Incidental Mutation 'IGL00921:Layn'
ID28157
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Layn
Ensembl Gene ENSMUSG00000060594
Gene Namelayilin
SynonymsLOC244864, E030012M19Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.071) question?
Stock #IGL00921
Quality Score
Status
Chromosome9
Chromosomal Location51054640-51077094 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 51057408 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 345 (T345I)
Ref Sequence ENSEMBL: ENSMUSP00000096379 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098782] [ENSMUST00000214452] [ENSMUST00000217212]
PDB Structure
Solution structure of the talin F3 in complex with layilin cytodomain [SOLUTION NMR]
Predicted Effect probably damaging
Transcript: ENSMUST00000098782
AA Change: T345I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000096379
Gene: ENSMUSG00000060594
AA Change: T345I

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
CLECT 41 185 6.18e-25 SMART
transmembrane domain 237 259 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000214452
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216453
Predicted Effect probably benign
Transcript: ENSMUST00000217212
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 A G 1: 71,285,729 I1530T probably damaging Het
Actb T C 5: 142,904,436 E237G probably damaging Het
Atrnl1 A G 19: 57,702,153 E931G probably damaging Het
Cenpc1 T C 5: 86,037,528 T375A probably benign Het
D1Pas1 A G 1: 186,968,786 D304G probably benign Het
Ddx49 G A 8: 70,294,756 Q345* probably null Het
Dnttip2 A T 3: 122,275,290 K51N probably benign Het
Fxr2 A G 11: 69,652,240 E621G probably damaging Het
Grhpr A G 4: 44,988,991 D216G probably damaging Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Hook2 T C 8: 85,002,497 probably benign Het
Hspbp1 A G 7: 4,664,751 S248P probably damaging Het
Kat6a C T 8: 22,940,263 P1878L unknown Het
Klrg1 A T 6: 122,282,752 D20E probably benign Het
Mpi G A 9: 57,552,266 L9F probably damaging Het
Nbn T C 4: 15,963,833 V78A possibly damaging Het
Pkdrej A G 15: 85,817,226 I1503T probably damaging Het
Pou2f2 C A 7: 25,092,700 E577* probably null Het
Prim2 G T 1: 33,512,160 H292Q probably damaging Het
Tg A G 15: 66,764,453 N630D probably benign Het
Trim80 A G 11: 115,447,664 N440S probably benign Het
Ttn T C 2: 76,936,402 S3111G probably damaging Het
Ubash3a A G 17: 31,228,186 T339A probably benign Het
Zbtb21 A C 16: 97,952,022 S354A probably damaging Het
Zfp335 T C 2: 164,894,776 T980A possibly damaging Het
Other mutations in Layn
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01145:Layn APN 9 51074046 missense probably benign 0.01
IGL02006:Layn APN 9 51057291 intron probably benign
IGL02226:Layn APN 9 51074017 missense probably damaging 1.00
PIT4677001:Layn UTSW 9 51057411 missense probably damaging 0.98
R1464:Layn UTSW 9 51057586 missense probably damaging 1.00
R1464:Layn UTSW 9 51057586 missense probably damaging 1.00
R1775:Layn UTSW 9 51059533 missense probably benign 0.03
R2156:Layn UTSW 9 51057397 missense probably benign
R3732:Layn UTSW 9 51059544 missense probably damaging 1.00
R3732:Layn UTSW 9 51059544 missense probably damaging 1.00
R3733:Layn UTSW 9 51059544 missense probably damaging 1.00
R3757:Layn UTSW 9 51059556 missense probably benign 0.11
R4840:Layn UTSW 9 51057382 missense probably damaging 1.00
R5792:Layn UTSW 9 51068161 missense probably damaging 1.00
R7185:Layn UTSW 9 51073873 missense possibly damaging 0.58
R7216:Layn UTSW 9 51077052 start gained probably benign
R7404:Layn UTSW 9 51057370 missense possibly damaging 0.94
Posted On2013-04-17