Incidental Mutation 'IGL02140:Igkc'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Igkc
Ensembl Gene ENSMUSG00000076609
Gene Nameimmunoglobulin kappa constant
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.150) question?
Stock #IGL02140
Quality Score
Chromosomal Location70726435-70726754 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to T at 70726575 bp
Amino Acid Change Arginine to Stop codon at position 47 (R47*)
Gene Model predicted gene model for transcript(s):
Predicted Effect probably benign
Transcript: ENSMUST00000103405
Predicted Effect noncoding transcript
Transcript: ENSMUST00000103406
Predicted Effect noncoding transcript
Transcript: ENSMUST00000103407
Predicted Effect probably benign
Transcript: ENSMUST00000103408
Predicted Effect noncoding transcript
Transcript: ENSMUST00000103409
Predicted Effect probably null
Transcript: ENSMUST00000103410
AA Change: R47*
SMART Domains Protein: ENSMUSP00000100206
Gene: ENSMUSG00000076609
AA Change: R47*

IGc1 22 97 1.76e-31 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197227
Predicted Effect probably benign
Transcript: ENSMUST00000198234
Predicted Effect probably benign
Transcript: ENSMUST00000199459
Predicted Effect probably benign
Transcript: ENSMUST00000199487
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous inactivation of this gene prevents the expression of rearranged kappa genes, leading to exclusive production of lambda chain-expressing B cells and alterations in immunization titers, germinal center development, and somatic hypermutation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G A 12: 71,148,260 V144I probably benign Het
B3gat1 A G 9: 26,757,747 K325E possibly damaging Het
Cd36 T A 5: 17,828,768 probably benign Het
Ces3a A G 8: 105,055,631 E325G probably benign Het
Col1a2 G A 6: 4,515,639 G136D unknown Het
Cyp3a25 T G 5: 146,009,463 probably benign Het
Cyp3a59 T C 5: 146,102,880 L321P probably damaging Het
Dag1 A G 9: 108,218,192 S34P probably damaging Het
Defa27 A T 8: 21,315,658 K13* probably null Het
Disp2 T C 2: 118,790,869 F694S probably benign Het
Dnah12 G T 14: 26,716,577 A454S probably benign Het
Dync2h1 A T 9: 7,147,791 D946E probably benign Het
Fcgbp A G 7: 28,091,954 E880G probably damaging Het
Fgfr4 T C 13: 55,161,179 V371A probably benign Het
Frem3 G T 8: 80,614,107 V1010F possibly damaging Het
Gm13283 G A 4: 88,761,035 V88I probably benign Het
Gm5134 G A 10: 75,986,111 V260I probably benign Het
Grhl2 A G 15: 37,270,586 probably benign Het
Hectd1 A T 12: 51,774,137 W1090R probably damaging Het
Hydin G A 8: 110,566,938 V3506I probably benign Het
Iglv3 T A 16: 19,241,410 Q56L probably damaging Het
Impg2 T A 16: 56,259,468 M436K probably benign Het
Kcnma1 T A 14: 23,309,045 K1110N probably damaging Het
Marf1 T C 16: 14,141,912 E694G probably damaging Het
Nup37 A C 10: 88,158,929 K118T probably benign Het
Olfr1246 T C 2: 89,590,242 E291G probably damaging Het
Olfr129 A G 17: 38,055,590 M1T probably null Het
P3h1 A G 4: 119,237,865 D273G probably damaging Het
Pcsk9 T C 4: 106,454,646 D178G probably benign Het
Phyhipl T C 10: 70,570,830 K53R probably damaging Het
Pkp3 T G 7: 141,089,336 L697R probably damaging Het
Rab11fip3 A G 17: 26,067,892 V429A probably benign Het
Rgl2 A G 17: 33,933,124 N295S probably damaging Het
Spag5 A T 11: 78,315,633 D817V possibly damaging Het
Tas2r117 C A 6: 132,803,595 T232K probably benign Het
Thumpd1 A G 7: 119,717,009 V239A possibly damaging Het
Timd4 T A 11: 46,820,014 S248T possibly damaging Het
Tmem207 A T 16: 26,516,740 N82K probably benign Het
Ttn T A 2: 76,708,213 T34714S possibly damaging Het
Vmn1r194 G A 13: 22,244,536 V108I probably benign Het
Vmn2r24 T A 6: 123,780,672 S166R probably damaging Het
Vmn2r32 A G 7: 7,476,697 F159S probably damaging Het
Wdr72 A T 9: 74,210,223 Q739L probably benign Het
Other mutations in Igkc
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02139:Igkc APN 6 70726575 nonsense probably null
R4090:Igkc UTSW 6 70726458 unclassified probably benign
R4677:Igkc UTSW 6 70726678 unclassified probably benign
R4925:Igkc UTSW 6 70726536 nonsense probably null
R8220:Igkc UTSW 6 70726682 missense
R8809:Igkc UTSW 6 70726518 missense
Posted On2015-04-16