Incidental Mutation 'IGL02145:Olfr310'
ID281700
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr310
Ensembl Gene ENSMUSG00000057540
Gene Nameolfactory receptor 310
SynonymsGA_x6K02T2NHDJ-9838699-9839697, MOR227-6P
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.081) question?
Stock #IGL02145
Quality Score
Status
Chromosome7
Chromosomal Location86268487-86277172 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 86269258 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Phenylalanine at position 177 (C177F)
Ref Sequence ENSEMBL: ENSMUSP00000151989 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081918] [ENSMUST00000217724]
Predicted Effect probably damaging
Transcript: ENSMUST00000081918
AA Change: C177F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000080589
Gene: ENSMUSG00000057540
AA Change: C177F

DomainStartEndE-ValueType
Pfam:7tm_4 29 307 8.9e-46 PFAM
Pfam:7tm_1 39 289 1.8e-18 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217724
AA Change: C177F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agt A G 8: 124,564,448 L40P probably damaging Het
Ahnak T C 19: 9,002,855 I501T probably benign Het
Aldh2 A G 5: 121,567,993 *196Q probably null Het
Ankrd65 A G 4: 155,791,391 D23G possibly damaging Het
Anln A T 9: 22,338,996 probably null Het
Armc3 G A 2: 19,286,137 probably null Het
Armc3 C T 2: 19,296,860 S663L possibly damaging Het
Cul5 A T 9: 53,635,075 probably benign Het
Cyba T C 8: 122,425,057 I134V probably damaging Het
Cybb T A X: 9,457,018 Q93H probably damaging Het
Cyp4f37 G T 17: 32,630,035 K292N probably benign Het
Dmxl2 T C 9: 54,374,697 I2850V probably benign Het
Ep300 T C 15: 81,601,166 I118T unknown Het
Ercc6l G T X: 102,145,542 P454T probably benign Het
Grxcr1 A G 5: 68,110,478 E190G probably damaging Het
Heatr3 C T 8: 88,144,599 R194C probably benign Het
Hspa12b C T 2: 131,143,735 probably benign Het
Inpp5d T C 1: 87,715,055 V644A probably damaging Het
Kif26a G A 12: 112,176,975 R1221H probably benign Het
Klra8 T C 6: 130,125,236 N79D probably benign Het
Kntc1 T C 5: 123,762,598 I253T possibly damaging Het
Lamp5 T C 2: 136,059,589 V111A possibly damaging Het
Lmo7 T C 14: 101,902,223 S859P probably benign Het
Mgarp T C 3: 51,389,032 Q205R possibly damaging Het
Morf4l1 A G 9: 90,093,795 Y315H probably benign Het
Naip6 A T 13: 100,296,978 V1117E possibly damaging Het
Nipal1 A G 5: 72,666,931 D206G probably damaging Het
Notch3 A G 17: 32,154,741 S498P probably benign Het
Npepps A G 11: 97,218,502 probably null Het
Olfr319 T C 11: 58,702,060 Y120H probably damaging Het
Phlpp1 A G 1: 106,389,883 H1278R probably damaging Het
Pprc1 C A 19: 46,064,890 probably benign Het
Rab8b A T 9: 66,847,718 probably benign Het
Ripor2 T A 13: 24,717,571 I875N probably damaging Het
Samd9l T C 6: 3,374,105 E1052G probably benign Het
Slit3 A T 11: 35,629,742 I569F probably damaging Het
Spata2l C T 8: 123,234,031 G173D possibly damaging Het
Stc2 T G 11: 31,367,875 probably benign Het
Tm6sf1 C A 7: 81,863,252 Y65* probably null Het
Tspan15 A G 10: 62,193,972 probably benign Het
Vmn2r14 A T 5: 109,220,588 Y179* probably null Het
Washc5 C A 15: 59,369,211 V92L probably benign Het
Wiz A G 17: 32,356,919 S838P probably benign Het
Zp2 T A 7: 120,139,851 probably null Het
Other mutations in Olfr310
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00095:Olfr310 APN 7 86269669 missense probably damaging 1.00
IGL00917:Olfr310 APN 7 86269441 missense probably damaging 1.00
IGL02639:Olfr310 APN 7 86269720 missense probably damaging 0.99
R0139:Olfr310 UTSW 7 86268979 missense probably benign 0.00
R0554:Olfr310 UTSW 7 86269657 missense probably damaging 0.99
R1392:Olfr310 UTSW 7 86268855 missense probably benign 0.01
R1392:Olfr310 UTSW 7 86268855 missense probably benign 0.01
R1474:Olfr310 UTSW 7 86269062 missense probably damaging 1.00
R2379:Olfr310 UTSW 7 86269649 missense probably damaging 1.00
R3692:Olfr310 UTSW 7 86269495 missense probably damaging 1.00
R4290:Olfr310 UTSW 7 86269760 missense probably damaging 1.00
R4291:Olfr310 UTSW 7 86269760 missense probably damaging 1.00
R4295:Olfr310 UTSW 7 86269760 missense probably damaging 1.00
R5071:Olfr310 UTSW 7 86269591 missense probably damaging 0.99
R5072:Olfr310 UTSW 7 86269591 missense probably damaging 0.99
R5074:Olfr310 UTSW 7 86269591 missense probably damaging 0.99
R5828:Olfr310 UTSW 7 86269520 missense probably benign 0.00
R6174:Olfr310 UTSW 7 86268801 missense probably benign
R6207:Olfr310 UTSW 7 86269760 missense probably damaging 1.00
R6493:Olfr310 UTSW 7 86268882 missense probably benign 0.21
R7068:Olfr310 UTSW 7 86269537 missense probably damaging 1.00
R7196:Olfr310 UTSW 7 86269441 missense probably damaging 1.00
R7694:Olfr310 UTSW 7 86269775 missense probably damaging 1.00
R7794:Olfr310 UTSW 7 86269133 missense probably damaging 0.99
Z1176:Olfr310 UTSW 7 86268947 missense probably damaging 1.00
Posted On2015-04-16