Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02142:Wdr20rt'

281583

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Wdr20rt

Ensembl Gene

ENSMUSG00000035560

Gene Name

WD repeat domain 20, retrogene

Synonyms

4921538B03Rik, Wdr20b, 4930427E19Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.403) question?

Stock #

IGL02142

Quality Score

Status

Chromosome

Chromosomal Location

65272291-65275228 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 65274039 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 328 (T328A)

Ref Sequence

ENSEMBL: ENSMUSP00000152626 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046331] [ENSMUST00000221658] [ENSMUST00000221980] [ENSMUST00000222822]

AlphaFold

Q9D5R2

Predicted Effect

probably benign
Transcript: ENSMUST00000046331
AA Change: T501A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000036682
Gene: ENSMUSG00000035560
AA Change: T501A

Domain	Start	End	E-Value	Type
WD40	140	178	1.33e1	SMART
WD40	205	246	1.38e-2	SMART
WD40	249	288	1.57e-6	SMART
WD40	291	380	8.29e-1	SMART
low complexity region	465	478	N/A	INTRINSIC
Blast:WD40	480	557	1e-29	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000221658

Predicted Effect

probably benign
Transcript: ENSMUST00000221980
AA Change: T328A

PolyPhen 2 Score 0.215 (Sensitivity: 0.92; Specificity: 0.88)

Predicted Effect

probably benign
Transcript: ENSMUST00000222822
AA Change: T400A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	T	C	3: 121,963,575 (GRCm39)	S2060P	probably benign	Het
Abcg4	A	G	9: 44,189,014 (GRCm39)	F426S	probably benign	Het
Actn1	C	T	12: 80,222,929 (GRCm39)		probably null	Het
Adgrd1	T	A	5: 129,208,648 (GRCm39)	H251Q	probably benign	Het
Adgrg3	C	T	8: 95,766,483 (GRCm39)	P385S	probably damaging	Het
Ampd2	G	T	3: 107,987,660 (GRCm39)		probably benign	Het
Arhgap42	A	G	9: 9,155,360 (GRCm39)	S86P	probably damaging	Het
Art5	C	T	7: 101,747,123 (GRCm39)	E121K	probably null	Het
Atad5	G	A	11: 79,985,023 (GRCm39)	E37K	probably benign	Het
Atp13a5	A	G	16: 29,053,315 (GRCm39)	V1084A	probably benign	Het
Cfap44	T	C	16: 44,241,507 (GRCm39)	I626T	probably benign	Het
Col16a1	T	A	4: 129,945,440 (GRCm39)		probably null	Het
Defa22	T	G	8: 21,653,130 (GRCm39)	C81G	possibly damaging	Het
Dnm2	A	G	9: 21,411,649 (GRCm39)	Y622C	probably damaging	Het
Efna5	T	A	17: 62,914,340 (GRCm39)	L201F	unknown	Het
Elac1	T	C	18: 73,871,991 (GRCm39)	R335G	probably benign	Het
Enpp5	T	C	17: 44,396,468 (GRCm39)	V460A	probably benign	Het
Esr2	A	G	12: 76,169,969 (GRCm39)	V453A	probably benign	Het
Fam210b	T	A	2: 172,194,497 (GRCm39)		probably benign	Het
Fcgr1	T	C	3: 96,191,893 (GRCm39)	Y305C	probably benign	Het
Fcrlb	A	G	1: 170,736,248 (GRCm39)	V176A	probably damaging	Het
Gabrq	T	A	X: 71,879,783 (GRCm39)	V256E	possibly damaging	Het
Gba1	T	C	3: 89,113,148 (GRCm39)	L193P	probably damaging	Het
Gm10717	C	T	9: 3,025,616 (GRCm39)	S67L	probably benign	Het
Helq	A	G	5: 100,930,960 (GRCm39)	F597L	probably benign	Het
Hrh1	A	T	6: 114,457,204 (GRCm39)	I162L	probably damaging	Het
Jph1	A	T	1: 17,161,884 (GRCm39)	F259L	probably damaging	Het
Kdm2b	C	T	5: 123,085,898 (GRCm39)	E238K	probably damaging	Het
Kdm4c	T	A	4: 74,225,253 (GRCm39)		probably null	Het
Kif13a	T	C	13: 46,925,011 (GRCm39)	T308A	probably benign	Het
Lars1	C	T	18: 42,360,345 (GRCm39)	V704M	probably benign	Het
Lcmt2	A	G	2: 120,969,394 (GRCm39)	L343P	possibly damaging	Het
Lhfpl1	A	G	X: 144,123,733 (GRCm39)	F125L	probably benign	Het
Lmbrd2	C	A	15: 9,186,772 (GRCm39)	D582E	probably damaging	Het
Lrrn2	T	A	1: 132,866,983 (GRCm39)	S683T	possibly damaging	Het
Macf1	T	C	4: 123,365,842 (GRCm39)	D1408G	probably benign	Het
Magi3	T	C	3: 103,923,219 (GRCm39)	K1166R	probably benign	Het
Marchf5	T	C	19: 37,197,892 (GRCm39)		probably benign	Het
Ms4a20	G	A	19: 11,087,695 (GRCm39)	Q79*	probably null	Het
Naa25	A	G	5: 121,564,825 (GRCm39)	Q555R	possibly damaging	Het
Npat	A	G	9: 53,481,207 (GRCm39)	T1005A	probably benign	Het
Nt5c3	G	A	6: 56,863,670 (GRCm39)	A108V	probably damaging	Het
Ocrl	T	A	X: 47,024,995 (GRCm39)	M322K	probably damaging	Het
Odad2	C	A	18: 7,214,601 (GRCm39)	W733C	probably damaging	Het
Or8g2	A	G	9: 39,821,935 (GRCm39)	T279A	possibly damaging	Het
Psg23	A	T	7: 18,344,345 (GRCm39)	V370E	probably benign	Het
Rassf2	A	T	2: 131,838,353 (GRCm39)	M311K	possibly damaging	Het
Rhobtb3	A	G	13: 76,025,614 (GRCm39)	Y501H	probably damaging	Het
Rpl4	A	G	9: 64,083,488 (GRCm39)	D179G	possibly damaging	Het
Scn2a	T	A	2: 65,546,182 (GRCm39)	I915N	probably damaging	Het
Scn3a	T	A	2: 65,356,965 (GRCm39)	T160S	possibly damaging	Het
Slx4ip	T	G	2: 136,909,942 (GRCm39)	N242K	possibly damaging	Het
Spidr	T	A	16: 15,865,945 (GRCm39)	Q288L	probably benign	Het
Sun1	A	T	5: 139,216,918 (GRCm39)	H255L	possibly damaging	Het
Tacc1	C	T	8: 25,665,233 (GRCm39)	G51S	probably damaging	Het
Tet2	T	A	3: 133,185,900 (GRCm39)	N1179I	possibly damaging	Het
Tgfbrap1	T	C	1: 43,101,752 (GRCm39)	Y349C	probably damaging	Het
Tnrc6a	T	C	7: 122,751,414 (GRCm39)		probably benign	Het
Trim32	T	C	4: 65,532,736 (GRCm39)	L431P	probably damaging	Het
Vmn1r35	A	G	6: 66,656,334 (GRCm39)	L112S	probably damaging	Het
Vmn2r100	A	C	17: 19,742,583 (GRCm39)	H319P	probably damaging	Het
Zbtb17	T	C	4: 141,192,293 (GRCm39)	Y413H	probably benign	Het

Other mutations in Wdr20rt

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00488:Wdr20rt	APN	12	65,272,744 (GRCm39)	missense	possibly damaging	0.95
IGL02938:Wdr20rt	APN	12	65,272,692 (GRCm39)	missense	probably benign	0.01
R0501:Wdr20rt	UTSW	12	65,272,581 (GRCm39)	missense	probably benign	0.02
R0548:Wdr20rt	UTSW	12	65,274,089 (GRCm39)	missense	probably benign	0.00
R0652:Wdr20rt	UTSW	12	65,272,689 (GRCm39)	missense	probably damaging	0.98
R1715:Wdr20rt	UTSW	12	65,274,088 (GRCm39)	missense	probably damaging	0.98
R1733:Wdr20rt	UTSW	12	65,274,055 (GRCm39)	missense	possibly damaging	0.87
R1851:Wdr20rt	UTSW	12	65,273,925 (GRCm39)	missense	possibly damaging	0.89
R2010:Wdr20rt	UTSW	12	65,273,988 (GRCm39)	missense	possibly damaging	0.88
R2214:Wdr20rt	UTSW	12	65,274,187 (GRCm39)	missense	probably damaging	1.00
R2254:Wdr20rt	UTSW	12	65,273,007 (GRCm39)	missense	probably damaging	1.00
R4793:Wdr20rt	UTSW	12	65,273,395 (GRCm39)	missense	probably damaging	0.99
R5169:Wdr20rt	UTSW	12	65,274,184 (GRCm39)	missense	probably damaging	0.99
R6238:Wdr20rt	UTSW	12	65,272,964 (GRCm39)	start gained	probably benign
R7018:Wdr20rt	UTSW	12	65,272,536 (GRCm39)	splice site	probably null
R7143:Wdr20rt	UTSW	12	65,272,692 (GRCm39)	missense	probably benign	0.08
R7707:Wdr20rt	UTSW	12	65,272,981 (GRCm39)	missense	probably damaging	1.00
R8436:Wdr20rt	UTSW	12	65,273,035 (GRCm39)	missense	probably damaging	1.00
R8473:Wdr20rt	UTSW	12	65,273,380 (GRCm39)	missense	probably damaging	1.00
R8556:Wdr20rt	UTSW	12	65,273,739 (GRCm39)	missense	probably benign	0.10
R9071:Wdr20rt	UTSW	12	65,274,222 (GRCm39)	missense	probably benign	0.09
R9159:Wdr20rt	UTSW	12	65,272,918 (GRCm39)	missense	probably damaging	0.99
R9513:Wdr20rt	UTSW	12	65,272,825 (GRCm39)	missense	probably damaging	1.00
R9655:Wdr20rt	UTSW	12	65,273,707 (GRCm39)	missense	probably benign
R9659:Wdr20rt	UTSW	12	65,273,343 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16