRCm39) |
Q187K |
possibly damaging |
Het |
| Sectm1b |
A |
T |
11: 120,947,075 (GRCm39) |
W17R |
probably damaging |
Het |
| Snu13 |
C |
A |
15: 81,926,516 (GRCm39) |
A60S |
probably benign |
Het |
| Sox30 |
T |
A |
11: 45,882,727 (GRCm39) |
F586I |
possibly damaging |
Het |
| Tnfsfm13 |
C |
A |
11: 69,575,127 (GRCm39) |
V220L |
probably benign |
Het |
| Ttn |
A |
T |
2: 76,593,117 (GRCm39) |
V20711E |
probably damaging |
Het |
| Vmn2r116 |
A |
G |
17: 23,604,969 (GRCm39) |
N94S |
possibly damaging |
Het |
| Zzef1 |
T |
C |
11: 72,765,999 (GRCm39) |
S1509P |
probably benign |
Het |
|
| Other mutations in Yipf2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02221:Yipf2
|
APN |
9 |
21,502,764 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
IGL02559:Yipf2
|
APN |
9 |
21,503,482 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03055:Yipf2
|
UTSW |
9 |
21,501,019 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0089:Yipf2
|
UTSW |
9 |
21,503,262 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R0113:Yipf2
|
UTSW |
9 |
21,501,412 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0725:Yipf2
|
UTSW |
9 |
21,503,519 (GRCm39) |
splice site |
probably null |
|
|
R2294:Yipf2
|
UTSW |
9 |
21,501,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3154:Yipf2
|
UTSW |
9 |
21,501,197 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3428:Yipf2
|
UTSW |
9 |
21,500,941 (GRCm39) |
intron |
probably benign |
|
|
R4956:Yipf2
|
UTSW |
9 |
21,503,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5353:Yipf2
|
UTSW |
9 |
21,503,228 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5490:Yipf2
|
UTSW |
9 |
21,503,487 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6599:Yipf2
|
UTSW |
9 |
21,501,144 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7050:Yipf2
|
UTSW |
9 |
21,503,474 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7206:Yipf2
|
UTSW |
9 |
21,501,657 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8271:Yipf2
|
UTSW |
9 |
21,501,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9267:Yipf2
|
UTSW |
9 |
21,501,489 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
| Posted On |
2013-04-17 |
Incidental Mutation