Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02152:Gpr146'

282056

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr146

Ensembl Gene

ENSMUSG00000044197

Gene Name

G protein-coupled receptor 146

Synonyms

PGR8

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02152

Quality Score

Status

Chromosome

Chromosomal Location

139377697-139396415 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 139392712 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Tryptophan at position 90 (R90W)

Ref Sequence

ENSEMBL: ENSMUSP00000098083 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000051293] [ENSMUST00000066052] [ENSMUST00000100514] [ENSMUST00000138631] [ENSMUST00000198474]

AlphaFold

Q99LE2

Predicted Effect

probably damaging
Transcript: ENSMUST00000051293
AA Change: R90W

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000049707
Gene: ENSMUSG00000044197
AA Change: R90W

Domain	Start	End	E-Value	Type
low complexity region	21	36	N/A	INTRINSIC
Pfam:7tm_1	43	294	2e-16	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000066052

SMART Domains

Protein: ENSMUSP00000069230
Gene: ENSMUSG00000053553

Domain	Start	End	E-Value	Type
low complexity region	54	77	N/A	INTRINSIC
Pfam:DUF2373	103	165	3e-26	PFAM
low complexity region	184	194	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000100514
AA Change: R90W

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000098083
Gene: ENSMUSG00000044197
AA Change: R90W

Domain	Start	End	E-Value	Type
low complexity region	21	36	N/A	INTRINSIC
Pfam:7tm_1	43	294	1.6e-13	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000138631
AA Change: R90W

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000119464
Gene: ENSMUSG00000044197
AA Change: R90W

Domain	Start	End	E-Value	Type
SCOP:d1l9ha_	26	80	3e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000196267

Predicted Effect

probably benign
Transcript: ENSMUST00000198474

SMART Domains

Protein: ENSMUSP00000142949
Gene: ENSMUSG00000053553

Domain	Start	End	E-Value	Type
low complexity region	54	77	N/A	INTRINSIC
Pfam:DUF2373	102	141	9e-12	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700016K19Rik	A	G	11: 76,003,225	I143V	probably benign	Het
1700028K03Rik	A	G	5: 107,548,117	T140A	probably benign	Het
4933430I17Rik	T	C	4: 62,542,754	Y289H	possibly damaging	Het
Adamts17	T	A	7: 67,125,000	S956T	probably benign	Het
Adamts6	A	T	13: 104,313,660	S290C	probably null	Het
Apaf1	A	T	10: 91,061,819	H267Q	probably benign	Het
Aplp2	G	A	9: 31,211,651	P26L	unknown	Het
Arid1b	C	T	17: 5,313,968	S1019F	probably damaging	Het
Armc3	G	A	2: 19,286,137		probably null	Het
Ass1	T	C	2: 31,492,324	I169T	probably damaging	Het
Ccser1	A	G	6: 61,311,708	D285G	possibly damaging	Het
Cenpf	A	G	1: 189,649,012	V2737A	probably benign	Het
Chrm5	A	G	2: 112,480,568	Y68H	probably damaging	Het
Cops4	A	G	5: 100,533,590	T164A	probably benign	Het
Cox4i1	A	G	8: 120,672,865	S72G	probably benign	Het
Cpox	A	G	16: 58,674,424	T275A	possibly damaging	Het
Cyb5a	T	C	18: 84,873,156	I68T	probably benign	Het
Efna5	T	C	17: 62,651,060	D67G	probably benign	Het
Enpp3	T	C	10: 24,774,002	E842G	probably damaging	Het
Fam208b	C	T	13: 3,585,371	E479K	probably benign	Het
Fam210b	A	G	2: 172,351,503	K79E	probably benign	Het
Gm17359	T	C	3: 79,345,532	I18T	possibly damaging	Het
Gm4799	T	C	10: 82,954,755		noncoding transcript	Het
Hal	A	G	10: 93,503,542	I498V	possibly damaging	Het
Hist1h2af	A	G	13: 23,534,281	H124R	probably benign	Het
Hnrnpm	C	T	17: 33,658,412	G365R	probably damaging	Het
Jakmip3	A	G	7: 139,025,488	D407G	probably damaging	Het
Kank1	A	G	19: 25,428,172	I1185V	possibly damaging	Het
Kcnj16	A	T	11: 111,025,210	M233L	probably benign	Het
Klhl5	A	T	5: 65,148,800	Q370L	probably damaging	Het
L3hypdh	C	T	12: 72,077,143		probably null	Het
Las1l	A	G	X: 95,953,302	V130A	probably damaging	Het
Lrp2bp	A	T	8: 46,023,044	Y274F	probably damaging	Het
Morc2b	T	A	17: 33,137,943	K285M	probably damaging	Het
Mpp3	A	T	11: 102,025,390	Y45*	probably null	Het
Muc4	T	A	16: 32,777,649		probably benign	Het
Muc5ac	T	C	7: 141,800,177	C837R	possibly damaging	Het
Mum1	A	G	10: 80,239,978	D466G	probably damaging	Het
Nr2f6	T	A	8: 71,376,166	I155F	probably damaging	Het
Nsg1	A	G	5: 38,144,801	F50L	probably benign	Het
Olfr304	T	A	7: 86,386,043	M206L	probably benign	Het
Ostf1	C	A	19: 18,590,458	G101C	probably damaging	Het
Pam	C	T	1: 97,840,749	R552Q	probably damaging	Het
Pkd1l3	A	G	8: 109,669,292	N2108S	probably damaging	Het
Prkdc	A	T	16: 15,669,285	H484L	probably benign	Het
Rfx5	G	A	3: 94,957,182	R213Q	probably damaging	Het
Ryr1	T	C	7: 29,052,015	S3715G	possibly damaging	Het
Sall2	A	G	14: 52,315,514	S73P	probably damaging	Het
Sec22c	G	A	9: 121,684,779	A264V	probably benign	Het
Sis	A	C	3: 72,888,986		probably benign	Het
Spam1	T	A	6: 24,800,803		probably benign	Het
St13	T	A	15: 81,366,382	I318F	probably damaging	Het
Syne1	T	C	10: 5,424,382	I142V	probably damaging	Het
Trpm6	A	T	19: 18,832,539	T1100S	possibly damaging	Het
Ttll6	G	A	11: 96,135,540	W90*	probably null	Het
Txndc12	T	A	4: 108,834,792	C9*	probably null	Het
Ubr7	C	T	12: 102,768,276	Q270*	probably null	Het
Vps33b	A	G	7: 80,285,069	S302G	probably benign	Het
Xylt1	T	A	7: 117,634,770	V508E	probably damaging	Het
Zbtb26	A	T	2: 37,436,691	L111Q	possibly damaging	Het
Zfp410	T	C	12: 84,332,928		probably benign	Het
Zscan18	A	T	7: 12,775,296		probably benign	Het

Other mutations in Gpr146

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01355:Gpr146	APN	5	139378904	intron	probably benign
IGL02369:Gpr146	APN	5	139392688	missense	probably benign	0.00
IGL02392:Gpr146	APN	5	139392778	missense	probably damaging	0.99
IGL02828:Gpr146	APN	5	139392821	missense	probably damaging	0.97
IGL03095:Gpr146	APN	5	139392950	missense	probably benign	0.11
R0360:Gpr146	UTSW	5	139379178	intron	probably benign
R0364:Gpr146	UTSW	5	139379178	intron	probably benign
R0746:Gpr146	UTSW	5	139393222	missense	probably damaging	1.00
R1446:Gpr146	UTSW	5	139393422	missense	probably benign	0.00
R1507:Gpr146	UTSW	5	139393369	missense	probably benign
R1758:Gpr146	UTSW	5	139393382	missense	probably benign	0.34
R2032:Gpr146	UTSW	5	139379147	intron	probably benign
R6513:Gpr146	UTSW	5	139392818	missense	probably damaging	1.00
R6797:Gpr146	UTSW	5	139393040	missense	possibly damaging	0.79
R7830:Gpr146	UTSW	5	139392602	missense	probably benign	0.02
R7977:Gpr146	UTSW	5	139392685	missense	possibly damaging	0.53
R7987:Gpr146	UTSW	5	139392685	missense	possibly damaging	0.53
R8225:Gpr146	UTSW	5	139392616	missense	probably benign	0.03
R8792:Gpr146	UTSW	5	139392794	missense	probably damaging	1.00
R9354:Gpr146	UTSW	5	139392611	missense	probably benign	0.00
X0064:Gpr146	UTSW	5	139378909	intron	probably benign

Posted On

2015-04-16