Incidental Mutation 'IGL00932:Olfr830'
ID28177
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr830
Ensembl Gene ENSMUSG00000062868
Gene Nameolfactory receptor 830
SynonymsGA_x6K02T2PVTD-12618399-12619337, MOR152-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.144) question?
Stock #IGL00932
Quality Score
Status
Chromosome9
Chromosomal Location18874693-18878369 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 18876014 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Stop codon at position 226 (L226*)
Ref Sequence ENSEMBL: ENSMUSP00000148394 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078861] [ENSMUST00000212723]
Predicted Effect probably null
Transcript: ENSMUST00000078861
AA Change: L229*
SMART Domains Protein: ENSMUSP00000077903
Gene: ENSMUSG00000062868
AA Change: L229*

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 1.8e-51 PFAM
Pfam:7tm_1 44 293 1.6e-20 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000212723
AA Change: L226*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano10 A T 9: 122,251,231 C571* probably null Het
Atp7b T C 8: 22,011,098 I930V possibly damaging Het
Azin2 A T 4: 128,950,666 V48E probably damaging Het
BC017643 A G 11: 121,228,330 V28A probably damaging Het
Camk2g C T 14: 20,737,330 G500S probably damaging Het
Clec4a1 G A 6: 122,930,695 C114Y probably damaging Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Huwe1 T C X: 151,860,161 probably benign Het
Lamb1 T A 12: 31,298,826 V571E possibly damaging Het
Lats1 T C 10: 7,712,742 V1041A possibly damaging Het
Mthfd1l A T 10: 3,989,971 probably benign Het
Ptbp3 A G 4: 59,477,228 S487P probably benign Het
Rpgrip1l A G 8: 91,275,637 F448S probably benign Het
Rpl7a T C 2: 26,911,055 probably benign Het
Sis T C 3: 72,940,956 probably benign Het
Sptan1 G T 2: 30,015,610 A1579S probably damaging Het
Tcl1b5 A T 12: 105,176,500 H29L probably benign Het
Ttll5 A T 12: 85,929,907 N811Y probably damaging Het
Vmn2r111 T A 17: 22,548,753 M588L probably benign Het
Other mutations in Olfr830
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00954:Olfr830 APN 9 18876073 missense probably benign 0.15
IGL01090:Olfr830 APN 9 18876242 missense probably benign 0.00
IGL01613:Olfr830 APN 9 18875321 splice site probably benign
IGL01987:Olfr830 APN 9 18875707 missense probably benign 0.00
IGL03018:Olfr830 APN 9 18876227 missense probably benign 0.15
IGL03037:Olfr830 APN 9 18875372 missense probably damaging 0.98
R0284:Olfr830 UTSW 9 18875552 missense probably benign
R1322:Olfr830 UTSW 9 18875521 missense possibly damaging 0.90
R1715:Olfr830 UTSW 9 18875794 missense probably benign 0.06
R1803:Olfr830 UTSW 9 18876080 missense probably damaging 1.00
R4360:Olfr830 UTSW 9 18875717 missense probably damaging 1.00
R4394:Olfr830 UTSW 9 18875611 missense probably damaging 0.98
R4642:Olfr830 UTSW 9 18876167 missense probably damaging 1.00
R4796:Olfr830 UTSW 9 18876179 missense probably damaging 0.96
R4814:Olfr830 UTSW 9 18875917 missense probably benign 0.30
R5210:Olfr830 UTSW 9 18875807 missense probably damaging 1.00
R5375:Olfr830 UTSW 9 18876146 missense probably benign 0.08
R6072:Olfr830 UTSW 9 18875422 missense probably benign
R6361:Olfr830 UTSW 9 18875731 missense probably damaging 1.00
R6602:Olfr830 UTSW 9 18875849 missense possibly damaging 0.81
R6920:Olfr830 UTSW 9 18875525 missense probably damaging 1.00
R7730:Olfr830 UTSW 9 18875413 missense probably benign 0.00
R7780:Olfr830 UTSW 9 18875614 missense possibly damaging 0.65
R8245:Olfr830 UTSW 9 18875830 missense probably benign
R8274:Olfr830 UTSW 9 18875499 missense probably benign 0.36
X0026:Olfr830 UTSW 9 18875635 missense probably damaging 1.00
Posted On2013-04-17