Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02152:Zscan18'

282039

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zscan18

Ensembl Gene

ENSMUSG00000070822

Gene Name

zinc finger and SCAN domain containing 18

Synonyms

EG232875

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.082) question?

Stock #

IGL02152

Quality Score

Status

Chromosome

Chromosomal Location

12768090-12803635 bp(-) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

A to T at 12775296 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046245] [ENSMUST00000210650] [ENSMUST00000211392]

AlphaFold

E9PUD6

Predicted Effect

unknown
Transcript: ENSMUST00000046245
AA Change: D92E

SMART Domains

Protein: ENSMUSP00000047088
Gene: ENSMUSG00000070822
AA Change: D92E

Domain	Start	End	E-Value	Type
low complexity region	10	21	N/A	INTRINSIC
low complexity region	30	45	N/A	INTRINSIC
low complexity region	72	102	N/A	INTRINSIC
low complexity region	118	132	N/A	INTRINSIC
low complexity region	134	154	N/A	INTRINSIC
internal_repeat_2	159	204	6.76e-5	PROSPERO
internal_repeat_1	197	221	2.66e-6	PROSPERO
low complexity region	225	256	N/A	INTRINSIC
low complexity region	262	310	N/A	INTRINSIC
low complexity region	312	335	N/A	INTRINSIC
internal_repeat_1	353	377	2.66e-6	PROSPERO
SCAN	397	509	1.16e-37	SMART
ZnF_C2H2	776	798	2.24e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000209869

Predicted Effect

unknown
Transcript: ENSMUST00000210650
AA Change: D92E

Predicted Effect

probably benign
Transcript: ENSMUST00000210891

Predicted Effect

unknown
Transcript: ENSMUST00000211392
AA Change: D92E

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000211665

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700016K19Rik	A	G	11: 76,003,225	I143V	probably benign	Het
1700028K03Rik	A	G	5: 107,548,117	T140A	probably benign	Het
4933430I17Rik	T	C	4: 62,542,754	Y289H	possibly damaging	Het
Adamts17	T	A	7: 67,125,000	S956T	probably benign	Het
Adamts6	A	T	13: 104,313,660	S290C	probably null	Het
Apaf1	A	T	10: 91,061,819	H267Q	probably benign	Het
Aplp2	G	A	9: 31,211,651	P26L	unknown	Het
Arid1b	C	T	17: 5,313,968	S1019F	probably damaging	Het
Armc3	G	A	2: 19,286,137		probably null	Het
Ass1	T	C	2: 31,492,324	I169T	probably damaging	Het
Ccser1	A	G	6: 61,311,708	D285G	possibly damaging	Het
Cenpf	A	G	1: 189,649,012	V2737A	probably benign	Het
Chrm5	A	G	2: 112,480,568	Y68H	probably damaging	Het
Cops4	A	G	5: 100,533,590	T164A	probably benign	Het
Cox4i1	A	G	8: 120,672,865	S72G	probably benign	Het
Cpox	A	G	16: 58,674,424	T275A	possibly damaging	Het
Cyb5a	T	C	18: 84,873,156	I68T	probably benign	Het
Efna5	T	C	17: 62,651,060	D67G	probably benign	Het
Enpp3	T	C	10: 24,774,002	E842G	probably damaging	Het
Fam208b	C	T	13: 3,585,371	E479K	probably benign	Het
Fam210b	A	G	2: 172,351,503	K79E	probably benign	Het
Gm17359	T	C	3: 79,345,532	I18T	possibly damaging	Het
Gm4799	T	C	10: 82,954,755		noncoding transcript	Het
Gpr146	A	T	5: 139,392,712	R90W	probably damaging	Het
Hal	A	G	10: 93,503,542	I498V	possibly damaging	Het
Hist1h2af	A	G	13: 23,534,281	H124R	probably benign	Het
Hnrnpm	C	T	17: 33,658,412	G365R	probably damaging	Het
Jakmip3	A	G	7: 139,025,488	D407G	probably damaging	Het
Kank1	A	G	19: 25,428,172	I1185V	possibly damaging	Het
Kcnj16	A	T	11: 111,025,210	M233L	probably benign	Het
Klhl5	A	T	5: 65,148,800	Q370L	probably damaging	Het
L3hypdh	C	T	12: 72,077,143		probably null	Het
Las1l	A	G	X: 95,953,302	V130A	probably damaging	Het
Lrp2bp	A	T	8: 46,023,044	Y274F	probably damaging	Het
Morc2b	T	A	17: 33,137,943	K285M	probably damaging	Het
Mpp3	A	T	11: 102,025,390	Y45*	probably null	Het
Muc4	T	A	16: 32,777,649		probably benign	Het
Muc5ac	T	C	7: 141,800,177	C837R	possibly damaging	Het
Mum1	A	G	10: 80,239,978	D466G	probably damaging	Het
Nr2f6	T	A	8: 71,376,166	I155F	probably damaging	Het
Nsg1	A	G	5: 38,144,801	F50L	probably benign	Het
Olfr304	T	A	7: 86,386,043	M206L	probably benign	Het
Ostf1	C	A	19: 18,590,458	G101C	probably damaging	Het
Pam	C	T	1: 97,840,749	R552Q	probably damaging	Het
Pkd1l3	A	G	8: 109,669,292	N2108S	probably damaging	Het
Prkdc	A	T	16: 15,669,285	H484L	probably benign	Het
Rfx5	G	A	3: 94,957,182	R213Q	probably damaging	Het
Ryr1	T	C	7: 29,052,015	S3715G	possibly damaging	Het
Sall2	A	G	14: 52,315,514	S73P	probably damaging	Het
Sec22c	G	A	9: 121,684,779	A264V	probably benign	Het
Sis	A	C	3: 72,888,986		probably benign	Het
Spam1	T	A	6: 24,800,803		probably benign	Het
St13	T	A	15: 81,366,382	I318F	probably damaging	Het
Syne1	T	C	10: 5,424,382	I142V	probably damaging	Het
Trpm6	A	T	19: 18,832,539	T1100S	possibly damaging	Het
Ttll6	G	A	11: 96,135,540	W90*	probably null	Het
Txndc12	T	A	4: 108,834,792	C9*	probably null	Het
Ubr7	C	T	12: 102,768,276	Q270*	probably null	Het
Vps33b	A	G	7: 80,285,069	S302G	probably benign	Het
Xylt1	T	A	7: 117,634,770	V508E	probably damaging	Het
Zbtb26	A	T	2: 37,436,691	L111Q	possibly damaging	Het
Zfp410	T	C	12: 84,332,928		probably benign	Het

Other mutations in Zscan18

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01930:Zscan18	APN	7	12775348	unclassified	probably benign
IGL02236:Zscan18	APN	7	12769324	missense	probably benign	0.02
IGL02591:Zscan18	APN	7	12775279	unclassified	probably benign
IGL02619:Zscan18	APN	7	12774866	unclassified	probably benign
IGL02711:Zscan18	APN	7	12775117	unclassified	probably benign
IGL03397:Zscan18	APN	7	12773561	missense	probably damaging	0.97
R0014:Zscan18	UTSW	7	12769417	missense	possibly damaging	0.48
R0465:Zscan18	UTSW	7	12775486	unclassified	probably benign
R0548:Zscan18	UTSW	7	12774176	missense	probably damaging	1.00
R1506:Zscan18	UTSW	7	12774202	missense	probably damaging	1.00
R1725:Zscan18	UTSW	7	12770857	missense	probably damaging	1.00
R2323:Zscan18	UTSW	7	12775459	unclassified	probably benign
R5034:Zscan18	UTSW	7	12774145	missense	probably damaging	1.00
R5180:Zscan18	UTSW	7	12775289	unclassified	probably benign
R5579:Zscan18	UTSW	7	12775381	unclassified	probably benign
R5635:Zscan18	UTSW	7	12770864	missense	probably benign	0.00
R5708:Zscan18	UTSW	7	12774456	missense	probably benign	0.01
R6088:Zscan18	UTSW	7	12775198	unclassified	probably benign
R6320:Zscan18	UTSW	7	12775220	unclassified	probably benign
R7048:Zscan18	UTSW	7	12774744	unclassified	probably benign
R7610:Zscan18	UTSW	7	12769310	missense	probably damaging	0.98
R7683:Zscan18	UTSW	7	12769605	nonsense	probably null
R8287:Zscan18	UTSW	7	12775371	missense	unknown
R8674:Zscan18	UTSW	7	12770900	splice site	probably benign
R8735:Zscan18	UTSW	7	12769698	missense	probably benign	0.16
R8928:Zscan18	UTSW	7	12775193	nonsense	probably null
R9290:Zscan18	UTSW	7	12774127	missense	probably damaging	0.99
R9342:Zscan18	UTSW	7	12771685	missense	probably damaging	1.00
R9471:Zscan18	UTSW	7	12774416	missense	possibly damaging	0.70
RF055:Zscan18	UTSW	7	12774425	small deletion	probably benign
Z1088:Zscan18	UTSW	7	12775067	missense	probably benign	0.18
Z1088:Zscan18	UTSW	7	12775093	unclassified	probably benign

Posted On

2015-04-16