Incidental Mutation 'IGL02134:Vmn1r11'
ID281212
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r11
Ensembl Gene ENSMUSG00000115236
Gene Namevomeronasal 1 receptor 11
SynonymsV1rc3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.172) question?
Stock #IGL02134
Quality Score
Status
Chromosome6
Chromosomal Location57133455-57139617 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 57138037 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Serine at position 229 (T229S)
Ref Sequence ENSEMBL: ENSMUSP00000154588 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071304] [ENSMUST00000176954] [ENSMUST00000226968] [ENSMUST00000228235]
Predicted Effect possibly damaging
Transcript: ENSMUST00000071304
AA Change: T229S

PolyPhen 2 Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000071272
Gene: ENSMUSG00000115236
AA Change: T229S

DomainStartEndE-ValueType
Pfam:V1R 28 293 4.5e-56 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000176954
AA Change: T229S

PolyPhen 2 Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000135192
Gene: ENSMUSG00000093635
AA Change: T229S

DomainStartEndE-ValueType
Pfam:V1R 28 293 9.7e-59 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000226968
AA Change: T229S

PolyPhen 2 Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228235
AA Change: T192S

PolyPhen 2 Score 0.607 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrf4 T C 17: 42,669,690 N168S probably damaging Het
Angptl3 A T 4: 99,031,112 R36S probably damaging Het
Ap5z1 T C 5: 142,474,459 F514L probably benign Het
Arhgef39 C A 4: 43,497,578 probably null Het
Aste1 A G 9: 105,397,844 S11G probably damaging Het
Cadm4 T C 7: 24,499,561 V87A probably benign Het
Cd177 A G 7: 24,752,352 I413T probably benign Het
Col5a2 A G 1: 45,391,070 probably null Het
Dera C T 6: 137,830,271 A239V probably damaging Het
Ecm1 T C 3: 95,736,187 E283G probably damaging Het
Eml6 G T 11: 29,759,066 H24N probably benign Het
Etl4 A G 2: 20,806,429 K1425E possibly damaging Het
Fgd3 G A 13: 49,296,749 S8L possibly damaging Het
Gli1 T C 10: 127,336,500 E228G probably benign Het
Hivep3 A G 4: 120,133,574 probably benign Het
Iqcc A G 4: 129,619,025 S11P probably damaging Het
Itpkc G A 7: 27,227,875 Q205* probably null Het
Jmjd1c T A 10: 67,220,392 S530R possibly damaging Het
Kcnq1 A G 7: 143,183,716 H257R possibly damaging Het
Kcnt2 G A 1: 140,376,383 V164I probably benign Het
Lgr5 T C 10: 115,452,858 H603R possibly damaging Het
Lrp2 T C 2: 69,513,379 probably null Het
Lrrn2 A G 1: 132,937,817 M207V possibly damaging Het
Miip A G 4: 147,865,278 probably benign Het
Mrps35 T C 6: 147,048,310 probably benign Het
Nuf2 A T 1: 169,513,500 M184K probably benign Het
Olfr113 C T 17: 37,575,358 E22K probably benign Het
Olfr1234 A T 2: 89,362,828 N200K probably damaging Het
Olfr1494 C A 19: 13,749,801 R232S probably benign Het
Olfr452 A G 6: 42,790,464 T142A probably benign Het
Olfr951 A T 9: 39,394,534 I248F probably damaging Het
Os9 T C 10: 127,120,992 I42V possibly damaging Het
Rapgef4 A C 2: 72,180,061 Q177P probably damaging Het
Rhpn2 T C 7: 35,371,111 probably benign Het
Scn5a T C 9: 119,485,892 R1916G probably damaging Het
Serpine1 T A 5: 137,067,035 probably benign Het
Snd1 C T 6: 28,880,279 P684L possibly damaging Het
Tgds T C 14: 118,113,122 N340D probably benign Het
Trpc4 A T 3: 54,315,654 Y706F possibly damaging Het
Ttn T A 2: 76,753,822 D22314V probably damaging Het
Utrn G A 10: 12,643,419 T2263I probably damaging Het
Zfp142 T G 1: 74,569,863 H1488P probably damaging Het
Zfp219 A G 14: 52,009,301 L78P probably damaging Het
Zfp629 T A 7: 127,611,870 T256S probably benign Het
Other mutations in Vmn1r11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02141:Vmn1r11 APN 6 57137379 nonsense probably null
IGL03147:Vmn1r11 UTSW 6 57137665 missense probably damaging 0.98
R0908:Vmn1r11 UTSW 6 57138064 missense probably damaging 1.00
R1185:Vmn1r11 UTSW 6 57137507 missense possibly damaging 0.89
R1185:Vmn1r11 UTSW 6 57137507 missense possibly damaging 0.89
R1185:Vmn1r11 UTSW 6 57137507 missense possibly damaging 0.89
R1347:Vmn1r11 UTSW 6 57137978 missense probably benign 0.23
R1347:Vmn1r11 UTSW 6 57137978 missense probably benign 0.23
R1348:Vmn1r11 UTSW 6 57137978 missense probably benign 0.23
R1349:Vmn1r11 UTSW 6 57137978 missense probably benign 0.23
R1373:Vmn1r11 UTSW 6 57137978 missense probably benign 0.23
R1497:Vmn1r11 UTSW 6 57137409 missense probably damaging 1.00
R2147:Vmn1r11 UTSW 6 57137598 missense probably benign 0.29
R2367:Vmn1r11 UTSW 6 57137431 missense probably benign 0.00
R3087:Vmn1r11 UTSW 6 57137706 missense possibly damaging 0.94
R4445:Vmn1r11 UTSW 6 57137530 missense probably benign 0.31
R4667:Vmn1r11 UTSW 6 57137498 missense probably damaging 1.00
R4769:Vmn1r11 UTSW 6 57137612 missense probably damaging 1.00
R5513:Vmn1r11 UTSW 6 57137632 missense probably damaging 0.97
R5841:Vmn1r11 UTSW 6 57137802 missense probably damaging 1.00
R6089:Vmn1r11 UTSW 6 57137660 missense possibly damaging 0.95
R7155:Vmn1r11 UTSW 6 57138162 missense probably benign 0.07
R7359:Vmn1r11 UTSW 6 57138199 missense probably damaging 1.00
Posted On2015-04-16