Incidental Mutation 'IGL02141:Olfr362'
ID281560
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr362
Ensembl Gene ENSMUSG00000075377
Gene Nameolfactory receptor 362
SynonymsMOR158-1, GA_x6K02T2NLDC-33797415-33796462
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.097) question?
Stock #IGL02141
Quality Score
Status
Chromosome2
Chromosomal Location37101706-37117910 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 37105425 bp
ZygosityHeterozygous
Amino Acid Change Serine to Phenylalanine at position 75 (S75F)
Ref Sequence ENSEMBL: ENSMUSP00000150819 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100144] [ENSMUST00000213817] [ENSMUST00000215927]
Predicted Effect probably benign
Transcript: ENSMUST00000100144
AA Change: S75F

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000097722
Gene: ENSMUSG00000075377
AA Change: S75F

DomainStartEndE-ValueType
Pfam:7tm_4 32 313 6.3e-50 PFAM
Pfam:7TM_GPCR_Srsx 36 164 1.6e-7 PFAM
Pfam:7tm_1 42 295 1.3e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000119049
Predicted Effect probably benign
Transcript: ENSMUST00000213817
AA Change: S75F

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
Predicted Effect probably benign
Transcript: ENSMUST00000215927
AA Change: S75F

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001J03Rik C T 5: 146,183,465 A188T probably benign Het
2310022B05Rik A T 8: 124,637,906 probably benign Het
4931423N10Rik T C 2: 23,230,200 F203L probably damaging Het
Arntl2 T A 6: 146,828,095 probably benign Het
Atf6b C A 17: 34,653,277 H539Q probably benign Het
Bpifb5 G T 2: 154,229,557 probably null Het
Cep89 T A 7: 35,420,924 M377K probably damaging Het
Clpx G T 9: 65,312,118 probably null Het
Cops5 T C 1: 10,035,117 K47E probably damaging Het
Cryba2 T C 1: 74,892,784 N35S probably benign Het
Ddx27 A G 2: 167,020,523 K162E possibly damaging Het
Dhx36 A G 3: 62,493,889 S319P probably benign Het
Dram2 A G 3: 106,571,696 probably benign Het
Eci2 T A 13: 34,978,673 T300S probably benign Het
Egf C A 3: 129,739,982 G70* probably null Het
Eif5b T C 1: 38,032,322 V444A probably benign Het
Elf3 T C 1: 135,257,707 D23G possibly damaging Het
Epb41l4b A T 4: 57,103,422 probably null Het
Fam167a T A 14: 63,452,259 S2T probably benign Het
Flrt3 A G 2: 140,660,688 V340A probably damaging Het
Gimap3 T C 6: 48,765,378 E206G probably benign Het
Gp6 T C 7: 4,394,104 probably benign Het
Gpr158 A T 2: 21,783,290 M581L probably damaging Het
Hapln3 A G 7: 79,118,145 V167A probably damaging Het
Hnrnpll G A 17: 80,050,713 T203I probably benign Het
Ighv3-6 A G 12: 114,288,362 I47T probably damaging Het
Iqgap1 G A 7: 80,738,121 T926M probably damaging Het
Lonp1 A T 17: 56,615,086 S765T probably benign Het
Lpp C T 16: 24,761,615 S27F probably damaging Het
Lrit2 T C 14: 37,068,074 probably benign Het
Luc7l C A 17: 26,253,080 T17K probably damaging Het
Mroh1 G T 15: 76,446,599 S1161I possibly damaging Het
Muc5b T G 7: 141,853,367 C1091G unknown Het
Mut A G 17: 40,938,817 T228A possibly damaging Het
Nppb A T 4: 147,986,006 I11F probably benign Het
Nsf A T 11: 103,828,525 D650E probably benign Het
Ogdh A G 11: 6,355,015 K907E probably damaging Het
Olfr1351 A G 10: 79,017,721 Y133C probably damaging Het
Olfr344 A G 2: 36,568,808 D70G probably damaging Het
Pcnx A T 12: 81,860,382 Q4L possibly damaging Het
Pgc T A 17: 47,726,931 L9H probably damaging Het
Pikfyve T A 1: 65,246,397 S887T probably benign Het
Plec T C 15: 76,175,615 D3239G probably damaging Het
Pole4 T C 6: 82,648,034 T116A probably benign Het
Prpf8 A G 11: 75,490,672 N300D possibly damaging Het
Rara T A 11: 98,968,081 Y119N probably damaging Het
Rbck1 G T 2: 152,318,374 R462S possibly damaging Het
Setdb2 C T 14: 59,402,315 R709Q probably damaging Het
Slfn2 C A 11: 83,069,844 N216K probably benign Het
Suox A G 10: 128,672,098 probably benign Het
Tars T A 15: 11,391,194 Y283F probably damaging Het
Trpm4 A T 7: 45,318,179 probably null Het
Ubtd2 A T 11: 32,499,262 K36N probably benign Het
Unkl T C 17: 25,229,434 L327P probably damaging Het
Vmn1r11 T A 6: 57,137,379 Y9* probably null Het
Vps13b T C 15: 35,572,081 V948A probably benign Het
Zbtb17 A G 4: 141,464,953 H403R probably damaging Het
Other mutations in Olfr362
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02032:Olfr362 APN 2 37104761 missense probably damaging 1.00
IGL02444:Olfr362 APN 2 37104774 missense probably damaging 0.99
IGL02453:Olfr362 APN 2 37105197 missense probably benign 0.22
R0699:Olfr362 UTSW 2 37105062 missense possibly damaging 0.92
R1053:Olfr362 UTSW 2 37105464 missense probably damaging 1.00
R1387:Olfr362 UTSW 2 37104868 missense probably benign 0.24
R4914:Olfr362 UTSW 2 37105158 missense possibly damaging 0.67
R4918:Olfr362 UTSW 2 37105158 missense possibly damaging 0.67
R5009:Olfr362 UTSW 2 37105455 missense possibly damaging 0.92
R5114:Olfr362 UTSW 2 37104802 missense probably damaging 1.00
R5301:Olfr362 UTSW 2 37105198 missense probably benign 0.01
R7322:Olfr362 UTSW 2 37105591 missense probably null 0.00
R7440:Olfr362 UTSW 2 37105169 missense possibly damaging 0.85
R7583:Olfr362 UTSW 2 37105527 nonsense probably null
Z1176:Olfr362 UTSW 2 37105636 missense probably benign
Posted On2015-04-16