Incidental Mutation 'IGL02138:Olfr406'
ID281411
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr406
Ensembl Gene ENSMUSG00000070375
Gene Nameolfactory receptor 406
SynonymsOlfr406-ps, GA_x6K02T2P1NL-4415162-4416133, MOR133-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.063) question?
Stock #IGL02138
Quality Score
Status
Chromosome11
Chromosomal Location74259808-74271625 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 74269718 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Leucine at position 110 (M110L)
Ref Sequence ENSEMBL: ENSMUSP00000148929 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000133561] [ENSMUST00000214303] [ENSMUST00000217016]
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127098
Predicted Effect probably benign
Transcript: ENSMUST00000133561
AA Change: M110L

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000125963
Gene: ENSMUSG00000070375
AA Change: M110L

DomainStartEndE-ValueType
Pfam:7tm_4 31 310 3.5e-56 PFAM
Pfam:7tm_1 41 292 3e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214303
AA Change: M110L

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Predicted Effect probably benign
Transcript: ENSMUST00000217016
AA Change: M110L

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik T G 14: 32,662,715 D431A possibly damaging Het
Adgrb1 T C 15: 74,529,782 M209T probably damaging Het
Ano8 T C 8: 71,484,842 H86R probably damaging Het
Camk1d G T 2: 5,445,084 Y87* probably null Het
Capza3 A G 6: 140,042,146 D157G probably benign Het
Ccdc36 G A 9: 108,406,621 T208I probably benign Het
Ckmt2 A T 13: 91,861,828 D124E probably benign Het
Col14a1 C A 15: 55,420,835 Q831K unknown Het
Copb2 C T 9: 98,587,552 P829S probably benign Het
Dlg5 A G 14: 24,158,351 V929A probably benign Het
Dolk A G 2: 30,285,979 V18A probably benign Het
Ecm2 G T 13: 49,522,828 L340F probably damaging Het
Hacl1 A G 14: 31,630,983 L149P probably benign Het
Higd2a A T 13: 54,590,422 probably null Het
Hspa12a A T 19: 58,828,298 S28R probably benign Het
Igkv5-37 A G 6: 69,963,451 Y70H probably damaging Het
Kif11 T C 19: 37,384,609 V92A probably damaging Het
Kif26a T C 12: 112,174,850 S696P probably damaging Het
Kng1 A T 16: 23,067,808 N168Y probably damaging Het
Krt26 C T 11: 99,333,645 R349Q probably benign Het
Lepr A G 4: 101,768,067 D473G probably damaging Het
Lipt1 G A 1: 37,875,786 E308K possibly damaging Het
Luc7l3 A T 11: 94,303,966 F76Y probably benign Het
Mapk1 A G 16: 17,023,452 I163V probably benign Het
Matn3 A G 12: 8,967,638 E430G possibly damaging Het
Med13 A T 11: 86,286,765 S1502T probably damaging Het
Mlf1 A T 3: 67,399,713 H237L probably benign Het
Mss51 A C 14: 20,484,855 Y282* probably null Het
Ncoa3 A G 2: 166,055,262 T658A probably benign Het
Olfr867 A T 9: 20,054,900 S188T probably benign Het
Phrf1 T A 7: 141,259,283 probably benign Het
Ppme1 C T 7: 100,333,932 M335I probably damaging Het
Ror2 C T 13: 53,110,728 S764N probably damaging Het
Sntg2 T A 12: 30,307,231 probably null Het
Spryd3 T C 15: 102,118,919 probably benign Het
Srpx A G X: 10,067,423 probably null Het
St8sia1 G T 6: 142,963,778 probably benign Het
Stab1 A G 14: 31,143,513 probably null Het
Sycp2 T A 2: 178,401,990 K108* probably null Het
Sycp2 A T 2: 178,358,254 S976R probably benign Het
Tagap1 T C 17: 6,956,086 T404A probably damaging Het
Tg C T 15: 66,717,233 T21I probably benign Het
Tlr4 A T 4: 66,840,965 Y665F probably damaging Het
Tmc8 T G 11: 117,791,255 S525A probably benign Het
Tor4a A T 2: 25,194,798 D364E probably benign Het
Trim44 T C 2: 102,380,908 I236V probably benign Het
Ube2o A G 11: 116,543,400 probably benign Het
Wdr38 A T 2: 38,998,412 N7I probably damaging Het
Xirp2 A T 2: 67,516,956 R3180S probably benign Het
Zfp335 A G 2: 164,893,804 C1077R probably damaging Het
Other mutations in Olfr406
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01370:Olfr406 APN 11 74269499 missense probably benign 0.01
IGL01480:Olfr406 APN 11 74269601 missense possibly damaging 0.64
IGL02986:Olfr406 APN 11 74270102 missense possibly damaging 0.82
R0018:Olfr406 UTSW 11 74270108 missense probably benign 0.39
R1822:Olfr406 UTSW 11 74270240 missense probably benign 0.11
R1823:Olfr406 UTSW 11 74270217 missense probably damaging 1.00
R1956:Olfr406 UTSW 11 74269844 missense probably damaging 1.00
R2017:Olfr406 UTSW 11 74270333 missense probably benign
R2879:Olfr406 UTSW 11 74270223 missense probably damaging 1.00
R3854:Olfr406 UTSW 11 74270279 nonsense probably null
R4750:Olfr406 UTSW 11 74269420 missense probably benign 0.00
R6076:Olfr406 UTSW 11 74270262 missense probably damaging 1.00
R6257:Olfr406 UTSW 11 74270007 missense probably damaging 1.00
R6431:Olfr406 UTSW 11 74269409 missense possibly damaging 0.95
R7032:Olfr406 UTSW 11 74269602 missense possibly damaging 0.95
R7216:Olfr406 UTSW 11 74269724 missense probably damaging 1.00
R7429:Olfr406 UTSW 11 74269753 missense probably damaging 1.00
Posted On2015-04-16