Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02138:Spryd3'

281433

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Spryd3

Ensembl Gene

ENSMUSG00000036966

Gene Name

SPRY domain containing 3

Synonyms

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02138

Quality Score

Status

Chromosome

Chromosomal Location

102024963-102044669 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

T to C at 102027354 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000155309 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046144] [ENSMUST00000154032] [ENSMUST00000169627] [ENSMUST00000228958] [ENSMUST00000230474]

AlphaFold

E9Q9B3

Predicted Effect

probably benign
Transcript: ENSMUST00000046144

SMART Domains

Protein: ENSMUSP00000041087
Gene: ENSMUSG00000037003

Domain	Start	End	E-Value	Type
C1	32	79	2.78e-9	SMART
SCOP:d1d5ra2	128	295	8e-24	SMART
PTEN_C2	297	424	6.63e-40	SMART
low complexity region	494	513	N/A	INTRINSIC
SH2	1136	1236	1.69e-16	SMART
PTB	1269	1407	6.66e-28	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000128884

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000139279

Predicted Effect

probably benign
Transcript: ENSMUST00000154032

SMART Domains

Protein: ENSMUSP00000121493
Gene: ENSMUSG00000036966

Domain	Start	End	E-Value	Type
low complexity region	28	38	N/A	INTRINSIC
SPRY	76	201	1.66e-11	SMART
SPRY	256	441	3.28e-15	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000169627

SMART Domains

Protein: ENSMUSP00000129146
Gene: ENSMUSG00000037003

Domain	Start	End	E-Value	Type
C1	32	79	2.78e-9	SMART
SCOP:d1d5ra2	128	295	8e-24	SMART
PTEN_C2	297	424	6.63e-40	SMART
low complexity region	494	513	N/A	INTRINSIC
SH2	1129	1229	1.69e-16	SMART
PTB	1262	1400	6.66e-28	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000228958

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000229097

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000229800

Predicted Effect

probably benign
Transcript: ENSMUST00000230474

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3425401B19Rik	T	G	14: 32,384,672 (GRCm39)	D431A	possibly damaging	Het
Adgrb1	T	C	15: 74,401,631 (GRCm39)	M209T	probably damaging	Het
Ano8	T	C	8: 71,937,486 (GRCm39)	H86R	probably damaging	Het
Camk1d	G	T	2: 5,449,895 (GRCm39)	Y87*	probably null	Het
Capza3	A	G	6: 139,987,872 (GRCm39)	D157G	probably benign	Het
Ckmt2	A	T	13: 92,009,947 (GRCm39)	D124E	probably benign	Het
Col14a1	C	A	15: 55,284,231 (GRCm39)	Q831K	unknown	Het
Copb2	C	T	9: 98,469,605 (GRCm39)	P829S	probably benign	Het
Dlg5	A	G	14: 24,208,419 (GRCm39)	V929A	probably benign	Het
Dolk	A	G	2: 30,175,991 (GRCm39)	V18A	probably benign	Het
Ecm2	G	T	13: 49,676,304 (GRCm39)	L340F	probably damaging	Het
Hacl1	A	G	14: 31,352,940 (GRCm39)	L149P	probably benign	Het
Higd2a	A	T	13: 54,738,235 (GRCm39)		probably null	Het
Hspa12a	A	T	19: 58,816,730 (GRCm39)	S28R	probably benign	Het
Igkv5-37	A	G	6: 69,940,435 (GRCm39)	Y70H	probably damaging	Het
Iho1	G	A	9: 108,283,820 (GRCm39)	T208I	probably benign	Het
Kif11	T	C	19: 37,373,057 (GRCm39)	V92A	probably damaging	Het
Kif26a	T	C	12: 112,141,284 (GRCm39)	S696P	probably damaging	Het
Kng1	A	T	16: 22,886,558 (GRCm39)	N168Y	probably damaging	Het
Krt26	C	T	11: 99,224,471 (GRCm39)	R349Q	probably benign	Het
Lepr	A	G	4: 101,625,264 (GRCm39)	D473G	probably damaging	Het
Lipt1	G	A	1: 37,914,867 (GRCm39)	E308K	possibly damaging	Het
Luc7l3	A	T	11: 94,194,792 (GRCm39)	F76Y	probably benign	Het
Mapk1	A	G	16: 16,841,316 (GRCm39)	I163V	probably benign	Het
Matn3	A	G	12: 9,017,638 (GRCm39)	E430G	possibly damaging	Het
Med13	A	T	11: 86,177,591 (GRCm39)	S1502T	probably damaging	Het
Mlf1	A	T	3: 67,307,046 (GRCm39)	H237L	probably benign	Het
Mss51	A	C	14: 20,534,923 (GRCm39)	Y282*	probably null	Het
Ncoa3	A	G	2: 165,897,182 (GRCm39)	T658A	probably benign	Het
Or1p1c	A	T	11: 74,160,544 (GRCm39)	M110L	probably benign	Het
Or7d11	A	T	9: 19,966,196 (GRCm39)	S188T	probably benign	Het
Phrf1	T	A	7: 140,839,196 (GRCm39)		probably benign	Het
Ppme1	C	T	7: 99,983,139 (GRCm39)	M335I	probably damaging	Het
Ror2	C	T	13: 53,264,764 (GRCm39)	S764N	probably damaging	Het
Sntg2	T	A	12: 30,357,230 (GRCm39)		probably null	Het
Srpx	A	G	X: 9,933,662 (GRCm39)		probably null	Het
St8sia1	G	T	6: 142,909,504 (GRCm39)		probably benign	Het
Stab1	A	G	14: 30,865,470 (GRCm39)		probably null	Het
Sycp2	A	T	2: 178,000,047 (GRCm39)	S976R	probably benign	Het
Sycp2	T	A	2: 178,043,783 (GRCm39)	K108*	probably null	Het
Tagap1	T	C	17: 7,223,485 (GRCm39)	T404A	probably damaging	Het
Tg	C	T	15: 66,589,082 (GRCm39)	T21I	probably benign	Het
Tlr4	A	T	4: 66,759,202 (GRCm39)	Y665F	probably damaging	Het
Tmc8	T	G	11: 117,682,081 (GRCm39)	S525A	probably benign	Het
Tor4a	A	T	2: 25,084,810 (GRCm39)	D364E	probably benign	Het
Trim44	T	C	2: 102,211,253 (GRCm39)	I236V	probably benign	Het
Ube2o	A	G	11: 116,434,226 (GRCm39)		probably benign	Het
Wdr38	A	T	2: 38,888,424 (GRCm39)	N7I	probably damaging	Het
Xirp2	A	T	2: 67,347,300 (GRCm39)	R3180S	probably benign	Het
Zfp335	A	G	2: 164,735,724 (GRCm39)	C1077R	probably damaging	Het

Other mutations in Spryd3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01638:Spryd3	APN	15	102,038,711 (GRCm39)	critical splice donor site	probably null
IGL02652:Spryd3	APN	15	102,027,425 (GRCm39)	splice site	probably null
IGL02716:Spryd3	APN	15	102,041,896 (GRCm39)	missense	possibly damaging	0.91
IGL02949:Spryd3	APN	15	102,026,544 (GRCm39)	missense	probably benign	0.03
B6819:Spryd3	UTSW	15	102,026,576 (GRCm39)	missense	probably benign	0.01
BB001:Spryd3	UTSW	15	102,026,762 (GRCm39)	missense	probably benign	0.18
BB011:Spryd3	UTSW	15	102,026,762 (GRCm39)	missense	probably benign	0.18
K7894:Spryd3	UTSW	15	102,026,576 (GRCm39)	missense	probably benign	0.01
R0111:Spryd3	UTSW	15	102,036,972 (GRCm39)	critical splice donor site	probably null
R0479:Spryd3	UTSW	15	102,038,835 (GRCm39)	nonsense	probably null
R0654:Spryd3	UTSW	15	102,036,969 (GRCm39)	splice site	probably null
R1014:Spryd3	UTSW	15	102,041,966 (GRCm39)	missense	probably damaging	0.98
R1448:Spryd3	UTSW	15	102,026,827 (GRCm39)	missense	possibly damaging	0.93
R1510:Spryd3	UTSW	15	102,027,396 (GRCm39)	missense	probably damaging	0.99
R1863:Spryd3	UTSW	15	102,026,094 (GRCm39)	missense	probably benign	0.17
R2069:Spryd3	UTSW	15	102,026,616 (GRCm39)	missense	probably benign	0.01
R2212:Spryd3	UTSW	15	102,038,711 (GRCm39)	critical splice donor site	probably null
R4581:Spryd3	UTSW	15	102,038,799 (GRCm39)	missense	probably damaging	0.98
R4892:Spryd3	UTSW	15	102,026,537 (GRCm39)	missense	probably benign	0.02
R5068:Spryd3	UTSW	15	102,037,046 (GRCm39)	missense	probably benign	0.02
R5586:Spryd3	UTSW	15	102,040,372 (GRCm39)	missense	probably benign
R5771:Spryd3	UTSW	15	102,025,342 (GRCm39)	unclassified	probably benign
R5945:Spryd3	UTSW	15	102,026,630 (GRCm39)	missense	probably benign	0.22
R7080:Spryd3	UTSW	15	102,026,627 (GRCm39)	missense	probably benign	0.04
R7816:Spryd3	UTSW	15	102,026,141 (GRCm39)	missense	probably damaging	0.99
R7924:Spryd3	UTSW	15	102,026,762 (GRCm39)	missense	probably benign	0.18
R8524:Spryd3	UTSW	15	102,026,583 (GRCm39)	nonsense	probably null
R8713:Spryd3	UTSW	15	102,041,920 (GRCm39)	missense	possibly damaging	0.86
R9027:Spryd3	UTSW	15	102,027,843 (GRCm39)	missense	probably damaging	0.99
R9187:Spryd3	UTSW	15	102,039,110 (GRCm39)	missense	probably damaging	1.00
R9286:Spryd3	UTSW	15	102,041,869 (GRCm39)	missense	possibly damaging	0.91
R9411:Spryd3	UTSW	15	102,027,843 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-04-16