Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02147:Lgalsl2'

281817

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lgalsl2

Ensembl Gene

ENSMUSG00000048398

Gene Name

galectin like 2

Synonyms

Gm5065

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.198) question?

Stock #

IGL02147

Quality Score

Status

Chromosome

Chromosomal Location

5353541-5363681 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 5362732 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 121 (I121N)

Ref Sequence

ENSEMBL: ENSMUSP00000146867 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000056639] [ENSMUST00000207531]

AlphaFold

Q7TPX9

Predicted Effect

probably damaging
Transcript: ENSMUST00000056639
AA Change: I121N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000055799
Gene: ENSMUSG00000048398
AA Change: I121N

Domain	Start	End	E-Value	Type
GLECT	31	165	1.56e-15	SMART
Gal-bind_lectin	37	165	2.51e-43	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000207531
AA Change: I121N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700021P04Rik	T	C	19: 24,042,327 (GRCm39)		noncoding transcript	Het
Acadsb	T	A	7: 131,027,610 (GRCm39)		probably benign	Het
Ambra1	A	G	2: 91,598,064 (GRCm39)	H75R	probably benign	Het
Arhgef28	T	A	13: 98,097,822 (GRCm39)	I931F	probably damaging	Het
Cdk5	T	C	5: 24,625,318 (GRCm39)	N165D	probably benign	Het
Col4a2	A	T	8: 11,458,140 (GRCm39)	Y272F	probably benign	Het
Csde1	T	A	3: 102,947,250 (GRCm39)	D67E	probably damaging	Het
Dhx34	T	C	7: 15,937,928 (GRCm39)	H724R	probably benign	Het
Dhx57	T	C	17: 80,567,752 (GRCm39)	D777G	possibly damaging	Het
Fat3	A	C	9: 15,907,281 (GRCm39)	V2907G	probably damaging	Het
Fst	T	C	13: 114,590,896 (GRCm39)	Y290C	probably damaging	Het
Ighg2b	A	T	12: 113,270,011 (GRCm39)	*336R	probably null	Het
Igkv4-92	C	T	6: 68,732,236 (GRCm39)	S46N	probably damaging	Het
Kdm2b	C	T	5: 123,085,898 (GRCm39)	E238K	probably damaging	Het
Lmtk2	A	G	5: 144,093,754 (GRCm39)	M244V	possibly damaging	Het
Mcoln1	T	C	8: 3,558,379 (GRCm39)	F211S	probably benign	Het
Mib2	C	A	4: 155,742,144 (GRCm39)	R209L	probably benign	Het
Msx3	C	A	7: 139,628,798 (GRCm39)	V39L	possibly damaging	Het
Mtnr1b	A	G	9: 15,774,672 (GRCm39)	F129S	probably damaging	Het
Nr3c2	A	G	8: 77,635,696 (GRCm39)	S266G	probably damaging	Het
Nup160	G	T	2: 90,534,285 (GRCm39)	L703F	probably benign	Het
Or10c1	T	A	17: 37,521,877 (GRCm39)	Y289F	probably damaging	Het
Or5t5	A	G	2: 86,616,494 (GRCm39)	N140S	probably benign	Het
Pcyt1a	T	A	16: 32,280,916 (GRCm39)	N105K	probably damaging	Het
Pdhx	A	G	2: 102,860,686 (GRCm39)		probably benign	Het
Qpct	T	C	17: 79,378,145 (GRCm39)	V105A	probably damaging	Het
Ros1	A	C	10: 51,996,991 (GRCm39)	F1227C	probably damaging	Het
Rrp12	A	T	19: 41,874,620 (GRCm39)	V342E	probably damaging	Het
Sart3	A	G	5: 113,901,004 (GRCm39)		probably benign	Het
Slc6a18	T	A	13: 73,816,281 (GRCm39)	K366M	probably damaging	Het
Smarca4	A	G	9: 21,546,999 (GRCm39)	N175D	probably damaging	Het
Sox14	T	C	9: 99,757,598 (GRCm39)	K47R	probably damaging	Het
Trcg1	A	T	9: 57,153,132 (GRCm39)	I592F	probably benign	Het
Ush2a	T	C	1: 188,596,900 (GRCm39)	M3880T	probably benign	Het
Usp20	T	C	2: 30,896,413 (GRCm39)	F172S	probably damaging	Het
Vmn2r4	C	T	3: 64,305,782 (GRCm39)		probably benign	Het

Other mutations in Lgalsl2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02060:Lgalsl2	APN	7	5,362,563 (GRCm39)	missense	probably damaging	0.99
R0771:Lgalsl2	UTSW	7	5,362,822 (GRCm39)	missense	probably damaging	1.00
R0906:Lgalsl2	UTSW	7	5,362,828 (GRCm39)	missense	probably damaging	0.99
R2018:Lgalsl2	UTSW	7	5,362,573 (GRCm39)	missense	probably benign	0.18
R2258:Lgalsl2	UTSW	7	5,362,401 (GRCm39)	missense	probably benign
R2519:Lgalsl2	UTSW	7	5,362,833 (GRCm39)	missense	probably damaging	1.00
R2865:Lgalsl2	UTSW	7	5,362,668 (GRCm39)	missense	probably benign	0.25
R5893:Lgalsl2	UTSW	7	5,362,623 (GRCm39)	missense	probably benign	0.00
R7485:Lgalsl2	UTSW	7	5,362,440 (GRCm39)	missense	probably benign	0.39
R7716:Lgalsl2	UTSW	7	5,362,819 (GRCm39)	missense	possibly damaging	0.56
R7836:Lgalsl2	UTSW	7	5,362,507 (GRCm39)	missense	probably damaging	1.00
R7898:Lgalsl2	UTSW	7	5,362,441 (GRCm39)	missense	probably benign	0.22
R8192:Lgalsl2	UTSW	7	5,362,595 (GRCm39)	missense	possibly damaging	0.77
R9324:Lgalsl2	UTSW	7	5,362,527 (GRCm39)	missense	possibly damaging	0.61

Posted On

2015-04-16