Incidental Mutation 'IGL02138:Or7d11'
ID 281428
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or7d11
Ensembl Gene ENSMUSG00000044454
Gene Name olfactory receptor family 7 subfamily D member 11
Synonyms GA_x6K02T2PVTD-13795933-13794938, MOR143-2, Olfr867
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # IGL02138
Quality Score
Status
Chromosome 9
Chromosomal Location 19965762-19966757 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 19966196 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 188 (S188T)
Ref Sequence ENSEMBL: ENSMUSP00000150378 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060780] [ENSMUST00000212098] [ENSMUST00000216538]
AlphaFold Q7TRF3
Predicted Effect probably benign
Transcript: ENSMUST00000060780
AA Change: S188T

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000057469
Gene: ENSMUSG00000044454
AA Change: S188T

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.2e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 301 1.6e-6 PFAM
Pfam:7tm_1 41 290 1.1e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212098
AA Change: S70T

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Predicted Effect probably benign
Transcript: ENSMUST00000216538
AA Change: S188T

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik T G 14: 32,384,672 (GRCm39) D431A possibly damaging Het
Adgrb1 T C 15: 74,401,631 (GRCm39) M209T probably damaging Het
Ano8 T C 8: 71,937,486 (GRCm39) H86R probably damaging Het
Camk1d G T 2: 5,449,895 (GRCm39) Y87* probably null Het
Capza3 A G 6: 139,987,872 (GRCm39) D157G probably benign Het
Ckmt2 A T 13: 92,009,947 (GRCm39) D124E probably benign Het
Col14a1 C A 15: 55,284,231 (GRCm39) Q831K unknown Het
Copb2 C T 9: 98,469,605 (GRCm39) P829S probably benign Het
Dlg5 A G 14: 24,208,419 (GRCm39) V929A probably benign Het
Dolk A G 2: 30,175,991 (GRCm39) V18A probably benign Het
Ecm2 G T 13: 49,676,304 (GRCm39) L340F probably damaging Het
Hacl1 A G 14: 31,352,940 (GRCm39) L149P probably benign Het
Higd2a A T 13: 54,738,235 (GRCm39) probably null Het
Hspa12a A T 19: 58,816,730 (GRCm39) S28R probably benign Het
Igkv5-37 A G 6: 69,940,435 (GRCm39) Y70H probably damaging Het
Iho1 G A 9: 108,283,820 (GRCm39) T208I probably benign Het
Kif11 T C 19: 37,373,057 (GRCm39) V92A probably damaging Het
Kif26a T C 12: 112,141,284 (GRCm39) S696P probably damaging Het
Kng1 A T 16: 22,886,558 (GRCm39) N168Y probably damaging Het
Krt26 C T 11: 99,224,471 (GRCm39) R349Q probably benign Het
Lepr A G 4: 101,625,264 (GRCm39) D473G probably damaging Het
Lipt1 G A 1: 37,914,867 (GRCm39) E308K possibly damaging Het
Luc7l3 A T 11: 94,194,792 (GRCm39) F76Y probably benign Het
Mapk1 A G 16: 16,841,316 (GRCm39) I163V probably benign Het
Matn3 A G 12: 9,017,638 (GRCm39) E430G possibly damaging Het
Med13 A T 11: 86,177,591 (GRCm39) S1502T probably damaging Het
Mlf1 A T 3: 67,307,046 (GRCm39) H237L probably benign Het
Mss51 A C 14: 20,534,923 (GRCm39) Y282* probably null Het
Ncoa3 A G 2: 165,897,182 (GRCm39) T658A probably benign Het
Or1p1c A T 11: 74,160,544 (GRCm39) M110L probably benign Het
Phrf1 T A 7: 140,839,196 (GRCm39) probably benign Het
Ppme1 C T 7: 99,983,139 (GRCm39) M335I probably damaging Het
Ror2 C T 13: 53,264,764 (GRCm39) S764N probably damaging Het
Sntg2 T A 12: 30,357,230 (GRCm39) probably null Het
Spryd3 T C 15: 102,027,354 (GRCm39) probably benign Het
Srpx A G X: 9,933,662 (GRCm39) probably null Het
St8sia1 G T 6: 142,909,504 (GRCm39) probably benign Het
Stab1 A G 14: 30,865,470 (GRCm39) probably null Het
Sycp2 A T 2: 178,000,047 (GRCm39) S976R probably benign Het
Sycp2 T A 2: 178,043,783 (GRCm39) K108* probably null Het
Tagap1 T C 17: 7,223,485 (GRCm39) T404A probably damaging Het
Tg C T 15: 66,589,082 (GRCm39) T21I probably benign Het
Tlr4 A T 4: 66,759,202 (GRCm39) Y665F probably damaging Het
Tmc8 T G 11: 117,682,081 (GRCm39) S525A probably benign Het
Tor4a A T 2: 25,084,810 (GRCm39) D364E probably benign Het
Trim44 T C 2: 102,211,253 (GRCm39) I236V probably benign Het
Ube2o A G 11: 116,434,226 (GRCm39) probably benign Het
Wdr38 A T 2: 38,888,424 (GRCm39) N7I probably damaging Het
Xirp2 A T 2: 67,347,300 (GRCm39) R3180S probably benign Het
Zfp335 A G 2: 164,735,724 (GRCm39) C1077R probably damaging Het
Other mutations in Or7d11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03130:Or7d11 APN 9 19,966,668 (GRCm39) missense probably benign 0.34
R1034:Or7d11 UTSW 9 19,966,661 (GRCm39) missense probably benign 0.02
R1238:Or7d11 UTSW 9 19,966,757 (GRCm39) start codon destroyed probably benign 0.12
R1412:Or7d11 UTSW 9 19,966,711 (GRCm39) missense possibly damaging 0.65
R1625:Or7d11 UTSW 9 19,966,678 (GRCm39) missense probably damaging 1.00
R1689:Or7d11 UTSW 9 19,966,422 (GRCm39) missense possibly damaging 0.94
R2060:Or7d11 UTSW 9 19,965,892 (GRCm39) missense probably damaging 1.00
R2204:Or7d11 UTSW 9 19,966,507 (GRCm39) missense possibly damaging 0.74
R2350:Or7d11 UTSW 9 19,966,384 (GRCm39) missense probably damaging 1.00
R3901:Or7d11 UTSW 9 19,966,169 (GRCm39) missense probably benign 0.00
R5637:Or7d11 UTSW 9 19,966,279 (GRCm39) missense possibly damaging 0.80
R6084:Or7d11 UTSW 9 19,966,179 (GRCm39) missense possibly damaging 0.71
R6150:Or7d11 UTSW 9 19,966,170 (GRCm39) missense probably benign 0.22
R6602:Or7d11 UTSW 9 19,966,342 (GRCm39) missense probably benign 0.01
R6902:Or7d11 UTSW 9 19,966,670 (GRCm39) missense possibly damaging 0.47
R6946:Or7d11 UTSW 9 19,966,670 (GRCm39) missense possibly damaging 0.47
R7085:Or7d11 UTSW 9 19,966,232 (GRCm39) missense probably benign 0.37
R7678:Or7d11 UTSW 9 19,965,901 (GRCm39) missense probably damaging 1.00
R8034:Or7d11 UTSW 9 19,966,301 (GRCm39) missense probably benign 0.01
R9194:Or7d11 UTSW 9 19,966,543 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16