Incidental Mutation 'IGL02135:Or7a37'
ID 281260
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or7a37
Ensembl Gene ENSMUSG00000042774
Gene Name olfactory receptor family 7 subfamily A member 37
Synonyms GA_x6K02T2QGN0-2842591-2841662, Olfr1353, MOR139-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # IGL02135
Quality Score
Status
Chromosome 10
Chromosomal Location 78799143-78806446 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 78805940 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Arginine at position 152 (S152R)
Ref Sequence ENSEMBL: ENSMUSP00000145073 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039718] [ENSMUST00000204849] [ENSMUST00000205193]
AlphaFold Q8VGU8
Predicted Effect probably damaging
Transcript: ENSMUST00000039718
AA Change: S152R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000038992
Gene: ENSMUSG00000042774
AA Change: S152R

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.2e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.9e-6 PFAM
Pfam:7tm_1 41 290 9.3e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000204849
AA Change: S152R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000145454
Gene: ENSMUSG00000042774
AA Change: S152R

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.2e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.9e-6 PFAM
Pfam:7tm_1 41 290 9.3e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000205193
AA Change: S152R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000145073
Gene: ENSMUSG00000042774
AA Change: S152R

DomainStartEndE-ValueType
Pfam:7tm_4 31 95 5.8e-10 PFAM
Pfam:7tm_1 41 94 3.5e-8 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219714
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik A G 15: 81,949,205 (GRCm39) H1034R possibly damaging Het
Aoc1l1 G A 6: 48,952,498 (GRCm39) R141Q probably benign Het
App A G 16: 84,876,726 (GRCm39) probably null Het
Arhgap23 G T 11: 97,342,528 (GRCm39) R270L probably damaging Het
Arhgap36 T C X: 48,586,066 (GRCm39) I342T possibly damaging Het
Arhgef12 A T 9: 42,883,461 (GRCm39) M1356K possibly damaging Het
Armh4 T C 14: 50,011,386 (GRCm39) K107R probably damaging Het
Asap3 A C 4: 135,968,464 (GRCm39) probably null Het
Atl2 A G 17: 80,167,214 (GRCm39) probably null Het
Cdh20 T A 1: 110,066,004 (GRCm39) Y759* probably null Het
Celsr3 A G 9: 108,704,755 (GRCm39) T413A probably benign Het
Cep97 A T 16: 55,743,330 (GRCm39) I102K probably damaging Het
Ces2a T C 8: 105,466,813 (GRCm39) S441P probably benign Het
Cops2 T C 2: 125,674,163 (GRCm39) T435A probably benign Het
Ctc1 A G 11: 68,911,989 (GRCm39) N56S probably benign Het
Dennd2a G A 6: 39,457,205 (GRCm39) R746* probably null Het
Dnah5 T A 15: 28,248,031 (GRCm39) C723S possibly damaging Het
Dnah7a A C 1: 53,662,632 (GRCm39) V643G probably benign Het
Dnah9 A T 11: 66,008,318 (GRCm39) S836T possibly damaging Het
Edc4 T A 8: 106,612,454 (GRCm39) V164D probably damaging Het
Gcfc2 A T 6: 81,918,381 (GRCm39) D357V probably damaging Het
Grem1 T C 2: 113,580,132 (GRCm39) N123S probably damaging Het
Gria1 T C 11: 57,076,679 (GRCm39) V94A probably damaging Het
Hipk2 G A 6: 38,795,934 (GRCm39) H112Y possibly damaging Het
Il7r T C 15: 9,508,092 (GRCm39) N410S probably benign Het
Insr A T 8: 3,308,741 (GRCm39) S98R probably damaging Het
Klhl7 T A 5: 24,346,279 (GRCm39) Y308* probably null Het
Lcp1 T C 14: 75,437,926 (GRCm39) V112A probably benign Het
Map2 A T 1: 66,419,920 (GRCm39) R84* probably null Het
Mgst1 A T 6: 138,124,766 (GRCm39) M27L probably damaging Het
Mroh7 A G 4: 106,559,707 (GRCm39) L740P probably damaging Het
Mybpc3 T C 2: 90,955,171 (GRCm39) F507L possibly damaging Het
Nqo2 A T 13: 34,169,326 (GRCm39) K183* probably null Het
Nt5c1b T C 12: 10,427,194 (GRCm39) Y315H probably damaging Het
Odc1 T A 12: 17,597,674 (GRCm39) I48N probably damaging Het
Or2a56 A G 6: 42,932,585 (GRCm39) D51G probably damaging Het
Osbpl5 T A 7: 143,258,862 (GRCm39) D236V probably damaging Het
Prkg1 A G 19: 30,970,476 (GRCm39) Y212H probably benign Het
Pttg1ip T C 10: 77,425,578 (GRCm39) probably null Het
Serpina1f T A 12: 103,659,974 (GRCm39) T103S possibly damaging Het
Skp2 T C 15: 9,125,234 (GRCm39) D115G probably benign Het
Slc25a30 C T 14: 76,004,435 (GRCm39) V221I probably benign Het
Slc7a3 A C X: 100,123,098 (GRCm39) D609E probably benign Het
Strc C T 2: 121,195,315 (GRCm39) G1656D probably damaging Het
Tbc1d8 A G 1: 39,441,891 (GRCm39) F234L probably damaging Het
Tgm7 T G 2: 120,929,519 (GRCm39) I252L possibly damaging Het
Tlr5 A G 1: 182,800,819 (GRCm39) D41G possibly damaging Het
Tns2 T C 15: 102,021,461 (GRCm39) L1034P probably damaging Het
Trim15 A G 17: 37,177,956 (GRCm39) V13A probably benign Het
Uros C T 7: 133,288,734 (GRCm39) V258M possibly damaging Het
Wdr75 A G 1: 45,853,723 (GRCm39) Y378C probably damaging Het
Wdr75 G A 1: 45,856,608 (GRCm39) probably null Het
Wdr82 G T 9: 106,048,443 (GRCm39) R9L possibly damaging Het
Ybx3 G A 6: 131,357,892 (GRCm39) R125C probably damaging Het
Zc3h12b A G X: 94,942,870 (GRCm39) T49A probably benign Het
Zfyve27 G A 19: 42,172,575 (GRCm39) V279M probably damaging Het
Other mutations in Or7a37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02159:Or7a37 APN 10 78,805,735 (GRCm39) missense probably damaging 1.00
R0355:Or7a37 UTSW 10 78,806,267 (GRCm39) missense probably damaging 1.00
R0561:Or7a37 UTSW 10 78,805,729 (GRCm39) nonsense probably null
R1305:Or7a37 UTSW 10 78,805,933 (GRCm39) missense probably benign 0.03
R1921:Or7a37 UTSW 10 78,805,975 (GRCm39) nonsense probably null
R1922:Or7a37 UTSW 10 78,805,975 (GRCm39) nonsense probably null
R2382:Or7a37 UTSW 10 78,805,990 (GRCm39) missense probably damaging 0.99
R2920:Or7a37 UTSW 10 78,805,846 (GRCm39) missense probably damaging 1.00
R4491:Or7a37 UTSW 10 78,806,151 (GRCm39) missense probably damaging 1.00
R5113:Or7a37 UTSW 10 78,806,037 (GRCm39) missense probably benign
R5305:Or7a37 UTSW 10 78,806,390 (GRCm39) missense possibly damaging 0.68
R5744:Or7a37 UTSW 10 78,806,017 (GRCm39) missense probably damaging 1.00
R5861:Or7a37 UTSW 10 78,805,765 (GRCm39) missense probably damaging 1.00
R6197:Or7a37 UTSW 10 78,805,974 (GRCm39) missense probably damaging 1.00
R6314:Or7a37 UTSW 10 78,806,179 (GRCm39) missense probably benign
R7693:Or7a37 UTSW 10 78,806,137 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16