Incidental Mutation 'IGL02134:Miip'
ID 281248
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Miip
Ensembl Gene ENSMUSG00000029022
Gene Name migration and invasion inhibitory protein
Synonyms D4Wsu114e
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # IGL02134
Quality Score
Status
Chromosome 4
Chromosomal Location 147945235-147953176 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 147949735 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000134085 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030886] [ENSMUST00000094481] [ENSMUST00000119975] [ENSMUST00000172710]
AlphaFold A2A7Y5
Predicted Effect probably benign
Transcript: ENSMUST00000030886
SMART Domains Protein: ENSMUSP00000030886
Gene: ENSMUSG00000029022

DomainStartEndE-ValueType
low complexity region 13 24 N/A INTRINSIC
low complexity region 60 69 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000094481
SMART Domains Protein: ENSMUSP00000092054
Gene: ENSMUSG00000070583

DomainStartEndE-ValueType
low complexity region 22 32 N/A INTRINSIC
coiled coil region 86 116 N/A INTRINSIC
low complexity region 438 451 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000119975
SMART Domains Protein: ENSMUSP00000113897
Gene: ENSMUSG00000029022

DomainStartEndE-ValueType
low complexity region 13 24 N/A INTRINSIC
Pfam:MIIP 41 382 1.4e-142 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141166
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141534
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156374
Predicted Effect probably benign
Transcript: ENSMUST00000172710
SMART Domains Protein: ENSMUSP00000134085
Gene: ENSMUSG00000029022

DomainStartEndE-ValueType
low complexity region 13 24 N/A INTRINSIC
low complexity region 60 69 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173034
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174081
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrf4 T C 17: 42,980,581 (GRCm39) N168S probably damaging Het
Angptl3 A T 4: 98,919,349 (GRCm39) R36S probably damaging Het
Ap5z1 T C 5: 142,460,214 (GRCm39) F514L probably benign Het
Arhgef39 C A 4: 43,497,578 (GRCm39) probably null Het
Aste1 A G 9: 105,275,043 (GRCm39) S11G probably damaging Het
Cadm4 T C 7: 24,198,986 (GRCm39) V87A probably benign Het
Cd177 A G 7: 24,451,777 (GRCm39) I413T probably benign Het
Col5a2 A G 1: 45,430,230 (GRCm39) probably null Het
Dera C T 6: 137,807,269 (GRCm39) A239V probably damaging Het
Ecm1 T C 3: 95,643,499 (GRCm39) E283G probably damaging Het
Eml6 G T 11: 29,709,066 (GRCm39) H24N probably benign Het
Etl4 A G 2: 20,811,240 (GRCm39) K1425E possibly damaging Het
Fgd3 G A 13: 49,450,225 (GRCm39) S8L possibly damaging Het
Gli1 T C 10: 127,172,369 (GRCm39) E228G probably benign Het
Hivep3 A G 4: 119,990,771 (GRCm39) probably benign Het
Iqcc A G 4: 129,512,818 (GRCm39) S11P probably damaging Het
Itpkc G A 7: 26,927,300 (GRCm39) Q205* probably null Het
Jmjd1c T A 10: 67,056,171 (GRCm39) S530R possibly damaging Het
Kcnq1 A G 7: 142,737,453 (GRCm39) H257R possibly damaging Het
Kcnt2 G A 1: 140,304,121 (GRCm39) V164I probably benign Het
Lgr5 T C 10: 115,288,763 (GRCm39) H603R possibly damaging Het
Lrp2 T C 2: 69,343,723 (GRCm39) probably null Het
Lrrn2 A G 1: 132,865,555 (GRCm39) M207V possibly damaging Het
Mrps35 T C 6: 146,949,808 (GRCm39) probably benign Het
Nuf2 A T 1: 169,341,069 (GRCm39) M184K probably benign Het
Or10q1 C A 19: 13,727,165 (GRCm39) R232S probably benign Het
Or14j2 C T 17: 37,886,249 (GRCm39) E22K probably benign Het
Or2f2 A G 6: 42,767,398 (GRCm39) T142A probably benign Het
Or4a15 A T 2: 89,193,172 (GRCm39) N200K probably damaging Het
Or8g32 A T 9: 39,305,830 (GRCm39) I248F probably damaging Het
Os9 T C 10: 126,956,861 (GRCm39) I42V possibly damaging Het
Rapgef4 A C 2: 72,010,405 (GRCm39) Q177P probably damaging Het
Rhpn2 T C 7: 35,070,536 (GRCm39) probably benign Het
Scn5a T C 9: 119,314,958 (GRCm39) R1916G probably damaging Het
Serpine1 T A 5: 137,095,889 (GRCm39) probably benign Het
Snd1 C T 6: 28,880,278 (GRCm39) P684L possibly damaging Het
Tgds T C 14: 118,350,534 (GRCm39) N340D probably benign Het
Trpc4 A T 3: 54,223,075 (GRCm39) Y706F possibly damaging Het
Ttn T A 2: 76,584,166 (GRCm39) D22314V probably damaging Het
Utrn G A 10: 12,519,163 (GRCm39) T2263I probably damaging Het
Vmn1r11 A T 6: 57,115,022 (GRCm39) T229S possibly damaging Het
Zfp142 T G 1: 74,609,022 (GRCm39) H1488P probably damaging Het
Zfp219 A G 14: 52,246,758 (GRCm39) L78P probably damaging Het
Zfp629 T A 7: 127,211,042 (GRCm39) T256S probably benign Het
Other mutations in Miip
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00531:Miip APN 4 147,950,322 (GRCm39) missense probably damaging 1.00
IGL02829:Miip APN 4 147,947,518 (GRCm39) missense probably benign 0.01
IGL03350:Miip APN 4 147,946,979 (GRCm39) missense probably benign 0.01
R0200:Miip UTSW 4 147,946,720 (GRCm39) missense probably damaging 0.99
R1647:Miip UTSW 4 147,949,691 (GRCm39) missense probably benign 0.02
R1783:Miip UTSW 4 147,950,231 (GRCm39) missense probably damaging 1.00
R1848:Miip UTSW 4 147,947,549 (GRCm39) missense probably damaging 0.99
R1944:Miip UTSW 4 147,950,422 (GRCm39) missense probably benign 0.15
R3615:Miip UTSW 4 147,950,371 (GRCm39) missense probably benign 0.00
R3616:Miip UTSW 4 147,950,371 (GRCm39) missense probably benign 0.00
R3882:Miip UTSW 4 147,945,509 (GRCm39) missense possibly damaging 0.93
R4579:Miip UTSW 4 147,945,518 (GRCm39) missense probably damaging 1.00
R5183:Miip UTSW 4 147,947,526 (GRCm39) missense probably damaging 1.00
R6054:Miip UTSW 4 147,950,135 (GRCm39) missense probably benign 0.00
R6056:Miip UTSW 4 147,946,792 (GRCm39) missense probably damaging 1.00
R6304:Miip UTSW 4 147,947,540 (GRCm39) missense probably benign 0.12
R6568:Miip UTSW 4 147,950,372 (GRCm39) missense probably benign
R6603:Miip UTSW 4 147,950,380 (GRCm39) missense possibly damaging 0.92
R7639:Miip UTSW 4 147,947,021 (GRCm39) missense probably benign 0.22
R7701:Miip UTSW 4 147,947,371 (GRCm39) missense probably null 0.86
R7795:Miip UTSW 4 147,947,375 (GRCm39) missense probably benign 0.17
R7796:Miip UTSW 4 147,947,375 (GRCm39) missense probably benign 0.17
R7797:Miip UTSW 4 147,947,375 (GRCm39) missense probably benign 0.17
R7872:Miip UTSW 4 147,947,375 (GRCm39) missense probably benign 0.17
R7920:Miip UTSW 4 147,947,375 (GRCm39) missense probably benign 0.17
R8468:Miip UTSW 4 147,945,928 (GRCm39) missense probably damaging 1.00
R8492:Miip UTSW 4 147,945,881 (GRCm39) missense probably damaging 1.00
R8677:Miip UTSW 4 147,947,503 (GRCm39) missense probably damaging 1.00
R8852:Miip UTSW 4 147,950,839 (GRCm39) start gained probably benign
R8860:Miip UTSW 4 147,950,839 (GRCm39) start gained probably benign
R9755:Miip UTSW 4 147,950,319 (GRCm39) nonsense probably null
Posted On 2015-04-16