Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02143:Ankar'

281691

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ankar

Ensembl Gene

ENSMUSG00000039342

Gene Name

ankyrin and armadillo repeat containing

Synonyms

4932422E22Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

IGL02143

Quality Score

Status

Chromosome

Chromosomal Location

72642980-72700579 bp(-) (GRCm38)

Type of Mutation

critical splice donor site (1 bp from exon)

DNA Base Change (assembly)

C to T at 72658649 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000148640 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000053499] [ENSMUST00000211837] [ENSMUST00000212573]

AlphaFold

A2RT91

Predicted Effect

probably null
Transcript: ENSMUST00000053499

SMART Domains

Protein: ENSMUSP00000054056
Gene: ENSMUSG00000039342

Domain	Start	End	E-Value	Type
low complexity region	46	51	N/A	INTRINSIC
low complexity region	484	496	N/A	INTRINSIC
ANK	532	561	1.25e2	SMART
ANK	582	611	3.49e0	SMART
ANK	615	644	4.44e2	SMART
ANK	651	680	3.8e-1	SMART
ANK	684	714	9.87e0	SMART
ARM	744	784	5.96e-3	SMART
ARM	785	825	4.09e0	SMART
Blast:ARM	827	865	1e-15	BLAST
ARM	867	907	8.34e0	SMART
ARM	909	949	8.34e0	SMART
Blast:ARM	951	991	2e-13	BLAST
ARM	1034	1077	4.82e1	SMART
ARM	1084	1123	1.3e1	SMART
ARM	1257	1297	6.01e0	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000211837

Predicted Effect

probably null
Transcript: ENSMUST00000212573

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700019N19Rik	C	A	19: 58,789,252	R34L	possibly damaging	Het
Abhd5	T	C	9: 122,365,213	M1T	probably null	Het
Ager	G	A	17: 34,599,118	G183E	probably damaging	Het
Alcam	C	A	16: 52,305,619	V112L	probably damaging	Het
Amot	T	A	X: 145,487,028	Q204H	probably damaging	Het
Armc9	A	G	1: 86,176,865	M279V	possibly damaging	Het
Bpifb1	C	T	2: 154,209,929	T218I	probably benign	Het
Cacna1f	A	C	X: 7,613,995		probably benign	Het
Cacna2d2	T	C	9: 107,518,275		probably null	Het
Ccdc57	A	T	11: 120,861,243	C837*	probably null	Het
Ctbp2	G	A	7: 132,991,156	A808V	probably damaging	Het
Dcbld2	T	C	16: 58,448,526		probably null	Het
Dis3	T	C	14: 99,091,318		probably benign	Het
Disp2	T	C	2: 118,789,969	F394S	probably damaging	Het
Dnah1	T	C	14: 31,283,289	N2336S	probably damaging	Het
Drap1	C	A	19: 5,423,843	L66F	probably damaging	Het
Eif5a2	C	T	3: 28,793,739	R109C	probably benign	Het
Enpp1	A	T	10: 24,677,974	D105E	probably damaging	Het
Evi5l	G	A	8: 4,191,293	M275I	probably damaging	Het
Flt1	T	C	5: 147,578,436	T1059A	probably benign	Het
Fndc3c1	T	C	X: 106,472,734		probably benign	Het
Git1	T	C	11: 77,505,987	V645A	possibly damaging	Het
Gm7735	T	A	16: 89,169,549	C20*	probably null	Het
Ighv1-42	G	T	12: 114,937,286	P60T	probably benign	Het
Jakmip2	A	T	18: 43,563,285	L533Q	probably damaging	Het
Kdm2b	C	T	5: 122,947,835	E238K	probably damaging	Het
Lpin2	T	C	17: 71,243,926	S694P	probably damaging	Het
Mab21l2	C	T	3: 86,547,255	R146Q	possibly damaging	Het
Mmp1b	A	T	9: 7,386,400	S174T	probably benign	Het
Neb	T	C	2: 52,291,199	Y1132C	probably damaging	Het
Nhsl1	A	T	10: 18,511,635	H219L	possibly damaging	Het
Nwd2	T	A	5: 63,791,653		probably null	Het
Obp1a	A	C	X: 78,090,843	M18R	possibly damaging	Het
Olfr525	A	T	7: 140,323,592	K298*	probably null	Het
Olfr695	T	C	7: 106,873,973	T91A	probably benign	Het
Pabpc5	T	A	X: 119,927,991	M1K	probably null	Het
Paxip1	A	G	5: 27,775,598		probably benign	Het
Perm1	A	G	4: 156,218,043	E348G	probably benign	Het
Pfkfb1	T	C	X: 150,622,142	F170L	probably damaging	Het
Pou3f3	A	G	1: 42,698,526	M461V	probably benign	Het
Ppfia2	G	A	10: 106,857,499	D622N	probably damaging	Het
Prtg	T	G	9: 72,892,324	S801R	probably damaging	Het
Rars2	T	A	4: 34,623,404		probably benign	Het
Rasal1	A	G	5: 120,652,852	D35G	probably damaging	Het
Repin1	T	A	6: 48,597,121	L272Q	probably damaging	Het
Stk36	T	C	1: 74,616,569		probably benign	Het
Tbxa2r	A	G	10: 81,334,486	T269A	probably benign	Het
Tmem132c	G	A	5: 127,563,402	R879Q	probably benign	Het
Vmn1r78	C	A	7: 12,152,480	A6E	probably benign	Het
Vps45	A	T	3: 96,033,821	N369K	probably benign	Het
Vps45	T	C	3: 96,019,646	I530V	probably benign	Het
Zkscan16	G	A	4: 58,956,911	G398R	probably damaging	Het

Other mutations in Ankar

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00338:Ankar	APN	1	72690131	missense	probably damaging	1.00
IGL01013:Ankar	APN	1	72650989	missense	possibly damaging	0.90
IGL01135:Ankar	APN	1	72665219	missense	probably benign	0.28
IGL01824:Ankar	APN	1	72651727	missense	probably benign	0.40
IGL01885:Ankar	APN	1	72658703	missense	probably damaging	1.00
IGL01932:Ankar	APN	1	72698987	missense	probably benign	0.25
IGL02326:Ankar	APN	1	72666355	missense	probably damaging	1.00
IGL02445:Ankar	APN	1	72666365	missense	probably benign	0.05
IGL02606:Ankar	APN	1	72690285	missense	possibly damaging	0.61
IGL02635:Ankar	APN	1	72652431	missense	possibly damaging	0.93
IGL02680:Ankar	APN	1	72670116	missense	probably damaging	1.00
IGL02704:Ankar	APN	1	72652343	missense	possibly damaging	0.88
IGL03086:Ankar	APN	1	72643278	missense	possibly damaging	0.84
IGL03269:Ankar	APN	1	72665201	missense	probably damaging	0.99
IGL03368:Ankar	APN	1	72675813	missense	probably damaging	1.00
R0050:Ankar	UTSW	1	72656164	missense	probably damaging	1.00
R0050:Ankar	UTSW	1	72656164	missense	probably damaging	1.00
R0488:Ankar	UTSW	1	72658732	missense	probably damaging	1.00
R0650:Ankar	UTSW	1	72656221	splice site	probably benign
R1121:Ankar	UTSW	1	72651663	splice site	probably null
R1163:Ankar	UTSW	1	72688705	missense	possibly damaging	0.82
R1300:Ankar	UTSW	1	72643164	missense	probably benign	0.00
R1309:Ankar	UTSW	1	72674004	missense	possibly damaging	0.59
R1366:Ankar	UTSW	1	72698649	missense	probably damaging	1.00
R1456:Ankar	UTSW	1	72665118	missense	probably benign	0.34
R1495:Ankar	UTSW	1	72643291	missense	probably benign
R1583:Ankar	UTSW	1	72679555	splice site	probably benign
R1635:Ankar	UTSW	1	72650138	missense	probably damaging	0.99
R1975:Ankar	UTSW	1	72658441	missense	possibly damaging	0.95
R2036:Ankar	UTSW	1	72666530	nonsense	probably null
R2511:Ankar	UTSW	1	72658694	missense	probably damaging	1.00
R2965:Ankar	UTSW	1	72675820	missense	probably benign	0.00
R3404:Ankar	UTSW	1	72643093	nonsense	probably null
R3417:Ankar	UTSW	1	72658976	critical splice donor site	probably null
R4072:Ankar	UTSW	1	72688592	missense	probably damaging	1.00
R4231:Ankar	UTSW	1	72658542	missense	probably benign	0.23
R4447:Ankar	UTSW	1	72687789	missense	possibly damaging	0.60
R4632:Ankar	UTSW	1	72647184	missense	probably benign	0.01
R4720:Ankar	UTSW	1	72699011	missense	possibly damaging	0.55
R4754:Ankar	UTSW	1	72698694	missense	probably damaging	1.00
R4884:Ankar	UTSW	1	72698807	missense	probably damaging	0.97
R5068:Ankar	UTSW	1	72680210	splice site	probably null
R5069:Ankar	UTSW	1	72680210	splice site	probably null
R5070:Ankar	UTSW	1	72680210	splice site	probably null
R5189:Ankar	UTSW	1	72658414	missense	probably benign	0.01
R5247:Ankar	UTSW	1	72680184	missense	probably benign	0.08
R5322:Ankar	UTSW	1	72690386	splice site	probably null
R5345:Ankar	UTSW	1	72670151	missense	possibly damaging	0.94
R5864:Ankar	UTSW	1	72659165	missense	probably benign	0.00
R5976:Ankar	UTSW	1	72643291	missense	probably benign
R6003:Ankar	UTSW	1	72698887	missense	probably damaging	1.00
R6042:Ankar	UTSW	1	72674054	nonsense	probably null
R6296:Ankar	UTSW	1	72643258	missense	probably damaging	1.00
R6488:Ankar	UTSW	1	72681808	critical splice donor site	probably null
R6885:Ankar	UTSW	1	72643036	missense	unknown
R6985:Ankar	UTSW	1	72658482	missense	probably damaging	1.00
R7060:Ankar	UTSW	1	72656113	missense	probably benign	0.18
R7099:Ankar	UTSW	1	72643293	missense	probably damaging	0.99
R7194:Ankar	UTSW	1	72659033	missense	probably benign	0.32
R7221:Ankar	UTSW	1	72650231	missense	probably damaging	1.00
R7222:Ankar	UTSW	1	72666355	missense	probably damaging	0.99
R7258:Ankar	UTSW	1	72651727	missense	probably benign	0.40
R7303:Ankar	UTSW	1	72659033	missense	probably benign	0.32
R7308:Ankar	UTSW	1	72651794	nonsense	probably null
R7384:Ankar	UTSW	1	72658465	missense	probably benign	0.00
R7424:Ankar	UTSW	1	72680058	missense	probably damaging	1.00
R7464:Ankar	UTSW	1	72698894	missense	possibly damaging	0.94
R7525:Ankar	UTSW	1	72688641	missense	probably benign	0.18
R7618:Ankar	UTSW	1	72675766	missense	probably benign	0.22
R7659:Ankar	UTSW	1	72690135	missense	possibly damaging	0.95
R7974:Ankar	UTSW	1	72698979	nonsense	probably null
R8008:Ankar	UTSW	1	72666484	missense	possibly damaging	0.47
R8119:Ankar	UTSW	1	72647001	missense	probably damaging	0.98
R8244:Ankar	UTSW	1	72651024	missense	probably benign
R8342:Ankar	UTSW	1	72652460	missense	probably damaging	1.00
R8494:Ankar	UTSW	1	72658794	missense	probably benign	0.16
R8851:Ankar	UTSW	1	72652376	missense	probably damaging	1.00
R8970:Ankar	UTSW	1	72652337	critical splice donor site	probably null
R9228:Ankar	UTSW	1	72674051	missense	probably benign	0.27
R9511:Ankar	UTSW	1	72680002	missense	probably benign	0.23
R9577:Ankar	UTSW	1	72681908	missense	probably benign	0.02
R9612:Ankar	UTSW	1	72665135	missense	possibly damaging	0.65
R9647:Ankar	UTSW	1	72650148	missense	probably damaging	1.00
R9803:Ankar	UTSW	1	72659181	missense	possibly damaging	0.47
Z1176:Ankar	UTSW	1	72689961	missense	possibly damaging	0.95

Posted On

2015-04-16