Incidental Mutation 'IGL02150:Or6b9'
ID 281948
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or6b9
Ensembl Gene ENSMUSG00000036647
Gene Name olfactory receptor family 6 subfamily B member 9
Synonyms MOR103-16, M50, GA_x6K02T2PBJ9-9337331-9336381, Olfr6
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # IGL02150
Quality Score
Status
Chromosome 7
Chromosomal Location 106555191-106556141 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 106555763 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Threonine at position 127 (P127T)
Ref Sequence ENSEMBL: ENSMUSP00000151272 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040983] [ENSMUST00000213552] [ENSMUST00000213651] [ENSMUST00000219365]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000040983
AA Change: P127T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000048740
Gene: ENSMUSG00000036647
AA Change: P127T

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 1.5e-58 PFAM
Pfam:7tm_1 39 288 3.5e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209125
Predicted Effect probably damaging
Transcript: ENSMUST00000213552
AA Change: P127T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000213651
AA Change: P127T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000219365
AA Change: P127T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankdd1a C T 9: 65,420,001 (GRCm39) G92S probably damaging Het
Arid1a A T 4: 133,414,568 (GRCm39) M1221K unknown Het
Arl10 G A 13: 54,726,662 (GRCm39) V147M probably damaging Het
Bbs4 T C 9: 59,243,651 (GRCm39) N152S probably benign Het
Cacna2d2 T G 9: 107,404,515 (GRCm39) probably benign Het
Capn9 A G 8: 125,340,582 (GRCm39) E582G probably benign Het
Cct2 A T 10: 116,898,004 (GRCm39) L61Q probably damaging Het
Clip4 A G 17: 72,106,071 (GRCm39) I85V probably damaging Het
Daam2 A T 17: 49,797,332 (GRCm39) L151Q possibly damaging Het
Dlst T A 12: 85,177,807 (GRCm39) I400N possibly damaging Het
Dock7 A T 4: 98,968,089 (GRCm39) probably benign Het
Dynlrb2 A G 8: 117,242,449 (GRCm39) N93S probably benign Het
Efl1 A G 7: 82,335,899 (GRCm39) T407A probably benign Het
Emilin1 A G 5: 31,077,517 (GRCm39) D891G possibly damaging Het
Enpp4 A C 17: 44,413,049 (GRCm39) S162A probably benign Het
Epas1 A G 17: 87,112,717 (GRCm39) D105G probably damaging Het
Fcgbpl1 T A 7: 27,846,204 (GRCm39) Y965* probably null Het
Gcn1 T A 5: 115,747,927 (GRCm39) I1778N probably damaging Het
Gm14496 A C 2: 181,633,140 (GRCm39) D41A probably damaging Het
Gm7008 T A 12: 40,273,257 (GRCm39) probably benign Het
Hcfc2 G A 10: 82,545,852 (GRCm39) S246N probably damaging Het
Hectd1 T C 12: 51,815,974 (GRCm39) N1366S probably damaging Het
Lgmn T C 12: 102,361,986 (GRCm39) R372G possibly damaging Het
Map2k7 A G 8: 4,293,818 (GRCm39) M153V possibly damaging Het
Megf8 T A 7: 25,045,842 (GRCm39) probably null Het
Mgat4c A C 10: 102,224,983 (GRCm39) E399A probably benign Het
Myorg A G 4: 41,499,183 (GRCm39) V149A possibly damaging Het
Nfat5 C T 8: 108,094,584 (GRCm39) Q942* probably null Het
Notch4 A G 17: 34,803,587 (GRCm39) E1502G probably damaging Het
Optn A C 2: 5,037,963 (GRCm39) I410M probably damaging Het
Or8c17 A T 9: 38,180,564 (GRCm39) I252L possibly damaging Het
Ppp1ca G A 19: 4,244,698 (GRCm39) probably benign Het
Pramel5 C A 4: 143,999,771 (GRCm39) L105F possibly damaging Het
Rad54b T A 4: 11,610,502 (GRCm39) N706K probably damaging Het
Rgs11 A T 17: 26,421,968 (GRCm39) T6S probably benign Het
Sbf1 T C 15: 89,179,683 (GRCm39) H1308R probably benign Het
Scart2 G A 7: 139,877,772 (GRCm39) G918D possibly damaging Het
Sec31a T C 5: 100,533,984 (GRCm39) probably benign Het
Sh2d5 G A 4: 137,985,553 (GRCm39) D334N probably benign Het
Skint5 T A 4: 113,742,988 (GRCm39) I360F unknown Het
Slc12a1 G A 2: 125,026,735 (GRCm39) D457N probably damaging Het
Slco2a1 C T 9: 102,962,017 (GRCm39) A563V probably damaging Het
Snrnp35 G A 5: 124,628,471 (GRCm39) A95T probably damaging Het
Snx25 C A 8: 46,569,318 (GRCm39) R193L possibly damaging Het
Stxbp5 T G 10: 9,638,565 (GRCm39) Q1078P probably damaging Het
Tmc2 A T 2: 130,082,073 (GRCm39) I419F probably damaging Het
Tmem87a A T 2: 120,190,557 (GRCm39) W525R probably damaging Het
Trhde A T 10: 114,428,013 (GRCm39) S428T probably damaging Het
Trp73 G A 4: 154,165,943 (GRCm39) A42V possibly damaging Het
Ttn T C 2: 76,679,316 (GRCm39) probably benign Het
Ttn C T 2: 76,598,846 (GRCm39) V19356M probably damaging Het
Vmn1r170 T A 7: 23,306,465 (GRCm39) L289* probably null Het
Vwa5b2 A T 16: 20,423,576 (GRCm39) Q1163L probably benign Het
Washc2 T A 6: 116,208,593 (GRCm39) probably benign Het
Wdr70 T G 15: 8,112,030 (GRCm39) K71T possibly damaging Het
Zbtb41 T C 1: 139,368,186 (GRCm39) S625P possibly damaging Het
Zfp518b A G 5: 38,830,686 (GRCm39) S440P probably damaging Het
Zfp518b A G 5: 38,831,132 (GRCm39) V291A probably damaging Het
Zmym2 G A 14: 57,148,526 (GRCm39) probably benign Het
Other mutations in Or6b9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01129:Or6b9 APN 7 106,555,634 (GRCm39) missense probably damaging 0.99
IGL02556:Or6b9 APN 7 106,555,598 (GRCm39) missense possibly damaging 0.82
R1550:Or6b9 UTSW 7 106,555,235 (GRCm39) missense probably benign
R1883:Or6b9 UTSW 7 106,555,981 (GRCm39) missense probably benign 0.42
R2069:Or6b9 UTSW 7 106,555,494 (GRCm39) nonsense probably null
R2250:Or6b9 UTSW 7 106,555,580 (GRCm39) missense probably benign 0.00
R2279:Or6b9 UTSW 7 106,555,834 (GRCm39) missense probably benign 0.00
R5283:Or6b9 UTSW 7 106,555,955 (GRCm39) missense probably benign 0.00
R9700:Or6b9 UTSW 7 106,555,630 (GRCm39) missense probably benign 0.12
R9733:Or6b9 UTSW 7 106,555,846 (GRCm39) missense possibly damaging 0.94
Posted On 2015-04-16