Incidental Mutation 'IGL02141:Olfr1351'
ID 281527
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1351
Ensembl Gene ENSMUSG00000063216
Gene Name olfactory receptor 1351
Synonyms MOR139-4, GA_x6K02T2QGN0-2794907-2793948
Accession Numbers
Essential gene? Probably non essential (E-score: 0.144) question?
Stock # IGL02141
Quality Score
Chromosome 10
Chromosomal Location 79012472-79019645 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 79017721 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 133 (Y133C)
Ref Sequence ENSEMBL: ENSMUSP00000149241 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080730] [ENSMUST00000203906] [ENSMUST00000216030]
AlphaFold Q8VGU6
Predicted Effect probably damaging
Transcript: ENSMUST00000080730
AA Change: Y133C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000079555
Gene: ENSMUSG00000063216
AA Change: Y133C

low complexity region 9 19 N/A INTRINSIC
Pfam:7tm_4 32 308 2e-49 PFAM
Pfam:7tm_1 42 291 1.9e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203906
AA Change: Y133C
SMART Domains Protein: ENSMUSP00000144814
Gene: ENSMUSG00000060205
AA Change: Y133C

low complexity region 9 19 N/A INTRINSIC
Pfam:7tm_4 32 308 2e-49 PFAM
Pfam:7tm_1 42 291 1.9e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216030
AA Change: Y133C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219714
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001J03Rik C T 5: 146,183,465 (GRCm38) A188T probably benign Het
2310022B05Rik A T 8: 124,637,906 (GRCm38) probably benign Het
4931423N10Rik T C 2: 23,230,200 (GRCm38) F203L probably damaging Het
Arntl2 T A 6: 146,828,095 (GRCm38) probably benign Het
Atf6b C A 17: 34,653,277 (GRCm38) H539Q probably benign Het
Bpifb5 G T 2: 154,229,557 (GRCm38) probably null Het
Cep89 T A 7: 35,420,924 (GRCm38) M377K probably damaging Het
Clpx G T 9: 65,312,118 (GRCm38) probably null Het
Cops5 T C 1: 10,035,117 (GRCm38) K47E probably damaging Het
Cryba2 T C 1: 74,892,784 (GRCm38) N35S probably benign Het
Ddx27 A G 2: 167,020,523 (GRCm38) K162E possibly damaging Het
Dhx36 A G 3: 62,493,889 (GRCm38) S319P probably benign Het
Dram2 A G 3: 106,571,696 (GRCm38) probably benign Het
Eci2 T A 13: 34,978,673 (GRCm38) T300S probably benign Het
Egf C A 3: 129,739,982 (GRCm38) G70* probably null Het
Eif5b T C 1: 38,032,322 (GRCm38) V444A probably benign Het
Elf3 T C 1: 135,257,707 (GRCm38) D23G possibly damaging Het
Epb41l4b A T 4: 57,103,422 (GRCm38) probably null Het
Fam167a T A 14: 63,452,259 (GRCm38) S2T probably benign Het
Flrt3 A G 2: 140,660,688 (GRCm38) V340A probably damaging Het
Gimap3 T C 6: 48,765,378 (GRCm38) E206G probably benign Het
Gp6 T C 7: 4,394,104 (GRCm38) probably benign Het
Gpr158 A T 2: 21,783,290 (GRCm38) M581L probably damaging Het
Hapln3 A G 7: 79,118,145 (GRCm38) V167A probably damaging Het
Hnrnpll G A 17: 80,050,713 (GRCm38) T203I probably benign Het
Ighv3-6 A G 12: 114,288,362 (GRCm38) I47T probably damaging Het
Iqgap1 G A 7: 80,738,121 (GRCm38) T926M probably damaging Het
Lonp1 A T 17: 56,615,086 (GRCm38) S765T probably benign Het
Lpp C T 16: 24,761,615 (GRCm38) S27F probably damaging Het
Lrit2 T C 14: 37,068,074 (GRCm38) probably benign Het
Luc7l C A 17: 26,253,080 (GRCm38) T17K probably damaging Het
Mroh1 G T 15: 76,446,599 (GRCm38) S1161I possibly damaging Het
Muc5b T G 7: 141,853,367 (GRCm38) C1091G unknown Het
Mut A G 17: 40,938,817 (GRCm38) T228A possibly damaging Het
Nppb A T 4: 147,986,006 (GRCm38) I11F probably benign Het
Nsf A T 11: 103,828,525 (GRCm38) D650E probably benign Het
Ogdh A G 11: 6,355,015 (GRCm38) K907E probably damaging Het
Olfr344 A G 2: 36,568,808 (GRCm38) D70G probably damaging Het
Olfr362 G A 2: 37,105,425 (GRCm38) S75F probably benign Het
Pcnx A T 12: 81,860,382 (GRCm38) Q4L possibly damaging Het
Pgc T A 17: 47,726,931 (GRCm38) L9H probably damaging Het
Pikfyve T A 1: 65,246,397 (GRCm38) S887T probably benign Het
Plec T C 15: 76,175,615 (GRCm38) D3239G probably damaging Het
Pole4 T C 6: 82,648,034 (GRCm38) T116A probably benign Het
Prpf8 A G 11: 75,490,672 (GRCm38) N300D possibly damaging Het
Rara T A 11: 98,968,081 (GRCm38) Y119N probably damaging Het
Rbck1 G T 2: 152,318,374 (GRCm38) R462S possibly damaging Het
Setdb2 C T 14: 59,402,315 (GRCm38) R709Q probably damaging Het
Slfn2 C A 11: 83,069,844 (GRCm38) N216K probably benign Het
Suox A G 10: 128,672,098 (GRCm38) probably benign Het
Tars T A 15: 11,391,194 (GRCm38) Y283F probably damaging Het
Trpm4 A T 7: 45,318,179 (GRCm38) probably null Het
Ubtd2 A T 11: 32,499,262 (GRCm38) K36N probably benign Het
Unkl T C 17: 25,229,434 (GRCm38) L327P probably damaging Het
Vmn1r11 T A 6: 57,137,379 (GRCm38) Y9* probably null Het
Vps13b T C 15: 35,572,081 (GRCm38) V948A probably benign Het
Zbtb17 A G 4: 141,464,953 (GRCm38) H403R probably damaging Het
Other mutations in Olfr1351
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00913:Olfr1351 APN 10 79,018,251 (GRCm38) missense probably benign 0.00
IGL01833:Olfr1351 APN 10 79,017,936 (GRCm38) missense probably benign
IGL02178:Olfr1351 APN 10 79,017,720 (GRCm38) missense possibly damaging 0.59
R1070:Olfr1351 UTSW 10 79,017,850 (GRCm38) missense probably damaging 0.99
R1631:Olfr1351 UTSW 10 79,017,405 (GRCm38) missense probably benign 0.00
R1646:Olfr1351 UTSW 10 79,017,506 (GRCm38) nonsense probably null
R1781:Olfr1351 UTSW 10 79,017,325 (GRCm38) start codon destroyed probably null 0.89
R2358:Olfr1351 UTSW 10 79,018,188 (GRCm38) missense probably damaging 1.00
R3161:Olfr1351 UTSW 10 79,017,604 (GRCm38) missense probably benign
R3162:Olfr1351 UTSW 10 79,017,604 (GRCm38) missense probably benign
R3162:Olfr1351 UTSW 10 79,017,604 (GRCm38) missense probably benign
R5874:Olfr1351 UTSW 10 79,017,357 (GRCm38) missense possibly damaging 0.95
R6382:Olfr1351 UTSW 10 79,017,517 (GRCm38) missense probably damaging 1.00
R7108:Olfr1351 UTSW 10 79,017,649 (GRCm38) nonsense probably null
R7567:Olfr1351 UTSW 10 79,017,545 (GRCm38) missense probably benign 0.04
R7568:Olfr1351 UTSW 10 79,017,507 (GRCm38) missense probably benign
R7915:Olfr1351 UTSW 10 79,017,430 (GRCm38) missense probably damaging 1.00
R7936:Olfr1351 UTSW 10 79,018,038 (GRCm38) missense probably damaging 1.00
R9687:Olfr1351 UTSW 10 79,018,009 (GRCm38) missense probably damaging 1.00
Z1176:Olfr1351 UTSW 10 79,018,205 (GRCm38) missense probably damaging 1.00
Posted On 2015-04-16