Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02134:Vmn1r11'

281212

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r11

Ensembl Gene

ENSMUSG00000115236

Gene Name

vomeronasal 1 receptor 11

Synonyms

V1rc3

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.104) question?

Stock #

IGL02134

Quality Score

Status

Chromosome

Chromosomal Location

57114338-57115237 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 57115022 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 229 (T229S)

Ref Sequence

ENSEMBL: ENSMUSP00000154588 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071304] [ENSMUST00000176954] [ENSMUST00000226968] [ENSMUST00000228235]

AlphaFold

Q3SXA2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000071304
AA Change: T229S

PolyPhen 2 Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000071272
Gene: ENSMUSG00000115236
AA Change: T229S

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	4.5e-56	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000176954
AA Change: T229S

PolyPhen 2 Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000135192
Gene: ENSMUSG00000093635
AA Change: T229S

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	9.7e-59	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000226968
AA Change: T229S

PolyPhen 2 Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000228235
AA Change: T192S

PolyPhen 2 Score 0.607 (Sensitivity: 0.87; Specificity: 0.91)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrf4	T	C	17: 42,980,581 (GRCm39)	N168S	probably damaging	Het
Angptl3	A	T	4: 98,919,349 (GRCm39)	R36S	probably damaging	Het
Ap5z1	T	C	5: 142,460,214 (GRCm39)	F514L	probably benign	Het
Arhgef39	C	A	4: 43,497,578 (GRCm39)		probably null	Het
Aste1	A	G	9: 105,275,043 (GRCm39)	S11G	probably damaging	Het
Cadm4	T	C	7: 24,198,986 (GRCm39)	V87A	probably benign	Het
Cd177	A	G	7: 24,451,777 (GRCm39)	I413T	probably benign	Het
Col5a2	A	G	1: 45,430,230 (GRCm39)		probably null	Het
Dera	C	T	6: 137,807,269 (GRCm39)	A239V	probably damaging	Het
Ecm1	T	C	3: 95,643,499 (GRCm39)	E283G	probably damaging	Het
Eml6	G	T	11: 29,709,066 (GRCm39)	H24N	probably benign	Het
Etl4	A	G	2: 20,811,240 (GRCm39)	K1425E	possibly damaging	Het
Fgd3	G	A	13: 49,450,225 (GRCm39)	S8L	possibly damaging	Het
Gli1	T	C	10: 127,172,369 (GRCm39)	E228G	probably benign	Het
Hivep3	A	G	4: 119,990,771 (GRCm39)		probably benign	Het
Iqcc	A	G	4: 129,512,818 (GRCm39)	S11P	probably damaging	Het
Itpkc	G	A	7: 26,927,300 (GRCm39)	Q205*	probably null	Het
Jmjd1c	T	A	10: 67,056,171 (GRCm39)	S530R	possibly damaging	Het
Kcnq1	A	G	7: 142,737,453 (GRCm39)	H257R	possibly damaging	Het
Kcnt2	G	A	1: 140,304,121 (GRCm39)	V164I	probably benign	Het
Lgr5	T	C	10: 115,288,763 (GRCm39)	H603R	possibly damaging	Het
Lrp2	T	C	2: 69,343,723 (GRCm39)		probably null	Het
Lrrn2	A	G	1: 132,865,555 (GRCm39)	M207V	possibly damaging	Het
Miip	A	G	4: 147,949,735 (GRCm39)		probably benign	Het
Mrps35	T	C	6: 146,949,808 (GRCm39)		probably benign	Het
Nuf2	A	T	1: 169,341,069 (GRCm39)	M184K	probably benign	Het
Or10q1	C	A	19: 13,727,165 (GRCm39)	R232S	probably benign	Het
Or14j2	C	T	17: 37,886,249 (GRCm39)	E22K	probably benign	Het
Or2f2	A	G	6: 42,767,398 (GRCm39)	T142A	probably benign	Het
Or4a15	A	T	2: 89,193,172 (GRCm39)	N200K	probably damaging	Het
Or8g32	A	T	9: 39,305,830 (GRCm39)	I248F	probably damaging	Het
Os9	T	C	10: 126,956,861 (GRCm39)	I42V	possibly damaging	Het
Rapgef4	A	C	2: 72,010,405 (GRCm39)	Q177P	probably damaging	Het
Rhpn2	T	C	7: 35,070,536 (GRCm39)		probably benign	Het
Scn5a	T	C	9: 119,314,958 (GRCm39)	R1916G	probably damaging	Het
Serpine1	T	A	5: 137,095,889 (GRCm39)		probably benign	Het
Snd1	C	T	6: 28,880,278 (GRCm39)	P684L	possibly damaging	Het
Tgds	T	C	14: 118,350,534 (GRCm39)	N340D	probably benign	Het
Trpc4	A	T	3: 54,223,075 (GRCm39)	Y706F	possibly damaging	Het
Ttn	T	A	2: 76,584,166 (GRCm39)	D22314V	probably damaging	Het
Utrn	G	A	10: 12,519,163 (GRCm39)	T2263I	probably damaging	Het
Zfp142	T	G	1: 74,609,022 (GRCm39)	H1488P	probably damaging	Het
Zfp219	A	G	14: 52,246,758 (GRCm39)	L78P	probably damaging	Het
Zfp629	T	A	7: 127,211,042 (GRCm39)	T256S	probably benign	Het

Other mutations in Vmn1r11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02141:Vmn1r11	APN	6	57,114,364 (GRCm39)	nonsense	probably null
IGL03147:Vmn1r11	UTSW	6	57,114,650 (GRCm39)	missense	probably damaging	0.98
R0908:Vmn1r11	UTSW	6	57,115,049 (GRCm39)	missense	probably damaging	1.00
R1185:Vmn1r11	UTSW	6	57,114,492 (GRCm39)	missense	possibly damaging	0.89
R1185:Vmn1r11	UTSW	6	57,114,492 (GRCm39)	missense	possibly damaging	0.89
R1185:Vmn1r11	UTSW	6	57,114,492 (GRCm39)	missense	possibly damaging	0.89
R1347:Vmn1r11	UTSW	6	57,114,963 (GRCm39)	missense	probably benign	0.23
R1347:Vmn1r11	UTSW	6	57,114,963 (GRCm39)	missense	probably benign	0.23
R1348:Vmn1r11	UTSW	6	57,114,963 (GRCm39)	missense	probably benign	0.23
R1349:Vmn1r11	UTSW	6	57,114,963 (GRCm39)	missense	probably benign	0.23
R1373:Vmn1r11	UTSW	6	57,114,963 (GRCm39)	missense	probably benign	0.23
R1497:Vmn1r11	UTSW	6	57,114,394 (GRCm39)	missense	probably damaging	1.00
R2147:Vmn1r11	UTSW	6	57,114,583 (GRCm39)	missense	probably benign	0.29
R2367:Vmn1r11	UTSW	6	57,114,416 (GRCm39)	missense	probably benign	0.00
R3087:Vmn1r11	UTSW	6	57,114,691 (GRCm39)	missense	possibly damaging	0.94
R4445:Vmn1r11	UTSW	6	57,114,515 (GRCm39)	missense	probably benign	0.31
R4667:Vmn1r11	UTSW	6	57,114,483 (GRCm39)	missense	probably damaging	1.00
R4769:Vmn1r11	UTSW	6	57,114,597 (GRCm39)	missense	probably damaging	1.00
R5513:Vmn1r11	UTSW	6	57,114,617 (GRCm39)	missense	probably damaging	0.97
R5841:Vmn1r11	UTSW	6	57,114,787 (GRCm39)	missense	probably damaging	1.00
R6089:Vmn1r11	UTSW	6	57,114,645 (GRCm39)	missense	possibly damaging	0.95
R7155:Vmn1r11	UTSW	6	57,115,147 (GRCm39)	missense	probably benign	0.07
R7359:Vmn1r11	UTSW	6	57,115,184 (GRCm39)	missense	probably damaging	1.00
R8846:Vmn1r11	UTSW	6	57,114,807 (GRCm39)	missense	probably benign	0.19
R9222:Vmn1r11	UTSW	6	57,114,992 (GRCm39)	missense	possibly damaging	0.94
R9300:Vmn1r11	UTSW	6	57,114,872 (GRCm39)	missense	probably benign	0.00
R9517:Vmn1r11	UTSW	6	57,114,555 (GRCm39)	missense	possibly damaging	0.88

Posted On

2015-04-16