Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02136:Vmn2r107'

281313

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r107

Ensembl Gene

ENSMUSG00000056910

Gene Name

vomeronasal 2, receptor 107

Synonyms

V2r6

Accession Numbers

Genbank: NM_001104569; MGI: 1316664

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

IGL02136

Quality Score

Status

Chromosome

Chromosomal Location

20345425-20375772 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 20374906 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Leucine at position 574 (V574L)

Ref Sequence

ENSEMBL: ENSMUSP00000048706 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042090]

AlphaFold

E9PZJ7

Predicted Effect

probably benign
Transcript: ENSMUST00000042090
AA Change: V574L

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000048706
Gene: ENSMUSG00000056910
AA Change: V574L

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	466	3.6e-40	PFAM
Pfam:NCD3G	509	562	5.1e-21	PFAM
Pfam:7tm_3	593	830	8e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	G	T	1: 71,247,142	T2511K	probably damaging	Het
Acta2	T	A	19: 34,251,830	D53V	probably damaging	Het
Banf1	G	A	19: 5,365,070	A71V	probably benign	Het
Cacng5	A	T	11: 107,881,731	I97N	probably benign	Het
Clec14a	T	A	12: 58,268,629	E69V	probably damaging	Het
Cracr2a	T	C	6: 127,629,930		probably benign	Het
Dysf	A	G	6: 84,108,167	R845G	probably benign	Het
Dzip3	T	C	16: 48,927,582	N949S	possibly damaging	Het
Eprs	T	G	1: 185,384,983	W408G	probably damaging	Het
Fgf14	G	A	14: 123,980,372	P240S	possibly damaging	Het
Fpgt	G	T	3: 155,093,352	A2E	probably benign	Het
Galntl5	T	A	5: 25,220,062	S392R	probably benign	Het
Gatd1	A	G	7: 141,408,960	*221Q	probably null	Het
Gcsam	T	A	16: 45,610,533	M1K	probably null	Het
Ksr2	A	G	5: 117,616,894	N351S	possibly damaging	Het
Map1a	T	C	2: 121,300,212	V503A	probably damaging	Het
Myl12a	T	A	17: 70,996,856	K9*	probably null	Het
Ncapg2	A	T	12: 116,460,583	M1129L	probably benign	Het
Olfr228	T	C	2: 86,483,465	I92M	probably damaging	Het
Olfr744	T	C	14: 50,618,251	S10P	possibly damaging	Het
Otof	T	C	5: 30,373,992	K1691E	possibly damaging	Het
Pdk4	A	T	6: 5,486,715	M353K	probably damaging	Het
Pkhd1	A	T	1: 20,275,615	W2730R	probably damaging	Het
Pkn2	T	A	3: 142,853,590	K58I	probably damaging	Het
Plk5	T	C	10: 80,363,167		probably null	Het
Prkcq	T	C	2: 11,260,668	F399L	probably benign	Het
Ptprz1	G	A	6: 22,972,822	V244M	probably damaging	Het
Rpusd2	T	C	2: 119,038,178	F361L	probably damaging	Het
Rttn	T	A	18: 89,046,128	L1168I	possibly damaging	Het
S100a9	T	C	3: 90,692,768	H107R	probably benign	Het
Serpinb3a	T	A	1: 107,046,285	M299L	probably benign	Het
Slfn8	G	A	11: 83,003,465	Q783*	probably null	Het
Smc3	T	C	19: 53,635,716	I721T	probably benign	Het
Top2b	C	A	14: 16,407,103		probably benign	Het
Uvssa	T	A	5: 33,391,848	W351R	probably damaging	Het
Wdr3	G	A	3: 100,138,725	R931*	probably null	Het

Other mutations in Vmn2r107

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01402:Vmn2r107	APN	17	20375747	missense	probably damaging	0.98
IGL01768:Vmn2r107	APN	17	20345606	missense	probably benign	0.32
IGL02086:Vmn2r107	APN	17	20357800	missense	probably benign	0.00
IGL02266:Vmn2r107	APN	17	20356777	missense	probably damaging	1.00
IGL02285:Vmn2r107	APN	17	20375561	missense	probably damaging	1.00
IGL02724:Vmn2r107	APN	17	20356744	missense	possibly damaging	0.49
IGL02998:Vmn2r107	APN	17	20357755	missense	probably damaging	0.99
IGL03089:Vmn2r107	APN	17	20375712	missense	probably benign	0.05
IGL03284:Vmn2r107	APN	17	20356911	missense	probably benign	0.07
IGL03307:Vmn2r107	APN	17	20356776	missense	probably benign	0.09
IGL03399:Vmn2r107	APN	17	20357958	splice site	probably benign
3-1:Vmn2r107	UTSW	17	20345504	missense	probably benign
BB006:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
BB016:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R0285:Vmn2r107	UTSW	17	20345611	missense	probably benign	0.00
R0455:Vmn2r107	UTSW	17	20374823	splice site	probably benign
R0497:Vmn2r107	UTSW	17	20375132	missense	probably damaging	1.00
R0506:Vmn2r107	UTSW	17	20357759	missense	probably benign
R0621:Vmn2r107	UTSW	17	20374990	missense	probably benign	0.01
R0667:Vmn2r107	UTSW	17	20355654	missense	possibly damaging	0.91
R1118:Vmn2r107	UTSW	17	20356598	missense	probably benign	0.03
R1204:Vmn2r107	UTSW	17	20357769	missense	probably benign
R1237:Vmn2r107	UTSW	17	20356685	nonsense	probably null
R1485:Vmn2r107	UTSW	17	20374847	missense	possibly damaging	0.95
R1783:Vmn2r107	UTSW	17	20356513	missense	possibly damaging	0.51
R1873:Vmn2r107	UTSW	17	20345578	missense	probably benign	0.10
R1974:Vmn2r107	UTSW	17	20355617	splice site	probably null
R2009:Vmn2r107	UTSW	17	20375467	missense	probably benign	0.01
R2029:Vmn2r107	UTSW	17	20375287	missense	probably benign	0.01
R2164:Vmn2r107	UTSW	17	20375642	missense	probably damaging	1.00
R2269:Vmn2r107	UTSW	17	20375555	missense	possibly damaging	0.58
R3087:Vmn2r107	UTSW	17	20360345	missense	probably benign	0.03
R3740:Vmn2r107	UTSW	17	20374889	missense	probably benign	0.00
R3961:Vmn2r107	UTSW	17	20375455	missense	probably damaging	1.00
R4031:Vmn2r107	UTSW	17	20375221	missense	probably benign	0.00
R4270:Vmn2r107	UTSW	17	20355779	missense	probably benign
R4963:Vmn2r107	UTSW	17	20375141	missense	probably damaging	1.00
R5121:Vmn2r107	UTSW	17	20355753	missense	probably benign	0.01
R5640:Vmn2r107	UTSW	17	20375164	missense	probably damaging	1.00
R6007:Vmn2r107	UTSW	17	20375054	missense	probably benign	0.19
R6238:Vmn2r107	UTSW	17	20345587	missense	probably benign	0.43
R6298:Vmn2r107	UTSW	17	20355782	missense	probably benign	0.00
R6467:Vmn2r107	UTSW	17	20375677	missense	probably damaging	0.99
R6726:Vmn2r107	UTSW	17	20375375	missense	probably damaging	0.96
R6782:Vmn2r107	UTSW	17	20356879	missense	probably damaging	1.00
R7299:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7301:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7375:Vmn2r107	UTSW	17	20355876	missense	probably benign
R7448:Vmn2r107	UTSW	17	20375732	missense	probably benign	0.00
R7495:Vmn2r107	UTSW	17	20375009	missense	possibly damaging	0.71
R7589:Vmn2r107	UTSW	17	20375372	missense	probably benign	0.05
R7594:Vmn2r107	UTSW	17	20360373	missense	probably benign	0.03
R7678:Vmn2r107	UTSW	17	20356639	missense	probably benign	0.01
R7929:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R7974:Vmn2r107	UTSW	17	20357008	missense	probably benign	0.00
R8040:Vmn2r107	UTSW	17	20375546	missense	probably damaging	1.00
R8263:Vmn2r107	UTSW	17	20360352	missense	probably damaging	1.00
R8426:Vmn2r107	UTSW	17	20356977	missense	possibly damaging	0.91
R9175:Vmn2r107	UTSW	17	20356789	missense	possibly damaging	0.79
R9537:Vmn2r107	UTSW	17	20374887	missense	probably benign	0.00
R9642:Vmn2r107	UTSW	17	20360399	missense	probably damaging	1.00
R9711:Vmn2r107	UTSW	17	20357000	missense	probably damaging	1.00
X0022:Vmn2r107	UTSW	17	20356968	missense	possibly damaging	0.85

Posted On

2015-04-16