Incidental Mutation 'IGL00907:Olfr836'
ID28130
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr836
Ensembl Gene ENSMUSG00000059303
Gene Nameolfactory receptor 836
SynonymsMOR152-3, GA_x6K02T2PVTD-12857805-12858749
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.108) question?
Stock #IGL00907
Quality Score
Status
Chromosome9
Chromosomal Location19120382-19125938 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 19121232 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 89 (D89E)
Ref Sequence ENSEMBL: ENSMUSP00000150026 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074986] [ENSMUST00000212730] [ENSMUST00000215981]
Predicted Effect possibly damaging
Transcript: ENSMUST00000074986
AA Change: D92E

PolyPhen 2 Score 0.651 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000074514
Gene: ENSMUSG00000059303
AA Change: D92E

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 1.2e-50 PFAM
Pfam:7TM_GPCR_Srsx 38 210 9.6e-6 PFAM
Pfam:7tm_1 44 293 2.4e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000212730
AA Change: D89E

PolyPhen 2 Score 0.879 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215981
AA Change: D89E

PolyPhen 2 Score 0.879 (Sensitivity: 0.82; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Armt1 A G 10: 4,454,051 F379V possibly damaging Het
Atp8b1 T C 18: 64,561,705 D502G possibly damaging Het
Brwd3 A G X: 108,784,246 probably benign Het
Ccdc171 T A 4: 83,864,249 H1259Q probably damaging Het
Chd7 T C 4: 8,840,435 I1401T probably damaging Het
Csf1 T C 3: 107,750,346 N76S probably damaging Het
Dld A G 12: 31,332,330 probably benign Het
Eif5 T A 12: 111,540,555 I141N probably damaging Het
Etl4 G A 2: 20,766,478 G674D possibly damaging Het
Fam234a G A 17: 26,213,526 R550W probably damaging Het
Hipk2 A G 6: 38,818,273 S347P probably damaging Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Hsd17b2 A T 8: 117,734,694 I157L probably benign Het
Ibtk A G 9: 85,690,331 S1269P possibly damaging Het
Igsf3 T C 3: 101,427,448 probably benign Het
Kin G A 2: 10,080,704 R25H probably damaging Het
Kin T C 2: 10,080,706 W26R probably damaging Het
Kir3dl1 G A X: 136,525,162 C95Y probably damaging Het
Lamc2 A G 1: 153,144,651 V383A probably benign Het
Mael A G 1: 166,204,849 Y314H probably damaging Het
Npat T C 9: 53,563,290 V794A possibly damaging Het
Nr4a2 T A 2: 57,109,217 I340F probably damaging Het
Olfr1195 A G 2: 88,683,294 V146A probably benign Het
Olfr477 A T 7: 107,990,890 D175V probably damaging Het
Pdcd11 T C 19: 47,107,564 V641A probably benign Het
Phf24 C T 4: 42,938,667 T264I probably benign Het
Sars2 G T 7: 28,753,423 probably benign Het
Scn1a A C 2: 66,327,797 S411A probably damaging Het
Srsf5 T C 12: 80,947,834 V112A probably damaging Het
Susd2 T C 10: 75,640,931 N206S probably benign Het
Thrap3 C T 4: 126,165,578 G892S probably benign Het
Ttc32 T A 12: 9,034,953 Y58N probably damaging Het
Other mutations in Olfr836
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01316:Olfr836 APN 9 19121422 missense probably benign 0.10
IGL01412:Olfr836 APN 9 19121599 missense probably benign 0.00
IGL01815:Olfr836 APN 9 19121326 missense probably damaging 1.00
IGL02003:Olfr836 APN 9 19121065 missense probably benign 0.06
IGL02313:Olfr836 APN 9 19121375 missense probably damaging 0.99
IGL03185:Olfr836 APN 9 19121738 missense probably damaging 1.00
IGL03186:Olfr836 APN 9 19121904 missense probably benign 0.16
R1337:Olfr836 UTSW 9 19121803 missense probably benign
R2267:Olfr836 UTSW 9 19121441 missense probably benign 0.22
R3969:Olfr836 UTSW 9 19121660 missense probably benign 0.00
R4695:Olfr836 UTSW 9 19121010 missense probably null 0.04
R4976:Olfr836 UTSW 9 19121501 missense probably damaging 1.00
R5176:Olfr836 UTSW 9 19121360 missense probably damaging 1.00
R5379:Olfr836 UTSW 9 19121077 missense probably damaging 1.00
R5638:Olfr836 UTSW 9 19121380 missense probably benign 0.00
R6084:Olfr836 UTSW 9 19121327 missense probably damaging 1.00
R6236:Olfr836 UTSW 9 19121113 missense possibly damaging 0.92
R6329:Olfr836 UTSW 9 19120957 start codon destroyed probably benign 0.08
R7151:Olfr836 UTSW 9 19121741 missense possibly damaging 0.91
R7326:Olfr836 UTSW 9 19121669 missense probably benign 0.42
R8460:Olfr836 UTSW 9 19121692 missense probably damaging 1.00
Posted On2013-04-17