Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02153:Tas2r126'

282106

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r126

Ensembl Gene

ENSMUSG00000048284

Gene Name

taste receptor, type 2, member 126

Synonyms

mGR26, T2R26, mt2r35, T2R12, Tas2r26

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

IGL02153

Quality Score

Status

Chromosome

Chromosomal Location

42411469-42412395 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 42411598 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Alanine at position 44 (S44A)

Ref Sequence

ENSEMBL: ENSMUSP00000056581 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000059534]

AlphaFold

P59532

Predicted Effect

probably benign
Transcript: ENSMUST00000059534
AA Change: S44A

PolyPhen 2 Score 0.321 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000056581
Gene: ENSMUSG00000048284
AA Change: S44A

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	303	2.5e-97	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
6820408C15Rik	T	C	2: 152,283,161 (GRCm39)	I275T	probably benign	Het
Chd9	A	T	8: 91,683,122 (GRCm39)	K521*	probably null	Het
Csn3	A	T	5: 88,077,956 (GRCm39)	N154I	possibly damaging	Het
Dock2	A	G	11: 34,180,670 (GRCm39)	S1716P	probably benign	Het
Dock7	A	T	4: 98,846,304 (GRCm39)	S18T	probably benign	Het
Esrra	G	A	19: 6,891,190 (GRCm39)	T190I	probably benign	Het
F13b	T	C	1: 139,444,115 (GRCm39)	I483T	probably damaging	Het
Foxb1	T	A	9: 69,666,985 (GRCm39)	M182L	probably benign	Het
Fsip2	T	C	2: 82,809,065 (GRCm39)	F1795L	probably benign	Het
Gkn2	G	A	6: 87,350,390 (GRCm39)		probably null	Het
Gm8439	G	A	4: 120,466,787 (GRCm39)	A93T	unknown	Het
Ift22	T	C	5: 136,940,550 (GRCm39)	S72P	probably benign	Het
Kcnmb2	A	G	3: 32,232,993 (GRCm39)	K24E	probably damaging	Het
Kcnq3	C	A	15: 65,897,040 (GRCm39)	V287L	probably damaging	Het
Lrriq1	T	A	10: 103,006,340 (GRCm39)	M1262L	probably benign	Het
Mb21d2	A	G	16: 28,748,240 (GRCm39)	I59T	probably benign	Het
Mogat2	A	T	7: 98,872,761 (GRCm39)	M141K	possibly damaging	Het
Mtdh	C	T	15: 34,131,396 (GRCm39)	L409F	possibly damaging	Het
Muc5ac	C	T	7: 141,372,537 (GRCm39)	Q2724*	probably null	Het
Myo15a	T	G	11: 60,389,223 (GRCm39)	L2040R	probably damaging	Het
Nodal	C	T	10: 61,260,324 (GRCm39)	T325I	probably damaging	Het
Pappa	A	T	4: 65,215,674 (GRCm39)	T1194S	probably damaging	Het
Pcdhb13	A	C	18: 37,576,738 (GRCm39)	D372A	probably damaging	Het
Phf14	T	A	6: 11,934,015 (GRCm39)	N292K	probably damaging	Het
Pigr	T	A	1: 130,776,793 (GRCm39)		probably null	Het
Plcb1	T	C	2: 135,229,773 (GRCm39)	I1131T	probably benign	Het
Plch1	T	A	3: 63,688,772 (GRCm39)	D132V	probably damaging	Het
Plxnb2	C	A	15: 89,050,016 (GRCm39)	E502*	probably null	Het
Prox2	T	C	12: 85,134,703 (GRCm39)	N526S	probably damaging	Het
Rdm1	T	A	11: 101,519,280 (GRCm39)		probably null	Het
Rxfp1	C	T	3: 79,567,427 (GRCm39)	E308K	probably benign	Het
Sgca	T	C	11: 94,854,110 (GRCm39)	T120A	probably damaging	Het
Sh3tc1	G	A	5: 35,860,696 (GRCm39)	R1054W	probably damaging	Het
Smarcal1	C	T	1: 72,672,214 (GRCm39)		probably benign	Het
Spata45	T	A	1: 190,771,958 (GRCm39)	M60K	probably benign	Het
St8sia6	T	C	2: 13,661,716 (GRCm39)	M372V	probably damaging	Het
Tcea3	T	A	4: 136,000,945 (GRCm39)		probably benign	Het
Thoc2l	A	G	5: 104,668,949 (GRCm39)	E1157G	probably benign	Het
Tln1	T	C	4: 43,546,857 (GRCm39)	I840V	possibly damaging	Het
Ttn	T	C	2: 76,728,685 (GRCm39)		probably benign	Het
Ubr4	T	A	4: 139,187,471 (GRCm39)	Y3846*	probably null	Het
Usp47	G	A	7: 111,703,256 (GRCm39)	D1171N	probably benign	Het
Vmn2r114	G	A	17: 23,510,782 (GRCm39)	T566I	probably benign	Het
Wdr35	G	A	12: 9,058,535 (GRCm39)	R575Q	probably null	Het
Xkr5	A	T	8: 18,983,683 (GRCm39)	C454S	probably benign	Het

Other mutations in Tas2r126

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00915:Tas2r126	APN	6	42,412,283 (GRCm39)	missense	possibly damaging	0.67
IGL01327:Tas2r126	APN	6	42,411,684 (GRCm39)	missense	probably benign	0.09
IGL01690:Tas2r126	APN	6	42,412,241 (GRCm39)	missense	probably benign	0.02
IGL02291:Tas2r126	APN	6	42,412,221 (GRCm39)	missense	probably benign	0.00
IGL03365:Tas2r126	APN	6	42,412,391 (GRCm39)	missense	probably benign	0.36
R0091:Tas2r126	UTSW	6	42,412,036 (GRCm39)	missense	probably benign
R0486:Tas2r126	UTSW	6	42,412,225 (GRCm39)	missense	probably benign	0.01
R0611:Tas2r126	UTSW	6	42,412,025 (GRCm39)	missense	probably damaging	0.99
R1527:Tas2r126	UTSW	6	42,412,070 (GRCm39)	missense	probably benign	0.03
R1529:Tas2r126	UTSW	6	42,411,502 (GRCm39)	missense	probably benign	0.00
R1883:Tas2r126	UTSW	6	42,411,961 (GRCm39)	missense	probably benign
R1884:Tas2r126	UTSW	6	42,411,961 (GRCm39)	missense	probably benign
R2039:Tas2r126	UTSW	6	42,411,557 (GRCm39)	missense	probably benign	0.22
R4863:Tas2r126	UTSW	6	42,412,324 (GRCm39)	missense	probably benign	0.02
R5975:Tas2r126	UTSW	6	42,411,934 (GRCm39)	missense	possibly damaging	0.69
R7127:Tas2r126	UTSW	6	42,411,739 (GRCm39)	missense	probably damaging	1.00
R7351:Tas2r126	UTSW	6	42,412,240 (GRCm39)	missense	probably benign	0.02
R7714:Tas2r126	UTSW	6	42,412,031 (GRCm39)	missense	probably benign	0.12
R9154:Tas2r126	UTSW	6	42,412,174 (GRCm39)	missense	probably benign	0.25
R9336:Tas2r126	UTSW	6	42,411,877 (GRCm39)	missense	probably benign	0.45
R9516:Tas2r126	UTSW	6	42,412,307 (GRCm39)	missense	probably null	0.98
R9722:Tas2r126	UTSW	6	42,412,082 (GRCm39)	missense	possibly damaging	0.78

Posted On

2015-04-16