Incidental Mutation 'IGL02141:Or1b1'
ID 281560
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or1b1
Ensembl Gene ENSMUSG00000075377
Gene Name olfactory receptor family 1 subfamily B member 1
Synonyms Olfr362, GA_x6K02T2NLDC-33797415-33796462, MOR158-1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.118) question?
Stock # IGL02141
Quality Score
Status
Chromosome 2
Chromosomal Location 36994707-36995660 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 36995437 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Phenylalanine at position 75 (S75F)
Ref Sequence ENSEMBL: ENSMUSP00000150819 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100144] [ENSMUST00000213817] [ENSMUST00000215927]
AlphaFold Q8VGV7
Predicted Effect probably benign
Transcript: ENSMUST00000100144
AA Change: S75F

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000097722
Gene: ENSMUSG00000075377
AA Change: S75F

DomainStartEndE-ValueType
Pfam:7tm_4 32 313 6.3e-50 PFAM
Pfam:7TM_GPCR_Srsx 36 164 1.6e-7 PFAM
Pfam:7tm_1 42 295 1.3e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000119049
Predicted Effect probably benign
Transcript: ENSMUST00000213817
AA Change: S75F

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
Predicted Effect probably benign
Transcript: ENSMUST00000215927
AA Change: S75F

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001J03Rik C T 5: 146,120,275 (GRCm39) A188T probably benign Het
2310022B05Rik A T 8: 125,364,645 (GRCm39) probably benign Het
Atf6b C A 17: 34,872,251 (GRCm39) H539Q probably benign Het
Bmal2 T A 6: 146,729,593 (GRCm39) probably benign Het
Bpifb5 G T 2: 154,071,477 (GRCm39) probably null Het
Cep89 T A 7: 35,120,349 (GRCm39) M377K probably damaging Het
Clpx G T 9: 65,219,400 (GRCm39) probably null Het
Cops5 T C 1: 10,105,342 (GRCm39) K47E probably damaging Het
Cryba2 T C 1: 74,931,943 (GRCm39) N35S probably benign Het
Ddx27 A G 2: 166,862,443 (GRCm39) K162E possibly damaging Het
Dhx36 A G 3: 62,401,310 (GRCm39) S319P probably benign Het
Dram2 A G 3: 106,479,012 (GRCm39) probably benign Het
Eci2 T A 13: 35,162,656 (GRCm39) T300S probably benign Het
Egf C A 3: 129,533,631 (GRCm39) G70* probably null Het
Eif5b T C 1: 38,071,403 (GRCm39) V444A probably benign Het
Elf3 T C 1: 135,185,445 (GRCm39) D23G possibly damaging Het
Epb41l4b A T 4: 57,103,422 (GRCm39) probably null Het
Fam167a T A 14: 63,689,708 (GRCm39) S2T probably benign Het
Flrt3 A G 2: 140,502,608 (GRCm39) V340A probably damaging Het
Gimap3 T C 6: 48,742,312 (GRCm39) E206G probably benign Het
Gp6 T C 7: 4,397,103 (GRCm39) probably benign Het
Gpr158 A T 2: 21,788,101 (GRCm39) M581L probably damaging Het
Hapln3 A G 7: 78,767,893 (GRCm39) V167A probably damaging Het
Hnrnpll G A 17: 80,358,142 (GRCm39) T203I probably benign Het
Ighv3-6 A G 12: 114,251,982 (GRCm39) I47T probably damaging Het
Iqgap1 G A 7: 80,387,869 (GRCm39) T926M probably damaging Het
Lonp1 A T 17: 56,922,086 (GRCm39) S765T probably benign Het
Lpp C T 16: 24,580,365 (GRCm39) S27F probably damaging Het
Lrit2 T C 14: 36,790,031 (GRCm39) probably benign Het
Luc7l C A 17: 26,472,054 (GRCm39) T17K probably damaging Het
Mmut A G 17: 41,249,708 (GRCm39) T228A possibly damaging Het
Mroh1 G T 15: 76,330,799 (GRCm39) S1161I possibly damaging Het
Muc5b T G 7: 141,407,104 (GRCm39) C1091G unknown Het
Nppb A T 4: 148,070,463 (GRCm39) I11F probably benign Het
Nsf A T 11: 103,719,351 (GRCm39) D650E probably benign Het
Ogdh A G 11: 6,305,015 (GRCm39) K907E probably damaging Het
Or1j15 A G 2: 36,458,820 (GRCm39) D70G probably damaging Het
Or7a35 A G 10: 78,853,555 (GRCm39) Y133C probably damaging Het
Pcnx1 A T 12: 81,907,156 (GRCm39) Q4L possibly damaging Het
Pgc T A 17: 48,037,856 (GRCm39) L9H probably damaging Het
Pikfyve T A 1: 65,285,556 (GRCm39) S887T probably benign Het
Plec T C 15: 76,059,815 (GRCm39) D3239G probably damaging Het
Pole4 T C 6: 82,625,015 (GRCm39) T116A probably benign Het
Potegl T C 2: 23,120,212 (GRCm39) F203L probably damaging Het
Prpf8 A G 11: 75,381,498 (GRCm39) N300D possibly damaging Het
Rara T A 11: 98,858,907 (GRCm39) Y119N probably damaging Het
Rbck1 G T 2: 152,160,294 (GRCm39) R462S possibly damaging Het
Setdb2 C T 14: 59,639,764 (GRCm39) R709Q probably damaging Het
Slfn2 C A 11: 82,960,670 (GRCm39) N216K probably benign Het
Suox A G 10: 128,507,967 (GRCm39) probably benign Het
Tars1 T A 15: 11,391,280 (GRCm39) Y283F probably damaging Het
Trpm4 A T 7: 44,967,603 (GRCm39) probably null Het
Ubtd2 A T 11: 32,449,262 (GRCm39) K36N probably benign Het
Unkl T C 17: 25,448,408 (GRCm39) L327P probably damaging Het
Vmn1r11 T A 6: 57,114,364 (GRCm39) Y9* probably null Het
Vps13b T C 15: 35,572,227 (GRCm39) V948A probably benign Het
Zbtb17 A G 4: 141,192,264 (GRCm39) H403R probably damaging Het
Other mutations in Or1b1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02032:Or1b1 APN 2 36,994,773 (GRCm39) missense probably damaging 1.00
IGL02444:Or1b1 APN 2 36,994,786 (GRCm39) missense probably damaging 0.99
IGL02453:Or1b1 APN 2 36,995,209 (GRCm39) missense probably benign 0.22
R0699:Or1b1 UTSW 2 36,995,074 (GRCm39) missense possibly damaging 0.92
R1053:Or1b1 UTSW 2 36,995,476 (GRCm39) missense probably damaging 1.00
R1387:Or1b1 UTSW 2 36,994,880 (GRCm39) missense probably benign 0.24
R4914:Or1b1 UTSW 2 36,995,170 (GRCm39) missense possibly damaging 0.67
R4918:Or1b1 UTSW 2 36,995,170 (GRCm39) missense possibly damaging 0.67
R5009:Or1b1 UTSW 2 36,995,467 (GRCm39) missense possibly damaging 0.92
R5114:Or1b1 UTSW 2 36,994,814 (GRCm39) missense probably damaging 1.00
R5301:Or1b1 UTSW 2 36,995,210 (GRCm39) missense probably benign 0.01
R7322:Or1b1 UTSW 2 36,995,603 (GRCm39) missense probably null 0.00
R7440:Or1b1 UTSW 2 36,995,181 (GRCm39) missense possibly damaging 0.85
R7583:Or1b1 UTSW 2 36,995,539 (GRCm39) nonsense probably null
R8892:Or1b1 UTSW 2 36,995,523 (GRCm39) missense probably damaging 1.00
R9264:Or1b1 UTSW 2 36,994,801 (GRCm39) missense probably damaging 1.00
Z1176:Or1b1 UTSW 2 36,995,648 (GRCm39) missense probably benign
Posted On 2015-04-16