Incidental Mutation 'IGL02139:Lcn3'
ID281464
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lcn3
Ensembl Gene ENSMUSG00000026936
Gene Namelipocalin 3
SynonymsVnsp1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.053) question?
Stock #IGL02139
Quality Score
Status
Chromosome2
Chromosomal Location25765569-25768099 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 25766634 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Serine at position 100 (F100S)
Ref Sequence ENSEMBL: ENSMUSP00000028304 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028304]
Predicted Effect possibly damaging
Transcript: ENSMUST00000028304
AA Change: F100S

PolyPhen 2 Score 0.664 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000028304
Gene: ENSMUSG00000026936
AA Change: F100S

DomainStartEndE-ValueType
Pfam:Lipocalin 37 171 2.5e-23 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3100002H09Rik G A 4: 124,610,576 T61M unknown Het
Ambn T C 5: 88,465,290 F217L probably benign Het
Cast T C 13: 74,728,365 D121G possibly damaging Het
Clmn T C 12: 104,781,099 I730V probably benign Het
Cryzl1 T C 16: 91,712,251 K54R possibly damaging Het
Cyp3a16 A G 5: 145,455,480 S222P probably benign Het
Dcstamp T C 15: 39,754,458 S88P probably damaging Het
F5 A G 1: 164,192,674 D906G possibly damaging Het
Fam193a A G 5: 34,444,737 T428A probably benign Het
Fbxw16 T G 9: 109,436,686 D355A probably benign Het
Focad T C 4: 88,129,054 probably null Het
Ftsj3 G A 11: 106,254,663 P82S possibly damaging Het
Gm5346 T A 8: 43,625,578 R536S probably benign Het
Grwd1 A T 7: 45,827,243 H307Q probably damaging Het
Hip1r T C 5: 123,996,244 F289S probably damaging Het
Igkc C T 6: 70,726,575 R47* probably null Het
Lmnb1 T C 18: 56,749,799 F572S probably benign Het
Mrps17 T A 5: 129,716,796 I18N probably damaging Het
Myo9a G A 9: 59,779,992 V127I probably benign Het
Olfr1000 T A 2: 85,608,230 K227* probably null Het
Olfr1260 T C 2: 89,978,429 V217A possibly damaging Het
Olfr168 T C 16: 19,530,890 D10G probably benign Het
Pcdhb21 A G 18: 37,515,246 D476G probably damaging Het
Pkd2l2 T A 18: 34,412,715 Y56* probably null Het
Pld1 C A 3: 28,120,812 D86E probably damaging Het
Plpp1 A G 13: 112,856,899 T122A probably benign Het
Prkag3 A G 1: 74,740,724 I484T probably benign Het
Prl7d1 T A 13: 27,712,083 I104F probably damaging Het
Prr14l A G 5: 32,827,532 S1540P probably damaging Het
Pyroxd1 T G 6: 142,354,731 S196A probably benign Het
Rbm42 G A 7: 30,645,705 P185S unknown Het
Ror2 T A 13: 53,111,164 I619F probably damaging Het
Slitrk4 T G X: 64,270,949 E704A probably benign Het
Sycp1 A G 3: 102,865,114 V626A probably benign Het
Trmt44 T A 5: 35,568,799 K345* probably null Het
Ugt1a6b T A 1: 88,107,805 probably benign Het
Ulk4 T A 9: 121,141,831 probably null Het
Zfp618 G T 4: 63,133,536 K758N probably damaging Het
Zfp819 G T 7: 43,612,110 probably null Het
Other mutations in Lcn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02041:Lcn3 APN 2 25765624 missense probably benign 0.27
IGL02221:Lcn3 APN 2 25766160 missense probably benign 0.01
IGL02665:Lcn3 APN 2 25766404 missense possibly damaging 0.66
IGL03049:Lcn3 APN 2 25765574 start codon destroyed probably null 0.02
R0552:Lcn3 UTSW 2 25766409 critical splice donor site probably null
R3522:Lcn3 UTSW 2 25766121 missense possibly damaging 0.56
R4227:Lcn3 UTSW 2 25766111 missense probably benign 0.00
R6684:Lcn3 UTSW 2 25766158 missense probably benign 0.00
R6937:Lcn3 UTSW 2 25767811 nonsense probably null
R7010:Lcn3 UTSW 2 25766056 missense probably damaging 0.99
R7487:Lcn3 UTSW 2 25766162 critical splice donor site probably null
Posted On2015-04-16