Incidental Mutation 'IGL02140:Or10al7'
ID 281483
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10al7
Ensembl Gene ENSMUSG00000081724
Gene Name olfactory receptor family 10 subfamily AL member 7
Synonyms MOR263-9, GA_x6K02T2PSCP-2503741-2502776, Olfr129
Accession Numbers
Essential gene? Probably non essential (E-score: 0.123) question?
Stock # IGL02140
Quality Score
Status
Chromosome 17
Chromosomal Location 38365490-38370675 bp(-) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) A to G at 38366481 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 1 (M1T)
Ref Sequence ENSEMBL: ENSMUSP00000113564 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000122318] [ENSMUST00000216476]
AlphaFold Q8VEY1
Predicted Effect probably null
Transcript: ENSMUST00000122318
AA Change: M1T

PolyPhen 2 Score 0.152 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000113564
Gene: ENSMUSG00000081724
AA Change: M1T

DomainStartEndE-ValueType
Pfam:7tm_4 46 323 4.6e-56 PFAM
Pfam:7TM_GPCR_Srsx 50 319 1.1e-5 PFAM
Pfam:7tm_1 56 305 3.2e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216476
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G A 12: 71,195,034 (GRCm39) V144I probably benign Het
B3gat1 A G 9: 26,669,043 (GRCm39) K325E possibly damaging Het
Cd36 T A 5: 18,033,766 (GRCm39) probably benign Het
Ces3a A G 8: 105,782,263 (GRCm39) E325G probably benign Het
Col1a2 G A 6: 4,515,639 (GRCm39) G136D unknown Het
Cyp3a25 T G 5: 145,946,273 (GRCm39) probably benign Het
Cyp3a59 T C 5: 146,039,690 (GRCm39) L321P probably damaging Het
Dag1 A G 9: 108,095,391 (GRCm39) S34P probably damaging Het
Defa27 A T 8: 21,805,674 (GRCm39) K13* probably null Het
Disp2 T C 2: 118,621,350 (GRCm39) F694S probably benign Het
Dnah12 G T 14: 26,437,732 (GRCm39) A454S probably benign Het
Dync2h1 A T 9: 7,147,791 (GRCm39) D946E probably benign Het
Fcgbp A G 7: 27,791,379 (GRCm39) E880G probably damaging Het
Fgfr4 T C 13: 55,308,992 (GRCm39) V371A probably benign Het
Frem3 G T 8: 81,340,736 (GRCm39) V1010F possibly damaging Het
Gm13283 G A 4: 88,679,272 (GRCm39) V88I probably benign Het
Gm5134 G A 10: 75,821,945 (GRCm39) V260I probably benign Het
Grhl2 A G 15: 37,270,830 (GRCm39) probably benign Het
Hectd1 A T 12: 51,820,920 (GRCm39) W1090R probably damaging Het
Hydin G A 8: 111,293,570 (GRCm39) V3506I probably benign Het
Igkc C T 6: 70,703,559 (GRCm39) R47* probably null Het
Iglv3 T A 16: 19,060,160 (GRCm39) Q56L probably damaging Het
Impg2 T A 16: 56,079,831 (GRCm39) M436K probably benign Het
Kcnma1 T A 14: 23,359,113 (GRCm39) K1110N probably damaging Het
Marf1 T C 16: 13,959,776 (GRCm39) E694G probably damaging Het
Nup37 A C 10: 87,994,791 (GRCm39) K118T probably benign Het
Or4a73 T C 2: 89,420,586 (GRCm39) E291G probably damaging Het
P3h1 A G 4: 119,095,062 (GRCm39) D273G probably damaging Het
Pcsk9 T C 4: 106,311,843 (GRCm39) D178G probably benign Het
Phyhipl T C 10: 70,406,660 (GRCm39) K53R probably damaging Het
Pkp3 T G 7: 140,669,249 (GRCm39) L697R probably damaging Het
Rab11fip3 A G 17: 26,286,866 (GRCm39) V429A probably benign Het
Rgl2 A G 17: 34,152,098 (GRCm39) N295S probably damaging Het
Spag5 A T 11: 78,206,459 (GRCm39) D817V possibly damaging Het
Tas2r117 C A 6: 132,780,558 (GRCm39) T232K probably benign Het
Thumpd1 A G 7: 119,316,232 (GRCm39) V239A possibly damaging Het
Timd4 T A 11: 46,710,841 (GRCm39) S248T possibly damaging Het
Tmem207 A T 16: 26,335,490 (GRCm39) N82K probably benign Het
Ttn T A 2: 76,538,557 (GRCm39) T34714S possibly damaging Het
Vmn1r194 G A 13: 22,428,706 (GRCm39) V108I probably benign Het
Vmn2r24 T A 6: 123,757,631 (GRCm39) S166R probably damaging Het
Vmn2r32 A G 7: 7,479,696 (GRCm39) F159S probably damaging Het
Wdr72 A T 9: 74,117,505 (GRCm39) Q739L probably benign Het
Other mutations in Or10al7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02163:Or10al7 APN 17 38,365,641 (GRCm39) missense probably benign 0.06
IGL02374:Or10al7 APN 17 38,366,412 (GRCm39) missense probably damaging 1.00
R0840:Or10al7 UTSW 17 38,366,463 (GRCm39) missense probably benign 0.00
R1774:Or10al7 UTSW 17 38,366,328 (GRCm39) missense probably benign 0.00
R3720:Or10al7 UTSW 17 38,366,259 (GRCm39) missense probably damaging 1.00
R3794:Or10al7 UTSW 17 38,365,786 (GRCm39) missense probably damaging 1.00
R3840:Or10al7 UTSW 17 38,366,239 (GRCm39) missense probably damaging 1.00
R4002:Or10al7 UTSW 17 38,365,879 (GRCm39) missense probably damaging 1.00
R4273:Or10al7 UTSW 17 38,366,163 (GRCm39) missense probably damaging 1.00
R4872:Or10al7 UTSW 17 38,366,467 (GRCm39) missense probably benign
R5606:Or10al7 UTSW 17 38,365,693 (GRCm39) missense probably damaging 0.98
R6309:Or10al7 UTSW 17 38,366,043 (GRCm39) missense probably damaging 1.00
R7269:Or10al7 UTSW 17 38,366,442 (GRCm39) missense probably damaging 1.00
R7450:Or10al7 UTSW 17 38,366,000 (GRCm39) missense probably benign 0.00
R7829:Or10al7 UTSW 17 38,366,220 (GRCm39) missense possibly damaging 0.64
R8103:Or10al7 UTSW 17 38,365,903 (GRCm39) missense probably damaging 1.00
R8994:Or10al7 UTSW 17 38,366,220 (GRCm39) missense possibly damaging 0.64
R9388:Or10al7 UTSW 17 38,366,148 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16