Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02141:Gpr158'

281548

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr158

Ensembl Gene

ENSMUSG00000045967

Gene Name

G protein-coupled receptor 158

Synonyms

5330427M13Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02141

Quality Score

Status

Chromosome

Chromosomal Location

21372378-21835355 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 21788101 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 581 (M581L)

Ref Sequence

ENSEMBL: ENSMUSP00000049708 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055946]

AlphaFold

Q8C419

Predicted Effect

probably damaging
Transcript: ENSMUST00000055946
AA Change: M581L

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000049708
Gene: ENSMUSG00000045967
AA Change: M581L

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
low complexity region	110	125	N/A	INTRINSIC
SCOP:d1edmb_	313	359	5e-4	SMART
Blast:EGF	318	365	2e-27	BLAST
Pfam:7tm_3	426	669	1.2e-35	PFAM
low complexity region	840	863	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000155760

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001J03Rik	C	T	5: 146,120,275 (GRCm39)	A188T	probably benign	Het
2310022B05Rik	A	T	8: 125,364,645 (GRCm39)		probably benign	Het
Atf6b	C	A	17: 34,872,251 (GRCm39)	H539Q	probably benign	Het
Bmal2	T	A	6: 146,729,593 (GRCm39)		probably benign	Het
Bpifb5	G	T	2: 154,071,477 (GRCm39)		probably null	Het
Cep89	T	A	7: 35,120,349 (GRCm39)	M377K	probably damaging	Het
Clpx	G	T	9: 65,219,400 (GRCm39)		probably null	Het
Cops5	T	C	1: 10,105,342 (GRCm39)	K47E	probably damaging	Het
Cryba2	T	C	1: 74,931,943 (GRCm39)	N35S	probably benign	Het
Ddx27	A	G	2: 166,862,443 (GRCm39)	K162E	possibly damaging	Het
Dhx36	A	G	3: 62,401,310 (GRCm39)	S319P	probably benign	Het
Dram2	A	G	3: 106,479,012 (GRCm39)		probably benign	Het
Eci2	T	A	13: 35,162,656 (GRCm39)	T300S	probably benign	Het
Egf	C	A	3: 129,533,631 (GRCm39)	G70*	probably null	Het
Eif5b	T	C	1: 38,071,403 (GRCm39)	V444A	probably benign	Het
Elf3	T	C	1: 135,185,445 (GRCm39)	D23G	possibly damaging	Het
Epb41l4b	A	T	4: 57,103,422 (GRCm39)		probably null	Het
Fam167a	T	A	14: 63,689,708 (GRCm39)	S2T	probably benign	Het
Flrt3	A	G	2: 140,502,608 (GRCm39)	V340A	probably damaging	Het
Gimap3	T	C	6: 48,742,312 (GRCm39)	E206G	probably benign	Het
Gp6	T	C	7: 4,397,103 (GRCm39)		probably benign	Het
Hapln3	A	G	7: 78,767,893 (GRCm39)	V167A	probably damaging	Het
Hnrnpll	G	A	17: 80,358,142 (GRCm39)	T203I	probably benign	Het
Ighv3-6	A	G	12: 114,251,982 (GRCm39)	I47T	probably damaging	Het
Iqgap1	G	A	7: 80,387,869 (GRCm39)	T926M	probably damaging	Het
Lonp1	A	T	17: 56,922,086 (GRCm39)	S765T	probably benign	Het
Lpp	C	T	16: 24,580,365 (GRCm39)	S27F	probably damaging	Het
Lrit2	T	C	14: 36,790,031 (GRCm39)		probably benign	Het
Luc7l	C	A	17: 26,472,054 (GRCm39)	T17K	probably damaging	Het
Mmut	A	G	17: 41,249,708 (GRCm39)	T228A	possibly damaging	Het
Mroh1	G	T	15: 76,330,799 (GRCm39)	S1161I	possibly damaging	Het
Muc5b	T	G	7: 141,407,104 (GRCm39)	C1091G	unknown	Het
Nppb	A	T	4: 148,070,463 (GRCm39)	I11F	probably benign	Het
Nsf	A	T	11: 103,719,351 (GRCm39)	D650E	probably benign	Het
Ogdh	A	G	11: 6,305,015 (GRCm39)	K907E	probably damaging	Het
Or1b1	G	A	2: 36,995,437 (GRCm39)	S75F	probably benign	Het
Or1j15	A	G	2: 36,458,820 (GRCm39)	D70G	probably damaging	Het
Or7a35	A	G	10: 78,853,555 (GRCm39)	Y133C	probably damaging	Het
Pcnx1	A	T	12: 81,907,156 (GRCm39)	Q4L	possibly damaging	Het
Pgc	T	A	17: 48,037,856 (GRCm39)	L9H	probably damaging	Het
Pikfyve	T	A	1: 65,285,556 (GRCm39)	S887T	probably benign	Het
Plec	T	C	15: 76,059,815 (GRCm39)	D3239G	probably damaging	Het
Pole4	T	C	6: 82,625,015 (GRCm39)	T116A	probably benign	Het
Potegl	T	C	2: 23,120,212 (GRCm39)	F203L	probably damaging	Het
Prpf8	A	G	11: 75,381,498 (GRCm39)	N300D	possibly damaging	Het
Rara	T	A	11: 98,858,907 (GRCm39)	Y119N	probably damaging	Het
Rbck1	G	T	2: 152,160,294 (GRCm39)	R462S	possibly damaging	Het
Setdb2	C	T	14: 59,639,764 (GRCm39)	R709Q	probably damaging	Het
Slfn2	C	A	11: 82,960,670 (GRCm39)	N216K	probably benign	Het
Suox	A	G	10: 128,507,967 (GRCm39)		probably benign	Het
Tars1	T	A	15: 11,391,280 (GRCm39)	Y283F	probably damaging	Het
Trpm4	A	T	7: 44,967,603 (GRCm39)		probably null	Het
Ubtd2	A	T	11: 32,449,262 (GRCm39)	K36N	probably benign	Het
Unkl	T	C	17: 25,448,408 (GRCm39)	L327P	probably damaging	Het
Vmn1r11	T	A	6: 57,114,364 (GRCm39)	Y9*	probably null	Het
Vps13b	T	C	15: 35,572,227 (GRCm39)	V948A	probably benign	Het
Zbtb17	A	G	4: 141,192,264 (GRCm39)	H403R	probably damaging	Het

Other mutations in Gpr158

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00340:Gpr158	APN	2	21,373,494 (GRCm39)	missense	probably damaging	1.00
IGL00469:Gpr158	APN	2	21,751,606 (GRCm39)	splice site	probably benign
IGL00706:Gpr158	APN	2	21,751,584 (GRCm39)	missense	probably damaging	1.00
IGL00780:Gpr158	APN	2	21,831,629 (GRCm39)	nonsense	probably null
IGL00885:Gpr158	APN	2	21,653,832 (GRCm39)	missense	probably damaging	1.00
IGL01339:Gpr158	APN	2	21,373,842 (GRCm39)	missense	possibly damaging	0.73
IGL01368:Gpr158	APN	2	21,831,909 (GRCm39)	missense	probably damaging	1.00
IGL02455:Gpr158	APN	2	21,373,511 (GRCm39)	missense	probably benign	0.00
IGL02554:Gpr158	APN	2	21,831,407 (GRCm39)	missense	probably benign
IGL02681:Gpr158	APN	2	21,820,441 (GRCm39)	missense	probably damaging	1.00
IGL02752:Gpr158	APN	2	21,831,638 (GRCm39)	missense	possibly damaging	0.95
IGL02756:Gpr158	APN	2	21,831,890 (GRCm39)	missense	possibly damaging	0.47
IGL03181:Gpr158	APN	2	21,787,972 (GRCm39)	missense	probably benign	0.02
IGL03258:Gpr158	APN	2	21,830,085 (GRCm39)	missense	probably damaging	1.00
IGL03386:Gpr158	APN	2	21,831,057 (GRCm39)	missense	probably damaging	1.00
PIT4810001:Gpr158	UTSW	2	21,831,682 (GRCm39)	missense	probably benign	0.01
R0071:Gpr158	UTSW	2	21,815,479 (GRCm39)	missense	probably benign	0.08
R0081:Gpr158	UTSW	2	21,831,528 (GRCm39)	missense	probably damaging	1.00
R0528:Gpr158	UTSW	2	21,830,019 (GRCm39)	missense	probably damaging	1.00
R0560:Gpr158	UTSW	2	21,830,085 (GRCm39)	missense	probably damaging	1.00
R0603:Gpr158	UTSW	2	21,820,480 (GRCm39)	missense	possibly damaging	0.67
R1560:Gpr158	UTSW	2	21,831,125 (GRCm39)	missense	probably damaging	1.00
R1561:Gpr158	UTSW	2	21,820,505 (GRCm39)	splice site	probably null
R1609:Gpr158	UTSW	2	21,788,104 (GRCm39)	missense	possibly damaging	0.61
R1741:Gpr158	UTSW	2	21,832,359 (GRCm39)	missense	probably benign	0.00
R1827:Gpr158	UTSW	2	21,832,129 (GRCm39)	missense	probably benign
R1854:Gpr158	UTSW	2	21,373,935 (GRCm39)	missense	probably damaging	1.00
R1871:Gpr158	UTSW	2	21,820,426 (GRCm39)	missense	probably damaging	1.00
R2151:Gpr158	UTSW	2	21,832,325 (GRCm39)	missense	possibly damaging	0.82
R2273:Gpr158	UTSW	2	21,831,674 (GRCm39)	missense	probably benign
R2275:Gpr158	UTSW	2	21,831,674 (GRCm39)	missense	probably benign
R3004:Gpr158	UTSW	2	21,831,810 (GRCm39)	missense	probably damaging	0.99
R3151:Gpr158	UTSW	2	21,581,771 (GRCm39)	missense	possibly damaging	0.68
R3943:Gpr158	UTSW	2	21,373,370 (GRCm39)	missense	possibly damaging	0.65
R4238:Gpr158	UTSW	2	21,373,362 (GRCm39)	missense	probably damaging	1.00
R4379:Gpr158	UTSW	2	21,830,025 (GRCm39)	missense	probably damaging	1.00
R4381:Gpr158	UTSW	2	21,832,403 (GRCm39)	missense	probably damaging	1.00
R4464:Gpr158	UTSW	2	21,831,810 (GRCm39)	missense	probably damaging	0.99
R4467:Gpr158	UTSW	2	21,831,810 (GRCm39)	missense	probably damaging	0.99
R4496:Gpr158	UTSW	2	21,831,810 (GRCm39)	missense	probably damaging	0.99
R4506:Gpr158	UTSW	2	21,831,810 (GRCm39)	missense	probably damaging	0.99
R4530:Gpr158	UTSW	2	21,373,811 (GRCm39)	missense	probably benign	0.03
R4646:Gpr158	UTSW	2	21,831,864 (GRCm39)	missense	probably benign
R4798:Gpr158	UTSW	2	21,787,993 (GRCm39)	missense	probably damaging	1.00
R4882:Gpr158	UTSW	2	21,830,059 (GRCm39)	missense	probably damaging	0.98
R4943:Gpr158	UTSW	2	21,831,968 (GRCm39)	missense	probably damaging	1.00
R5334:Gpr158	UTSW	2	21,832,316 (GRCm39)	missense	probably benign	0.01
R5560:Gpr158	UTSW	2	21,831,101 (GRCm39)	missense	possibly damaging	0.67
R5600:Gpr158	UTSW	2	21,832,046 (GRCm39)	missense	probably benign
R5637:Gpr158	UTSW	2	21,788,083 (GRCm39)	missense	probably benign	0.00
R5701:Gpr158	UTSW	2	21,751,520 (GRCm39)	missense	probably damaging	1.00
R5744:Gpr158	UTSW	2	21,373,331 (GRCm39)	missense	probably damaging	1.00
R5911:Gpr158	UTSW	2	21,373,932 (GRCm39)	missense	possibly damaging	0.95
R5991:Gpr158	UTSW	2	21,373,319 (GRCm39)	missense	probably damaging	0.99
R6200:Gpr158	UTSW	2	21,404,227 (GRCm39)	missense	probably damaging	0.97
R6306:Gpr158	UTSW	2	21,820,422 (GRCm39)	missense	possibly damaging	0.84
R6324:Gpr158	UTSW	2	21,815,365 (GRCm39)	missense	probably damaging	1.00
R6384:Gpr158	UTSW	2	21,831,099 (GRCm39)	missense	probably damaging	1.00
R6698:Gpr158	UTSW	2	21,831,921 (GRCm39)	missense	probably damaging	1.00
R6997:Gpr158	UTSW	2	21,653,802 (GRCm39)	missense	possibly damaging	0.46
R7086:Gpr158	UTSW	2	21,831,386 (GRCm39)	missense	probably benign	0.01
R7175:Gpr158	UTSW	2	21,373,113 (GRCm39)	missense	probably benign	0.13
R7197:Gpr158	UTSW	2	21,815,412 (GRCm39)	missense	probably damaging	0.99
R7293:Gpr158	UTSW	2	21,581,750 (GRCm39)	missense	possibly damaging	0.47
R7427:Gpr158	UTSW	2	21,832,129 (GRCm39)	missense	probably benign
R7515:Gpr158	UTSW	2	21,373,092 (GRCm39)	missense	probably damaging	1.00
R7730:Gpr158	UTSW	2	21,831,158 (GRCm39)	missense	probably damaging	1.00
R8122:Gpr158	UTSW	2	21,831,674 (GRCm39)	missense	probably benign
R8311:Gpr158	UTSW	2	21,373,701 (GRCm39)	missense	probably benign	0.00
R8754:Gpr158	UTSW	2	21,581,693 (GRCm39)	missense	probably benign	0.00
R8782:Gpr158	UTSW	2	21,404,149 (GRCm39)	missense	probably damaging	1.00
R8792:Gpr158	UTSW	2	21,558,137 (GRCm39)	missense	probably damaging	1.00
R8842:Gpr158	UTSW	2	21,581,751 (GRCm39)	missense	possibly damaging	0.88
R9009:Gpr158	UTSW	2	21,581,760 (GRCm39)	missense	probably damaging	1.00
R9102:Gpr158	UTSW	2	21,830,078 (GRCm39)	missense	probably damaging	1.00
R9150:Gpr158	UTSW	2	21,831,251 (GRCm39)	missense	probably benign	0.17
R9254:Gpr158	UTSW	2	21,373,042 (GRCm39)	start gained	probably benign
R9317:Gpr158	UTSW	2	21,832,037 (GRCm39)	missense	probably benign
R9379:Gpr158	UTSW	2	21,373,042 (GRCm39)	start gained	probably benign
R9428:Gpr158	UTSW	2	21,787,972 (GRCm39)	missense	probably benign
R9497:Gpr158	UTSW	2	21,831,825 (GRCm39)	missense	probably benign	0.00
R9667:Gpr158	UTSW	2	21,830,054 (GRCm39)	missense	probably damaging	0.99
R9681:Gpr158	UTSW	2	21,831,315 (GRCm39)	missense	probably damaging	0.99
X0062:Gpr158	UTSW	2	21,831,180 (GRCm39)	missense	probably damaging	1.00
Z1176:Gpr158	UTSW	2	21,815,501 (GRCm39)	critical splice donor site	probably null
Z1177:Gpr158	UTSW	2	21,832,083 (GRCm39)	missense	possibly damaging	0.46

Posted On

2015-04-16