Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02141:Olfr1351'

281527

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr1351

Ensembl Gene

ENSMUSG00000063216

Gene Name

olfactory receptor 1351

Synonyms

MOR139-4, GA_x6K02T2QGN0-2794907-2793948

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.144) question?

Stock #

IGL02141

Quality Score

Status

Chromosome

Chromosomal Location

79012472-79019645 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 79017721 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 133 (Y133C)

Ref Sequence

ENSEMBL: ENSMUSP00000149241 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080730] [ENSMUST00000203906] [ENSMUST00000216030]

AlphaFold

Q8VGU6

Predicted Effect

probably damaging
Transcript: ENSMUST00000080730
AA Change: Y133C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000079555
Gene: ENSMUSG00000063216
AA Change: Y133C

Domain	Start	End	E-Value	Type
low complexity region	9	19	N/A	INTRINSIC
Pfam:7tm_4	32	308	2e-49	PFAM
Pfam:7tm_1	42	291	1.9e-23	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000203906
AA Change: Y133C

SMART Domains

Protein: ENSMUSP00000144814
Gene: ENSMUSG00000060205
AA Change: Y133C

Domain	Start	End	E-Value	Type
low complexity region	9	19	N/A	INTRINSIC
Pfam:7tm_4	32	308	2e-49	PFAM
Pfam:7tm_1	42	291	1.9e-23	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000216030
AA Change: Y133C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219714

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001J03Rik	C	T	5: 146,183,465 (GRCm38)	A188T	probably benign	Het
2310022B05Rik	A	T	8: 124,637,906 (GRCm38)		probably benign	Het
4931423N10Rik	T	C	2: 23,230,200 (GRCm38)	F203L	probably damaging	Het
Arntl2	T	A	6: 146,828,095 (GRCm38)		probably benign	Het
Atf6b	C	A	17: 34,653,277 (GRCm38)	H539Q	probably benign	Het
Bpifb5	G	T	2: 154,229,557 (GRCm38)		probably null	Het
Cep89	T	A	7: 35,420,924 (GRCm38)	M377K	probably damaging	Het
Clpx	G	T	9: 65,312,118 (GRCm38)		probably null	Het
Cops5	T	C	1: 10,035,117 (GRCm38)	K47E	probably damaging	Het
Cryba2	T	C	1: 74,892,784 (GRCm38)	N35S	probably benign	Het
Ddx27	A	G	2: 167,020,523 (GRCm38)	K162E	possibly damaging	Het
Dhx36	A	G	3: 62,493,889 (GRCm38)	S319P	probably benign	Het
Dram2	A	G	3: 106,571,696 (GRCm38)		probably benign	Het
Eci2	T	A	13: 34,978,673 (GRCm38)	T300S	probably benign	Het
Egf	C	A	3: 129,739,982 (GRCm38)	G70*	probably null	Het
Eif5b	T	C	1: 38,032,322 (GRCm38)	V444A	probably benign	Het
Elf3	T	C	1: 135,257,707 (GRCm38)	D23G	possibly damaging	Het
Epb41l4b	A	T	4: 57,103,422 (GRCm38)		probably null	Het
Fam167a	T	A	14: 63,452,259 (GRCm38)	S2T	probably benign	Het
Flrt3	A	G	2: 140,660,688 (GRCm38)	V340A	probably damaging	Het
Gimap3	T	C	6: 48,765,378 (GRCm38)	E206G	probably benign	Het
Gp6	T	C	7: 4,394,104 (GRCm38)		probably benign	Het
Gpr158	A	T	2: 21,783,290 (GRCm38)	M581L	probably damaging	Het
Hapln3	A	G	7: 79,118,145 (GRCm38)	V167A	probably damaging	Het
Hnrnpll	G	A	17: 80,050,713 (GRCm38)	T203I	probably benign	Het
Ighv3-6	A	G	12: 114,288,362 (GRCm38)	I47T	probably damaging	Het
Iqgap1	G	A	7: 80,738,121 (GRCm38)	T926M	probably damaging	Het
Lonp1	A	T	17: 56,615,086 (GRCm38)	S765T	probably benign	Het
Lpp	C	T	16: 24,761,615 (GRCm38)	S27F	probably damaging	Het
Lrit2	T	C	14: 37,068,074 (GRCm38)		probably benign	Het
Luc7l	C	A	17: 26,253,080 (GRCm38)	T17K	probably damaging	Het
Mroh1	G	T	15: 76,446,599 (GRCm38)	S1161I	possibly damaging	Het
Muc5b	T	G	7: 141,853,367 (GRCm38)	C1091G	unknown	Het
Mut	A	G	17: 40,938,817 (GRCm38)	T228A	possibly damaging	Het
Nppb	A	T	4: 147,986,006 (GRCm38)	I11F	probably benign	Het
Nsf	A	T	11: 103,828,525 (GRCm38)	D650E	probably benign	Het
Ogdh	A	G	11: 6,355,015 (GRCm38)	K907E	probably damaging	Het
Olfr344	A	G	2: 36,568,808 (GRCm38)	D70G	probably damaging	Het
Olfr362	G	A	2: 37,105,425 (GRCm38)	S75F	probably benign	Het
Pcnx	A	T	12: 81,860,382 (GRCm38)	Q4L	possibly damaging	Het
Pgc	T	A	17: 47,726,931 (GRCm38)	L9H	probably damaging	Het
Pikfyve	T	A	1: 65,246,397 (GRCm38)	S887T	probably benign	Het
Plec	T	C	15: 76,175,615 (GRCm38)	D3239G	probably damaging	Het
Pole4	T	C	6: 82,648,034 (GRCm38)	T116A	probably benign	Het
Prpf8	A	G	11: 75,490,672 (GRCm38)	N300D	possibly damaging	Het
Rara	T	A	11: 98,968,081 (GRCm38)	Y119N	probably damaging	Het
Rbck1	G	T	2: 152,318,374 (GRCm38)	R462S	possibly damaging	Het
Setdb2	C	T	14: 59,402,315 (GRCm38)	R709Q	probably damaging	Het
Slfn2	C	A	11: 83,069,844 (GRCm38)	N216K	probably benign	Het
Suox	A	G	10: 128,672,098 (GRCm38)		probably benign	Het
Tars	T	A	15: 11,391,194 (GRCm38)	Y283F	probably damaging	Het
Trpm4	A	T	7: 45,318,179 (GRCm38)		probably null	Het
Ubtd2	A	T	11: 32,499,262 (GRCm38)	K36N	probably benign	Het
Unkl	T	C	17: 25,229,434 (GRCm38)	L327P	probably damaging	Het
Vmn1r11	T	A	6: 57,137,379 (GRCm38)	Y9*	probably null	Het
Vps13b	T	C	15: 35,572,081 (GRCm38)	V948A	probably benign	Het
Zbtb17	A	G	4: 141,464,953 (GRCm38)	H403R	probably damaging	Het

Other mutations in Olfr1351

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00913:Olfr1351	APN	10	79,018,251 (GRCm38)	missense	probably benign	0.00
IGL01833:Olfr1351	APN	10	79,017,936 (GRCm38)	missense	probably benign
IGL02178:Olfr1351	APN	10	79,017,720 (GRCm38)	missense	possibly damaging	0.59
R1070:Olfr1351	UTSW	10	79,017,850 (GRCm38)	missense	probably damaging	0.99
R1631:Olfr1351	UTSW	10	79,017,405 (GRCm38)	missense	probably benign	0.00
R1646:Olfr1351	UTSW	10	79,017,506 (GRCm38)	nonsense	probably null
R1781:Olfr1351	UTSW	10	79,017,325 (GRCm38)	start codon destroyed	probably null	0.89
R2358:Olfr1351	UTSW	10	79,018,188 (GRCm38)	missense	probably damaging	1.00
R3161:Olfr1351	UTSW	10	79,017,604 (GRCm38)	missense	probably benign
R3162:Olfr1351	UTSW	10	79,017,604 (GRCm38)	missense	probably benign
R3162:Olfr1351	UTSW	10	79,017,604 (GRCm38)	missense	probably benign
R5874:Olfr1351	UTSW	10	79,017,357 (GRCm38)	missense	possibly damaging	0.95
R6382:Olfr1351	UTSW	10	79,017,517 (GRCm38)	missense	probably damaging	1.00
R7108:Olfr1351	UTSW	10	79,017,649 (GRCm38)	nonsense	probably null
R7567:Olfr1351	UTSW	10	79,017,545 (GRCm38)	missense	probably benign	0.04
R7568:Olfr1351	UTSW	10	79,017,507 (GRCm38)	missense	probably benign
R7915:Olfr1351	UTSW	10	79,017,430 (GRCm38)	missense	probably damaging	1.00
R7936:Olfr1351	UTSW	10	79,018,038 (GRCm38)	missense	probably damaging	1.00
R9687:Olfr1351	UTSW	10	79,018,009 (GRCm38)	missense	probably damaging	1.00
Z1176:Olfr1351	UTSW	10	79,018,205 (GRCm38)	missense	probably damaging	1.00

Posted On

2015-04-16