Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02134:Or8g32'

281211

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or8g32

Ensembl Gene

ENSMUSG00000094269

Gene Name

olfactory receptor family 8 subfamily G member 32

Synonyms

GA_x6K02T2PVTD-33090395-33091330, MOR171-33P, MOR171-49, Olfr951

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

IGL02134

Quality Score

Status

Chromosome

Chromosomal Location

39305089-39306033 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 39305830 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 248 (I248F)

Ref Sequence

ENSEMBL: ENSMUSP00000077615 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078531] [ENSMUST00000216107]

AlphaFold

Q9EQ94

Predicted Effect

probably damaging
Transcript: ENSMUST00000078531
AA Change: I248F

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000077615
Gene: ENSMUSG00000094269
AA Change: I248F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	34	311	2.5e-52	PFAM
Pfam:7tm_1	44	293	5e-19	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000216107
AA Change: I245F

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrf4	T	C	17: 42,980,581 (GRCm39)	N168S	probably damaging	Het
Angptl3	A	T	4: 98,919,349 (GRCm39)	R36S	probably damaging	Het
Ap5z1	T	C	5: 142,460,214 (GRCm39)	F514L	probably benign	Het
Arhgef39	C	A	4: 43,497,578 (GRCm39)		probably null	Het
Aste1	A	G	9: 105,275,043 (GRCm39)	S11G	probably damaging	Het
Cadm4	T	C	7: 24,198,986 (GRCm39)	V87A	probably benign	Het
Cd177	A	G	7: 24,451,777 (GRCm39)	I413T	probably benign	Het
Col5a2	A	G	1: 45,430,230 (GRCm39)		probably null	Het
Dera	C	T	6: 137,807,269 (GRCm39)	A239V	probably damaging	Het
Ecm1	T	C	3: 95,643,499 (GRCm39)	E283G	probably damaging	Het
Eml6	G	T	11: 29,709,066 (GRCm39)	H24N	probably benign	Het
Etl4	A	G	2: 20,811,240 (GRCm39)	K1425E	possibly damaging	Het
Fgd3	G	A	13: 49,450,225 (GRCm39)	S8L	possibly damaging	Het
Gli1	T	C	10: 127,172,369 (GRCm39)	E228G	probably benign	Het
Hivep3	A	G	4: 119,990,771 (GRCm39)		probably benign	Het
Iqcc	A	G	4: 129,512,818 (GRCm39)	S11P	probably damaging	Het
Itpkc	G	A	7: 26,927,300 (GRCm39)	Q205*	probably null	Het
Jmjd1c	T	A	10: 67,056,171 (GRCm39)	S530R	possibly damaging	Het
Kcnq1	A	G	7: 142,737,453 (GRCm39)	H257R	possibly damaging	Het
Kcnt2	G	A	1: 140,304,121 (GRCm39)	V164I	probably benign	Het
Lgr5	T	C	10: 115,288,763 (GRCm39)	H603R	possibly damaging	Het
Lrp2	T	C	2: 69,343,723 (GRCm39)		probably null	Het
Lrrn2	A	G	1: 132,865,555 (GRCm39)	M207V	possibly damaging	Het
Miip	A	G	4: 147,949,735 (GRCm39)		probably benign	Het
Mrps35	T	C	6: 146,949,808 (GRCm39)		probably benign	Het
Nuf2	A	T	1: 169,341,069 (GRCm39)	M184K	probably benign	Het
Or10q1	C	A	19: 13,727,165 (GRCm39)	R232S	probably benign	Het
Or14j2	C	T	17: 37,886,249 (GRCm39)	E22K	probably benign	Het
Or2f2	A	G	6: 42,767,398 (GRCm39)	T142A	probably benign	Het
Or4a15	A	T	2: 89,193,172 (GRCm39)	N200K	probably damaging	Het
Os9	T	C	10: 126,956,861 (GRCm39)	I42V	possibly damaging	Het
Rapgef4	A	C	2: 72,010,405 (GRCm39)	Q177P	probably damaging	Het
Rhpn2	T	C	7: 35,070,536 (GRCm39)		probably benign	Het
Scn5a	T	C	9: 119,314,958 (GRCm39)	R1916G	probably damaging	Het
Serpine1	T	A	5: 137,095,889 (GRCm39)		probably benign	Het
Snd1	C	T	6: 28,880,278 (GRCm39)	P684L	possibly damaging	Het
Tgds	T	C	14: 118,350,534 (GRCm39)	N340D	probably benign	Het
Trpc4	A	T	3: 54,223,075 (GRCm39)	Y706F	possibly damaging	Het
Ttn	T	A	2: 76,584,166 (GRCm39)	D22314V	probably damaging	Het
Utrn	G	A	10: 12,519,163 (GRCm39)	T2263I	probably damaging	Het
Vmn1r11	A	T	6: 57,115,022 (GRCm39)	T229S	possibly damaging	Het
Zfp142	T	G	1: 74,609,022 (GRCm39)	H1488P	probably damaging	Het
Zfp219	A	G	14: 52,246,758 (GRCm39)	L78P	probably damaging	Het
Zfp629	T	A	7: 127,211,042 (GRCm39)	T256S	probably benign	Het

Other mutations in Or8g32

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01527:Or8g32	APN	9	39,305,114 (GRCm39)	missense	probably benign	0.01
IGL01650:Or8g32	APN	9	39,305,252 (GRCm39)	missense	probably damaging	0.99
IGL03113:Or8g32	APN	9	39,305,981 (GRCm39)	missense	probably damaging	1.00
R0127:Or8g32	UTSW	9	39,305,238 (GRCm39)	missense	probably benign	0.16
R1730:Or8g32	UTSW	9	39,305,518 (GRCm39)	missense	probably benign	0.01
R1783:Or8g32	UTSW	9	39,305,518 (GRCm39)	missense	probably benign	0.01
R1924:Or8g32	UTSW	9	39,305,163 (GRCm39)	missense	possibly damaging	0.93
R3785:Or8g32	UTSW	9	39,305,678 (GRCm39)	missense	probably benign	0.07
R3787:Or8g32	UTSW	9	39,305,678 (GRCm39)	missense	probably benign	0.07
R4607:Or8g32	UTSW	9	39,306,031 (GRCm39)	makesense	probably null
R4803:Or8g32	UTSW	9	39,305,932 (GRCm39)	missense	probably benign	0.26
R5314:Or8g32	UTSW	9	39,305,785 (GRCm39)	missense	probably damaging	1.00
R5338:Or8g32	UTSW	9	39,305,371 (GRCm39)	missense	probably damaging	1.00
R5360:Or8g32	UTSW	9	39,305,698 (GRCm39)	missense	probably benign	0.00
R5468:Or8g32	UTSW	9	39,305,257 (GRCm39)	missense	probably benign	0.33
R6590:Or8g32	UTSW	9	39,305,845 (GRCm39)	missense	probably benign	0.00
R6690:Or8g32	UTSW	9	39,305,845 (GRCm39)	missense	probably benign	0.00
R6925:Or8g32	UTSW	9	39,305,157 (GRCm39)	missense	probably benign	0.01
R6925:Or8g32	UTSW	9	39,305,156 (GRCm39)	missense	probably benign	0.32
R6982:Or8g32	UTSW	9	39,305,618 (GRCm39)	missense	probably damaging	1.00
R7662:Or8g32	UTSW	9	39,305,389 (GRCm39)	missense	probably benign	0.01
R8074:Or8g32	UTSW	9	39,305,242 (GRCm39)	missense	probably damaging	1.00
R8389:Or8g32	UTSW	9	39,305,912 (GRCm39)	missense	probably damaging	1.00
R9444:Or8g32	UTSW	9	39,305,365 (GRCm39)	missense	probably benign	0.19
R9642:Or8g32	UTSW	9	39,305,857 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16